COMPARISON OF SINGLE DRUSEN SIZE ON COLOR FUNDUS PHOTOGRAPHY AND SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY

Purpose: To determine the relationship of drusen size as determined by spectral domain optical coherence tomography ( SD-OCT ), with that measured on registered Color fundus photography (CFP) images, to derive an OCT-based classification system that was comparable to that determined by CFP. Methods: Custom software was developed to register CFP images to the scanning laser ophthalmoscopy fundus images obtained simultaneously with the corresponding SD-OCT images, so that individual drusen observed on CFP could be matched with those seen on SD-OCT . Single druse size (diameter, area, volume, height) on CFP and SD-OCT images from a phase 2 clinical trial was determined with ...