1. Articles from Joan L. Jefferys

    1-5 of 5
    1. Detection of Age-Related Macular Degeneration by Portable Optical Coherence Tomography Operated by Nonexpert Personnel: Potential Use for Screenings

      Detection of Age-Related Macular Degeneration by Portable Optical Coherence Tomography Operated by Nonexpert Personnel: Potential Use for Screenings

      Purpose: The purpose of this study is to determine the sensitivity and specificity of detecting age-related macular degeneration (AMD) using portable optical coherence tomography (OCT) operated by nonexpert photographers on undilated patients. Methods: In this case-control study, 92 individuals were recruited from the glaucoma and retina clinics at the Wilmer Eye Institute (Johns Hopkins University, Baltimore, MD). Using the portable iVue (Optovue, Inc, Fremont, CA) spectral-domain OCT (SD-OCT), 2 nonexpert photographers acquired retina map scans on undilated eyes of all participants. In total, 33 AMD eyes and 105 control eyes were evaluated and graded by ophthalmologists masked to the diagnoses ...

      Read Full Article
    2. Evaluation of Automated Segmentation Algorithms for Optic Nerve Head Structures in Optical Coherence Tomography Images

      Evaluation of Automated Segmentation Algorithms for Optic Nerve Head Structures in Optical Coherence Tomography Images

      Purpose : To compare the identification of optic nerve head (ONH) structures in optical coherence tomography images by observers and automated algorithms. Methods : ONH images in 24 radial scan sets by optical coherence tomography were obtained in 51 eyes of 29 glaucoma patients and suspects. Masked intraobserver and interobserver comparisons were made of marked endpoints of Bruch's membrane opening (BMO) and the anterior lamina cribrosa (LC). BMO and LC positional markings were compared between observer and automated algorithm. Repeated analysis on 20 eyes by the algorithm was compared. Regional ONH data were derived from the algorithms. Results : Intraobserver difference in ...

      Read Full Article
    3. Comparison of Dynamic Changes in Anterior Ocular Structures Examined with Anterior Segment Optical Coherence Tomography in a Cohort of Various Origins

      Comparison of Dynamic Changes in Anterior Ocular Structures Examined with Anterior Segment Optical Coherence Tomography in a Cohort of Various Origins

      Purpose: To identify risk factors for angle closure from iris and angle anterior segment optical coherence tomography (ASOCT) measurements and to determine if these differ by geographic origin. Methods: ASOCT images from 267 clinic-based persons were compared between bright and dark conditions. An automated program quantified angle and iris parameters. Results: Iris area in bright light was larger with increasing age (univariate regression, p=0.0005), and largest in European and African-derived and smallest in Korean and Chinese eyes (multivariable regression, p=0.0001). Iris area was significantly larger in AC groups compared to normal and open angle glaucoma groups ...

      Read Full Article
    4. Choroidal Thickness Change after Water Drinking Is Greater in Angle Closure than in Open Angle Eyes [Glaucoma]

      Choroidal Thickness Change after Water Drinking Is Greater in Angle Closure than in Open Angle Eyes [Glaucoma]

      Purpose. To study change in choroidal thickness (CT) after water drinking test (WDT), comparing angle closure (AC) to open angle (OA) eyes.

      Methods. Before and 30 minutes after drinking 1 L of water, 88 glaucoma subjects underwent measurements of CT by spectral domain-optical coherence tomography, IOP, blood pressure (BP), axial length (AL), and anterior chamber depth (ACD).

      Results. Baseline CT was significantly greater in AC than in OA eyes (P = 0.002). After WDT, BP, IOP, and AL increased significantly (all P ≤ 0.0001). Mean CT increased significantly in the AC group (5.6 μm, P = 0.04, n = 40 ...

      Read Full Article
    5. Detection of New-Onset Choroidal Neovascularization Using Optical Coherence Tomography: The Amd Doc Study

      Detection of New-Onset Choroidal Neovascularization Using Optical Coherence Tomography: The Amd Doc Study

      Purpose To determine the sensitivity of time domain optical coherence tomography (OCT) in detecting conversion to neovascular age-related macular degeneration (AMD) in eyes at high risk for choroidal neovascularization (CNV), compared with detection using fluorescein angiography (FA) as the gold standard. Design Prospective, multicenter, observational study. Participants Individuals aged ≥50 years with nonneovascular AMD at high risk of progressing to CNV in the study eye and evidence of neovascular AMD in the fellow eye. Methods At study entry and every 3 months through 2 years, participants underwent best-corrected visual acuity, supervised Amsler grid testing, preferential hyperacuity perimetry (PHP) testing, stereoscopic ...

      Read Full Article
    1-5 of 5
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (5 articles) Johns Hopkins University
    2. (1 articles) Lawrence J. Singerman
    3. (1 articles) Jeffrey S. Heier
    4. (1 articles) Optovue
    5. (1 articles) Duke University
    6. (1 articles) National Institutes of Health
    7. (1 articles) Massachusetts General Hospital
    8. (1 articles) Capital Medical University
    9. (1 articles) Osaka University
    10. (1 articles) Tokyo Medical & Dental University
    11. (1 articles) FDA
    12. (1 articles) Cleveland Clinic
    13. (1 articles) University College London
    14. (1 articles) University of Bonn
  3. Popular Articles

  4. Picture Gallery

    Detection of New-Onset Choroidal Neovascularization Using Optical Coherence Tomography: The Amd Doc Study Choroidal Thickness Change after Water Drinking Is Greater in Angle Closure than in Open Angle Eyes [Glaucoma] Comparison of Dynamic Changes in Anterior Ocular Structures Examined with Anterior Segment Optical Coherence Tomography in a Cohort of Various Origins Evaluation of Automated Segmentation Algorithms for Optic Nerve Head Structures in Optical Coherence Tomography Images Detection of Age-Related Macular Degeneration by Portable Optical Coherence Tomography Operated by Nonexpert Personnel: Potential Use for Screenings Clinical Usefulness of a Novel Optical Coherence Tomography Procedure, “Low Molecular Weight Dextran Infusion Followed by Catheter PUSH (D-PUSH)” Optical Coherence Tomography to Guide Percutaneous Coronary Intervention of the Left Main Coronary Artery: the LEMON study Impact of optical coherence tomography findings on clinical outcomes in ST-segment elevation myocardial infarction patients: a MATRIX (Minimizing Adverse Hemorrhagic Events by Trans-radial Access Site and angioX) OCT sub-study OCTA Multilayer and Multisector Peripapillary Microvascular Modeling for Diagnosing and Staging of Glaucoma Optical coherence tomography angiography for identifying choroidal neovascular membranes: a masked study in clinical practice Preclinical ocular features in patients with Behçet’s disease detected by optical coherence tomography angiography Reconstruction of Optical Coherence Tomography Images Using Mixed Low Rank Approximation and Second Order Tensor Based Total Variation Method