1. Articles from Ari Green

    1-3 of 3
    1. The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment

      The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment

      Background Retinal optical coherence tomography (OCT) is an imaging biomarker for neurodegeneration in multiple sclerosis (MS). In order to become validated as an outcome measure in multicenter studies, reliable quality control (QC) criteria with high inter-rater agreement are required. Methods/Principal Findings A prospective multicentre study on developing consensus QC criteria for retinal OCT in MS: (1) a literature review on OCT QC criteria; (2) application of these QC criteria to a training set of 101 retinal OCT scans from patients with MS; (3) kappa statistics for inter-rater agreement; (4) identification reasons for inter-rater disagreement; (5) development of new consensus ...

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    2. Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis

      Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis

      Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL). Meta-analyses of data for time domain OCT show RNFL thinning of 20·38 μm (95% CI 17·91—22·86, n=2063, p<0·0001) after optic neuritis in MS, and of 7·08 μm (5·52—8·65, n=3154, p<0·0001) in MS without optic neuritis. The estimated RNFL thinning in patients with MS is greater than the extent expected in normal ageing, probably because of retrograde trans-synaptic degeneration ...

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    3. Adaptive Optics Scanning Laser Ophthalmoscopy Images Demonstrate Abnormal Cone Structure in a Family with the Mitochondrial DNA T8993C Mutation

      Purpose: To study the effect of mitochondrial DNA (mtDNA) mutation T8993C on cone structure in a family expressing neurogenic muscle weakness, ataxia, retinitis pigmentosa (NARP) syndrome. Methods: Five family members were studied, using clinical examination, nerve conduction studies, perimetry, optical coherence tomography (OCT) measures of central retinal thickness and electroretinography. High-resolution images of cone structure using adaptive optics scanning laser ophthalmoscopy (AOSLO) were obtained in 4 subjects with stable fixation. Cone spacing was compared to 18 age-similar normal subjects and converted to Z-scores at each location where unambiguous cones were identified. Tissue levels of T8993C mutant heteroplasmy in blood and ...

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    1-3 of 3
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    1. (2 articles) UCSF
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