1. Articles from Kevin A. Gallagher

    1-4 of 4
    1. Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study

      Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study

      Intracoronary optical frequency domain imaging (OFDI), requires the displacement of blood for clear visualization of the artery wall. Radiographic contrast agents are highly effective at displacing blood however, may increase the risk of contrast-induced nephropathy. Flushing media viscosity, flow rate, and flush duration influence the efficiency of blood displacement necessary for obtaining diagnostic quality OFDI images. The aim of this work was to determine the optimal flushing parameters necessary to reliably perform intracoronary OFDI while reducing the volume of administered radiographic contrast, and assess the influence of flushing media choice on vessel wall measurements. 144 OFDI pullbacks were acquired together ...

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    2. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Background Biopsy surveillance protocols for the assessment of Barrett's esophagus can be subject to sampling errors, resulting in diagnostic uncertainty. Optical coherence tomography is a cross-sectional imaging technique that can be used to conduct volumetric laser endomicroscopy (VLE) of the entire distal esophagus. We have developed a biopsy guidance platform that places endoscopically visible marks at VLE-determined biopsy sites. Objective The objective of this study was to demonstrate in human participants the safety and feasibility of VLE-guided biopsy in vivo. Design A pilot feasibility study. Setting Massachusetts General Hospital. Patients A total of 22 participants were enrolled from January ...

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    3. Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure

      Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure

      Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 μm (lateral) × 7 μm (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.

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    4. Optical frequency domain imaging system and catheters for volumetric imaging of the human esophagus

      Optical frequency domain imaging system and catheters for volumetric imaging of the human esophagus

      Barrett's esophagus (BE) is a metaplastic disorder that can undergo dysplastic progression, leading to esophageal adenocarcinoma. Upper endoscopy is the standard of care for screening for BE, but this technique has a relatively low diagnostic accuracy and high cost due to the requirement of conscious sedation. Optical frequency domain imaging (OFDI) is a high-speed imaging modality that generates cross-sectional images of tissues with a resolution of approximately 10µm that is sufficient for detecting microscopic tissue architecture. In combination with a balloon-centering catheter, this method enables BE diagnosis over the entire distal esophagus.   Full Text: PDFReferences S. H. Yun ...

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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) Harvard University
    2. (4 articles) Massachusetts General Hospital
    3. (4 articles) Guillermo J. Tearney
    4. (4 articles) Brett E. Bouma
    5. (4 articles) Melissa J. Suter
    6. (3 articles) Norman S. Nishioka
    7. (2 articles) Michalina J. Góra
    8. (1 articles) Cardiovascular Research Foundation
    9. (1 articles) Massachusetts Institute of Technology
    10. (1 articles) Hongki Yoo
    11. (1 articles) University of Pennsylvania
    12. (1 articles) National Institutes of Health
    13. (1 articles) Peking University
    14. (1 articles) FDA
    15. (1 articles) Washington University in St. Louis
    16. (1 articles) Lehigh University
    17. (1 articles) Duke University
    18. (1 articles) Massachusetts Institute of Technology
    19. (1 articles) Chao Zhou
    20. (1 articles) James G. Fujimoto
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    Optical frequency domain imaging system and catheters for volumetric imaging of the human esophagus Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study Optical Coherence Tomography Characteristics of the Choroid Underlying Congenital Hypertrophy of the Retinal Pigment Epithelium Kylee Hall joins Cylite as VP Sales and Marketing Consolidation of Imaging Modalities Utilizing Digitally Assisted Visualization Systems: The Development of a Surgical Information Handling Cockpit Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis Identification of atherosclerotic plaques in intravascular optical coherence tomography images based on textures and artificial neural network Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter Unstable Angina Caused by Honeycomb-Like Coronary Lesion Identified with Use of Optical Coherence Tomography Diagnostic ability of vessel density measured by spectral-domain optical coherence tomography angiography for glaucoma in patients with high myopia