1. Articles from Hiroto Terasaki

    1-16 of 16
    1. Risk factors and characteristics of central serous chorioretinopathy with later development of macular neovascularisation detected on OCT angiography: a retrospective multicentre observational study

      Risk factors and characteristics of central serous chorioretinopathy with later development of macular neovascularisation detected on OCT angiography: a retrospective multicentre observational study

      Objective: To identify the risk factors and characteristics of central serous chorioretinopathy (CSC) with subsequent macular neovascularisation (MNV) detected on optical coherence tomography angiography (OCTA). Methods and analysis: We included patients from six institutions who were initially diagnosed with CSC and subsequently did or did not develop MNV detected by OCTA. Potential influencing factors were identified by evaluating the patients' baseline demographics, multimodal fundus imaging, treatment options, recurrence and outcomes in both groups. Results: We enrolled 176 eyes in 152 patients (112 men, 40 women; mean age: 52.1±10.4 years) with a mean follow-up of 30.4±16 ...

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    2. Comparison of multicolor scanning laser ophthalmoscopy and optical coherence tomography angiography for detection of microaneurysms in diabetic retinopathy

      Comparison of multicolor scanning laser ophthalmoscopy and optical coherence tomography angiography for detection of microaneurysms in diabetic retinopathy

      This study aimed to evaluate the usefulness of multicolor (MC) scanning laser ophthalmoscopy (MC-SLO) in detecting microaneurysm (MA) in eyes with diabetic retinopathy (DR). This was a retrospective cross-sectional study. Eyes with DR underwent fluorescein angiography (FA), MC-SLO, optical coherence tomography angiography (OCTA), and color fundus photography (CFP) were analyzed. The foveal region was cut in an 6 × 6 mm image and the number of MA in each image was counted by retina specialists to determine the sensitivity and positive predictive value. FA results were used as the ground standard. MAs were classified as those with early, late, or no ...

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    3. Macular irregularities of optical coherence tomographic vertical cross sectional images in school age children

      Macular irregularities of optical coherence tomographic vertical cross sectional images in school age children

      The purpose of this study was to compare the incidences of macular irregularities of elementary school (ES) and junior high school (JHS) students. This was a prospective cross-sectional observational study of 122 right eyes of 122 ES students (8-9 years) and 173 right eyes of 173 JHS students (12-13 years). Vertical cross-sectional images of the macula were obtained by optical coherence tomography. The eyes were classified based on the vertical symmetry of the posterior pole, and then sub-classified as convex-, flat-, concave-, or dome-shaped based on the direction of the curvature of the retinal pigment epithelium. One hundred and two ...

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    4. Quantitative analyses of diameter and running pattern of choroidal vessels in central serous chorioretinopathy by en face images

      Quantitative analyses of diameter and running pattern of choroidal vessels in central serous chorioretinopathy by en face images

      This study was to investigate the choroidal vessels in eyes with central serous chorioretinopathy (CSC) quantitatively. We studied 41 CSC eyes and their fellow eyes, and 41 normal eyes of 41 age-adjusted individuals. En-face optical coherence tomography image of the top 25% slab of Haller’s layer was analyze. The mean vessel area, vessel length, and vessel diameter were calculated. The running pattern of the vessels was quantified and used to determine the degree of symmetry, the “symmetry index”. The vessel area of CSC eyes was not significantly different from that of fellow eyes but significantly larger than that of ...

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    5. Regional Differences of Choroidal Structure Determined by Wide-Field Optical Coherence Tomography

      Regional Differences of Choroidal Structure Determined by Wide-Field Optical Coherence Tomography

      Purpose : To compare the submacular to the perimacular choroidal structure in images obtained by wide-field optical coherence tomography (OCT). Methods : Thirty eyes of 30 healthy volunteers (15 men) were studied. Twelve wide-field radial circumferential scans were recorded with enhanced depth imaging OCT from the macular and perimacular zones. The sizes of the luminal and stromal areas of the choroid were determined. The two zones were subdivided into the superior, inferior, nasal, and temporal sectors. The total choroidal area, the luminal and stromal areas, and the luminal ratio of each sector were compared. Results : All of the choroidal structural parameters analyzed ...

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    6. Automated segmentation of en face choroidal images obtained by optical coherent tomography by machine learning

      Automated segmentation of en face choroidal images obtained by optical coherent tomography by machine learning

      Purpose To develop an automated method to segment the choroidal layers of en face optical coherent tomography (OCT) images by machine learning. Study design A cross-sectional, prospective study of 276 eyes of 181 healthy subjects. Methods OCT en face images of the choroid were obtained every 2.6 μm from the retinal pigment epithelium (RPE) to the chorioscleral border. The images at the start of the choriocapillaris, start of Sattler’s layer, and start of Haller’s layer were identified, and the image numbers from the RPE line were taken as the teacher data. Forty-one feature quantities of each image ...

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    7. Objective evaluation of size and shape of superficial foveal avascular zone in normal subjects by optical coherence tomography angiography

      Objective evaluation of size and shape of superficial foveal avascular zone in normal subjects by optical coherence tomography angiography

      This study was conducted to investigate the size and shape of the foveal avascular zone (FAZ) determined by optical coherence tomography angiography (OCTA) and the relationship of the size and shape to the clinical findings in normal subjects. This was a cross-sectional study with seventy eyes of 70 volunteers. The size of the superficial FAZs were assessed by its area, length of perimeter, and Feret’s diameter, and the shape by the circularity, axial ratio, roundness, and solidity. The correlations between each parameter and the clinical findings were statistically determined. The coefficients of variation (CV) of the parameters of FAZ ...

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    8. Evaluation of Shape of Foveal Avascular Zone by Optical Coherence Tomography Angiography in Eyes With Branch Retinal Vein Occlusion

      Evaluation of Shape of Foveal Avascular Zone by Optical Coherence Tomography Angiography in Eyes With Branch Retinal Vein Occlusion

      Purpose: To determine the relationship between morphological parameters of the foveal avascular zone (FAZ) in the optical coherence tomography angiographic (OCTA) images and the best-corrected visual acuity (BCVA) in branch retinal vein occlusion (BRVO). Methods: This was a retrospective cross-sectional study. Eyes with BRVO without apparent macular edema were studied. The superficial FAZ in 3 × 3 mm OCTA images were delineated manually. The size and shape, the circularity and axial ratio, of the FAZ were determined, and the values were compared to that of the controls. The correlation of these parameters with the BCVA was analyzed. Results: The mean FAZ ...

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    9. Correlations between local peripapillary choroidal thickness and axial length, optic disc tilt, and papillo-macular position in young healthy eyes

      Correlations between local peripapillary choroidal thickness and axial length, optic disc tilt, and papillo-macular position in young healthy eyes

      Optical coherence tomography (OCT) has made it possible for clinicians to measure the peripapillary choroidal thickness (ppCT) noninvasively in various ocular diseases. However, the ocular factors associated with the ppCT have not been conclusively determined. The purpose of this study was to determine the relationship between the local ppCT and the axial length, optic disc tilt, and the angle of the papillo-macular position (PMP) in healthy eyes. This was a prospective, observational cross-sectional study of 119 right eyes of 119 healthy Japanese volunteers. The ppCT was manually measured at eight sectors around the optic disc using the B-scan images of ...

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    10. Minification of fundus optical coherence tomographic images in gas-filled eye

      Minification of fundus optical coherence tomographic images in gas-filled eye

      Background Optical coherence tomography (OCT) is being used increasingly to evaluate and manage a variety of retinal diseases, but not much is known about the minification of the OCT images in gas-filled eyes. The purpose of this study was to investigate the effect of gas-filled eyes on the size of the OCT images. Methods This was retrospective case series of 81 consecutive eyes of 79 patients who had macular hole surgery between April 2012 and September 2014. Images of the optic disc were taken with a spectral domain-OCT instrument 2 days after surgery in gas-filled, pseudophakic eyes and from the ...

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    11. Blood Components and OCT Reflectivity Evaluated in Animal Model

      Blood Components and OCT Reflectivity Evaluated in Animal Model

      Background/purpose : To see the relationship between blood components and optical coherence tomography ( OCT ) reflectivity using an animal model in which the aqueous humor was substituted by different experimental solutions without changing the integrity of the retina. Materials and methods : The aqueous humor of an enucleated swine eye was replaced with plasma obtained from healthy volunteers. The OCT reflectivity of the anterior chamber filled with each plasma was calculated from individual OCT images, and was expressed by an arbitrary unit (AU). The concentration of blood components such as cholesterol, hemoglobin (Hb) and bilirubin of each individual was measured, and the ...

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    12. Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images

      Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images

      Purpose. To determine changes in choroidal structure by binarization of optical coherence tomographic (OCT) images. Methods. Choroidal images were recorded by enhanced depth imaging OCT. The subfoveal choroidal images were analyzed, and the luminal and interstitial areas were converted to binary images by the Niblack method. The interrater, intrarater, and intersession agreements of the binary images were determined for healthy eyes. In eyes with age-related macular degeneration (AMD), the binary images of the choroid before photodynamic therapy (PDT) were compared to those after PDT. The untreated fellow eyes were studied as controls. Results. In healthy eyes, the average ratio of ...

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    13. Comparisons of Choroidal Thickness of Normal Eyes Obtained by Two Different Spectral-Domain OCT Instruments and One Swept-Source OCT Instrument

      Comparisons of Choroidal Thickness of Normal Eyes Obtained by Two Different Spectral-Domain OCT Instruments and One Swept-Source OCT Instrument

      Purpose. We compared the subfoveal choroidal thickness (SFCT) measured on the images obtained by two spectral-domain optical coherence tomographic (SD-OCT) instruments and one swept-source OCT (SS-OCT) instrument. Methods. A cross-sectional, prospective noninterventional study was done in which SFCT was measured in the images obtained by two SD-OCT instruments; Heidelberg Spectralis-OCT (Spectralis-SD-OCT) and Topcon 3D OCT-1000 Mark II (Topcon-SD-OCT). Images also were obtained with SS-OCT Atlantis DRI OCT-1 (DRI-SS-OCT). After manual segmentation, the measurements were made using the calipers embedded in each instrument. The intrarater, interrater, and intermachine agreements were assessed. Results. We studied 35 subjects. The intrarater correlation coefficient (95 ...

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    14. Correlation Between Reflectivity of Subretinal Fluid in OCT Images and Concentration of Intravitreal VEGF in Eyes With Diabetic Macular Edema

      Correlation Between Reflectivity of Subretinal Fluid in OCT Images and Concentration of Intravitreal VEGF in Eyes With Diabetic Macular Edema

      Purpose. The reflectivity of optical coherence tomographic (OCT) images has been used to evaluate retinal diseases. The purpose of our study was to determine whether a significant correlation exists between the reflectivity of the subretinal fluid (SRF) and the concentration of intravitreal cytokines in eyes with diabetic macular edema (DME). Methods. A retrospective comparative study was done of eyes with DME with SRF before vitrectomy. The reflectivity of the SRF was determined from the OCT images. Vitreous samples were collected during vitrectomy, and analyzed for the concentrations of VEGF, IL-6, and IL-8. To determine the factors in the SRF that ...

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    15. Comparison of Foveal Microstructure Imaging with Different Spectral Domain Optical Coherence Tomography Machines

      Comparison of Foveal Microstructure Imaging with Different Spectral Domain Optical Coherence Tomography Machines

      Purpose: To investigate the reproducibility of imaging the foveal microstructures of healthy eyes with 3 spectral domain optical coherence tomography (SD-OCT) machines: Cirrus (Carl Zeiss Meditec Inc.), Spectralis (Heidelberg Engineering), and Topcon (Topcon 3D OCT-1000 Mark II).Design: Cross-sectional, prospective, noninterventional study.Participants: Images were obtained for 50 eyes of 50 healthy undilated volunteers without ocular pathology in a clinical setting.Methods: The fovea of all subjects was imaged using Cirrus, Spectralis, and Topcon.Main Outcome Measures: Among the 4 hyperreflective bands in the outer subfovea on SD-OCT imaging, the innermost band (external limiting membrane [ELM] band), the second innermost ...

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    16. Repeatability and Reproducibility of Subfoveal Choroidal Thickness in Normal Eyes of Japanese Using Different SD-OCT Devices

      Repeatability and Reproducibility of Subfoveal Choroidal Thickness in Normal Eyes of Japanese Using Different SD-OCT Devices

      Purpose. To compare subfoveal choroidal thickness (SCT) measurements of three different commercially available spectral-domain optical coherence tomography instruments with healthy eyes of Japanese. Methods. A prospective, cross-sectional study was performed at a single institution. SCT of the right eye of 43 normal subjects was measured using three different SD-OCTs: Heidelberg Spectralis-OCT (Spectralis), Cirrus HD-OCT (Cirrus), and Topcon 3D OCT-1000 Mark II (Topcon). Two separate measurements were performed for the same eye with a maximum by a single examiner. SCT was defined as the distance from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction. After manual ...

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    1-16 of 16
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    Repeatability and Reproducibility of Subfoveal Choroidal Thickness in Normal Eyes of Japanese Using Different SD-OCT Devices Comparison of Foveal Microstructure Imaging with Different Spectral Domain Optical Coherence Tomography Machines Correlation Between Reflectivity of Subretinal Fluid in OCT Images and Concentration of Intravitreal VEGF in Eyes With Diabetic Macular Edema Comparisons of Choroidal Thickness of Normal Eyes Obtained by Two Different Spectral-Domain OCT Instruments and One Swept-Source OCT Instrument Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images Blood Components and OCT Reflectivity Evaluated in Animal Model Minification of fundus optical coherence tomographic images in gas-filled eye Correlations between local peripapillary choroidal thickness and axial length, optic disc tilt, and papillo-macular position in young healthy eyes Evaluation of Shape of Foveal Avascular Zone by Optical Coherence Tomography Angiography in Eyes With Branch Retinal Vein Occlusion Automated segmentation of en face choroidal images obtained by optical coherent tomography by machine learning Intraoperative Optical Coherence Tomography in Idiopathic Macular Epiretinal Membrane Surgery Quantitative approaches in multimodal fundus imaging: State of the art and future perspectives