1. Articles from Jean Lambert

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    1. Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr-/-:hApoB+/+ mice and improves cerebral blood flow

      Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr-/-:hApoB+/+ mice and improves cerebral blood flow

      Endothelial dysfunction and oxidative stress contribute to the atherosclerotic process that includes stiffening of large peripheral arteries. In contrast, we previously reported a paradoxical increase in cerebrovascular compliance in LDLr-/-: hApoB+/+ atherosclerotic (ATX) mice. We hypothesized that prevention of cerebral artery endothelial function with a chronic dietary antioxidant intake would normalize the changes in cerebral artery wall structure and biomechanics and prevent the decline in basal cerebral blood flow (CBF) associated with atherosclerosis. Three-month old ATX mice were treated, or not, for 3 months with the polyphenol (+)-catechin (CAT, 30 mg/kg/day) and compared to wild-type (WT) controls. In ...

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  2. Topics in the News

    1. (2 articles) Medical University of Vienna
    2. (2 articles) Christoph K. Hitzenberger
    3. (1 articles) University of Montreal
    4. (1 articles) Polytechnique Montreal
    5. (1 articles) Frédéric Lesage
    6. (1 articles) Harvard University
    7. (1 articles) Massachusetts General Hospital
    8. (1 articles) Kobe University Graduate School of Medicine
    9. (1 articles) Federal University of Pernambuco
    10. (1 articles) Toshiro Shinke
    11. (1 articles) Junya Shite
    12. (1 articles) Adolf F. Fercher
    13. (1 articles) Takayuki Okamura
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