1. Articles from Michelle T. Cabrera

    1-14 of 14
    1. Quantitative Handheld Swept-Source Optical Coherence Tomography Angiography in Awake Preterm and Full-Term Infants

      Quantitative Handheld Swept-Source Optical Coherence Tomography Angiography in Awake Preterm and Full-Term Infants

      Purpose : To compare retinal vascular parameters acquired by handheld swept-source optical coherence tomography angiography (SS-OCTA) between nonsedated preterm and full-term infants. Methods : Preterm and full-term infants at the University of Washington Medical Center were enrolled. Retinal angiograms (nominal size ∼7 × 7 mm 2 ) were obtained at each routine retinopathy of prematurity (ROP) screening session for preterms and once during the first 72 hours of life for full-terms. Macular vessel area density and nonperfusion area were evaluated on the binarized vasculature map in both small (1.5 × 1.5 mm) and large (3 × 3 mm) quadrants. Average vessel diameter and tortuosity ...

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    2. Vitreous Findings by Handheld Spectral Domain Optical Coherence Tomography Correlate with Retinopathy of Prematurity Severity

      Vitreous Findings by Handheld Spectral Domain Optical Coherence Tomography Correlate with Retinopathy of Prematurity Severity

      Objective To evaluate the association between retinopathy of prematurity and vitreous findings in premature infants detected by handheld spectral-domain optical coherence tomography. Design Prospective, observational cohort study. Participants Consecutive sample of 92 premature infants requiring retinopathy of prematurity screening at two academic neonatal intensive care units, between July 2015 and March 2018. Methods Infants underwent handheld spectral domain optical coherence tomography at the time of routine retinopathy of prematurity examinations. Two masked, trained graders analyzed right eye vitreoretinal findings including semi-automated quantification of punctate hyperreflective vitreous opacities within 5 foveal/parafoveal B-scans (Vitreous Opacity Ratio). Main Outcome Measures: Excluding post-treatment ...

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    3. Introduction to Retinal Optical Coherence Tomography (OCT) Interpretation

      Introduction to Retinal Optical Coherence Tomography (OCT) Interpretation

      This interactive online course with twenty case vignettes is designed to teach residents about the various elements and layers of a normal retina in an OCT scan, how to accurately identify and describe retinal pathologies and the location of abnormalities in OCT images, and how to diagnose retinal pathology and suggest next steps in the evaluation or treatment of eye disease.

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    4. Handheld swept-source optical coherence tomography with angiography in awake premature neonates

      Handheld swept-source optical coherence tomography with angiography in awake premature neonates

      Background: Retinopathy of prematurity (ROP) can lead to retinal detachment and severe vision loss and is a common cause of childhood blindness. Optical coherence tomography angiography (OCTA) is a non-invasive imaging modality that can be used to detect potential abnormalities in the microvasculature in this population. The objective of this study is to assess the feasibility of a newly developed handheld swept source OCT (SS-OCT) device to successfully acquire structural vitreoretinal and retinal microvascular images in awake premature infants. Methods: OCT and OCTA images were acquired at the time of routine ROP examinations from awake, unsedated preterm infants in the ...

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    5. EXUDATIVE RETINAL DETACHMENT DOCUMENTED BY HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AFTER RETINAL LASER PHOTOCOAGULATION FOR RETINOPATHY OF PREMATURITY

      EXUDATIVE RETINAL DETACHMENT DOCUMENTED BY HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AFTER RETINAL LASER PHOTOCOAGULATION FOR RETINOPATHY OF PREMATURITY

      Background: Few cases of exudative retinal detachments have been reported in the literature after laser treatment for retinopathy of prematurity , and none of the cases include optical coherence tomography images. Methods: Case report. Results: A 469-g birth weight, 25-week gestational age baby girl at 35-week postmenstrual age received a retinal laser (1,724 spots in the right eye and 1,287 spots in the left eye) for bilateral Stage 3 Zone II plus disease retinopathy of prematurity . The patient developed a large macular exudative retinal detachment seen in the right eye at the first follow-up, 5 days after the laser ...

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    6. Vitreous Bands Identified by Handheld Spectral-Domain Optical Coherence Tomography Among Premature Infants

      Vitreous Bands Identified by Handheld Spectral-Domain Optical Coherence Tomography Among Premature Infants

      Importance Handheld spectral-domain optical coherence tomography (SD-OCT) can provide insights into the complex interactions occurring at the vitreoretinal interface in retinopathy of prematurity (ROP) to enhance our understanding of ROP pathology. Objective To characterize vitreous bands in premature infants with use of handheld SD-OCT. Design, Setting, and Participants Prospective cohort study conducted from July 7, 2015, to February 28, 2017, at 2 university-based neonatal intensive care units. Seventy-three premature infants who required routine ROP screening examination were recruited. Informed consent was obtained from all legal guardians. Trained graders who were masked to the clinical assessment analyzed each SD-OCT scan of ...

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    7. The Characteristics and Short-term Refractive Error Outcomes of Cystoid Macular Edema in Premature Neonates as Detected by Spectral-Domain Optical Coherence Tomography

      The Characteristics and Short-term Refractive Error Outcomes of Cystoid Macular Edema in Premature Neonates as Detected by Spectral-Domain Optical Coherence Tomography

      BACKGROUND AND OBJECTIVE: To explore characteristics associated with cystoid macular edema (CME) in neonates screened for retinopathy of prematurity (ROP). PATIENTS AND METHODS: In this institutional review board-approved, prospective, observational study, premature neonates underwent imaging with handheld spectral-domain optical coherence tomography. RESULTS: Of 73 included infants (median gestational age [GA]: 28 weeks, range 23–33 weeks; birth weight: 966 g, range 506 g – 1695 g), 28 (38%) had CME and 17/28 (61%) had ROP. CME was associated with ROP ( P = .03) and younger GA ( P = .04), but not associated with sex, race, birth weight, postmenstrual age at imaging, ROP ...

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    8. Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography

      Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography

      Purpose To characterize optic nerve head (ONH) morphology and parameters, including vertical disk diameter, vertical cup diameter, and vertical cup/disk ratio in healthy, full-term newborns using a handheld spectral domain optical coherence tomography (SD-OCT) device. Methods In this prospective observational case series, healthy white, black, and Hispanic full-term newborns delivered at the Duke Birthing Center between August 2010 and May 2011 underwent dilated fundus examination and SD-OCT imaging of the optic nerve in each eye. OCT parameters were calculated and compared for each group of infants. Results A total of 58 consecutive newborns of white (n = 22), black (n ...

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    9. Macular Findings in Healthy Full-term Hispanic Newborns Observed by Hand-held Spectral-Domain Optical Coherence Tomography

      Macular Findings in Healthy Full-term Hispanic Newborns Observed by Hand-held Spectral-Domain Optical Coherence Tomography

      BACKGROUND AND OBJECTIVE: To enhance understanding of ethnically diverse normal newborn retinal morphology, the authors report spectral-domain optical coherence tomography (SD-OCT) macular findings in healthy Hispanic newborns. PATIENTS AND METHODS: In this IRB-approved prospective, observational case series, 20 full-term Hispanic newborns had dilated retinal examinations and imaging by hand-held SD-OCT without sedation at the Duke Birthing Center. RESULTS: Of 20 newborns imaged (35% male; median gestational age: 39 weeks; range: 36 to 40 weeks), two (10%) had bilateral subfoveal fluid, including one case of bilateral double subretinal fluid pockets. Three eyes of two infants (10%) had retinal macular cystoid structures ...

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    10. Choroid Development and Feasibility of Choroidal Imaging in the Preterm and Term Infants Utilizing SDOCT

      Choroid Development and Feasibility of Choroidal Imaging in the Preterm and Term Infants Utilizing SDOCT

      Purpose: To determine whether choroidal imaging is feasible in preterm and term infants using an 840-nm portable spectral domain optical coherence tomography (SDOCT) system without the use of enhanced- depth imaging techniques and to assess choroidal development by comparing choroidal thickness of preterm infants, term infants, and adults. Methods: SDOCT images were obtained from 86 preterm infants, 59 term infants and 9 adults using a portable SDOCT (Bioptigen, Inc., NC, USA) system plus 9 adults using a tabletop system. An unprocessed image across the macula from one randomly selected eye of each participant was selected for determination of whether the ...

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    11. Photoreceptor and Choroid Development Assessed with Handheld SD-OCT

      Photoreceptor and Choroid Development Assessed with Handheld SD-OCT

      Objective: Optical coherence tomography (OCT) allows examination of the human retina. While conventional OCT devices are limited mainly to adults, the availability of a handheld system has expanded the use of this technique to pediatric populations, with the primary clinical applications being shaken baby syndrome and retinopathy of prematurity. We sought to apply OCT imaging to neonatal population to assess retinal development. Methods: Subjects imaged at the Duke Neonatal Intensive Care Unit (NICU) and Duke Birthing Center. Subjects were imaged with a Bioptigen Hand Held Probe SD-OCT (HHP-SDOCT) (Bioptigen, Research Triangle Park, NC, USA). For this study, only "normal" subjects ...

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    12. Subfoveal Fluid in Healthy Full-term Newborns Observed by Handheld Spectral-Domain Optical Coherence Tomography

      Subfoveal Fluid in Healthy Full-term Newborns Observed by Handheld Spectral-Domain Optical Coherence Tomography
      Purpose: To report retinal findings for healthy newborn infants imaged with handheld spectral-domain optical coherence tomography (SD OCT). Design: Prospective, observational case series. Methods: Thirty-nine full-term newborn infants underwent dilated retinal examinations by indirect ophthalmoscopy and retinal imaging by handheld SD OCT, without sedation, at the Duke Birthing Center. Results: Of the 39 infants imaged, 44% (17/39) were male. Race and ethnicity composition was 56% white, 38% black, 3% Asian, and 3% Hispanic. Median gestational age was 39 weeks (range, 36 to 41 weeks). Six (15%) of the 39 infants had bilateral subfoveal fluid on SD OCT not seen ...
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    1-14 of 14
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    Subfoveal Fluid in Healthy Full-term Newborns Observed by Handheld Spectral-Domain Optical Coherence Tomography Subfoveal fluid in healthy full-term newborns observed by handheld spectral domain optical coherence tomography Photoreceptor and Choroid Development Assessed with Handheld SD-OCT Choroid Development and Feasibility of Choroidal Imaging in the Preterm and Term Infants Utilizing SDOCT Macular Findings in Healthy Full-term Hispanic Newborns Observed by Hand-held Spectral-Domain Optical Coherence Tomography Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography The Characteristics and Short-term Refractive Error Outcomes of Cystoid Macular Edema in Premature Neonates as Detected by Spectral-Domain Optical Coherence Tomography Vitreous Bands Identified by Handheld Spectral-Domain Optical Coherence Tomography Among Premature Infants EXUDATIVE RETINAL DETACHMENT DOCUMENTED BY HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AFTER RETINAL LASER PHOTOCOAGULATION FOR RETINOPATHY OF PREMATURITY Handheld swept-source optical coherence tomography with angiography in awake premature neonates In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography Negative Vessel Remodeling in Stargardt Disease Quantified with Volume-Rendered Optical Coherence Tomography Angiography