1. Articles from Raghavan Lavanya

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    1. Referenced scans improve the repeatability of optical coherence tomography angiography measurements in normal and glaucoma eyes

      Referenced scans improve the repeatability of optical coherence tomography angiography measurements in normal and glaucoma eyes

      Aim To compare the repeatability of peripapillary perfusion density and flux index measurements on referenced and non-referenced optical microangiography (OMAG) scans in normal, glaucoma suspect and glaucoma eyes. Methods In a cross-sectional study, 48 eyes (33 subjects) underwent three repeat, non-referenced peripapillary OMAG scans in the same session and 43 eyes (25 subjects) underwent three referenced peripapillary OMAG scans. In the referenced scan group, repeat scans (second and the third scan) were acquired exactly on the baseline (first) scan using the ‘track to prior scan’ option on the device. Repeatability estimates of the mean and four-sector (temporal, superior, nasal and ...

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      Mentions: UCSD
    2. Changes in Anterior Segment Morphology after Laser Peripheral Iridotomy: An Anterior Segment Optical Coherence Tomography Study

      Changes in Anterior Segment Morphology after Laser Peripheral Iridotomy: An Anterior Segment Optical Coherence Tomography Study

      Purpose Novel anterior segment optical coherence tomography (ASOCT) parameters associated with angle closure include anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), iris area (I-area), and iris curvature (I-curv). We aimed to investigate changes in these parameters after laser peripheral iridotomy (LPI) in a cohort of primary angle-closure suspects (PACS). Design Prospective observational study. Participants and Controls A total of 176 PACS aged ≥50 years who underwent LPI in 1 eye. Methods We analyzed ASOCT images (Visante, Carl Zeiss Meditec, Dublin, CA) from all subjects using customized software before and ...

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    3. Association of Narrow Angles With Anterior Chamber Area and Volume Measured With Anterior-Segment Optical Coherence Tomography]

      Association of Narrow Angles With Anterior Chamber Area and Volume Measured With Anterior-Segment Optical Coherence Tomography]
      Objectives To describe the measurement of anterior chamber area and anterior chamber volume by anterior-segment optical coherence tomography and to investigate the association of these parameters with the presence of narrow angles. Methods This was a cross-sectional study of subjects aged at least 50 years without ophthalmic symptoms recruited from a community clinic. All participants underwent standardized ocular examination and anterior-segment optical coherence tomography. Customized software was used to measure anterior chamber area (cross-sectional area bounded by the corneal endothelium, anterior surface of iris, and lens within the pupil) and anterior chamber volume (calculated by rotating the anterior chamber area ...
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    4. Single versus sequential testing with scanning peripheral anterior chamber depth analyser, IOLMaster and anterior segment optical coherence tomography for the detection of narrow angles

      Single versus sequential testing with scanning peripheral anterior chamber depth analyser, IOLMaster and anterior segment optical coherence tomography for the detection of narrow angles
      Background Scanning peripheral anterior chamber depth analyser (SPAC), IOLMaster and anterior segment optical coherence tomography (AS-OCT) are devices that can screen non-invasively for narrow angles (NAs) and may reduce the need for gonioscopy, especially where the availability of ophthalmologists is limited. When used individually to detect NAs, neither SPAC, AS-OCT nor IOLMaster were able to achieve both high sensitivity and specificity when using gonioscopy as a gold standard. Aims To assess whether sequential testing improves discrimination of NAs over single testing. Methods In a prospective community-based cross-sectional study in Singapore, 2047 phakic right eyes underwent SPAC, IOLMaster and AS-OCT. NA ...
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    5. Diagnostic Performance of Anterior Chamber Angle Measurements for Detecting Eyes With Narrow Angles: An Anterior Segment OCT Study: An Anterior Segment OCT Study

      Diagnostic Performance of Anterior Chamber Angle Measurements for Detecting Eyes With Narrow Angles: An Anterior Segment OCT Study: An Anterior Segment OCT Study

      Objective  To assess the diagnostic performance of angle measurements from anterior segment optical coherence tomography (AS-OCT) images for identifying eyes with narrow angles. Methods  We conducted a community-based cross-sectional study of individuals 50 years or older who had phakic eyes and who underwent AS-OCT imaging in the dark by a single operator and gonioscopy by an ophthalmologist masked to AS-OCT findings. An eye was considered to have narrow angles if the posterior pigmented trabecular meshwork was not visible for at least 180° on gonioscopy. Horizontal AS-OCT images were analyzed for the following measurements using customized software: angle opening distance (AOD ...

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    6. Evaluation of Scanning Protocols for Imaging the Anterior Chamber Angle With Anterior Segment-Optical Coherence Tomography

      Purpose: To evaluate different anterior segment-optical coherence tomography (AS-OCT) scanning protocols for detecting eyes with angle closure. Methods: This cross-sectional study enrolled 2104 subjects from a community clinic in Singapore. All participants underwent AS-OCT imaging in the dark (Visante, Carl-Zeiss, Meditec, Dublin, CA), and gonioscopy with a Goldmann 2-mirror and a Sussman lens by an experienced examiner. The anterior chamber angle in a particular quadrant was considered closed on gonioscopy if the posterior trabecular meshwork could not be seen; and on AS-OCT by the presence of contact between the iris and angle wall anterior to the scleral spur. Protocols using ...
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    7. Screening for Narrow Angles in the Singapore Population: Evaluation of New Noncontact Screening Methods

      Purpose: To assess the screening effectiveness of 3 new noncontact devices, the scanning peripheral anterior chamber depth analyzer (SPAC) (Takagi, Nagano, Japan), which measures peripheral anterior chamber depth (ACD); IOLMaster (Carl Zeiss Meditec, Jena, Germany), which measures central ACD; and Visante anterior segment optical coherence tomography (AS-OCT) (Visante, Carl Zeiss Meditec, Dublin, CA), which images the angles, and to compare these instruments with gonioscopy in identifying people with narrow angles (NAs).Design: Cross-sectional, observational, community-based study.Participants: Phakic subjects aged ≥50 years without ophthalmic symptoms who were recruited from a community polyclinic in Singapore.Methods: All subjects underwent examination with ...

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    8. Assessment of the Scleral Spur in Anterior Segment Optical Coherence Tomography Images

      Objective  To assess visibility of the scleral spur in anterior segment optical coherence tomography (AS-OCT) images. Methods  This cross-sectional observational study included 502 participants aged 50 years or older who had no previous ophthalmic problems and were recruited from a community clinic in Singapore. All participants underwent gonioscopy and AS-OCT (Visante; Carl Zeiss Meditec, Dublin, California). Scleral spur location was assessed in AS-OCT images by 2 examiners with glaucoma subspecialty training and was defined as the point where there was an inward protrusion of the sclera with a change in curvature of its inner surface. Results  Scleral spur location could ...

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  2. Topics in the News

    1. (7 articles) Johns Hopkins University
    2. (7 articles) National University of Singapore
    3. (6 articles) Singapore Eye Research Institute
    4. (3 articles) Sun Yat-Sen University
    5. (3 articles) Carl Zeiss Meditec
    6. (1 articles) UCSD
    7. (1 articles) Northwestern University
    8. (1 articles) Jikei University School of Medicine
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    Diagnostic Performance of Anterior Chamber Angle Measurements for Detecting Eyes With Narrow Angles: An Anterior Segment OCT Study: An Anterior Segment OCT Study Single versus sequential testing with scanning peripheral anterior chamber depth analyser, IOLMaster and anterior segment optical coherence tomography for the detection of narrow angles Association of Narrow Angles With Anterior Chamber Area and Volume Measured With Anterior-Segment Optical Coherence Tomography] Changes in Anterior Segment Morphology after Laser Peripheral Iridotomy: An Anterior Segment Optical Coherence Tomography Study Referenced scans improve the repeatability of optical coherence tomography angiography measurements in normal and glaucoma eyes PREcise Percutaneous Coronary Intervention for Stent OptimizatION in Treatment of COMPLEX Lesion (PRECISION-COMPLEX) Real-Time Risk Score for Glaucoma Mass Screening by Spectral Domain Optical Coherence Tomography: Development and Validation Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease Vertical scan imaging of Anterior Segment Optical Coherence Tomography for descemet anchoring caterpillar seta: A case report and review of literature Evaluation of signal degradation due to birefringence in a multiple reference optical coherence tomography system with polarization-based balanced detection An improved method for murine laser-induced choroidal neovascularization lesion quantification from optical coherence tomography images Multimodal Imaging Including Swept Source Optical Coherence Tomography Angiography in A Case with Sclerochoroidal Calcification