1. Articles from Kenichi Komukai

    25-33 of 33 « 1 2
    1. Relation of Microchannel Structure Identified by Optical Coherence Tomography to Plaque Vulnerability in Patients With Coronary Artery Disease

      Relation of Microchannel Structure Identified by Optical Coherence Tomography to Plaque Vulnerability in Patients With Coronary Artery Disease
      Increased neovascularization in atherosclerotic plaques is associated with plaque vulnerability. The high resolution of optical coherence tomography (OCT) might provide a chance to directly visualize plaque neovascularization in vivo. The aim of the present study was to investigate the relation between microchannels in culprit plaques identified by OCT and plaque vulnerability in patients with coronary artery disease. A total of 63 consecutive patients with coronary artery disease who had undergone both OCT and intravascular ultrasound before any interventions to examine culprit lesion morphologies were enrolled. Microchannel was defined as a no-signal tubuloluminal structure on the cross-sectional optical coherence tomographic image ...
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    2. Multiple Coronary Lesion Instability in Patients With Acute Myocardial Infarction as Determined by Optical Coherence Tomography

      Autopsy studies have suggested that acute myocardial infarction (AMI) represents a pan-coronary process of vulnerable plaque development. We performed multifocal optical coherence tomographic (OCT) examination to compare coronary lesion instability between AMI and stable angina pectoris (SAP). A total of 42 patients with AMI (n = 26) or SAP (n = 16) who had multivessel disease and underwent multivessel coronary intervention were enrolled in the present study. The OCT examination was performed not only in the infarct-related/target lesions, but also in the noninfarct-related/nontarget lesions. OCT-derived thin-cap fibroatheroma (TCFA) was defined as a lesion with a fibrous cap thickness of
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    3. Feasibility of Noninvasive Assessment of Thin-Cap Fibroatheroma by Multidetector Computed Tomography

      Objectives The purpose of this study was to investigate whether multidetector computed tomography (MDCT) can noninvasively help assess thin-cap fibroatheroma (TCFA). Background Plaque rupture and thrombus formation play key roles in the onset of acute coronary syndrome. TCFA is recognized as a precursor lesion for plaque rupture, and MDCT angiography can potentially help identify plaques prone to rupture. Methods We enrolled 105 patients with coronary artery disease (acute coronary syndromes, n = 31; stable angina pectoris, n = 74). Culprit lesions were assessed by both MDCT and optical coherence tomography (OCT). Patients were divided into a TCFA and a non-TCFA group according ...
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    4. Activated Platelet is Associated With Subclinical Stent Thrombosis Detected by Optical Coherence Tomography

      Activated Platelet is Associated With Subclinical Stent Thrombosis Detected by Optical Coherence Tomography

      Backgrounds: While stent thrombosis is a critical issue in the drug-eluting stent era, there are few monitoring markers for stent thrombosis. Optical coherence tomography (OCT) introducing as a high-resolution modality allows us to assess plaque characteristics, including in-stent micro-thrombus. We hypothesized that in vivo activated platelet was associated with in-stent thrombus formation. The aim of this study was to investigate the relationship between in vivo platelet activity and in-stent thrombus formation assessed by OCT. Methods: We enrolled 54 patients who were treated with coronary stent. OCT was performed at a 8-month follow-up angiography. The frequency of uncovered struts was assessed ...

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    5. Impact of Culprit Lesion Characteristics on Microvascular Obstruction in Patients With Acute Coronary Syndrome: An Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging Study

      Background: The degree of myocardial damage is an important determinant of clinical outcomes in patients with acute coronary syndrome (ACS). We have reported that lesion characteristics are associated with slow flow phenomenon. The aim of this study was to investigate whether culprit lesion characteristics identified by optical coherence tomography (OCT) were associated with microvascular obstruction (MVO) assessed by contrast-enhanced magnetic resonance imaging (ce-MRI) in patients with ACS. Methods: We enrolled 46 patients with ACS who were successfully recanalized with primary percutaneous coronary intervention (PCI). They were divided into a thin-cap fibroatheroma (TCFA) group (n=17) and a non-TCFA group (n ...
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    6. Advantage of next-generation frequency-domain optical coherence tomography compared with conventional time-domain system in the assessment of coronary lesion

      Background: Intracoronary optical coherence tomography (OCT) is a high-resolution imaging modality used for evaluation of coronary lesion morphology. However, current time-domain OCT (TD-OCT) have a number of limitations with regard to both procedural usage and safety in the clinical setting. The next-generation frequency-domain OCT (FD-OCT), which has a much faster frame rate and pullback speed than TD-OCT, is expected to overcome these limitations. The aim of this study was to evaluate the feasibility and usability of next generation FD-OCT in the assessment of coronary lesions. Methods: A comparison study was performed between FD-OCT and TD-OCT from the aspect of usability ...
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    7. Lipid-rich plaque and myocardial perfusion after successful stenting in patients with non-ST-segment elevation acute coronary syndrome: an optical coherence tomography study

      Aims: Although some recent guidelines recommend an early invasive strategy for non-ST-segment elevation acute coronary syndrome (NSTEACS), several studies have failed to identify any benefit for very early intervention for NSTEACS. The no-reflow phenomenon may inhibit the expected benefit from very early recanalization for NSTEACS subjects. The aim of this study was to investigate whether optical coherence tomography (OCT) could predict no-reflow in patients with NSTEACS. Methods and results: This study comprised 83 consecutive patients with NSTEACS who underwent OCT and successful emergent primary stenting. On the basis of post-stent TIMI flow, patients were divided into two groups: no-reflow group ...
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    8. Relationship between Coronary Arterial Remodeling and Fibrous Cap Thickness in Patients with Acute Coronary Syndrome

      The aim of this study was to evaluate the relationship between coronary arterial remodeling and the thickness of fibrous cap in patients with acute coronary syndrome (ACS). Thin-capped fibroatheroma is recognized as a precursor lesion for ACS. Positive remodeling (PR) is predominant pattern of arterial remodeling in patients with ACS. However, the relationship between PR and the thickness of fibrous cap has not been elucidated in vivo. We enrolled 41 patients with ACS who underwent both intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The arterial remodeling was assessed by IVUS and the thickness of fibrous cap was measured by ...
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    25-33 of 33 « 1 2
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    1. (32 articles) Kenichi Komukai
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    Activated Platelet is Associated With Subclinical Stent Thrombosis Detected by Optical Coherence Tomography Relation of Microchannel Structure Identified by Optical Coherence Tomography to Plaque Vulnerability in Patients With Coronary Artery Disease Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris Clinical Classification and Plaque Morphology Determined by Optical Coherence Tomography in Unstable Angina Pectoris Assessment by Optical Coherence Tomography of Stent Struts Across Side Branch – Comparison of Bare-Metal Stents and Drug-Eluting Stents – Virtual Histology Intravascular Ultrasound Compared With Optical Coherence Tomography for Identification of Thin-Cap Fibroatheroma Thin-Cap Fibroatheroma as High Risk Plaque for Microvascular Obstruction in Patients With Acute Coronary Syndrome Comparison of diagnostic accuracy between multidetector computed tomography and virtual histology intravascular ultrasound for detecting optical coherence tomography-derived fibroatheroma Intravitreal Ranibizumab Monotherapy or Combined with Laser for Diabetic Macular Edema (OCT guided study) Prospective evaluation of drug eluting self‐apposing stent for the treatment of unprotected left main coronary artery disease: 1‐year results of the TRUNC study Clinical validation of the RTVue optical coherence tomography angiography image quality indicators Intraoperative OCT-Assisted Retinal Detachment Repair in the DISCOVER Study: Impact and Outcomes