1. Articles from Muneeswar G. Nittala

    1-11 of 11
    1. AMISH EYE STUDY: Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration

      AMISH EYE STUDY: Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration

      Purpose: To describe spectral domain optical coherence tomography (SD-OCT) findings in an Amish cohort to assess SD-OCT markers for early age-related macular degeneration (AMD). Methods: The authors performed a family-based prospective cohort study of 1,146 elderly Amish subjects (age range 50–99 years) (2,292 eyes) who had a family history of at least 1 individual with AMD. All subjects underwent complete ophthalmic examinations, SD-OCT using both Cirrus and Spectralis (20 × 20° scan area) instruments, fundus autofluorescence, infrared imaging, and color fundus photography. Spectral domain optical coherence tomography characteristics were analyzed in subjects with AMD (with and without subretinal ...

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    2. Assessment Of Retinal Blood Flow In Diabetic Retinopathy Using Doppler FOURIER-DOMAIN Optical Coherence Tomography

      Assessment Of Retinal Blood Flow In Diabetic Retinopathy Using Doppler FOURIER-DOMAIN Optical Coherence Tomography

      Purpose: To evaluate retinal blood flow measurements in normal eyes and eyes with varying levels of diabetic retinopathy (DR) using Doppler Fourier-domain optical coherence tomography (FD-OCT). Methods: Twenty-two eyes of 19 subjects, 10 with severe nonproliferative DR (NPDR) and 12 with proliferative DR (PDR), were compared with 44 eyes of 40 healthy control subjects. All eyes were scanned by RTvue FD-OCT. Color disk photographs and cube/volume scans of the optic nerve head were obtained. Doppler OCT scans and accessory imaging data were imported into Doppler OCT of Retinal Circulation grading software to calculate TRBF and vascular parameters (e.g ...

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    3. Proposal of a simple optical coherence tomography-based scoring system for progression of age-related macular degeneration

      Proposal of a simple optical coherence tomography-based scoring system for progression of age-related macular degeneration

      Purpose To develop a simple, clinically practical, optical coherence tomography (OCT)-based scoring system for early age-related macular degeneration (AMD) to prognosticate risk for progression to late AMD. Methods We retrospectively reviewed OCT images (512 × 128 macular cube, Cirrus) from 138 patients diagnosed of early AMD in at least one eye and follow-up of at least 12 months. For patients with early AMD in both eyes, only the right eye was chosen as the study eye for longitudinal assessment. Scans were graded on four SD-OCT criteria associated with disease progression in previous studies: drusen volume within a central 3-mm circle ...

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    4. QUANTIFICATION OF INTRARETINAL HARD EXUDATES IN EYES WITH DIABETIC RETINOPATHY BY OPTICAL COHERENCE TOMOGRAPHY

      QUANTIFICATION OF INTRARETINAL HARD EXUDATES IN EYES WITH DIABETIC RETINOPATHY BY OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To evaluate the reproducibility of intraretinal hard exudate (HE) quantification from spectral domain optical coherence tomography (SD-OCT) images of eyes with diabetic retinopathy (DR). Methods: Cases with diabetic macular edema were enrolled. The area of HE obtained by B-scan segmentation was compared with the area obtained by en face segmentation. Results: The mean +/- SD for the HE area was 1.78 +/- 1.37 mm2 with B-scan segmentation and 0.72 +/- 0.82 mm2 with the automated en face analysis tool; the absolute difference was 1.01 +/- 0.64 mm2. There was excellent correlation in total HE area between the ...

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    5. Quantitative Characteristics of Spectral-Domain Optical Coherence Tomography in Corresponding Areas of Increased Autofluorescence at the Margin of Geographic Atrophy in Patients With Age-Related Macular Degeneration

      Quantitative Characteristics of Spectral-Domain Optical Coherence Tomography in Corresponding Areas of Increased Autofluorescence at the Margin of Geographic Atrophy in Patients With Age-Related Macular Degeneration

      BACKGROUND AND OBJECTIVE: To evaluate the spectral-domain optical coherence tomography (SD-OCT) characteristics of the junctional zone corresponding to areas of increased autofluorescence (IAF) at the margin of geographic atrophy (GA) in patients with age-related macular degeneration (AMD). PATIENTS AND METHODS: SD-OCT and fundus autofluorescence (FAF) images from untreated eyes with GA available from archived studies at Doheny Image Reading Center were evaluated. Areas of definite decreased autofluorescence (DDAF) corresponding to GA, and areas of IAF at the margins of the GA were manually segmented. Eyes with evidence of IAF were selected. Following manual registration of FAF and OCT data, areas ...

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    6. Measurement of retinal blood flow in normal Chinese American subjects by Doppler Fourier-domain optical coherence tomography

      Measurement of retinal blood flow in normal Chinese American subjects by Doppler Fourier-domain optical coherence tomography

      PURPOSE: To measure total retinal blood flow (TRBF) in normal, healthy Chinese-Americans using semi-automated analysis of Doppler Fourier-domain optical coherence tomography (FD-OCT) scans. METHODS: Two hundred sixty-six normal, healthy Chinese-American participants (266 eyes) were enrolled from The Chinese American Eye Study (CHES). All participants underwent complete ophthalmic examination, including best-corrected visual acuity, indirect ophthalmoscopy and Doppler FD-OCT imaging, using the circumpapillary double circular scan protocol. TRBF and other vascular parameters (e.g. venous and arterial cross-sectional area and their velocities) were calculated using Doppler OCT of Retinal Circulation software. Associations between TRBF and other clinical parameters were assessed using bivariate ...

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    7. Reproducibility of Anterior Segment Angle Metrics Measurements Derived From Cirrus Spectral Domain Optical Coherence Tomography

      Reproducibility of Anterior Segment Angle Metrics Measurements Derived From Cirrus Spectral Domain Optical Coherence Tomography

      Purpose: To investigate the reproducibility of anterior segment angle (ACA) metrics measurements in normal subjects on Cirrus spectral domain optical coherence tomography (SD-OCT). Methods: 40 eyes from 20 healthy, normal subjects underwent anterior segment imaging using a Cirrus SD-OCT. For each eye, 2 acquisitions of 5-line raster scans were performed perpendicularly on the inferior (270 degrees) angle. The Schwalbe's line-angle opening distance (SL-AOD) and Schwalbe's line-trabecular-iris space area (SL-TISA) measurements were performed by masked certified reading center graders using customized grading software. Intra-acquisition, intergrader, and intragrader reproducibility of SL-AOD and SL-TISA measurements were evaluated by intraclass correlation coefficients ...

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    8. Comparison of Retinal Layer Intensity Profiles From Different OCT Devices

      Comparison of Retinal Layer Intensity Profiles From Different OCT Devices

      BACKGROUND AND OBJECTIVE: The purpose of this study is to use automated multiple retinal layer segmentation to compare retinal layer intensity profiles between different spectral-domain optical coherence tomography (SD-OCT) devices with and without normalization. PATIENTS AND METHODS: A graph-based multistage segmentation approach was used to identify 11 boundaries in horizontal SD-OCT B-scans passing through the foveal center. Four acquisition protocols from two different SD-OCT devices were applied on 34 eyes from 17 healthy participants. The mean intensity of the 11 layers was compared within each device and between the two devices. In addition, the intensity of the various layers was ...

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    9. Optical Coherence Tomographic Correlates of Angiographic Subtypes of Occult Choroidal Neovascularization

      Optical Coherence Tomographic Correlates of Angiographic Subtypes of Occult Choroidal Neovascularization

      Purpose: To compare the optical coherence tomographic (OCT) correlates of two previously described angiographic subtypes of occult choroidal neovascularization (CNV). Methods: We retrospectively analyzed 17 consecutive patients with previously untreated occult CNV who had both fluorescein angiography (FA) and volume spectral domain (SD) OCT images obtained on the same visit. Planimetric grading was performed on the FA images by certified reading center graders to precisely outline the boundaries of the fibrovascular pigment epithelial detachment (FVPED) and/or late leakage of undetermined source (LLUS) components of occult CNV for each case. In the SDOCT images, the inner retinal pigment epithelial (RPE ...

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    10. Comparison of Dresen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging

      Comparison of Dresen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging

      Purpose: To compare the measurements of drusen area from manual segmentation of color fundus photographs with those generated by an automated algorithm designed to detect elevations of the retinal pigment epithelium (RPE) on spectral domain optical coherence tomography (SDOCT) images. Methods: Fifty eyes with drusen secondary to non-exudative age-related macular degeneration (AMD) were enrolled. All eyes were imaged with the Cirrus HD-OCT instrument (Carl Zeiss Meditec, Dublin, CA) using a 200x200 A-scan raster pattern covering a 6mm X 6mm area centered on the fovea. Digital color fundus images were taken on the same day. Drusen were traced manually on the ...

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    11. Reproducibility of Retinal Blood Flow Measurements Derived From Semi-Automated Doppler OCT Analysis

      Reproducibility of Retinal Blood Flow Measurements Derived From Semi-Automated Doppler OCT Analysis
      BACKGROUND AND OBJECTIVE: To evaluate reproducibility and intergrader agreement of total retinal blood flow (TRBF) measurements obtained by semi-automated grading of Doppler Fourier-domain optical coherence tomography (FD-OCT) scans. PATIENTS AND METHODS: Doppler FD-OCT scans were obtained from 20 eyes of 18 subjects (10 glaucomatous, 10 normal). Scans were obtained using a circumpapillary scan protocol and analyzed using the Doppler OCT of Retinal Circulation software (version 2). Two masked, independent human graders manually refined the scans, adding or deleting vessels, changing vessel boundaries, and classifying vessels as veins or arteries. TRBF was calculated automatically by software summing flow in all veins ...
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    1-11 of 11
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    1. (11 articles) Srinivas R. Sadda
    2. (7 articles) UCLA
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    Reproducibility of Retinal Blood Flow Measurements Derived From Semi-Automated Doppler OCT Analysis Comparison of Dresen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging Optical Coherence Tomographic Correlates of Angiographic Subtypes of Occult Choroidal Neovascularization Comparison of Retinal Layer Intensity Profiles From Different OCT Devices Reproducibility of Anterior Segment Angle Metrics Measurements Derived From Cirrus Spectral Domain Optical Coherence Tomography Measurement of retinal blood flow in normal Chinese American subjects by Doppler Fourier-domain optical coherence tomography Quantitative Characteristics of Spectral-Domain Optical Coherence Tomography in Corresponding Areas of Increased Autofluorescence at the Margin of Geographic Atrophy in Patients With Age-Related Macular Degeneration QUANTIFICATION OF INTRARETINAL HARD EXUDATES IN EYES WITH DIABETIC RETINOPATHY BY OPTICAL COHERENCE TOMOGRAPHY Proposal of a simple optical coherence tomography-based scoring system for progression of age-related macular degeneration Assessment Of Retinal Blood Flow In Diabetic Retinopathy Using Doppler FOURIER-DOMAIN Optical Coherence Tomography The multi-spectral signal properties of multiple reference optical coherence tomography (Thesis) Calibration-free time-stretch optical coherence tomography with large imaging depth