All Articles from Tsunenari Soeda -Optical Coherence Tomography News

Articles from Tsunenari Soeda

1-24 of 48 1 2 »
1. Characteristics of non-culprit plaques in acute coronary syndrome patients with layered culprit plaque
  
  Explore Journals Dec 21 2019 Cardiology
  
  Aims Layered plaques represent signs of previous plaque destabilization. A recent study showed that acute coronary syndrome (ACS) patients with layered culprit plaque have more vulnerability at the culprit lesion and systemic inflammation. We aimed to compare the characteristics of non-culprit plaques between patients with or without layered plaque at the culprit lesion. We also evaluated the characteristics of layered non-culprit plaques, irrespective of culprit plaque phenotype. Methods and results We studied ACS patients who had undergone pre-intervention optical coherence tomography (OCT) imaging. The number of non-culprit lesions was evaluated on coronary angiogram and morphological characteristics of plaques were studied ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
2. Usefulness of longitudinal reconstructed optical coherence tomography images for predicting the need for the reverse wire technique during coronary bifurcation interventions
  
  Explore Wiley Online Library Nov 25 2018 Cardiology
  
  Objectives The aim is to investigate the usefulness of longitudinal reconstructed optical coherence tomography (OCT) images in selecting the reverse wire (RW) technique for inserting a guidewire into a side branch (SB). Background It is sometimes necessary to protect the SB with a guidewire to prevent SB complications in PCI for bifurcation lesions. The RW is a novel method for guidewire insertion into an extremely angulated SB when the standard antegrade wire (AW) approach is difficult. Methods This retrospective study included 46 consecutive patients who underwent OCT‐guided PCI in bifurcation lesions with significant SB stenosis. Patients were divided into ...
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  Mentions: Kawasaki Medical School Tsunenari Soeda Yoshihiko Saito
3. Plaque modification of severely calcified coronary lesions by scoring balloon angioplasty using Lacrosse non-slip element: insights from an optical coherence tomography evaluation
  
  Explore Home - Springer Oct 24 2018 Cardiology
  
  Percutaneous coronary intervention (PCI) for heavily calcified lesions is challenging because these lesions are resistant to balloon dilatation and stenting. Lacrosse non-slip element (NSE) may have the potential to dilate heavily calcified lesions. We aimed to investigate predictors of successful lesion modification using Lacrosse NSE angioplasty via optical coherence tomography (OCT)-guided PCI. We investigated 32 patients with severe target lesion calcification treated with OCT-guided PCI. Successful lesion modification was defined as the complete fracture of calcification after Lacrosse NSE angioplasty. Before PCI, 172 segments with calcification were identified. After pre-dilatation using Lacrosse NSE, successful lesion modification was achieved in ...
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  Mentions: Tsunenari Soeda Yoshihiko Saito Hiroyuki Okura
4. Progression of a Calcified Nodule Causing Acute Myocardial Infarction in a Patient on Hemodialysis　― Serial Optical Coherence Tomography ―
  
  Explore jstage.jst.go.jp Aug 28 2018 Cardiology
  
  No abstract provided.
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  Mentions: Tsunenari Soeda Yoshihiko Saito Hiroyuki Okura
5. Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study
  
  Explore jaha.ahajournals.org Nov 16 2017
  
  Background Previous studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin‐cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is to identify clinical predictors for the lack of a favorable vascular response to statin therapy in patients with coronary artery disease. Methods and Results A total of 140 nonculprit plaques from 84 patients with coronary artery disease who were treated with a statin and had serial optical coherence tomography imaging (median interval, 6.3 months) were included. Thin ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Massachusetts General Hospital
6. SYNTAX Score, and Pre- and Post-Stent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients with Stable Angina Pectoris
  
  Explore ScienceDirect Jul 5 2017 Cardiology
  
  SYNTAX score (SS) has been reported to be an independent predictor of future cardiac events including target lesion revascularization (TLR). The aim of this study was to assess the relationship between SS and plaque characteristics and post-stent vascular response using optical coherence tomography (OCT) in coronary artery tree and left anterior descending artery (LAD) in patients with stable angina. A total of 179 lesions among 165 patients, including 100 lesions in LAD, were analyzed. Patients were stratified into tertiles. In pre-PCI analysis of whole coronary tree and LAD, lesions of the 3 rd tertile had the highest prevalence of lipid ...
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  Mentions: University of Queensland Massachusetts General Hospital Ik-Kyung Jang
7. SYNTAX Score and Pre- and Poststent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients With Stable Angina Pectoris
  
  Explore American Journal of Cardiology Jun 28 2017 Cardiology
  
  SYNTAX score (SS) has been reported to be an independent predictor of future cardiac events including target lesion revascularization. The aim of this study was to assess the relation between SS and plaque characteristics and poststent vascular response using optical coherence tomography in coronary artery tree and left anterior descending artery (LAD) in patients with stable angina. A total of 179 lesions among 165 patients, including 100 lesions in LAD, were analyzed. Patients were stratified into tertiles. In pre–percutaneous coronary intervention analysis of whole coronary tree and LAD, lesions of the third tertile had the highest prevalence of lipid-rich ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
8. The mechanism of microvascular obstruction in patients with acute ST-segment elevation myocardial infarction: new light from optical coherence tomography
  
  Explore LWW Online Apr 13 2017 Cardiology
  
  An unexpected situation, no reflow phenomenon, occurs occasionally when we implant a coronary stent at the culprit lesion of ST-=segment elevation myocardioal infarction (STEMI)...
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  Mentions: Tsunenari Soeda Nara Medical University
9. Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study
  
  Explore jaha.ahajournals.org Mar 1 2017 Cardiology
  
  Background Plaque rupture and erosion are the 2 most common mechanisms for acute coronary syndromes. However, the outcome of these 2 distinct pathologies in patients with acute coronary syndromes has never been studied. Methods and Results We retrospectively studied 141 patients with acute coronary syndromes who underwent optical coherence tomography ( OCT ) imaging of the culprit lesion prior to stenting from the Massachusetts General Hospital OCT Registry. Management (stent versus no stent), poststent OCT findings, and outcomes were compared. Among the 141 culprit lesions, rupture was found in 79 (56%) patients and erosion in 62 (44%). Stent implantation was performed in ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Shaosong Zhang
10. Is age an important factor for vascular response to statin therapy? A serial optical coherence tomography and intravascular ultrasound study
  
  Explore LWW Online Jan 10 2017
  
  Objective: Age-related structural and functional changes in vessel wall may affect the time course of vascular response to statin therapy. In this study, we sought to compare the response of lipid-rich plaque to statin therapy in elderly versus younger patients using optical coherence tomography and intravascular ultrasound. Patients and methods: Sixty-nine patients who underwent serial optical coherence tomography and intravascular ultrasound at the time point of baseline, 6, and 12 months were divided into two groups according to median age: group A (age<57 years, n=35) and group B (age>=57 years, n=34). Patients were treated with intensive ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Shaosong Zhang
11. Impact of branching angle on neointimal coverage of drug-eluting stents implanted in bifurcation lesions
  
  Explore LWW Online Nov 24 2016 Cardiology
  
  Objectives: To investigate the impact of branching angle (BA) on neointimal coverage of drug-eluting stents (DESs) in bifurcation lesions. Background: Previous experimental studies indicated that BA influences the local flow turbulence and wall shear stress, which are associated with neointimal coverage of DESs. Methods: Fifty-five bifurcation lesions in 47 patients were evaluated by serial optical coherence tomography (OCT) before DES implantation and at follow-up. Neointimal coverage was assessed in cross-sectional OCT images containing the side branch; regions including the side branch ostium (SO) and vessel wall (VW) were assessed separately. BA was measured using angiography (Angio-BA) and longitudinal OCT imaging ...
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  Mentions: Kawasaki Medical School Satoshi Okayama Tsunenari Soeda
12. Prevalence and Predictors of Multiple Coronary Plaque Ruptures In Vivo 3-Vessel Optical Coherence Tomography Imaging Study
  
  Explore atvb.ahajournals.org Oct 27 2016 Cardiology
  
  Objective— Plaque rupture may be the local expression of a widespread coronary instability. This study aimed to investigate: (1) the prevalence and characteristics of nonculprit plaque rupture; (2) the pancoronary atherosclerotic phenotype in patients with and without nonculprit plaque rupture; and (3) the prevalence and predictors of multiple plaque ruptures. Approach and Results— Six hundred and seventy-five nonculprit plaques from 261 patients (34 acute myocardial infarction, 73 unstable angina pectoris, and 154 stable angina pectoris) were analyzed by 3-vessel optical coherence tomography. Nonculprit plaque ruptures were identified in 51 patients (20%). Patients with nonculprit plaque ruptures had higher prevalence of ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
13. Does Residual Thrombus After Aspiration Thrombectomy Affect the Outcome of Primary PCI in Patients With ST-Segment Elevation Myocardial Infarction? An Optical Coherence Tomography Study
  
  Explore interventions.onlinejacc.org Oct 8 2016 Cardiology
  
  Objectives The aim of this study was to evaluate if residual thrombus burden after aspiration thrombectomy affects the outcomes of primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction (STEMI). Background Recent studies failed to show clinical benefit of aspiration thrombectomy in STEMI patients. This might be due to insufficient removal of thrombus at the culprit lesion. Methods A total of 109 STEMI patients who underwent aspiration thrombectomy followed by stenting within 24 h from symptom onset were included. Optical coherence tomography was performed after thrombectomy to measure residual thrombus burden. Patients were divided into tertiles based on ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
14. Coronary Plaque Characteristics Associated With Reduced TIMI (Thrombolysis in Myocardial Infarction) Flow Grade in Patients With ST-Segment–Elevation Myocardial Infarction A Combined Optical Coherence Tomography and Intravascular Ultrasound Study
  
  Explore Circulation Sep 14 2016 Cardiology
  
  Background— Previous studies reported that reduced TIMI (Thrombolysis in Myocardial Infarction) flow grade before procedure was associated with worse clinical outcomes in patients with ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention. The aim of this study was to identify specific morphological characteristics of the culprit plaque associated with poor TIMI flow grade at baseline in patients with ST-segment–elevation myocardial infarction using both optical coherence tomography and intravascular ultrasound. Methods and Results— A total of 111 ST-segment–elevation myocardial infarction patients who underwent percutaneous coronary intervention within 24 hours of symptom onset were included. Both optical coherence tomography ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
15. Coronary Plaque Characteristics Associated With Reduced TIMI (Thrombolysis in Myocardial Infarction) Flow Grade in Patients With ST-Segment–Elevation Myocardial Infarction A Combined Optical Coherence Tomography and Intravascular Ultrasound Study
  
  Explore Circulation Sep 1 2016 Cardiology
  
  Background— Previous studies reported that reduced TIMI (Thrombolysis in Myocardial Infarction) flow grade before procedure was associated with worse clinical outcomes in patients with ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention. The aim of this study was to identify specific morphological characteristics of the culprit plaque associated with poor TIMI flow grade at baseline in patients with ST-segment–elevation myocardial infarction using both optical coherence tomography and intravascular ultrasound. Methods and Results— A total of 111 ST-segment–elevation myocardial infarction patients who underwent percutaneous coronary intervention within 24 hours of symptom onset were included. Both optical coherence tomography ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
16. Associations between the Framingham Risk Score and coronary plaque characteristics as assessed by three-vessel optical coherence tomography
  
  Explore LWW Online May 25 2016 Cardiology
  
  Objectives: This study sought to explore the association between the Framingham Risk Score (FRS) and coronary plaque characteristics assessed by optical coherence tomography (OCT) imaging. Background: Clinical prediction models are useful for identifying high-risk patients. However, coronary events often occur in individuals estimated to be at low risk. Methods: A total of 254 patients with coronary artery disease who underwent three-vessel OCT were divided into tertiles according to FRS. Nonculprit plaque characteristics were compared among the three groups. Results: A total of 663 plaques were analyzed. FRS was significantly associated with calcification [37% (low FRS) vs. 46% (intermediate FRS) vs ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
17. Thin-cap fibroatheroma and large calcification at the proximal stent edge correlate with a high proportion of uncovered stent struts in the chronic phase
  
  Explore LWW Online May 14 2016 Cardiology
  
  Objective: A high proportion of uncovered stent struts is associated with late stent thrombosis after drug-eluting stent (DES) implantation, which frequently results in myocardial infarction or death. However, the predictors of uncovered stent struts remain unknown. Here, using optical coherence tomography (OCT), we studied the baseline tissue characteristics of the target coronary segment and evaluated their influence on the neointimal coverage of the strut in the chronic phase. Methods: We analyzed 118 coronary lesions treated with OCT-guided DES implantation. OCT examinations of target lesions were performed before and after DES implantation, and tissue characteristics were evaluated within 5 mm outer ...
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  Mentions: Kawasaki Medical School Hiroyuki Kawata Satoshi Okayama
18. Multifocal coronary thrombosis on nondisrupted plaque: observation with optical coherence tomography
  
  Explore LWW Online May 10 2016 Cardiology
  
  A 47-year-old man was admitted with anterior ST-segment elevation myocardial infarction (STEMI)...
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  Mentions: Tsunenari Soeda Yoshihiko Saito Hiroyuki Okura
19. Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy: a serial optical coherence tomography study
  
  Explore LWW Online Apr 23 2016 Cardiology
  
  Objective: Previous studies have suggested that intensive statin therapy, compared with moderate statin therapy, provided greater reduction of LDL and better protection against major cardiovascular events. However, the exact dose-dependent mechanism of plaque stabilization remains unclear. The aim of this study is to investigate the three-dimensional (3D) response of fibrous caps overlying lipid plaques to statin therapy. Methods: We applied a novel computer algorithm to investigate the fibrous cap 3D morphological change over time in patients with coronary artery disease. Patients were treated with either atorvastatin 20 mg/day (moderate intensity) or atorvastatin 60 mg/day (high intensity). Optical coherence ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Massachusetts General Hospital
20. Serial Optical Coherence Tomography and Intravascular Ultrasound Analysis of Gender Difference in Changes of Plaque Phenotype in Response to Lipid-lowering Therapy
  
  Explore American Journal of Cardiology Apr 5 2016 Cardiology
  
  Although the clinical benefit of statins have been demonstrated in both genders, gender differences in the response to statin therapy on plaque morphological changes have not been reported. A total of 66 non-culprit plaques from 46 patients who had serial image acquisition at baseline, 6 months, and 12 months by both optical coherence tomography (OCT) and intravascular ultrasound (IVUS) were included. Patients were treated with atorvastatin 60mg (AT60) or 20mg (AT20). The baseline characteristics were similar between women (n=16) and men (n=30) except for age (59.3±6.8 vs. 52.5±10.6, years, P=0.027 ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Shaosong Zhang
21. Coronary Calcification and Plaque Vulnerability An Optical Coherence Tomographic Study
  
  Explore Circulation Jan 12 2016 Cardiology
  
  Background— Spotty superficial calcium deposits have been implicated in plaque vulnerability based on previous intravascular imaging studies. Biomechanical models suggest that microcalcifications between 5 and 65 µm in diameter can intensify fibrous cap stress, promoting plaque rupture. However, the 100- to 200-µm resolution of intravascular ultrasound limits its ability to discriminate single calcium deposits from clusters of smaller deposits, and a previous optical coherence tomographic investigation evaluated calcifications within a long segment of artery, which may not truly reflect the mechanics involved in potentiating focal plaque rupture. Methods and Results— Detailed optical coherence tomographic assessment of coronary calcification at ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
22. Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents
  
  Explore LWW Online Nov 14 2015 Cardiology
  
  Objective: Methods for intravascular assessment of the side-branch (SB) orifice after stenting are not readily available. The aim of this study was to assess the utility of an en-face projection processing for optical coherence tomography (OCT) images for SB evaluation. Methods: Measurements of the SB orifice obtained using en-face OCT images were validated using a phantom model. Linear regression modeling was applied to estimated area measurements made on the en-face images. The SB orifice was then analyzed in 88 patients with bifurcation lesions treated with either Xience V (everolimus-eluting stent) or Resolute Integrity [zotarolimus-eluting stent (ZES)]. The SB orifice area ...
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  Mentions: Brigham and Women’s Hospital Massachusetts Institute of Technology James G. Fujimoto
23. Incidence and Clinical Significance of Poststent Optical Coherence Tomography Findings: One-Year Follow-Up Study From a Multicenter Registry
  
  Explore Circulation Sep 15 2015 Cardiology
  
  Background— Optical coherence tomography (OCT) was recently introduced to optimize percutaneous coronary intervention. However, the exact incidence and significance of poststent OCT findings are unknown. Methods and Results— A total of 900 lesions treated with 1001 stents in 786 patients who had postprocedure OCT imaging were analyzed to evaluate the incidence of poststent OCT findings and to identify the OCT predictors for device-oriented clinical end points, including cardiac death, target vessel–related myocardial infarction, target lesion revascularization, and stent thrombosis. Patients were followed up to 1 year. Stent edge dissection was detected in 28.7% of lesions, and incomplete stent ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Shaosong Zhang
24. Clinical utility of quantitative bright spots analysis in patients with acute coronary syndrome: an optical coherence tomography study
  
  Explore Home - Springer Jul 26 2015 Cardiology
  
  To investigate the clinical significance of bright spots in coronary plaque detected by optical coherence tomography (OCT) in patients with coronary artery disease. We identified 112 patients [acute coronary syndromes (ACS): n = 50, stable angina pectoris (SAP): n = 62] who underwent OCT imaging of the culprit lesion. A novel OCT algorithm was applied to detect bright spots representing the juxtaposition of a variety of plaque components including macrophages. The density of bright spots within the most superficial 250 μm of the vessel wall was measured at the site of culprit lesion. Bright spot density in the culprit lesion was significantly ...
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  Mentions: Massachusetts General Hospital Ik-Kyung Jang Thomas E. Milner
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