All Articles from Tin Aung -Optical Coherence Tomography News

Articles from Tin Aung

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1. A Deep Learning System for Automated Angle-Closure Detection in Anterior Segment Optical Coherence Tomography Images
  
  Explore American Journal of Ophthalmology Mar 5 2019 Ophthalmology
  
  Purpose Anterior segment optical coherence tomography (AS-OCT) provides an objective imaging modality for visually identifying anterior segment structures. An automated detection system could assist ophthalmologists in interpreting AS-OCT images for presence of angle closure. Design Development of an artificial intelligence automated detection system for the presence of angle closure. Methods A deep learning system for automated angle-closure detection in AS-OCT images was developed, and this was compared with another automated angle-closure detection system based on quantitative features. A total of 4135 Visante AS-OCT images from 2113 subjects (8270 anterior chamber angle (ACA) images with 7375 open-angle and 895 angle-closure) were ...
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  Mentions: Singapore Eye Research Institute Mani Baskaran Tin Aung
2. Assessment of Circumferential Angle Closure with Swept-Source Optical Coherence Tomography: a community based study
  
  Explore American Journal of Ophthalmology Nov 28 2018 Ophthalmology
  
  Purpose To evaluate the diagnostic performance of swept-source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) for angle closure detection, in comparison with gonioscopy in a community setting. Design Reliability analysis. Methods A total of 2027 phakic subjects aged ≥50 years, with no previous history of glaucoma, laser (including peripheral iridotomy), intraocular surgery or ocular trauma, were consecutively recruited from a community polyclinic in Singapore. Gonioscopy was performed by a single trained ophthalmologist. SS-OCT angle scans, which obtain radial scans for the entire circumference of the angle, were analyzed by a single examiner, masked to the subject’s ...
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  Mentions: Johns Hopkins University Singapore Eye Research Institute David S. Friedman
3. A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head
  
  Explore arxiv.org Oct 9 2018 Ophthalmology
  
  Purpose: To develop a deep learning approach to de-noise optical coherence tomography (OCT) B-scans of the optic nerve head (ONH). Methods: Volume scans consisting of 97 horizontal B-scans were acquired through the center of the ONH using a commercial OCT device (Spectralis) for both eyes of 20 subjects. For each eye, single-frame (without signal averaging), and multi-frame (75x signal averaging) volume scans were obtained. A custom deep learning network was then designed and trained with 2,328 "clean B-scans" (multi-frame B-scans), and their corresponding "noisy B-scans" (clean B-scans + gaussian noise) to de-noise the single-frame B-scans. The performance of the de-noising ...
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4. DRUNET: a dilated-residual U-Net deep learning network to segment optic nerve head tissues in optical coherence tomography images
  
  Explore OSA | OSA Publishing Jul 1 2018 Ophthalmology
  
  Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be of great interest for the clinical diagnosis and management of this pathology. A deep learning algorithm (custom U-NET) was designed and trained to segment 6 ONH tissue layers by capturing both the local (tissue texture) and contextual information (spatial arrangement of tissues). The overall Dice coefficient (mean of all tissues) was 0.91 ± 0.05 when assessed against manual segmentations performed by an expert observer ...
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  Mentions: University College London Singapore Eye Research Institute National University of Singapore
5. DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images
  
  Explore arxiv.org Mar 8 2018 Ophthalmology
  
  Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be of great interest for the clinical diagnosis and management of this pathology. A deep learning algorithm was designed and trained to digitally stain (i.e. highlight) 6 ONH tissue layers by capturing both the local (tissue texture) and contextual information (spatial arrangement of tissues). The overall dice coefficient (mean of all tissues) was 0.91 ± 0.05 when assessed against manual segmentations performed by an ...
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  Mentions: University College London Singapore Eye Research Institute National University of Singapore
6. Role of anterior segment optical coherence tomography in angle closure disease: a review
  
  Explore Wiley Online Library Nov 30 2017 Ophthalmology
  
  This article aims to review the published literature pertaining to the use of anterior segment optical coherence tomography (AS-OCT) in the evaluation of angle closure disease. Searches on the available published literature were last conducted on June 15, 2017. Rated as Level I evidence, we found that AS-OCT has shown good sensitivity and moderate diagnostic accuracy to detect narrow angles when compared with gonioscopy. AS-OCT quantitative and qualitative parameters demonstrated strong association with the presence of gonioscopically closed-angles. This technology provides an objective non-contact method of assessing the angle that is well tolerated by the patient and correlates well with ...
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  Mentions: Singapore Eye Research Institute Mani Baskaran Tin Aung
7. Plateau Iris Distribution Across Anterior Segment Optical Coherence Tomography Defined Subgroups of Subjects With Primary Angle Closure Glaucoma
  
  Explore IOVS Journal Oct 8 2017 Ophthalmology
  
  Purpose : We previously identified three distinct subgroups of patients with primary angle closure glaucoma (PACG) based on anterior segment optical coherence tomography (ASOCT) imaging. Group 1 was characterized by a large iris area with deepest anterior chambers, group 2 by a large lens vault (LV) and shallow anterior chamber depth (ACD), and group 3 displayed intermediate values across iris area, LV, and ACD. The purpose of the present study was to determine the distribution of plateau iris in these subgroups using ultrasound biomicroscopy (UBM) features. Methods : UBM images of the 210 subjects who were previously enrolled for the ASOCT subgrouping ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Tin Aung
8. Segmentation and Quantification for Angle-Closure Glaucoma Assessment in Anterior Segment OCT
  
  Explore IEEE Xplore Aug 31 2017 Ophthalmology
  
  Angle-closure glaucoma is a major cause of irreversible visual impairment and can be identified by measuring the anterior chamber angle (ACA) of the eye. The ACA can be viewed clearly through anterior segment optical coherence tomography (AS-OCT), but the imaging characteristics and the shapes and locations of major ocular structures can vary significantly among different AS-OCT modalities, thus complicating image analysis. To address this problem, we propose a data-driven approach for automatic AS-OCT structure segmentation, measurement, and screening. Our technique first estimates initial markers in the eye through label transfer from a hand-labeled exemplar data set, whose images are collected ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Mani Baskaran
9. A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head
  
  Explore arxiv.org Aug 7 2017 Ophthalmology
  
  Purpose. To develop a deep learning approach to digitally-stain optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods. A horizontal B-scan was acquired through the center of the ONH using OCT (Spectralis) for 1 eye of each of 100 subjects (40 normal & 60 glaucoma). All images were enhanced using adaptive compensation. A custom deep learning network was then designed and trained with the compensated images to digitally stain (i.e. highlight) 6 tissue layers of the ONH. The accuracy of our algorithm was assessed (against manual segmentations) using the Dice coefficient, sensitivity, and specificity. We further studied ...
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  Mentions: Heidelberg Engineering Singapore Eye Research Institute National University of Singapore
10. Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements
  
  Explore Optical Coherence Tomography News May 28 2017 Ophthalmology
  
  Glaucoma is characterized by an irreversible damage of retinal ganglion cells within the optic nerve head (ONH) at the back of the eye. Currently we know that elevated intraocular pressure (IOP) is associated with increased prevalence of glaucoma but not all glaucoma patients have an elevated IOP. The biomechanical theory of glaucoma hypothesizes that elevated (or fluctuating) IOP deforms the ONH tissues, including the lamina cribrosa (LC), and that these deformations drive retinal ganglion cell injury and death. However, IOP is not the only load that can deform the ONH. Eye movements have recently been hypothesized to be able to ...
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  Mentions: Duke University University College London National University of Singapore
11. A Digital Staining Algorithm for Optical Coherence Tomography Images of the Optic Nerve Head
  
  Explore TVST Journal Feb 7 2017 Ophthalmology
  
  Purpose : To digitally stain spectral-domain optical coherence tomography (OCT) images of the optic nerve head (ONH), and highlight either connective or neural tissues. Methods : OCT volumes of the ONH were acquired from one eye of 10 healthy subjects. We processed all volumes with adaptive compensation to remove shadows and enhance deep tissue visibility. For each ONH, we identified the four most dissimilar pixel-intensity histograms, each of which was assumed to represent a tissue group. These four histograms formed a vector basis on which we ‘projected' each OCT volume in order to generate four digitally stained volumes P1 to P4. Digital ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Tin Aung
12. Investigation of the variability of anterior chamber scan protocol with Cirrus high definition optical coherence tomography
  
  Explore Wiley Online Library Jan 18 2017 Ophthalmology
  
  Importance The evaluation of anterior chamber scan (ACS) of Cirrus optical coherence tomography (OCT) for routine clinical use Background To assess the variability of anterior chamber angle (ACA) measurements using the ACS Design Cross-sectional observational study Participants Forty subjects aged 40-80 years Methods One randomly selected eye from 40 subjects was imaged with Cirrus OCT (model 5000, Carl Zeiss Meditec, Dublin, CA) by two different operators (expert vs non-expert) with a 15-minute interval for inter- and intra-observer variability of image acquisition. For image grading, the angle opening distance (AOD750) and the trabecular iris space area (TISA750) of nasal and temporal ...
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  Mentions: National Institutes of Health Singapore Eye Research Institute Carl Zeiss Meditec
13. Evaluation of the Anterior Segment Angle-to-Angle Scan of Cirrus High-Definition Optical Coherence Tomography and Comparison With Gonioscopy and With the Visante OCT
  
  Explore IOVS Journal Jan 10 2017 Ophthalmology
  
  Purpose : To evaluate the diagnostic performance of the anterior segment angle-to-angle scan of the Cirrus high-definition optical coherence tomography (HD-OCT) in detecting eyes with closed angles. Methods : All subjects underwent dark-room gonioscopy by an ophthalmologist. A technician performed anterior segment imaging with Cirrus ( n = 202) and Visante OCT ( n = 85) under dark-room conditions. All eyes were categorized by two masked graders as per number of closed quadrants. Each quadrant of anterior chamber angle was categorized as a closed angle if posterior trabecular meshwork could not be seen on gonioscopy or if there was any irido-corneal contact anterior to scleral spur ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Zeiss Cirrus HD-OCT
14. Methods and systems for characterizing angle closure glaucoma for risk assessment or screening
  
  Explore uspto.gov Nov 22 2016 Ophthalmology , Patents
  
  A method is proposed for analyzing an optical coherence tomography (OCT) image of the anterior segment (AS) of a subject's eye. A region of interest is defined which is a region of the image containing the junction of the cornea and iris, and an estimated position the junction within the region of interest is derived. Using this a second region of the image is obtained, which is a part of the image containing the estimated position of the junction. Features of the second region are obtained, and those features are input to an adaptive model to generate data characterizing ...
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  Mentions: Tin Aung
15. Discriminant Function of Optical Coherence Tomography Angiography to Determine Disease Severity in Glaucoma
  
  Explore IOVS Journal Nov 13 2016 Ophthalmology
  
  Purpose : To determine the discriminant function of optical coherence tomography angiography (OCTA) by disease severity in glaucoma. Methods : In this prospective, observational cross-sectional study, all subjects underwent visual fields, retinal nerve fiber layer (RNFL) measurements, and OCTA imaging. Local fractal analysis was applied to OCTA images (radial peripapillary capillaries [RPC] layer). Vessel density en face and inside the disc and spacing between large and small vessels were quantified. Stepwise logistic regression was performed and a glaucoma severity score (range, 0–1: 0, normal; 1, severe glaucoma) was developed by using global and regional (superotemporal [ST], inferotemporal [IT], temporal, superonasal [SN ...
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  Mentions: Singapore Eye Research Institute Tin Aung Harsha L. Rao
16. Axial Alignment for Anterior Segment Swept Source Optical Coherence Tomography via Robust Low-Rank Tensor Recovery
  
  Explore Home - Springer Oct 23 2016 Ophthalmology
  
  We present a one-step approach based on low-rank tensor recovery for axial alignment in 360-degree anterior chamber optical coherence tomography. Achieving translational alignment and rotation correction of cross-sections simultaneously, this technique obtains a better anterior segment topographical representation and improves quantitative measurement accuracy and reproducibility of disease related parameters. Through its use of global information, the proposed method is more robust compared to using only individual or paired slices, and less sensitive to noise and motion artifacts. In angle closure analysis on 30 patient eyes, the preliminary results indicate that the proposed axial alignment method can not only facilitate manual ...
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  Mentions: Brigham and Women’s Hospital University College London Harvard University
17. In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements
  
  Explore IOVS Journal Oct 12 2016 Ophthalmology
  
  Purpose : To measure lamina cribrosa (LC) strains (deformations) following abduction and adduction in healthy subjects and to compare them with those resulting from a relatively high acute intraocular pressure (IOP) elevation. Methods : A total of 16 eyes from 8 healthy subjects were included. Among the 16 eyes, 11 had peripapillary atrophy (PPA). For each subject, both optic nerve heads (ONHs) were imaged using optical coherence tomography (OCT) at baseline (twice), in different gaze positions (adduction and abduction of 20°) and following an acute IOP elevation of approximately 20 mm Hg from baseline (via ophthalmodynamometry). Strains of LC for all loading ...
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  Mentions: National University of Singapore Mani Baskaran Tin Aung
18. Association of iris surface features with iris parameters assessed by swept-source optical coherence tomography in Asian eyes
  
  Explore BJO Online Mar 18 2016 Ophthalmology
  
  Background/aims To characterise the association of iris surface features (crypts, furrows and colour) with iris volume and curvature assessed by swept-source optical coherence tomography (SSOCT) in Asian eyes. Methods Iris crypts (by number and size) and furrows (by number and circumferential extent) were graded from iris photographs. Iris colour was measured by a customised algorithm written on MATLAB (MathWorks, Natick, Massachusetts, USA). The iris was imaged by SSOCT (SS-1000, CASIA, Tomey, Nagoya, Japan). The associations of surface features with iris parameters were analysed using a generalised estimating equation. Results A total of 1704 subjects (3297 eyes) were included in ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Tomey Corporation
19. In Vivo 3-Dimensional Strain Mapping of the Optic Nerve Head Following Intraocular Pressure Lowering by Trabeculectomy
  
  Explore Ophthalmology Mar 16 2016 Ophthalmology
  
  Purpose To map the 3-dimensional (3D) strain of the optic nerve head (ONH) in vivo after intraocular pressure (IOP) lowering by trabeculectomy (TE) and to establish associations between ONH strain and retinal sensitivity. Design Observational case series. Participants Nine patients with primary open-angle glaucoma (POAG) and 3 normal controls. Methods The ONHs of 9 subjects with POAG (pre-TE IOP: 25.3±13.9 mmHg; post-TE IOP: 11.8±8.6 mmHg) were imaged (1 eye per subject) using optical coherence tomography (OCT) (Heidelberg Spectralis, Heidelberg Engineering GmbH, Heidelberg, Germany) before (<21 days) and after (<50 days) TE. The imaging protocol ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Tin Aung
20. Changes in Japanese eyes after laser peripheral iridotomy: an anterior segment optical coherence tomography study
  
  Explore Wiley Online Library Oct 20 2015 Ophthalmology
  
  Background To investigate the changes in anterior segment parameters, as assessed by anterior segment optical coherence tomography (ASOCT) in Japanese subjects after laser peripheral iridotomy (LPI). Design Prospective observational study Participants 72 subjects with angle closure including primary angle closure suspect (PACS), primary angle closure (PAC), and primary angle closure glaucoma (PACG). Methods Customized software was used to measure ASOCT parameters. Complete data of 51 subjects were available for final analysis. Main Outcome Measures Angle opening distance (AOD), trabecular-iris space area (TISA), anterior chamber depth, width, area and volume (ACD, ACW, ACA, ACV), iris thickness, curvature, and area, and lens ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Tin Aung
21. Automatic Feature Extraction of Optical Coherence Tomography for Lamina Cribrosa Detection
  
  Explore Journal of Image and Graphics Sep 19 2015 Ophthalmology
  
  T his paper presents a framework to segment and extract key features automatically in Optical Coherence Tomography (OCT) scans. One of the main features to be detected is the Lamina Cribrosa (LC), which is an optic nerve head structure believed to play a crucial role in glaucomatous optic neuropathy. Detection of the LC aids in understanding pathogenesis and detection of glaucoma. Automatic segmentation allows a quick and objective way of identifying the LC. In previous work, LC segmentation has been manual; hence, the aim is to achieve automatic and accurate segmentation. Automatic detection is a novel approach, and very important ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Heidelberg Spectralis
22. Relationship of ocular and systemic factors to the visibility of choroidal–scleral interface using spectral domain optical coherence tomography
  
  Explore Wiley Online Library Jun 28 2015 Ophthalmology
  
  Purpose To assess the visibility of the choroidal–scleral interface (CSI) from spectral domain optical coherence tomography (SD-OCT) and evaluate the ocular and systemic factors influencing the visibility of CSI in healthy eyes from population-based Malay sample. Methods Participants were consecutively recruited from the population-based Singapore Malay Eye Study-2 (SiMES-2). SD-OCT images were obtained by Spectralis OCT with enhanced depth imaging (EDI) mode. Visibility of CSI was assessed by a grading system ranging from 0 to 2 scores. The reliability of choroidal thickness measurement in different grades of CSI visibility was assessed using intraclass correlation coefficient. Ordinal regression analyses were ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Heidelberg Spectralis
23. Determinants of Optical Coherence Tomography–Derived Minimum Neuroretinal Rim Width in a Normal Chinese Population
  
  Explore IOVS Journal May 30 2015 Ophthalmology
  
  Purpose. To characterize an optical coherence tomography (OCT)–derived parameter, Bruch's membrane opening–minimum rim width (BMO-MRW), and its association with demographic and clinical parameters in normal Chinese subjects. Methods. Right eyes of 466 consecutive healthy subjects from a population-based study of Singaporean Chinese underwent Cirrus OCT imaging. The retinal internal limiting membrane (ILM) and BMO were automatically delineated using the built-in Cirrus algorithm. The standard 36 interpolated radial B-scans (72 BMO points, 5° increments) of each optic nerve head were manually extracted from the central circle (3.46-mm diameter). We used Matlab to measure the shortest distance from ...
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  Mentions: Duke University Singapore Eye Research Institute Zeiss Cirrus HD-OCT
24. Lamina Cribrosa Visibility using Optical Coherence Tomography: Comparison of Devices and Effects of Image Enhancement Techniques
  
  Explore iovs.org Jan 17 2015 Ophthalmology
  
  Purpose: To compare the visibility of the lamina cribrosa (LC) in optic disc images acquired from 60 glaucoma and 60 control subjects using three optical coherence tomography (OCT) devices, with and without enhanced depth imaging (EDI) and adaptive compensation (AC). Methods: A horizontal B-scan was acquired through the centre of the disc using two spectral-domain (Spectralis and Cirrus; with and without EDI) and a swept-source (DRI) OCT. AC was applied post-acquisition to improve image quality. To assess LC visibility, four masked observers graded the 1,200 images in a randomised sequence. The anterior LC was graded from 0 to 4 ...
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  Mentions: University College London Singapore Eye Research Institute National University of Singapore
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