1. Articles from Maria Riga

    1-9 of 9
    1. Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’

      Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’

      Aims The association of low endothelial shear stress (ESS) with high-risk plaque (HRP) has not been thoroughly investigated in humans. We investigated the local ESS and lumen remodelling patterns in HRPs using optical coherence tomography (OCT), developed the shear stress score , and explored its association with the prevalence of HRPs and clinical outcomes. Methods and results A total of 35 coronary arteries from 30 patients with stable angina or acute coronary syndrome (ACS) were reconstructed with three dimensional (3D) OCT. ESS was calculated using computational fluid dynamics and classified into low, moderate, and high in 3-mm-long subsegments. In each subsegment ...

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    2. Improved vascular healing after successful treatment of very late sirolimus-eluting stent thrombosis with a bare metal stent implantation - A serial optical coherence tomography study

      Improved vascular healing after successful treatment of very late sirolimus-eluting stent thrombosis with a bare metal stent implantation - A serial optical coherence tomography study

      We present a case of a patient with non-ST-elevation myocardial infarction due to very late stent thrombosis, 2 years after a sirolimus-eluting stent implantation (SES). Optical coherence tomography (OCT) imaging identified vessel wall destruction of the whole stented coronary segment with multiple cavity formations along the entire stent length, severe struts malapposition and thrombi. The patient was treated successfully with the implantation of a bare metal stent (BMS). Follow-up OCT imaging at 12 months revealed improvement of vascular healing with complete re-endothelialization of the distal parts of the new BMS, while the stent body remained partly uncover suggesting vascular toxicity ...

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    3. Impact of coronary artery stent edge dissections on long-term clinical outcome in patients with acute coronary syndrome: An Optical Coherence Tomography Study

      Impact of coronary artery stent edge dissections on long-term clinical outcome in patients with acute coronary syndrome: An Optical Coherence Tomography Study

      Aims: The purpose of the present study was to assess the incidence, predictors and long term prognosis of stent edge dissections identified by (OCT) after the implantation of bare metal (BMS) and drug eluting stents (DES). Methods and results: We studied 74 patients who underwent percutaneous coronary intervention (PCI) because of an acute coronary syndrome. Edge dissections were found in 29 of 74 patients (39.1%). Independent predictors of edge dissections were: the presence of ST-elevation myocardial infarction (STEMI) (p=0.005, odds ratio 11.78; 95% Cl 2.06-67.10), the small reference lumen diameter ( p= 0.009, odds ...

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    4. Clinical Validation of an Algorithm for Rapid and Accurate Automated Segmentation of Intracoronary Optical Coherence Tomography Image

      Clinical Validation of an Algorithm for Rapid and Accurate Automated Segmentation of Intracoronary Optical Coherence Tomography Image

      Objectives The analysis of intracoronary optical coherence tomography (OCT) images is based on manual identification of the lumen contours and relevant structures. However, manual image segmentation is a cumbersome and time-consuming process, subject to significant intra- and inter-observer variability. This study aims to present and validate a fully-automated method for segmentation of intracoronary OCT images. Methods We studied 20 coronary arteries (mean length = 39.7 ± 10.0 mm) from 20 patients who underwent a clinically indicated cardiac catheterization. The OCT images (n = 1812) were segmented manually, as well as with a fully-automated approach. A semi-automated variation of the fully-automated algorithm ...

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    5. Optical coherence tomography assessment of the spatial distribution of culprit ruptured plaques and thin-cap fibroatheromas in acute coronary syndrome

      Optical coherence tomography assessment of the spatial distribution of culprit ruptured plaques and thin-cap fibroatheromas in acute coronary syndrome

      Aims: Plaque rupture and subsequent thrombosis is known to be the most important pathology leading to acute coronary syndrome (ACS). We investigated by optical coherence tomography (OCT) whether in ACS there is an association of the location of the culprit plaque in the coronary tree with plaque rupture and/or thin cap fibroatheroma (TCFA). Methods and results: We included 74 patients presenting with ACS that underwent OCT study of the culprit lesion. The distance of the culprit lesion from the ostium was measured angiographically, and the presence of rupture and/or TCFA was assessed by OCT. Sixty-seven patients were analysed ...

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    6. Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation

      Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation

      Objectives: The purpose of this document is to make the output of the International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available to medical and scientific communities, through a peer-reviewed publication, in the interest of improving the diagnosis and treatment of patients with atherosclerosis, including coronary artery disease.Background: Intravascular optical coherence tomography (IVOCT) is a catheter-based modality that acquires images at a resolution of 10 μm, enabling visualization of blood vessel wall microstructure in vivo at an unprecedented level of detail. IVOCT devices are now commercially available worldwide, there is an active user base, and ...

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    7. New insights by optical coherence tomography into the differences and similarities of culprit ruptured plaque morphology in non–ST-elevation myocardial infarction and ST-elevation myocardial infarction

      New insights by optical coherence tomography into the differences and similarities of culprit ruptured plaque morphology in non–ST-elevation myocardial infarction and ST-elevation myocardial infarction

      BackgroundPlaque rupture is the most common pathology associated with non–ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI). However, limited data are available regarding ruptured plaque morphology and its relationship with the clinical syndrome. This study aimed (1) to provide a morphologic description of ruptured culprit lesions by optical coherence tomography (OCT) and (2) to investigate whether ruptured plaque morphology differs between NSTEMI and STEMI.MethodsWe included 84 consecutive patients with NSTEMI and STEMI undergoing OCT study of the culprit lesion. We identified patients with plaque rupture in the OCT study and used them as the study population. Qualitative ...

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    8. Morphological Characteristics of the Culprit Lesion Correlate With the Angiographic Flow Grade Following Thrombolysis in Myocardial Infarction. An Optical Coherence Tomography Study

      Background: Intravenous thrombolysis fails to restore blood flow in a significant percentage of patients with ST-elevation myocardial infarction (STEMI). It remains unknown, whether certain morphological characteristics of the culprit lesion (CL) can predict the success of thrombolysis. We hypothesized that the thickness of the fibrous cap and the incidence of plaque rupture at the CL, as measured by Optical Coherence Tomography (OCT), may correlate with the outcome of thrombolysis. Methods: We prospectively enrolled 55 consecutive patients with STEMI that were treated with thrombolysis 6 hours from symptom onset. All patients underwent coronary angiography within 24 hours from thrombolysis. We estimated ...

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    9. Fibrous Caps with Excessive Macrophage Infiltration in Culprit Lesions of Patients with Acute Coronary Syndromes are Associated with Increased Local Temperature

      Fibrous Caps with Excessive Macrophage Infiltration in Culprit Lesions of Patients with Acute Coronary Syndromes are Associated with Increased Local Temperature

      Background: Optical coherence tomography (OCT) provides detailed analysis of the morphological characteristics of the culprit lesion (CL) and determines macrophage density within fibrous caps. Intracoronary thermography (ICT) detects the local inflammatory activation of the CL. We investigated the correlation between morphological and functional characteristics of the CL as analysed by OCT and ICT in patients with acute coronary syndromes (ACS). Methods: We studied 31 CL of 31 pts (mean age 61±14 years) with ACS. We measured by ICT the temperature difference between the lesion and the healthy proximal vessel wall (T). Thereafter, we measured the minimal thickness of the ...

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    1-9 of 9
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    Fibrous Caps with Excessive Macrophage Infiltration in Culprit Lesions of Patients with Acute Coronary Syndromes are Associated with Increased Local Temperature New insights by optical coherence tomography into the differences and similarities of culprit ruptured plaque morphology in non–ST-elevation myocardial infarction and ST-elevation myocardial infarction Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation Optical coherence tomography assessment of the spatial distribution of culprit ruptured plaques and thin-cap fibroatheromas in acute coronary syndrome Clinical Validation of an Algorithm for Rapid and Accurate Automated Segmentation of Intracoronary Optical Coherence Tomography Image Impact of coronary artery stent edge dissections on long-term clinical outcome in patients with acute coronary syndrome: An Optical Coherence Tomography Study Improved vascular healing after successful treatment of very late sirolimus-eluting stent thrombosis with a bare metal stent implantation - A serial optical coherence tomography study Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’ Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes Pearls and Pitfalls of Optical Coherence Tomography Angiography Image Interpretation Novel optical coherence tomography findings in idiopathic choroidal folds