Validation of a deep learning-based algorithm for segmentation of the ellipsoid zone on optical coherence tomography images of an USH2A-related retinal degeneration clinical trial

Purpose: To assess the generalizability of a deep learning-based algorithm to segment the ellipsoid zone (EZ). Methods: The dataset consisted of 127 spectral-domain optical coherence tomography volumes from eyes of participants with USH2A-related retinal degeneration enrolled in the RUSH2A clinical trial ( NCT03146078 ). The EZ was segmented manually by trained Readers and automatically by DOCTAD, a deep learning-based algorithm originally developed for macular telangiectasia type 2. Performance was evaluated using the Dice similarity coefficient (DSC) between the segmentations, and the absolute difference and Pearson's correlation of measurements of interest obtained from the segmentations. Results: With DOCTAD, the average (mean ± SD ...