1. Articles from Francesco Pichi

    1-24 of 30 1 2 »
    1. Standardization of optical coherence tomography angiography nomenclature in retinal vascular diseases: first survey results

      Standardization of optical coherence tomography angiography nomenclature in retinal vascular diseases: first survey results

      Purpose: To develop a consensus nomenclature for optical coherence tomography angiography (OCTA) findings in retinal vascular diseases. Design: Online survey using Delphi Method SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Members of The Retina Society, European Society of Retina Specialists (EURETINA) and the Japanese Retina and Vitreous Society (JRVS). Methods, intervention, or testing: An online questionnaire on OCTA terminology in retinal vascular diseases was sent to members of The Retina Society, EURETINA and the JRVS. The respondents were divided into two groups (experts vs users) based on the number of their publications in this field. The respondents who had more than 5 ...

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    2. Diagnostic Value of Optical Coherence Tomography in the Early Diagnosis of Macular Complications in Chronic Vogt-Koyanagi-Harada Disease

      Diagnostic Value of Optical Coherence Tomography in the Early Diagnosis of Macular Complications in Chronic Vogt-Koyanagi-Harada Disease

      Purpose: To describe the role of optical coherence tomography (OCT) in detecting subclinical choroidal inflammation and early diagnosis of macular complications in chronic Vogt-Koyanagi-Harada (VKH) disease with sunset glow fundus. Methods: Retrospective observational study. Clinical features, OCT images, treatment, and visual outcome were analyzed. Results: Fourteen patients (9 females and 5 males) were included in the study. Mean age was 39 years (range 7-67 years). Mean duration of disease was 5.25 years (range 1-15 years). Anterior uveitis was seen in 14 eyes (52%). Fundus examination showed sunset glow fundus in all patients with no obvious macular pathology. OCT showed ...

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    3. Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results

      Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results

      Aim To standardise the nomenclature for reporting optical coherence angiography (OCT-A) findings in the field of uveitis. Methods Members of the International Uveitis Study Group, of the American Uveitis Society and of the Sociedad Panamericana de Infermedades Oculares that choose to participate responded to an online questionnaire about their preferred terminology when reporting on OCT-A findings in uveitis. The response of individuals with several publications on OCT-A (experts) was compared with uveitis specialists (users) who have less than five publications on the field of uveitis and OCT-A. Results A total of 108 uveitis specialists who participated in the survey were ...

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    4. Wide-field optical coherence tomography angiography for the detection of proliferative diabetic retinopathy

      Wide-field optical coherence tomography angiography for the detection of proliferative diabetic retinopathy

      Purpose To compare the ability of wide-field optical coherence tomography angiography (WF-OCTA) to that of ultra-wide field fluorescein angiography (UWF-FA) and ultra-wide-field color fundus photography (UWF-CP) to detect retinal neovascularization (NV) in eyes with proliferative diabetic retinopathy (PDR). Methods In this cross-sectional study, naïve patients with active PDR underwent UWF-FA and UWF-CP using the Optos 200Tx and WF-OCTA with 12 × 12 mm fields of five visual fixations using the PLEX Elite 9000. NV was defined on OCTA when the co-registered B-scan with flow overlay of the vitreoretinal interface (VRI) segmentation showed extraretinal proliferation. Three masked readers examined the UWF-FA ...

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    5. CHOROIDAL GRANULOMAS VISUALIZED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      CHOROIDAL GRANULOMAS VISUALIZED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To assess the visualization of choroidal granulomas with swept-source optical coherence tomography angiography (OCTA). Methods: Consecutive patients with granulomatous choroiditis due to tuberculosis, sarcoidosis, or Vogt–Koyanagi–Harada disease underwent baseline OCTA images using a 12 × 12-mm field of view, and the choroidal slabs were analyzed by two independent examiners who counted the oval areas of flow void. Simultaneously, indocyanine green angiography (ICGA) and enhanced-depth imaging OCT were performed to mark visible choroidal changes corresponding to granulomatous lesions. The lesion areas on OCTA and ICGA were assessed using the in-built caliper tool. Results: Three hundred and one round-shaped areas ...

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    6. Optical coherence tomography angiography findings in systemic lupus erythematosus patients with no ocular disease

      Optical coherence tomography angiography findings in systemic lupus erythematosus patients with no ocular disease

      Purpose Retinal manifestations are present in 10% of patients with systemic lupus erythematosus (SLE) and consist of vascular changes that can be sight-threatening. Optical coherence tomography angiography (OCTA) is a novel imaging modality that detects movement inside the blood vessels without dye injection and transforms this movement into an angiographic map. The aim of this study is to describe subclinical vessels changes in the eyes of patients with SLE but no retinal manifestations. Methods In this cross-sectional study, 15 patients with SLE but no clinical ophthalmic manifestations were scanned through OCTA of the iris and at the level of the ...

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    7. Optical coherence tomography diagnostic signs in posterior uveitis

      Optical coherence tomography diagnostic signs in posterior uveitis

      A diagnostic sign refers to a quantifiable biological parameter that is measured and evaluated as an indicator of normal biological, pathogenic, or pharmacologic responses to a therapeutic intervention. When used in translational research discussions, the term itself often alludes to a signs used to accelerate or aid in diagnosis or monitoring and provide insight into “personalized” medicine. Many new diagnostic signs are being developed that involve imaging technology. Optical coherence tomography is an imaging technique that provides in vivo quasi-histological images of the ocular tissues and as such it's able to capture the structural and functional modifications that accompany ...

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    8. The broad spectrum of application of optical coherence tomography angiography to the anterior segment of the eye in inflammatory conditions: a review of the literature

      The broad spectrum of application of optical coherence tomography angiography to the anterior segment of the eye in inflammatory conditions: a review of the literature

      Background With an increased number of papers on how to interpret optical coherence tomography angiography (OCTA) findings in uveitis, the aim of this review is to assess its efficacy for the quantitative monitoring of structural and functional changes in inflamed conjunctiva and iris vessels in patients with acute anterior uveitis and iris neovascularization. Main body OCTA, currently designed as a retinal vascular imaging system, has been recently adapted for anterior segment and showed good potential for successful imaging of the conjunctiva, the cornea, and the iris. OCTA can successfully delineate corneal vessels with substantial image quality. At the same time ...

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    9. Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects

      Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects

      Background/Aims Hydroxychloroquine (HCQ) retinopathy may result in severe and irreversible vision loss, emphasising the importance of screening and early detection. The purpose of this study is to report the novel finding of early optical coherence tomography (OCT) abnormalities due to HCQ toxicity that may develop in the setting of normal Humphrey visual field (HVF) testing. Methods Data from patients with chronic HCQ exposure was obtained from seven tertiary care retina centres. Ten patients with HCQ-associated OCT abnormalities and normal HVF testing were identified. Detailed analysis of the OCT findings and ancillary tests including colour fundus photography, fundus autofluorescence, multifocal ...

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    10. The overlapping spectrum of flat irregular pigment epithelial detachment investigated by optical coherence tomography angiography

      The overlapping spectrum of flat irregular pigment epithelial detachment investigated by optical coherence tomography angiography

      Purpose To describe the OCT angiography characteristics of flat irregular pigment epithelial detachments (PEDs), an overlapping tomographic feature of various macular disorders. Methods Consecutive patients with a dimpled retinal pigment epithelium profile on OCT, referred for a second opinion, were enrolled. Fluorescein (FA) and indocyanine green angiography (ICGA) were performed in all patients and compared to previous examinations, when available. In all patients, enhanced depth imaging-OCT and OCT angiography were performed upon referral and at subsequent follow-ups. Results Twenty-five eyes from 25 patients (9 women and 16 men, mean age of 63.4 years) were enrolled. The diagnoses of CSCR ...

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    11. Pearls and pitfalls of optical coherence tomography angiography in the multimodal evaluation of uveitis

      Pearls and pitfalls of optical coherence tomography angiography in the multimodal evaluation of uveitis

      Background Optical coherence tomography angiography (OCTA) employs a novel imaging algorithm that detects the amplitude or phase decorrelation of blood cell movement. It thus provides a flow map with depth-resolved visualization of the various vascular layers in the posterior pole of the eye including the retina capillary plexus and the choroid. In the past 3 years, the number of research papers on the subject of OCTA in retinal diseases has grown exponentially including important applications in the field of uveitis. While the study of OCTA in uveitic diseases has gained remarkable relevance worldwide, interpretation can be challenging, and many limitations ...

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      Mentions: UCLA Vishali Gupta
    12. The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases

      The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases

      Since its introduction in the early 1990s, optical coherence tomography (OCT) has evolved in resolution and technological advances, and in recent years its initial application of assessing the morphology of a tissue has been implemented by the study of its functional blood flow, through optical coherence tomography angiography (OCTA). This novel technique details capillary networks by comparing the amount of light returned from static and moving targets without the need for intravenous dye administration. While this imaging modality has been used for various ocular conditions, the application OCTA to uveitis conditions remains sparse. This review aims to establish the basis ...

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    13. Optical Coherence Tomography Angiography Reveals Choriocapillaris Flow Reduction in Placoid Chorioretinitis

      Optical Coherence Tomography Angiography Reveals Choriocapillaris Flow Reduction in Placoid Chorioretinitis

      Purpose To elucidate the origin of disease in acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and related placoid disorders, and to determine the principle tissue level of involvement: retinal pigment epithelium (RPE) versus choriocapillaris (CC). To determine the prevalence, extent, and persistence of choroidal flow reduction in placoid chorioretinitis using en face optical coherence tomography (OCT) and OCT angiography (OCTA). Design Multicenter, prospective case series. Participants Patients with a clinical diagnosis of APMPPE, persistent placoid maculopathy (PPM), or relentless placoid chorioretinitis (RPC). Methods Morphologic evaluation of en face structural OCT and OCTA images with customized segmentation through the deep capillary ...

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    14. EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF MULTIPLE EVANESCENT WHITE DOT SYNDROME: New Insights Into Pathogenesis

      EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF MULTIPLE EVANESCENT WHITE DOT SYNDROME: New Insights Into Pathogenesis

      Purpose: To localize the various levels of abnormalities in multiple evanescent white dot syndrome by comparing "en face" optical coherence tomography (OCT) and OCT angiography with various conventional imaging modalities. Methods: In this retrospective case series, multimodal imaging was performed in 9 retinal centers on 36 patients with multiple evanescent white dot syndrome and included widefield fundus autofluorescence (FAF), fluorescein angiography (FA), and indocyanine green angiography, and B-scan and "en face" C-scan enhanced depth imaging and spectral domain OCT. Optical coherence tomography angiography was also performed at the level of the superficial and deep retinal capillary plexus and choroid. Results ...

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    15. A Focal Chorioretinal Bartonella Lesion Analyzed by Optical Coherence Tomography Angiography

      A Focal Chorioretinal Bartonella Lesion Analyzed by Optical Coherence Tomography Angiography

      Neovascularization may be associated with cat-scratch neuroretinitis in the absence of retinal vascular occlusion. Bartonella organisms establish an intimate relationship with the vascular endothelium, causing angioproliferative lesions, which might represent a dedicated pathogenic strategy for expanding the bacterial host cell habitat. In the eye, pathological angiogenesis caused by Bartonella has been described as peripapillary or macular choroidal neovascularization, but the presence of neovascularization within foci of chorioretinitis has never before been reported. The authors present a case of Bartonella chorioretinitis in which optical coherence tomography angiography, by detecting erythrocyte motion, was able to identify neovessels inside the infectious focus.

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    16. New appraisals of Kyrieleis plaques: a multimodal imaging study

      New appraisals of Kyrieleis plaques: a multimodal imaging study

      Purpose Kyrieleis retinal periarteritis reflects the severe intraocular inflammation experienced by the eye. Its aetiology has not been well established, since only nine cases have been reported and there is no pathological study available in the literature. We determine the pathogenesis of Kyrieleis periarteritis based on interpretation of multimodal imaging findings. Methods Charts of patients with Kyrieleis arteritis seen between 2006 and 2014 were retrieved from eight uveitis referral centres throughout the world. Follow-up ranged from 5 to 12 months. Results Twenty-five eyes with Kyrieleis arteritis from 25 patients were included in the study. Nineteen patients (72%) were male and ...

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    17. RETINAL ASTROCYTIC HAMARTOMA: Optical Coherence Tomography Classification and Correlation With Tuberous Sclerosis Complex

      RETINAL ASTROCYTIC HAMARTOMA: Optical Coherence Tomography Classification and Correlation With Tuberous Sclerosis Complex

      Purpose: To propose a classification of retinal astrocytic hamartoma based on spectral domain optical coherence tomography and correlate each class with systemic manifestations of tuberous sclerosis complex. Methods: Retrospective chart review conducted at four international referral medical retina centers. There were 43 consecutive patients with an established diagnosis of tuberous sclerosis complex based on presence of at least 2 major or 1 major and 2 minor features of the diagnostic criteria. Clinical and spectral domain optical coherence tomography features regarding retinal astrocytic hamartoma were documented. Results: The mean patient age at presentation was 16.2 years. The retinal astrocytic hamartoma ...

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    18. WIDE-FIELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      WIDE-FIELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To describe wide-field spectral domain optical coherence tomography morphologic relationships of the vitreous, retina, and choroid in healthy and pathologic eyes. Methods: Standardized horizontal, vertical, and two oblique (supertemporal to inferonasal and supranasal to inferotemporal) spectral domain optical coherence tomography sections were collected for each patient. For extramacular imaging, images were obtained from 8 locations: 1) nasal to the optic disk, 2) extreme nasal periphery, 3) superior to the superotemporal vascular arcade, 4) extreme superior periphery, 5) inferior to the inferotemporal vascular arcade, 6) extreme inferior periphery, 7) temporal to the macula, and 8) extreme temporal periphery. Wide-angle montage ...

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    19. A case of acute exudative polymorphous vitelliform maculopathy: follow-up and wide-field spectral-domain optical coherence tomography

      A case of acute exudative polymorphous vitelliform maculopathy: follow-up and wide-field spectral-domain optical coherence tomography

      To present a case of an HIV-positive patient with acute exudative polymorphous vitelliform maculopathy (AEPVM) and evaluate the presence of specific spectral-domain optical coherence tomography (SD-OCT) findings. Case report. We reviewed the AEPVM cases reported in the literature and compared those to our patient to determine if there is a correspondence between the etiology that leads to the onset of AEPVM and clinical and SD-OCT findings. Acute exudative polymorphous vitelliform maculopathy is a disease that involves the outer retinal layers with lipofuscin deposits and serous detachment of the neuroepithelium with or without intraretinal cysts. Not much is known about the ...

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    20. Wide-field spectral domain-optical coherence tomography in central serous chorioretinopathy

      Wide-field spectral domain-optical coherence tomography in central serous chorioretinopathy

      The aim the study was to describe wide-field spectral-domain optical coherence tomography morphologic relationships of the vitreous, retina, and choroid in central serous chorioretinopathy (CSCR) eyes. Standardized horizontal, vertical, and two oblique (supertemporal to inferonasal and supranasal to inferotemporal) SD-OCT sections were collected for 40 patient with CSCR. For extramacular imaging, images were obtained from eight locations: (1) nasal to the optic disk, (2) extreme nasal periphery, (3) superior to the superotemporal vascular arcade, (4) extreme superior periphery, (5) inferior to the inferotemporal vascular arcade, (6) extreme inferior periphery, (7) temporal to the macula, and (8) extreme temporal periphery. Wide-angle ...

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      Mentions: Jost B. Jonas
    21. Spectral-domain optical coherence tomography findings in pediatric tilted disc syndrome

      Spectral-domain optical coherence tomography findings in pediatric tilted disc syndrome

      Purpose To report a novel spectral-domain optical coherence tomography (SD-OCT) finding in children affected by tilted disc syndrome (TDS), and to correlate it with early visual field defects. Methods Patients between 5 and 17 years old with TDS were enrolled in this study. The diagnosis of TDS was made by stereoscopic fundus photography, when the upper edge of the optic disc protruded anteriorly relative to its lower edge. All eyes were examined with 12 radial SD-OCT B-scans of 12 mm centered on the optic disc; the fundus area encompassing the optic nerve was additionally scanned using several vertical and horizontal ...

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    22. Spectral Domain Optical Coherence Tomography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopathy

      Spectral Domain Optical Coherence Tomography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopathy

      Purpose: To describe the appearance of acute syphilitic posterior placoid chorioretinitis, a rare ocular manifestation of syphilis, on spectral domain optical coherence tomography (SD OCT) both before and after treatment. Methods: Ophthalmic examination and imaging studies of 30 eyes of 19 confirmed cases were analyzed both at the time of presentation and at each follow-up visit. Patients with SD OCT and fluorescein angiography at the time of presentation, and at least three documented follow-up visits after initiation of therapy, were included in the study. Standard treatment of neurosyphilis was given to each patient, including 4 million units of penicillin G ...

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    23. Spectral Domain Optical Coherence Tomography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopath

      Spectral Domain Optical Coherence Tomography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopath

      Purpose: To describe the appearance of acute syphilitic posterior placoid chorioretinitis, a rare ocular manifestation of syphilis, on spectral domain optical coherence tomography (SD OCT) both before and after treatment. Methods: Ophthalmic examination and imaging studies of 30 eyes of 19 confirmed cases were analyzed both at the time of presentation and at each follow-up visit. Patients with SD OCT and fluorescein angiography at the time of presentation, and at least three documented follow-up visits after initiation of therapy, were included in the study. Standard treatment of neurosyphilis was given to each patient, including 4 million units of penicillin G ...

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    1-24 of 30 1 2 »
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    A spectral domain optical coherence tomography and autofluorescence classification of retinal astrocytic hamartomas: Old and new frontiers Perivenular Whitening in Central Vein Occlusion Described by Fundus Autofluorescence and Spectral Domain Optical Coherence Tomography Intraoperative SD-OCT in Macular Surgery Retinal astrocytic hamartoma: Spectral-domain optical coherence tomography classification and correlation with tuberous sclerosis complex Neovascular Glaucoma Induced by Peripheral Retinal Ischemia in Neurofibromatosis Type 1: Management and Imaging Features Assessment of OCT measurements as prognostic factors in myopic macular hole surgery without foveoschisis Spectral Domain Optical Coherence Tomography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopath Spectral Domain Optical Coherence Tomography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopathy Spectral-domain optical coherence tomography findings in pediatric tilted disc syndrome A case of acute exudative polymorphous vitelliform maculopathy: follow-up and wide-field spectral-domain optical coherence tomography Systems and methods for reflectance-based projection-resolved optical coherence tomography angiography Health collaborations forged at CIIE begin to bear fruit