1. Articles from Irina Larina

    1-3 of 3
    1. Optical Modalities for Embryonic Imaging

      Optical Modalities for Embryonic Imaging

      tudies of disease etiology often rely on the murine (mouse) model, which provides valuable genotypic information. Yet associated phenotypic information from murine embryos is often lacking. Of the various techniques that have been proposed for imaging such embryos, optical modalities may provide the best compromise among speed, penetration depth and resolution. This year, we developed approaches to improve embryonic imaging with optical coherence tomography (OCT), 1 and also provided a detailed comparison of OCT and another modality, optical projection tomography (OPT), in murine-embryo studies. 2 Most commonly used for ophthalmological imaging, 3 OCT has proved a powerful embryonic-imaging modality as ...

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    2. Refining imaging strategies to enhance understanding of congenital anomalies

      Refining imaging strategies to enhance understanding of congenital anomalies

      Optical coherence tomography in live animal models offers dynamic imaging capabilities for analyzing how aberrant morphologies and other birth defects occur during embryogenesis. Studying the mechanisms that regulate normal and abnormal development in murine (mouse) embryos can yield deeper insights into how and why anomalies sometimes appear. A great deal of knowledge can be gained from imaging studies of murine cells, tissues, and organs during early development that could ultimately lead to improved strategies for the prevention and treatment of birth defects in humans. In the past, such imaging has involved tissue staining to enable researchers to visualize cellular development ...

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    3. Label-free in utero imaging of mouse embryos

      Label-free in utero imaging of mouse embryos
      The mouse is a classic mammalian model used to study the anatomical and physiological development of different organ systems. Hundreds of mouse mutants associated with human diseases have been reported, helping to advance our understanding of the genetic basis of development and disease. Moreover, the proven value of genetic approaches to study gene function in the mouse, and the efficiency with which individual mutations can be mapped and cloned, has led to several large-scale, international, genome-wide screens for new and advanced models of human disease. Traditionally, primary analysis of embryonic mutant phenotypes has been based on static examination of histological ...
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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) University of Houston
    2. (3 articles) Baylor College of Medicine
    3. (3 articles) Mary E. Dickinson
    4. (3 articles) Kirill V. Larin
    5. (3 articles) Irina V. Larina
    6. (1 articles) American Heart Association
    7. (1 articles) National Institutes of Health
    8. (1 articles) Saratov State University
    9. (1 articles) Saba H. Syed
    10. (1 articles) Narendran Sudheendran
    11. (1 articles) University of Sydney
    12. (1 articles) University of Zurich
    13. (1 articles) UCSD
    14. (1 articles) University of Pittsburgh
    15. (1 articles) L V Prasad Eye Institute
    16. (1 articles) Giuseppe Querques
    17. (1 articles) Carl Zeiss Meditec
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