1. Articles from Gisèle Soubrane

    1-16 of 16
    1. SD-OCT stages of progression of type 2 macular telangiectasia in a patient followed for 3 years

      SD-OCT stages of progression of type 2 macular telangiectasia in a patient followed for 3 years

      Purpose: To describe the natural course of type 2 idiopathic macular telangiectasia (MT) using spectral-domain optical coherence tomography (SD-OCT). Methods: Analysis of the different stages of progression of type 2 MT during a period of 3 years using multimodal imaging, including SD-OCT correlated with angiographic and autofluorescence images. The analysis of the different steps was obtained initially from the first eye, then successively from the fellow eye when progressive changes appeared. Results: The earliest visible alteration at SD-OCT was the interruption of the interface between inner segment and ellipsoid (IS/EL) (stage 1). The second stage was characterized by the ...

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    2. Macular edema in central retinal vein occlusion: correlation between optical coherence tomography, angiography and visual acuity

      Macular edema in central retinal vein occlusion: correlation between optical coherence tomography, angiography and visual acuity

      Abstract  To analyze the characteristics and the course of macular edema secondary to central retinal vein occlusion (CRVO) using optical coherence tomography (OCT) and to determine correlations between clinical, tomographic and angiographic data, in particular including retinal ischemia. In this retrospective study, 53 consecutive patients with CRVO were included. At each follow-up visit, patients underwent complete ophthalmological examination, including best-corrected visual acuity (BCVA) and OCT. Fluorescein angiography was performed at baseline and on demand during follow-up. 243 OCTs were analyzed. Mean age was 61 years and mean follow-up 13 months. The first structural change, observed very early after the onset ...

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    3. Optical coherence tomography in tadalafil-associated retinal toxicity

      Optical coherence tomography in tadalafil-associated retinal toxicity

      Purpose. Tadalafil (Cialis) is a potent phosphodiesterase type 5 inhibitor that is widely used to treat erectile dysfunction. Phosphodiesterase-5 inhibitors have long been recognized to cause temporary and minor visual changes. Methods. We report for the first time a case of visual disturbances due to reversible damage to the parafoveal photoreceptors following the use of tadalafil. The patient was examined using confocal scanning laser ophthalmoscopy combined with spectral domain optical coherence tomography (OCT). Results. Spectral domain OCT of the right eye revealed a hyperreflective dense area and the appearance of a serous retinal detachment (SRD). The photoreceptors’ internal segment–outer ...

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    4. Insights into pathology of cuticular drusen from integrated confocal scanning laser ophthalmoscopy imaging and corresponding spectral domain optical coherence tomography

      Insights into pathology of cuticular drusen from integrated confocal scanning laser ophthalmoscopy imaging and corresponding spectral domain optical coherence tomography

      Background To analyze the integrated confocal scanning laser ophthalmoscopy (cSLO) fundus and angiographic imaging and corresponding spectral domain optical coherence tomography (SD-OCT) features of cuticular drusen. Methods Twenty-one consecutive patients with cuticular drusen were submitted to cSLO fundus and angiographic imaging [infrared reflectance (IR), fundus autofluorescence (FAF), near-infrared autofluorescence (NIA), fluorescein angiography (FA), and indocyanine green angiography (ICGA)) and “eye-tracked” SD-OCT. Results A total of 42 eyes were included for analysis. BCVA ranged from 20/20 to 20/400. In 5/42 eyes, cSLO imaging and corresponding SD-OCT showed coincident vitelliform macular detachment, and in 9/42 eyes showed coincident ...

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    5. Spectral-Domain versus Time Domain Optical Coherence Tomography before and after Ranibizumab for Age-Related Macular Degeneration

      Spectral-Domain versus Time Domain Optical Coherence Tomography before and after Ranibizumab for Age-Related Macular Degeneration

      Purpose: To study the ability to appreciate qualitative features that indicate disease activity in patients with neovascular age-related macular degeneration (AMD) and to analyze the differences in automated retinal thickness measurement, using 1 time domain optical coherence tomography (TD-OCT) and 2 different spectral-domain OCT (SD-OCT) machines. Methods: Thirty-three consecutive naïve patients with neovascular AMD underwent Stratus TD-OCT, Cirrus SD-OCT and Spectralis SD-OCT, at baseline, 1 h, 1 day, 1 week and 1 month after intravitreal ranibizumab injection. Results: As regards the ability to detect retinal cysts, subretinal fluid and pigment epithelium detachment, at each follow-up visit, there was a significant ...

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    6. Polypoidal choroidal vasculopathy and macroaneurysm: respective roles of scanning laser ophthalmoscopy-indocyanine green angiography and optical coherence tomography

      Polypoidal choroidal vasculopathy and macroaneurysm: respective roles of scanning laser ophthalmoscopy-indocyanine green angiography and optical coherence tomography
      Purpose. To report on a patient with exudative age-related macular degeneration, polypoidal choroidal vasculopathy, and macroaneurysm. Methods. Scanning laser ophthalmoscopy (SLO)-indocyanine green angiography (ICGA) demonstrated the coexistence of several lesions in the same patient. Optical coherence tomography (OCT) combined with ICGA defined the nature of the lesions and the severity of the exudative phenomena. Results. The eye tracking system ensured precise follow-up of the course of the lesions on both ICGA and spectral domain (SD) OCT. Image correlation provided a precise diagnosis, defining the indications for local and systemic therapy. Conclusions. In this patient with multiple lesions, only correlation ...
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    7. Angiographic Analysis of Retinal-Choroidal Anastomosis By Confocal Scanning Laser Ophthalmoscopy Technology and Corresponding (Eye-Tracked) Spectral-Domain Optical Coherence Tomography

      Purpose: The purpose of this study was to analyze the angiographic (confocal scanning laser ophthalmoscopy technology) and corresponding (eye-tracked) spectral-domain optical coherence tomography (SD-OCT) features and to propose a classification for the progressive phases establishing retinal-choroidal anastomosis (RCA).Methods: We reviewed all consecutive eyes with RCA that underwent Heidelberg Retina Angiograph angiography and tracked Spectralis SD-OCT at the University Eye Clinic of Creteil between September 2007 and March 2009.Results: Twenty-six eyes of 23 patients (8 men and 15 women, aged 70-88 years) showing RCA naive to any treatment were included for analysis. In 6 of 7 eyes showing a ...

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    8. In vivo visualization of photoreceptor layer and lipofuscin accumulation in Stargardt’s disease and fundus flavimaculatus by high resolution spectral-domain optical coherence tomography

      In vivo visualization of photoreceptor layer and lipofuscin accumulation in Stargardt’s disease and fundus flavimaculatus by high resolution spectral-domain optical coherence tomography

      Introduction: To assess photoreceptor (PR) layer morphology in patients with Stargardt’s disease (STGD) and fundus flavimaculatus (FFM) using high resolution spectral domain optical coherence tomography (HD-OCT; OCT 4000 Cirrus, Humphrey-Zeiss, San Leandro, CA).Methods: This was a prospective observational case series. Sixteen consecutive patients with STGD and FFM underwent a complete ophthalmologic examination. Optical coherence tomography examination was performed with HD-OCT, a high-speed (27,000 axial scans per second) OCT system using spectral/Fourier domain detection, with an axial image resolution of 5 µm.Results: A total of 31 eyes were included in the study. Transverse loss of the ...

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    9. Optical Coherence Tomography Features Of X-Linked Choroideremia.

      Purpose: To describe the optical coherence tomography (OCT) features of X-linked choroideremia (CHM). Design: Prospective, observational case series. Patients and Methods: Color fundus photography, fluorescein angiography, indocyanine green angiography, and OCT were performed for four patients (eight eyes) with CHM. Results: In areas of angiographic choriocapillaris loss, OCT revealed retinal thinning (mean, 124 μm [range, 97-150 μm) and increased reflectivity of the choroid. On the contrary, in areas of preserved choriocapillaris, retinal thickness was within normal limits (mean, 256 μm [range, 238-284 μm]; P < 0.001). Conclusion: OCT revealed a correlation between retinal thickness and choriocapillaris preservation in CHM.Intravitreal injection of triamcinolone acetonide might temporarily improve visual acuity in eyes with cystoid foveal edema associated with Coats disease.

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    10. High-resolution Spectral Domain Optical Coherence Tomography Findings in Multifocal Vitelliform Macular Dystrophy

      Abstract: We describe the abnormalities seen in the mid periphery and posterior pole of two patients with multifocal vitelliform macular distrophy as evaluated by high-definition spectral domain optical coherence tomography (HD-OCT). In patient 1, HD-OCT scans revealed, in the central area, a thicker and more reflective layer compared with the normal macula, located between the retinal pigment epitelium and the interface of the inner segment /outer segment, corresponding to the Verhoeff‘s membrane. Moreover, HD-OCT macular scans, as well as C-scans, revealed a slight hyper-reflective lesion just above an area of reduced reflectivity between the photoreceptor layer (interface of the ...

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    11. Infrared features of classic choroidal neovascularisation in exudative age-related macular degeneration

      Aim: Wet age-related macular degeneration (AMD) represents a heterogeneous group of phenotypes, all defined by fluorescein angiography features (FA). Imaging of wet AMD is extensively described in literature, including colour pictures, FA, indocyanine green angiography (ICG) and optical coherence tomography (OCT). The purpose of this study was to describe features of infrared (IR) pictures of a homogeneous subgroup of classic choroidal neovascularisation (CNV) associated with wet AMD, Methods: We analysed 22 eyes of 22 consecutive patients with classic CNV. All patients underwent a complete ophthalmological examination including colour fundus photography, infrared picture, fluorescein angiography, indocyanine green angiography and an optical ...
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    12. Infrared features of classic choroidal neovascularization in exudative age related macular degeneration

      Aim: Wet age-related macular degeneration (AMD) represents a heterogeneous group of phenotypes, all defined by fluorescein angiography features (FA). Imaging of wet AMD is extensively described in literature, including color pictures, FA, indocyanine green angiography (ICG) and optical coherent tomography (OCT). The purpose of this study was to describe features of infrared (IR) pictures of a homogeneous subgroup of classic choroidal neovascularization (CNV) associated with wet AMD. Methods: We analyzed 22 eyes of 22 consecutive patients with classic CNV. All patients underwent a complete ophthalmologic examination including color fundus photography, infrared picture, fluorescein angiography, indocyanine green angiography and an optical ...
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    13. High-Definition Optical Coherence Tomography Features in Vitelliform Macular Dystrophy

      Purpose: To correlate high-definition optical coherence tomography (HD OCT) and fundus examination findings at different phases of vitelliform macular dystrophy and to determine the anatomic location of vitelliform material.Design: Prospective, noncomparative, observational case series.Methods: A complete ophthalmologic examination, including fundus biomicroscopy and HD OCT, was performed in 11 consecutive patients with a diagnosis of vitelliform macular dystrophy.Results: Using HD OCT, we were able to demonstrate for the first time the presence of previtelliform lesions, characterized by a thicker layer between the retinal pigment epithelium (RPE) and the inner segment and outer segment (IS/OS) interface. At this ...

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    14. Confocal (En Face) Optical Coherence Tomography In Vascularized Retinal Pigment Epithelium Detachment.

      The authors describe the relationship between pigment epithelial detachment (PED) and choroidal neovascularization (CNV) by overlay of en face optical coherence tomography (OCT) and indocyanine green (ICG) angiography/scanning laser ophthalmoscopy (SLO) images in a 75-year-old patient with age-related macular degeneration who presented with reduced vision.Page: 94DOI: 10.1097/ICB.0b013e31804576a9Authors: Coscas, Florence M. MD *+; Coscas, Gabriel J. MD *+; Souied, Eric H. MD, PhD *; Soubrane, Gisele MD, PhD *
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    15. Correlation of visual function impairment and OCT findings in patients with Stargardt disease and fundus flavimaculatus.

      PURPOSE. To investigate the relationship between morphologic lesions of the retina and functional abnormalities in patients with Stargardt disease (STGD) and fundus flavimaculatus (FFM). DESIGN. Case-controlled, prospective, comparative observational study. METHODS. A complete ophthalmologic examination, including best-corrected visual acuity (BCVA) and optical coherence tomography (OCT), was performed in 61 eyes of 32 consecutive patients with STGD/FFM and in 60 eyes of 30 matched healthy control subjects. Furthermore, fundus-related perimetry was performed in 12 of the affected eyes. RESULTS. The age ranged from 21 to 71 years in STGD/FFM patients and from 21 to 72 years in controls. BCVA ...

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    16. Technology needs for tomorrow's treatment and diagnosis of macular diseases

      Gisele Soubrane Retinal imaging is the basis of macular disease's diagnosis. Currently available technologies in clinical practice are fluorescein and indocyanin green (ICG) angiographies, in addition to optical coherence tomography (OCT), which is an in vivo "histology-like" cross-sectional images of the retina. R ... [Proc. SPIE Int. Soc. Opt. Eng. 6844, 68440F (2008)] published Mon Feb 11, 2008.
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    1-16 of 16
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    1. (16 articles) Centre Hospitalier Intercommunal de Créteil
    2. (16 articles) Gisèle Soubrane
    3. (14 articles) Eric H. Souied
    4. (10 articles) Gabriel J. Coscas
    5. (8 articles) Giuseppe Querques
    6. (3 articles) University of Foggia
    7. (2 articles) Francesco Bandello
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    In vivo visualization of photoreceptor layer and lipofuscin accumulation in Stargardt’s disease and fundus flavimaculatus by high resolution spectral-domain optical coherence tomography Polypoidal choroidal vasculopathy and macroaneurysm: respective roles of scanning laser ophthalmoscopy-indocyanine green angiography and optical coherence tomography Spectral-Domain versus Time Domain Optical Coherence Tomography before and after Ranibizumab for Age-Related Macular Degeneration Insights into pathology of cuticular drusen from integrated confocal scanning laser ophthalmoscopy imaging and corresponding spectral domain optical coherence tomography Spectral Domain Optical Coherence Tomography Imaging Performance Improvement Based on Field Curvature Aberration-Corrected Spectrometer Pentosan polysulfate maculopathy versus inherited macular dystrophies: comparative assessment with multimodal imaging Complementary Use of Active Infrared Thermography and Optical Coherent Tomography in Non-destructive Testing Inspection of Ancient Marquetries Spectral domain optical coherence tomography–based prevalence of hydroxychloroquine maculopathy in Indian patients on hydroxychloroquine therapy: A utopia of underdiagnosis Consistency Between Optical Coherence Tomography and Humphrey Visual Field for Evaluating Glaucomatous Defects in High Myopic Eyes Tethered capsule en face optical coherence tomography for imaging Barrett’s esophagus in unsedated patients Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography Interobserver reproducibility and interocular symmetry of the macular ganglion cell complex: assessment in healthy children using optical coherence tomography