1. Articles from Jacqueline Saw

    1-6 of 6
    1. Case reports of coronary fibromuscular dysplasia and spontaneous coronary artery dissections

      Case reports of coronary fibromuscular dysplasia and spontaneous coronary artery dissections

      Spontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome especially in women. The most common underlying predisposing cause of SCAD is fibromuscular dysplasia (FMD), a non‐inflammatory arteriopathy that results in weakening of the affected arteries, and can cause dissection or aneurysm. Coronary FMD (CFMD) was described as rare, and was shown to cause SCAD in histopathological case reports. Unfortunately, CFMD is challenging to diagnose on coronary angiography, as the findings can be similar to other causes of coronary artery disease. Therefore, we illustrate two case examples of CFMD on coronary angiography, and highlight findings on ...

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    2. Angiographic and Intracoronary Manifestations of Coronary Fibromuscular Dysplasia

      Angiographic and Intracoronary Manifestations of Coronary Fibromuscular Dysplasia

      Background— We previously described a strong association between fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection. Angiographic manifestations of coronary FMD aside from dissection were considered rare. However, we observed several coronary FMD angiographic abnormalities with corresponding optical coherence tomography abnormalities. Methods and Results— Baseline demographics and imaging of patients with suspected coronary FMD at Vancouver General Hospital were reviewed. Presence of multifocal (string-of-beads) extracoronary FMD was confirmed by 2 specialists. In these patients, coronary angiographic findings (excluding dissected segments) were reviewed and classified by 2 experienced angiographers for irregular stenosis, that is, stenosis with irregular borders in a focal ...

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      Mentions: Hiram G. Bezerra
    3. Optical coherence tomography (OCT) evaluation of intermediate coronary lesions in patients with NSTEMI - Cardiovascular Revascularization Medicine

      Optical coherence tomography (OCT) evaluation of intermediate coronary lesions in patients with NSTEMI - Cardiovascular Revascularization Medicine

      Introduction Coronary angiography is commonly performed following non-ST segment elevation myocardial infarction (NSTEMI) to assess the need for revascularization. Some of these patients have myocardial infarction (MI) with no obstructive coronary atherosclerosis (MINOCA). Patients without severe obstructive lesions are usually treated conservatively. However, coronary angiography has known limitations in the assessment of lesion severity. We report our experience of using coronary Optical Coherence Tomography (OCT) in a series of patients without severe obstructive coronary lesions. Methods 165 patients underwent coronary OCT at Vancouver General Hospital. NSTEMI was the clinical presentation in 70 patients and 26 had angiographically intermediate lesions with ...

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    4. Angiographic appearance of spontaneous coronary artery dissection with intramural hematoma proven on intracoronary imaging

      Angiographic appearance of spontaneous coronary artery dissection with intramural hematoma proven on intracoronary imaging

      Background The pathognomonic appearance of multiple radiolucent lumen on angiography is used to diagnose spontaneous coronary artery dissection (SCAD). However, this finding is absent in >70% of SCAD, in which case optical coherence tomography (OCT) or intravascular ultrasound (IVUS) is useful to assess arterial wall integrity. Methods We report the angiographic appearance of SCAD that were proven on intracoronary imaging with OCT or IVUS. Our angiographic classification and algorithm for SCAD diagnosis was previously reported. Patients with type 1 SCAD (multiple radiolucent lumen) do not require OCT/IVUS, whereas, it was recommended for those with suspected type 2 (diffuse stenosis ...

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    5. Intracoronary imaging of coronary fibromuscular dysplasia with OCT and IVUS

      Intracoronary imaging of coronary fibromuscular dysplasia with OCT and IVUS

      Fibromuscular dysplasia (FMD) is a segmental non-atherosclerotic, non-inflammatory vasculopathy typically of small-medium muscular arteries. Coronary FMD (CFMD) is believed to be rare. However, we have found an association between spontaneous coronary artery dissection (SCAD) and FMD as the cause of myocardial infarction in ∼25% of young women age <50. It is plausible that preexisting CFMD predisposed these women to SCAD. Definitive diagnosis of CFMD entails autopsy that is obviously impractical, and prior angiographic description does not differentiate superimposed SCAD from obliterative arteriopathy of CFMD. Adjunctive intravascular ultrasound or optical coherence tomography may aid the diagnosis of CFMD and we report ...

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    6. Spontaneous Coronary Artery Dissection in Patients With Fibromuscular Dysplasia: A Case Series

      Spontaneous Coronary Artery Dissection in Patients With Fibromuscular Dysplasia: A Case Series

      Young women with acute coronary syndrome (ACS) frequently have nonatherosclerotic coronary artery disease (NACAD) and may be misdiagnosed. Coronary fibromuscular dysplasia (CFMD) commonly is overlooked, as the angiographic appearance is often subtle. Our group previously described CFMD as a diffuse obliterative disease starting abruptly at the mid-distal vessel, involving long segments.1 Spontaneous coronary dissection (SCAD) is another common form of NACAD and may be superimposed on CFMD, causing ACS. We report the first case series of SCAD and concomitant fibromuscular dysplasia (FMD).

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    1-6 of 6
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    Spontaneous Coronary Artery Dissection in Patients With Fibromuscular Dysplasia: A Case Series Intracoronary imaging of coronary fibromuscular dysplasia with OCT and IVUS Angiographic appearance of spontaneous coronary artery dissection with intramural hematoma proven on intracoronary imaging Optical coherence tomography (OCT) evaluation of intermediate coronary lesions in patients with NSTEMI - Cardiovascular Revascularization Medicine Angiographic and Intracoronary Manifestations of Coronary Fibromuscular Dysplasia Case reports of coronary fibromuscular dysplasia and spontaneous coronary artery dissections The Effect of Anti-Tubercular Drugs on Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography A Cross-sectional Optical Coherence Tomography Study in Patients on Taxane-based Therapy and A Case Report with the Literature Review Association of systemic inflammatory biomarkers with morphological characteristics of the coronary atherosclerotic plaque by intravascular optical coherence tomography. OCT angiography improves views of retina blood flow Real-time retinal layer segmentation of OCT Volumes with GPU and Deep learning Baylor College of Medicine Receives a 2020 NIH Grant for Biomechanics of Early Mammalian Cardiogenesis