1. Articles from Paul J. Foster

    1-12 of 12
    1. Feature Of The Week 07/08/2018: Retinal Nerve Fibre Layer Thickness & Cognition - Results from UK Biobank

      Feature Of The Week 07/08/2018: Retinal Nerve Fibre Layer Thickness & Cognition - Results from UK Biobank

      Importance: Identifing potential screening tests for future cognitive decline is a priority for developing treatments for and the prevention of dementia. Objective: To examine the potential of retinal nerve fiber layer (RNFL) thickness measurement in identifying those at greater risk of cognitive decline in a large community cohort of healthy people. Design, Setting, and Participants: UK Biobank is a prospective, multicenter, community-based study of UK residents aged 40 to 69 years at enrollment who underwent baseline retinal optical coherence tomography imaging, a physical examination, and a questionnaire. The pilot study phase was conducted from March 2006 to June 2006, and ...

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    2. Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline A Study Using Optical Coherence Tomography

      Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline A Study Using Optical Coherence Tomography

      Importance Identifing potential screening tests for future cognitive decline is a priority for developing treatments for and the prevention of dementia. Objective To examine the potential of retinal nerve fiber layer (RNFL) thickness measurement in identifying those at greater risk of cognitive decline in a large community cohort of healthy people. Design, Setting, and Participants UK Biobank is a prospective, multicenter, community-based study of UK residents aged 40 to 69 years at enrollment who underwent baseline retinal optical coherence tomography imaging, a physical examination, and a questionnaire. The pilot study phase was conducted from March 2006 to June 2006, and ...

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    3. Optical Coherence Tomography in the UK Biobank Study – Rapid Automated Analysis of Retinal Thickness for Large Population-Based Studies

      Optical Coherence Tomography in the UK Biobank Study – Rapid Automated Analysis of Retinal Thickness for Large Population-Based Studies

      Purpose To describe an approach to the use of optical coherence tomography (OCT) imaging in large, population-based studies, including methods for OCT image acquisition, storage, and the remote, rapid, automated analysis of retinal thickness. Methods In UK Biobank, OCT images were acquired between 2009 and 2010 using a commercially available “spectral domain” OCT device (3D OCT-1000, Topcon). Images were obtained using a raster scan protocol, 6 mm x 6 mm in area, and consisting of 128 B-scans. OCT image sets were stored on UK Biobank servers in a central repository, adjacent to high performance computers. Rapid, automated analysis of retinal ...

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    4. Spectral-Domain Optical Coherence Tomography Imaging in 67,321 Adults

      Spectral-Domain Optical Coherence Tomography Imaging in 67,321 Adults

      Purpose To derive macular thickness measures and their associations by performing rapid, automated segmentation of spectral-domain optical coherence tomography (SD OCT) images collected and stored as part of the UK Biobank (UKBB) study. Design Large, multisite cohort study in the United Kingdom. Analysis of cross-sectional data. Participants Adults from the United Kingdom aged 40 to 69 years. Methods Participants had nonmydriatic SD OCT (Topcon 3D OCT-1000 Mark II; Topcon GB, Newberry, Berkshire, UK) performed as part of the ocular assessment module. Rapid, remote, automated segmentation of the images was performed using custom optical coherence tomography (OCT) image analysis software (Topcon ...

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    5. Spectral domain optical coherence tomography imaging of the aqueous outflow structures in normal participants of the EPIC-Norfolk Eye Study

      Spectral domain optical coherence tomography imaging of the aqueous outflow structures in normal participants of the EPIC-Norfolk Eye Study

      Purpose To measure the dimensions of aqueous outflow structures and to investigate associations with intraocular pressure (IOP) and ocular biometry parameters in an older British population. Method Fifty-two participants from the European Prospective Investigation of Cancer-Norfolk eye study underwent imaging using the Heidelberg Spectralis optical coherence tomographer with an anterior segment module. Pseudophakic participants and those known or suspected to have glaucoma were excluded, leaving 46 participants for analysis. Schwalbe's line (SL), scleral spur (SS), Schlemm's canal (SC) diameter and the trabecular meshwork cross-sectional area (TM cross-sectional area (CSA)) were identified and traced using ImageJ software. IOP was ...

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    6. Changes in Anterior Segment Morphology after Laser Peripheral Iridotomy: An Anterior Segment Optical Coherence Tomography Study

      Changes in Anterior Segment Morphology after Laser Peripheral Iridotomy: An Anterior Segment Optical Coherence Tomography Study

      Purpose Novel anterior segment optical coherence tomography (ASOCT) parameters associated with angle closure include anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), iris area (I-area), and iris curvature (I-curv). We aimed to investigate changes in these parameters after laser peripheral iridotomy (LPI) in a cohort of primary angle-closure suspects (PACS). Design Prospective observational study. Participants and Controls A total of 176 PACS aged ≥50 years who underwent LPI in 1 eye. Methods We analyzed ASOCT images (Visante, Carl Zeiss Meditec, Dublin, CA) from all subjects using customized software before and ...

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    7. Diagnostic Performance of Anterior Chamber Angle Measurements for Detecting Eyes With Narrow Angles: An Anterior Segment OCT Study: An Anterior Segment OCT Study

      Diagnostic Performance of Anterior Chamber Angle Measurements for Detecting Eyes With Narrow Angles: An Anterior Segment OCT Study: An Anterior Segment OCT Study

      Objective  To assess the diagnostic performance of angle measurements from anterior segment optical coherence tomography (AS-OCT) images for identifying eyes with narrow angles. Methods  We conducted a community-based cross-sectional study of individuals 50 years or older who had phakic eyes and who underwent AS-OCT imaging in the dark by a single operator and gonioscopy by an ophthalmologist masked to AS-OCT findings. An eye was considered to have narrow angles if the posterior pigmented trabecular meshwork was not visible for at least 180° on gonioscopy. Horizontal AS-OCT images were analyzed for the following measurements using customized software: angle opening distance (AOD ...

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    8. Variation of Angle Parameters in Asians: An Anterior Segment Optical Coherence Tomography Study in a Population of Singapore Malays

      Objective: To assess variations in angle parameters using anterior segment optical coherence tomography (AS-OCT) and to investigate demographic, ocular and systemic associations of angle width. Methods: This was a sub-study of a population based, cross-sectional survey of 3,280 (78.7% response rate) Malay people aged 40-80 years in Singapore. All participants underwent a standardized interview and ocular and systemic examination. AS-OCT was performed on 291 consecutive patients under standardized dark conditions. Angle opening distance (AOD-500) and trabecular-iris space area (TISA-500) 500 um from the scleral spur were determined for the nasal and temporal angles. Anterior chamber depth (ACD) was ...

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    9. Screening for Narrow Angles in the Singapore Population: Evaluation of New Noncontact Screening Methods

      Purpose: To assess the screening effectiveness of 3 new noncontact devices, the scanning peripheral anterior chamber depth analyzer (SPAC) (Takagi, Nagano, Japan), which measures peripheral anterior chamber depth (ACD); IOLMaster (Carl Zeiss Meditec, Jena, Germany), which measures central ACD; and Visante anterior segment optical coherence tomography (AS-OCT) (Visante, Carl Zeiss Meditec, Dublin, CA), which images the angles, and to compare these instruments with gonioscopy in identifying people with narrow angles (NAs).Design: Cross-sectional, observational, community-based study.Participants: Phakic subjects aged ≥50 years without ophthalmic symptoms who were recruited from a community polyclinic in Singapore.Methods: All subjects underwent examination with ...

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    10. Changes in Angle Configuration After Phacoemulsification Measured by Anterior Segment Optical Coherence Tomography.

      Purpose: To measure changes in angle width after phacoemulsification and intraocular lens (IOL) implantation using anterior segment optical coherence tomography (AS-OCT). Materials and Methods: Twenty-one patients undergoing cataract surgery were recruited from the National University Hospital, Singapore. AS-OCT images were obtained of nasal and temporal angle quadrants before and at 1-month after surgery. Optical measurements of central anterior chamber depth were obtained, and gonioscopic measurement of angle width was recorded. AS-OCT angle width parameters measured in the nasal and temporal quadrants included the angle opening distance at 500 [mu]m (AOD500) anterior to the scleral spur and the trabecular iris ...

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    11. Assessment of the Scleral Spur in Anterior Segment Optical Coherence Tomography Images

      Objective  To assess visibility of the scleral spur in anterior segment optical coherence tomography (AS-OCT) images. Methods  This cross-sectional observational study included 502 participants aged 50 years or older who had no previous ophthalmic problems and were recruited from a community clinic in Singapore. All participants underwent gonioscopy and AS-OCT (Visante; Carl Zeiss Meditec, Dublin, California). Scleral spur location was assessed in AS-OCT images by 2 examiners with glaucoma subspecialty training and was defined as the point where there was an inward protrusion of the sclera with a change in curvature of its inner surface. Results  Scleral spur location could ...

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    12. Changes in anterior segment morphology in response to illumination and after laser iridotomy in Asian eyes: an anterior segment OCT study

      Aim: Using the anterior segment optical coherence tomography (AS-OCT) to quantify changes in anterior segment morphology going from light to dark and following laser iridotomy (LI). Methods: Prospective observational study. 17 consecutive subjects without peripheral anterior synechiae undergoing LI were evaluated using gonioscopy and AS-OCT. Angle configuration including angle opening distance (AOD) at 500 microns anterior to the scleral spur, AOD500, trabecular-iris space area up to 750 microns from the scleral spur, TISA750 and the increase in angle opening going from dark to light conditions was determined. Results: Both mean AOD500 and TISA750 increased nearly threefold going from dark to ...

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    1-12 of 12
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    1. (12 articles) Paul J. Foster
    2. (7 articles) National University of Singapore
    3. (7 articles) Singapore Eye Research Institute
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    Diagnostic Performance of Anterior Chamber Angle Measurements for Detecting Eyes With Narrow Angles: An Anterior Segment OCT Study: An Anterior Segment OCT Study Changes in Anterior Segment Morphology after Laser Peripheral Iridotomy: An Anterior Segment Optical Coherence Tomography Study Spectral domain optical coherence tomography imaging of the aqueous outflow structures in normal participants of the EPIC-Norfolk Eye Study Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline A Study Using Optical Coherence Tomography Feature Of The Week 07/08/2018: Retinal Nerve Fibre Layer Thickness & Cognition - Results from UK Biobank In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances The Association of Optical Coherence Tomography Results With Neuroimaging Signs and Some Clinical Parameters in Idiopathic Intracranial Hypertension Low cost scalable monolithic common path probe design for the application in endoscopic optical coherence tomography Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: a Comparative Study Using Optical Coherence Tomography Angiography Longitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using Optical Coherence Tomography Angiography Morphometric characteristics of the optical disc and thickness of retinal nerve fibre layer using Cirrus 5000 optical coherence tomography in healthy patients attending the National Institute of Ophthalmology Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography