1. Articles from Alexander Bykov

    1-5 of 5
    1. Quantification of cell-free layer thickness and cell distribution of blood by optical coherence tomography

      Quantification of cell-free layer thickness and cell distribution of blood by optical coherence tomography

      A high-speed optical coherence tomography (OCT) with 1 - μ m axial resolution was applied to assess the thickness of a cell-free layer (CFL) and a spatial distribution of red blood cells (RBC) next to the microchannel wall. The experiments were performed in vitro in a plain glass microchannel with a width of 2 mm and height of 0.2 mm. RBCs were suspended in phosphate buffered saline solution at the hematocrit level of 45%. Flow rates of 0.1 to 0.5    ml / h were used to compensate gravity induced CFL. The results indicate that OCT can be efficiently used for ...

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    2. Optical clearing of articular cartilage: a comparison of clearing agents

      Optical clearing of articular cartilage: a comparison of clearing agents

      Optical clearing technique was applied to the problem of OCT imaging of articular cartilage and subchondral bone. We show that optical clearing significantly enhances visualization of articular cartilage and cartilage-bone interface. The effect of different clearing agents was analyzed. For the clearing, iohexol solution and propylene glycol (PG) were used. Clearing was performed in vitro at room temperature by immersion method. Cylindrical osteochondral samples (d=4.8mm) were drilled from bovine lateral femur and stored in phosphate-buffered saline at -20°C until clearing. Monitoring of clearing process was performed using high-speed spectral-domain OCT system providing axial resolution of 5.8 ...

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    3. Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage

      Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage

      Optical clearing is an effective method to reduce light scattering of biological tissues that provides significant enhancement of light penetration into the biological tissues making non-invasive diagnosis more feasible. In current report Optical Coherence Tomography (OCT) in conjunction with optical clearing is applied for assessment of deep cartilage layers and cartilage-bone interface. The solution of Iohexol in water has been used as an optical clearing agent. The cartilage-bone boundary becomes visible after 15 min of optical clearing that enabling non-invasive estimation of its roughness: S a = 10 ± 1 µm. The results show that for 0.9 mm thick cartilage optical ...

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    4. Gold nanostructures for OCT imaging of capillary flow

      Gold nanostructures for OCT imaging of capillary flow

      In this paper, plasmon-resonant nanostructures, such as gold nanostars and their silica-coated composites, were used for enhancement of OCT image contrast of water flows in glass capillaries. The contrasting properties of the synthesized nanostars and nanocomposites with silica shell thickness of about 5 nm and 50 nm were compared in the framework of capillary stasis model. The most intensive signal was detected from the nanocomposites with the thickest silica shell. The nanocomposites were characterized by optical spectroscopy and electron microscopy. Nontoxicity of nanostars and nanocomposites up to ~ 3 mg/mL concentration was showed by MTT assay suggesting practical applications of ...

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    5. Glucose sensing in flowing blood and Intralipid by laser pulse time-of-flight and optical coherence tomography techniques

      Glucose sensing in flowing blood and Intralipid by laser pulse time-of-flight and optical coherence tomography techniques
      In this paper, we compare the sensitivities of the two optical modalities, laser pulse time-of-flight (TOF) and optical coherence tomography (OCT), in regard to glucose sensing within the range of 0-1000 mg/dl in flowing blood and tissue-mimicking liquid (Intralipid). We show that TOF technique is about twice more sensitive than OCT, as well for blood as for Intralipid measurements. In case of TOF technique, glucose sensitivity in Intralipid is higher than in blood. We speculate that all this is associated with longer pathlengths of detected photons in TOF than in OCT, which is confirmed by comparison with Monte Carlo ...
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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) University of Oulu
    2. (5 articles) Alexander V. Bykov
    3. (4 articles) Matti Kinnunen
    4. (3 articles) Valery V. Tuchin
    5. (1 articles) Moscow State University
    6. (1 articles) Saratov State University
    7. (1 articles) Janne Lauri
    8. (1 articles) Igor V. Meglinski
    9. (1 articles) Alexander V. Priezzhev
    10. (1 articles) Risto A. Myllylä
    11. (1 articles) Samsung
    12. (1 articles) Johns Hopkins University
    13. (1 articles) National Institutes of Health
    14. (1 articles) Sungkyunkwan University
    15. (1 articles) University of São Paulo
    16. (1 articles) Massachusetts Institute of Technology
    17. (1 articles) L V Prasad Eye Institute
    18. (1 articles) Gong Je Seong
    19. (1 articles) Chan Yun Kim
    20. (1 articles) James G. Fujimoto
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    Glucose sensing in flowing blood and Intralipid by laser pulse time-of-flight and optical coherence tomography techniques Gold nanostructures for OCT imaging of capillary flow Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage Optical clearing of articular cartilage: a comparison of clearing agents Quantification of cell-free layer thickness and cell distribution of blood by optical coherence tomography Factors Associated with Changes in Retinal Layers Following Acute Optic Neuritis: A Longitudinal Study Using Optical Coherence Tomography Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma Historic Effort to 'End Blindness" Marks a Major Milestone with Leading Scientist Recognized for Pioneering Work at VIP Ceremony Featuring Tribute to Ruth Bader Ginsburg Healing and early stent coverage after ultrathin strut biodegradable polymer‐coated sirolimus‐eluting stent implantation: SiBi optical coherence tomography study Influences of hypomagnesemia on optic nerve and retinal vascular structure determined using optical coherence tomography angiography Repeatability and agreement of total corneal and sublayer pachymetry with 2 different algorithms of Fourier-domain optical coherence tomography in myopic and postphotorefractive keratectomy eyes Vessel Density around Foveal Avascular Zone as a Potential Imaging Biomarker for Detecting Preclinical Diabetic Retinopathy: An Optical Coherence Tomography Angiography Study