1. Articles from Shuliang Jiao

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    1. Optical coherence tomography for whole eye segment imaging

      Optical coherence tomography for whole eye segment imaging

      We proposed a dual focus dual channel spectral domain optical coherence tomography (SD-OCT) for simultaneous imaging of the whole eye segments from cornea to the retina. By using dual channels the system solved the problem of limited imaging depth of SD-OCT. By using dual focus the system solved the problem of simultaneous light focusing on the anterior segment of the eye and the retina. Dual focusing was achieved by adjusting the collimating lenses so the divergence of the two probing beams was tuned to make them focused at different depth in the eye. We further achieved full range complex (FRC ...

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    2. Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

      Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

      The ultimate goal of the study is to provide an imaging tool to detect the earliest signs of glaucoma before clinically visible damage occurs to the retinal nerve fiber layer (RNFL). Studies have shown that the optical reflectance of the damaged RNFL at short wavelength ( reduced much more than that at long wavelength, which provides spectral contrasts for imaging the earliest damage to the RNFL. To image the spectral contrasts we built a dual-band spectral-domain optical coherence tomography (SD-OCT) with centered wavelength of 415nm (VIS) and 808nm (NIR), respectively. The light at the two bands was provided by the fundamental ...

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    3. Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

      Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

      The ultimate goal of the study is to provide an imaging tool to detect the earliest signs of glaucoma before clinically visible damage occurs to the retinal nerve fiber layer (RNFL). Studies have shown that the optical reflectance of the damaged RNFL at short wavelength (<560nm) is reduced much more than that at long wavelength, which provides spectral contrast for imaging the earliest damage to the RNFL. To image the spectral contrast we built a dual-band spectral-domain optical coherence tomography (SD-OCT) centered at 808nm (NIR) and 415nm (VIS). The light at the two bands was provided by the fundamental and frequency-doubled outputs of a broadband Ti:Sapphire laser. The depth resolution of the NIR and VIS OCT systems are 4.7µm and 12.2µm in the air, respectively. The system was applied to imaging the rat retina in vivo. Significantly different appearances between the OCT cross sectional images at the two bands were observed. The ratio of the light reflected from the RNFL over that reflected from the entire retina at the two bands were quantitatively compared. The experimental results showed that the dual-band OCT system is feasible for imaging the spectral contrasts of the RNFL.

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    4. Systems and methods for photoacoustic opthalmoscopy

      Systems and methods for photoacoustic opthalmoscopy
      Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser ophthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes.
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    5. In-vivo full depth of eye imaging spectral domain optical coherence tomography

      In-vivo full depth of eye imaging spectral domain optical coherence tomography

      It is necessary to apply the spectral-domain optical coherence tomography (SD-OCT) to image the whole eye segment for practically iatrical application, but the imaging depth of SD-OCT is limited by the spectral resolution of the spectrometer. By now, no result about this research has been reported. In our study, a new dual channel dual focus OCT system is adopted to image the whole eye segment. The cornea and the crystalline lens are simultaneously imaged by using full range complex spectral-domain OCT in one channel, the retina is detected by the other. The new system was successfully tested in imaging of ...

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    6. Photoacoustic Ophthalmoscopy for In Vivo Retinal Imaging: Current Status and Prospects

      Photoacoustic Ophthalmoscopy for In Vivo Retinal Imaging: Current Status and Prospects

      Photoacoustic ophthalmoscopy (PAOM) is a new retinal imaging technology that offers the unique capability to measure optical absorption in the retina. Because PAOM is compatible with optical coherence tomography, scanning laser ophthalmoscopy, and autofluorescence imaging, registered multimodal images can be acquired from a single device at comparable resolution for comprehensive anatomic and functional retinal characterizations. Therefore, PAOM is anticipated to have applications in both research and clinical diagnosis of many blinding diseases. The authors explain the basic principles of the photoacoustic effect and imaging. Then, different types of photoacoustic microscopy are introduced and compared. Finally, the current status of photoacoustic ...

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    7. Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen

      Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen
      We proposed to measure the metabolic rate of oxygen (MRO2) in small animals in vivo using a multimodal imaging system that combines laser-scanning optical-resolution photoacoustic microscopy (LSOR-PAM) and spectral-domain optical coherence tomography (SD-OCT). We first tested the capability of the multimodal system to measure flow rate in a phantom made of two capillary tubes of different diameters. We then demonstrated the capability of measuring MRO2 by imaging two parallel vessels selected from the ear of a Swiss Webster mouse. The hemoglobin oxygen saturation (sO2) and the vessel diameter were measured by the LSOR-PAM and the blood flow velocity was measured ...
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    8. Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography

      Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography
      PURPOSE. To reveal three-dimensional (3D) information about the retinal structures of birds of prey in vivo METHODS. An ultra-high resolution spectral-domain optical coherence tomography (SDOCT) system was built for in vivo imaging of bird of prey retina. The calibrated imaging depth and axial resolution of the system were 3.1 mm and 2.8 µm (in tissue), respectively. 3D segmentation was performed for calculation of the retinal nerve fiber layer (RNFL) map. RESULTS. High resolution OCT images of the retinas of four species of birds of prey: two diurnal hawks (Buteo platypterus and Buteo brachyurus) and two nocturnal owls (Bubo ...
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    9. Ultrahigh-Resolution Measurement by Optical Coherence Tomography of Dynamic Tear Film Changes on Contact Lenses

      Purpose. To determine the dynamic pre- and postlens tear film (PLTF and PoLTF) thicknesses by using optical coherence tomography (OCT). Methods. Ultrahigh-resolution OCT was used to image the tear film of 22 subjects before and after contact lens wear. A soft lens with 1 drop of artificial tears on its concave surface was inserted onto one randomly selected eye. OCT images were taken before insertion, immediately afterward, and every 2 minutes for 10 minutes. For the contralateral eye, the lens inserted was not prewetted on the concave surface. OCT images were taken before insertion, immediately afterward, and at 3 minutes ...
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    10. Effective bandwidth in spectral-domain OCT

      Effective bandwidth in spectral-domain OCT

      We found that the bandwidth in the formula calculating the depth resolution of OCT is usually not the same as the bandwidth of the light source; the effective spectral profile for the interfering signal is determined by the dot product of the electric vectors of the light field in the two interfering arms. We thus introduced a new concept: the effective bandwidth in spectraldomain OCT (SD-OCT). Through theoretical and experimental analyses we found that the effective bandwidth is a function of both the polarization matching conditions (PMC) and the path length difference (PLD) between the sample and reference arms.

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    11. Use of Ultra-High-Resolution Optical Coherence Tomography to Detect in Vivo Characteristics of Descemet's Membrane in Fuchs' Dystrophy

      Purpose: To demonstrate the capability of ultra-high-resolution (UHR) anterior segment optical coherence tomography (OCT) to image Descemet's membrane (DM) and measure its thickness in vivo. (2) To evaluate the use of DM characteristics and thickness in the diagnosis of Fuchs' dystrophy.Design: Case-control study.Participants: Twenty eyes of 12 Fuchs' dystrophy patients, 20 eyes of 13 young normal, and 20 eyes of 15 elderly normal subjects.Methods: Subjects were imaged using novel, custom-built UHR-OCT. Images were used to describe the characteristics of DM. Custom-made software was used to measure DM thickness and central corneal thickness (CCT). Specimens of DM ...
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    12. Photoacoustic ophthalmoscopy for in vivo retinal imaging

      Photoacoustic ophthalmoscopy for in vivo retinal imaging

      We have developed a non-invasive photoacousticophthalmoscopy (PAOM) for in vivo retinal imaging. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. Byusing a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetricimaging of the retinal micro-vasculature and retinal pigment epithelium at ahigh speed. For B-scan frames containing 256 A-lines, the current PAOMhas a frame rate of 93 Hz, which is comparable with state-of-the-artcommercial spectral-domain optical coherence tomography (SD-OCT). Byintegrating PAOM with SD-OCT, we further achieved OCT-guided PAOM,which can provide multi-modal retinal imaging simultaneously ...

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    13. Ultra-high Resolution Measurement by Optical Coherence Tomography of Dynamic Tear Film Changes on Contact Lenses

      Purpose: To determine the dynamic pre- (PLTF) and post-lens (PoLTF) tear film thicknesses using optical coherence tomography (OCT). Methods: Ultra-high resolution OCT was used to image the tear film of 22 subjects before and after contact lens wear. A soft lens with one drop of artificial tears on its concave surface was inserted onto one randomly selected eye. OCT images were taken before insertion, immediately afterwards, and every 2 minutes for 10 minutes. For the contralateral eye, the lens inserted was not pre-wetted on the concave surface. OCT images were taken before insertion, immediately afterwards, and at 3 minutes. Then ...
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    14. Ultra-High Resolution Spectral Domain Optical Coherence Tomography of Traumatic Maculopathy

      The authors describe a patient who suffered traumatic maculopathy following blunt trauma to the eye with commotio retinae, subretinal and preretinal hemorrhage, traumatic macular hole, and outer retinal and retinal pigment epithelium disruption. Serial imaging with commercially available and ultra-high resolution spectral domain optical coherence tomography characterized the evolution of the injury. [Ophthalmic Surg Lasers Imaging 2009;40:516-521.]

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    15. Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography

      Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography
      We have developed a multimodal imaging technique by integrating photoacoustic microscopy and spectral domain optical coherence tomography to provide simultaneous volumetric microscopic imaging of both optical absorption and scattering contrasts in biological tissues. In the integrated system, the two imaging modalities share the same optical scanning and delivery mechanisms after their probing and illumination light beams are combined. By further synchronizing the image acquisitions, the images from the two modalities are intrinsically registered. The capabilities of this novel technique were demonstrated by imaging both the microanatomy and microvasculature in mouse ears in vivo.
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    16. Dual channel dual focus optical coherence tomography for imaging accommodation of the eye

      Dual channel dual focus optical coherence tomography for imaging accommodation of the eye

      A dual channel dual focus spectral-domain optical coherence tomography was developed for imaging the accommodation of the eye in real time. The system can provide simultaneous cross-sectional imaging of all the surfaces of the anterior segment of the eye including the cornea, anterior chamber, anterior and posterior surfaces of the crystalline lens. Thus, the modification of the curvatures of the anterior and posterior surfaces of the crystalline lens and the dimensions of the anterior segment ofthe eye with accommodation can be calculated. The system was successfully tested in imaging accommodation. The preliminary resultsdemonstrated the feasibility of this novel approach.

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    17. In Situ Visualization of Tears on Contact Lens Using Ultra High Resolution Optical Coherence Tomography.

      Objective: To demonstrate the capability of directly visualizing the tear film on contact lenses using optical coherence tomography (OCT). Methods: Six eyes of three healthy subjects wearing PureVision and ACUVUE Advance soft and Boston RGP hard contact lenses were imaged with a custom built, high speed, ultra-high resolution spectral domain optical coherence tomograph. Refresh Liquigel was used to demonstrate the effect of artificial tears on the tear film. Results: Ultra high resolution images of the pre- and post-lens films were directly visualized when each lens was inserted onto the eye. After the instillation of artificial tears during lens wear, the ...
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    18. Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography

      Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography

      We have successfully imaged the retinal tumor in a mouse model using an ultra-high resolution spectral-domain optical coherence tomography (SD-OCT) designed for small animal retinal imaging. For segmentation of the tumor boundaries and calculation of the tumor volume, we developed a novel segmentation algorithm. The algorithm is based on parametric deformable models (active contours) and is driven by machine learning-based region classification, namely a Conditional Random Field. With this algorithm we are able to obtain the tumor boundaries automatically, while the user can specify additional constraints (points on the boundary) to correct the segmentation result, if needed. The system and ...

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    19. Polarization effect on the depth resolution of optical coherence tomography

      Shuliang Jiao and Marco Ruggeri We find for the first time that polarization mismatch of the sample and reference arms in optical-fiber-based optical coherence tomography (OCT) has critical effect on its depth resolution when the light source is partially polarized. When the polarization states of the two arms are matched, the mea ... [J. Biomed. Opt. 13, 060503 (2008)] published Thu Dec 11, 2008.
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    20. In vivo burn imaging using Mueller optical coherence tomography

      Miloš Todorovic, Shuliang Jiao, Jun Ai, David Pereda-Cubián, George Stoica, Lihong V. Wang. We report on the use of a high-speed, fiber-based Mueller-matrix optical coherence tomography system with continuous source-polarization modulation for in vivo burn depth evaluation and healing monitoring. A homemade hand-held probe with integrated optical scanning and beam delivering optics was ... [Opt. Express 16, 10279-10284 (2008)]
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    21. Direct visualization of tear film on soft contact lens using ultra-high resolution spectral domain optical coherence tomography

      Jianhua Wang, Shuliang Jiao, Marco Ruggeri et al. The integrity of the tear film on the surface of contact lenses is essential to maintaining visual clarity and the overall health of the superficial structures of the eye (cornea and conjunctiva) for contact lens wearers. It is very critical to evaluate pre- and post-lens tear films in contact lens ... [Proc. SPIE Int. Soc. Opt. Eng. 6844, 68441E (2008)] published Mon Feb 11, 2008.
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    22. In vivo imaging of raptor retina with ultra high resolution spectral domain optical coherence tomography

      Among birds, raptors are well known for their exceptional eyesight, which is partly due to the unique structure of their retina. Because the raptor retina is the most advanced of any animal species, in vivo examination of its structure would be remarkable. Furthermore, a noticeable percentage of traumatic ocular injuries are identified in birds of prey presented to rehabilitation facilities. Injuries affecting the posterior segment have been considered as a major impact on raptor vision. Hence, in vivo examination of the structure of the posterior segment of the raptors would be helpful for the diagnosis of traumatized birds. The purpose ...

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    23. Enhanced optical coherence tomography for anatomical mapping

      A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye ...
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    24. Automatic retinal blood flow calculation using spectral domain optical coherence tomography

      Keywords (OCIS): (110.4500) Imaging systems : Optical coherence tomography (120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation (170.4580) Medical optics and biotechnology : Optical diagnostics for medicine Abstract Optical Doppler tomography (ODT) is a branch of optical coherence tomography (OCT) that can measure the speed of a blood flow by measuring the Doppler shift impinged on the probing sample light by the moving blood cells. However, the measured speed
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    25. Method and apparatus for obtaining information from polarization-sensitive optical coherence tomography

      An apparatus includes a first section operable to detect polarization-sensitive radiation emitted by an object, and a second section operable to determine a Jones matrix based on information obtained by the first section from the polarization-sensitive radiation. The second section thereafter transforms the Jones matrix into a Mueller matrix, the Mueller matrix being representative of properties of the object.
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    26. Polarization-sensitive Mueller-matrix optical coherence tomography (Thesis)

      Polarization-sensitive Mueller-matrix optical coherence tomography (Thesis)
      Measuring the Mueller matrix with optical coherence tomography (OCT) makes it possible to acquire the complete polarization properties of scattering media with three-dimensional spatial resolution. We first proved that the measured degree-of-polarization (DOP) of the backscattered light by OCT remains unity-a conclusion that validated the use of Jones calculus in OCT. A multi-channel Mueller-matrix OCT system was then built to measure the Jones-matrix, which can be transformed into a Mueller matrix, images of scattering biological tissues accurately with single depth scan. We showed that when diattenuation is negligible, the round-trip Jones matrix represents a linear retarder, which is the foundation ...
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    1. (49 articles) Shuliang Jiao
    2. (23 articles) University of Miami
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    Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography Photoacoustic ophthalmoscopy for in vivo retinal imaging Effective bandwidth in spectral-domain OCT Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging Postdoctoral Associate Position at Duke Vision and Image Processing Laborator Anterior segment optical coherence tomography angiography Refining percutaneous coronary intervention: intracoronary imaging, haemodynamics, P2Y12 antagonists, and public outcomes reporting Optical Coherence Tomography/Fluorescence Imaging: Fiber assembly enables efficient multimodal endoscopy Optical Fabrication: Glassblowing technique creates arrays of axicon lenses University of Alabama Receives NIH Grant  for Clinical and Translational Core.