1. Articles from Songhao Liu

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    1. Quantitative measurement on optical attenuation coefficient of cell lines 5-8F and 6-10B using optical coherence tomography

      Quantitative measurement on optical attenuation coefficient of cell lines 5-8F and 6-10B using optical coherence tomography

      Oncogenesis and metastasis of tumor are difficult to detect during the clinic therapy. To explore the optical properties of tumorigenesis and metastasis in nasopharyngeal carcinoma (NPC), we assessed the NPC cell lines 5-8F and 6-10B by optical coherence tomography (OCT): first, the OCT images of the two different types of cell pellets were captured. Second, by fitting Beer’s law to the averaged A-scans in these OCT datasets, the attenuation coefficients ( μ t ) of the cells were extracted. The median attenuation coefficients (interquartile range (IQR)) of 5-8F and 6-10B were 6.79 mm −1 (IQR 6.52 to 7.23 mm ...

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    2. Quantitative measurement of optical attenuation coefficients of cell lines CNE1, CNE2, and NP69 using optical coherence tomography

      Quantitative measurement of optical attenuation coefficients of cell lines CNE1, CNE2, and NP69 using optical coherence tomography

      The radiotherapy-related types of nasopharyngeal carcinoma (NPC) have been established, which give the most effective treatment for NPC patients using the individual therapy. To diagnose the types of NPC, we assess the general NPC cell lines CNE1, CNE2 and normal nasopharyngeal cell line NP69 using optical coherence tomography (OCT) in two steps: firstly, the OCT images of the three different types of cell pellets are captured. Secondly, by fitting Beer’s law to the averaged A-scans in these OCT datasets, the attenuation coefficients (μ t ) of the cells can be extracted. The median attenuation coefficients (interquartile range) of CNE1, CNE2 ...

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    3. Quantitative measurement of optical parameters of cell lines 5-8F and 6-10B using polarization sensitive optical coherence tomography

      Quantitative measurement of optical parameters of cell lines 5-8F and 6-10B using polarization sensitive optical coherence tomography

      The aim was to test whether the typical NPC cell lines of 5-8F (high tumorigenesis and metastasis) and 6-10B (low tumorigenesis and metastasis) could be differentiated by polarization sensitive optical coherence tomography (PS-OCT). We imaged the two types of low cellular differentiated NPC cell lines 5-8F and 6-10B pellets using PS-OCT; then extracted the optical parameters of attenuate coefficient and anisotropy from the A-scan lines based on the multiple scattering model; and compared their phase retardation. The fitting scattering coefficients were μs = 10.91 ± 0.45 and μs = 11.33 ± 0.27 cm−1 for 5-8F and 6-10B pellets (p < 0.05), respectively; and the anisotropy factors were g = 0.900 ± 0.013 and g = 0.885 ± 0.008 for 5-8F and 6-10B pellets (p < 0.01), respectively. While the phase retardation of 6-10B was a little faster than 5-8F. These results indicated that PS-OCT could differentiate the two cell lines, and had the potential ability for typing the tissue of NPC.

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    4. Quantitative discrimination of NPC cell lines using optical coherence tomography

      Quantitative discrimination of NPC cell lines using optical coherence tomography

      We tried to explore the intrinsic differences in the optical properties of the four representative NPC cell lines on the models of radiobiology and metastasis by OCT. The scattering coefficients and anisotropies were extracted by fitting the average a-scan attenuation curves based on the multiple scatter effect. The values of scattering coefficients and anisotropy factors were 5.21 ± 0.11, 5.30 ± 0.09, 5.92 ± 0.21, 6.97 ± 0.22, and 0.892 ± 0.009, 0.886 ± 0.006, 0.884 ± 0.009, 0.86 ± 0.01 for CNE1, CNE2, 5-8F and 6-10B pellets (p < 0.05, P = 0.07 for CNE1 and CNE2), respectively. The results showed that the radiobiology and metastasis cell's model could be distinguished obviously; which implied that the corresponding types of NPC tissue might be potentially differentiated by OCT.

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    5. In vitro study of ultrasound and different-concentration glycerolinduced changes in human skin optical attenuation assessed with optical coherence tomography

      In vitro study of ultrasound and different-concentration glycerolinduced changes in human skin optical attenuation assessed with optical coherence tomography

      Previous studies have demonstrated the ultrasound-induced skin optical clearing enhancement with topical application of 60% glycerol (G) on in vitro porcine skin and in vivo human skin. Our purpose was to find the relation between the effect of optical skin clearing and different concentrations of glycerol and to find more effective ultrasound-glycerol combinations on optical skin clearing. The enhancement effect of ultrasound [Sonophoresis (SP) delivery] in combination with 40% G, 60% G, and 80% G on in vitro human skin optical clearing was investigated. Light imaging depths of skin were measured using optical coherence tomography. Different concentrations of glycerol and ...

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    6. Synergistic Effect of Ultrasound and Thiazone–PEG 400 on Human Skin Optical Clearing In Vivo

      Synergistic Effect of Ultrasound and Thiazone–PEG 400 on Human Skin Optical Clearing In Vivo

      In this paper, we propose a new physical method in combination with mixed solution of thiazone and polyethylene glycol 400 (thiazone PEG 400 solution) penetration into tissue to assess the skin optical clearing. Four treatments were performed: (1) control group (C); (2) polyethylene glycol 400 (PEG400); (3) 0.25% thiazone (0.25%T); (4) 0.25% thiazone and 5-min ultrasound (0.25%T/SP). The diffuse reflectance spectra and imaging depth of human skin in vivo at different times were measured by spectroscopy and optical coherence tomography (OCT). The optical clearing efficacy of skin was qualitatively and quantitatively analyzed. The ...

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    7. Application of hyperosmotic agent to determine gastric cancer with optical coherence tomography ex vivo in mice

      Noninvasive tumor imaging could lead to the early detection and timely treatment of cancer. Optical coherence tomography (OCT) has been reported as an ideal diagnostic tool for distinguishing tumor tissues from normal tissues based on structural imaging. In this study, the capability of OCT for functional imaging of normal and tumor tissues based on time- and depth-resolved quantification of the permeability of biomolecules through these tissues is investigated. The orthotopic graft model of gastric cancer in nude mice is used, normal and tumor tissues from the gastric wall are imaged, and a diffusion of 20% aqueous solution of glucose in ...
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    8. Potential ability of hematoporphyrin to enhance an optical coherence tomographic image of gastric cancer in vivo in mice

      Abstract. An ideal diagnostic system for the tumor tissues should be able to detect and define the location of tumor tissues and the early development of malignant diseases. There is great need for enhancement of imaging ability to tumor tissues. Optical coherence tomography (OCT) is used in detection and location of varied tumor tissues. In order to improve the sensitivity and specificity of an OCT image, hematoporphyrin as a new type of contrast agent was used in this study. The orthotopic graft model of gastric cancer in nude mice was used. The image formations of the tumor tissues without and ...

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    1-8 of 8
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    1. (5 articles) Tsinghua University
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    Synergistic Effect of Ultrasound and Thiazone–PEG 400 on Human Skin Optical Clearing In Vivo In vitro study of ultrasound and different-concentration glycerolinduced changes in human skin optical attenuation assessed with optical coherence tomography Quantitative discrimination of NPC cell lines using optical coherence tomography Quantitative measurement of optical parameters of cell lines 5-8F and 6-10B using polarization sensitive optical coherence tomography Quantitative measurement of optical attenuation coefficients of cell lines CNE1, CNE2, and NP69 using optical coherence tomography Quantitative measurement on optical attenuation coefficient of cell lines 5-8F and 6-10B using optical coherence tomography A Deep Learning Framework for the Detection and Quantification of Reticular Pseudodrusen and Drusen on Optical Coherence Tomography Quantitative assessment of textural features in the early detection of diabetic retinopathy with optical coherence tomography angiography Line-field confocal optical coherence tomography of fibroepithelioma of Pinkus Assessment of demineralized tooth lesions using optical coherence tomography and other state-of-the-art technologies: a review Optic disc and retinal vessel densities assessment by optical coherence tomography angiography in patients with keratoconus Optical coherence tomography angiography in Bietti crystalline dystrophy