1. Articles from Prema Sriram

    1-3 of 3
    1. Relationship between Optical Coherence Tomography and Electrophysiology of the Visual Pathway in Non-Optic Neuritis Eyes of Multiple Sclerosis Patients

      Relationship between Optical Coherence Tomography and Electrophysiology of the Visual Pathway in Non-Optic Neuritis Eyes of Multiple Sclerosis Patients

      Purpose Loss of retinal ganglion cells in in non-optic neuritis eyes of Multiple Sclerosis patients (MS-NON) has recently been demonstrated. However, the pathological basis of this loss at present is not clear. Therefore, the aim of the current study was to investigate associations of clinical (high and low contrast visual acuity) and electrophysiological (electroretinogram and multifocal Visual Evoked Potentials) measures of the visual pathway with neuronal and axonal loss of RGC in order to better understand the nature of this loss. Methods Sixty-two patients with relapsing remitting multiple sclerosis with no previous history of optic neuritis in at least one ...

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    2. Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study

      Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study

      Purpose. Recently demonstrated neuronal loss in the inner nuclear layer of the retina in multiple sclerosis (MS) and glaucoma raises the question of a primary (possibly immune-mediated) or secondary (transsynaptic) mechanism of retinal damage in these diseases. In the present study we used optical coherence tomography to investigate retrograde retinal transsynaptic degeneration in patients with long-standing and severe loss of ganglion cells due to optic neuropathy. Methods. Fifteen eyes of glaucoma patients with visual field defect limited to upper hemifield and 15 eyes of MS patients with previous episode of optic neuritis (ON) and extensive loss of ganglion cells were ...

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    3. Trans-synaptic retinal degeneration in optic neuropathies: Optical Coherence Tomography study

      Trans-synaptic retinal degeneration in optic neuropathies: Optical Coherence Tomography study
      Purpose. Recently demonstrated neuronal loss in the inner nuclear layer of the retina in multiple sclerosis (MS) and glaucoma raises the question of a primary (possibly immune-mediated) or secondary (trans-synaptic) mechanism of retinal damage in these diseases. In the present study we used Optical Coherence Tomography to investigate retrograde retinal trans-synaptic degeneration in patients with long-standing and severe loss of ganglion cells due to optic neuropathy. Methods. Ten eyes of glaucoma patients with visual field defect limited to upper hemifield and 10 eyes of MS patients with previous episode of optic neuritis (ON) and extensive loss of ganglion cells were ...
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    1-3 of 3
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    1. (3 articles) Macquarie University
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    3. (3 articles) Alexander Klistorner
    4. (3 articles) Stuart L. Graham
    5. (2 articles) Kyungpook National University
    6. (2 articles) University of Washington
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