1. Articles from Yih-Chung Tham

    1-8 of 8

    1. Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study

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      Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study

      Objective: To describe the normative quantitative parameters of macular retinal vasculature and their systemic and ocular associations, using optical coherence tomography angiography (OCTA). Design: Population based cross sectional study SUBJECTS: Adults above 50 years old were recruited from the third examination of the population-based Singapore Malay Eye Study. Methods: All participants underwent standardized comprehensive examination and Spectral domain-OCTA (Optovue, USA) of the macula. OCTA scans with pre-existing retinal disease, macular pathology, and poor quality were excluded. Main outcome measures: Normative quantitative vessel densities of the superficial, deep layer and foveal avascular zone were evaluated. Ocular and systemic associations with macular ...

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      Mentions: Visionix Singapore Eye Research Institute National University of Singapore

    2. Deep learning in glaucoma with optical coherence tomography: a review

      Explore Nature Publishing Group Ophthalmology
      Deep learning in glaucoma with optical coherence tomography: a review

      Deep learning (DL), a subset of artificial intelligence (AI) based on deep neural networks, has made significant breakthroughs in medical imaging, particularly for image classification and pattern recognition. In ophthalmology, applying DL for glaucoma assessment with optical coherence tomography (OCT), including OCT traditional reports, two-dimensional (2D) B-scans, and three-dimensional (3D) volumetric scans, has increasingly raised research interests. Studies have demonstrated that using DL for interpreting OCT is efficient, accurate, and with good performance for discriminating glaucomatous eyes from normal eyes, suggesting that incorporation of DL technology in OCT for glaucoma assessment could potentially address some gaps in the current practice ...

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      Mentions: The Chinese University of Hong Kong

    3. Agreement in Measures of Macular Perfusion between Optical Coherence Tomography Angiography Machines

      Explore Nature Publishing Group Ophthalmology
      Agreement in Measures of Macular Perfusion between Optical Coherence Tomography Angiography Machines

      We evaluated the agreements in foveal avascular zone (FAZ) area and vessel density (VD) parameters (within the superficial capillary plexus region), between two widely used optical coherence tomography angiography machines. Participants who attended the Singapore Malay Eye Study III between 29th March and 6th August 2018, were enrolled in this study. Participants underwent fovea-centered 6×6-mm macular cube scan, using both AngioVue and Cirrus HDOCT machines. Scans were analyzed automatically using built-in review software of each machine. 177 eyes (95 participants) without retinal diseases were included for final analysis. Mean FAZ area was 0.38 ± 0.11 mm 2 and ...

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      Mentions: Visionix Carl Zeiss Meditec National University of Singapore

    4. Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study

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      Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study

      This study aimed to evaluate the association between optical coherence tomography (OCT)-measured retinal layer thickness parameters with clinical and patient-centred visual outcomes in healthy eyes. Participants aged 40 and above were recruited from the Singapore Epidemiology of Eye Diseases Study, a multi-ethnic population-based study. Average macular, ganglion cell-inner plexiform layer (GCIPL), and outer retinal thickness parameters were obtained using the Cirrus High Definition-OCT. Measurements of best-corrected visual acuity (BCVA) and 11-item visual functioning questionnaire (VF-11) were performed. Associations between macular thickness parameters, with BCVA and Rasch-transformed VF-11 scores (in logits) were assessed using multivariable linear regression models with generalized ...

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      Mentions: Singapore Eye Research Institute National University of Singapore

    5. Factors affecting signal strength in spectral-domain optical coherence tomography

      Explore Wiley Online Library Ophthalmology
      Factors affecting signal strength in spectral-domain optical coherence tomography

      Purpose To identify ocular factors that affect signal strength in spectral-domain optical coherence tomography (SD-OCT). Methods Data from 1312 participants of the population-based Singapore Malay Eye Study-2 (SiMES-2) were included in the analysis. All participants underwent standardized ophthalmic examination, including measurements of best-corrected visual acuity (BCVA), refractive error, axial length, corneal curvature and presence of cataracts. Optic disc and macular cube scans were acquired using the Cirrus HD-OCT (software version 6.0, Carl Zeiss Meditec, Dublin, CA, USA). Signal strength of the optical coherence tomography (OCT) scan was recorded for each study eye. Multivariable linear regression analyses were performed to ...

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      Mentions: Carl Zeiss Meditec

    6. Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Explore iovs.org Ophthalmology
      Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Purpose. To determine the distribution, variation, and determinants of ganglion cell–inner plexiform layer (GC-IPL) thickness in nonglaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT). Methods. Six hundred twenty-three Chinese adults aged 40 to 80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination, and automated perimetry. HD-OCT with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors. Results. The mean (±SD) age of study subjects was 52.84 ± 6.14 ...

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      Mentions: Singapore Eye Research Institute Carl Zeiss Meditec University of Melbourne

    7. Determinants of Ganglion Cell-Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Explore iovs.org Ophthalmology
      Determinants of Ganglion Cell-Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Purpose. To determine the distribution, variation and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in non-glaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT). Methods. 623 Chinese adults aged 40-80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination and automated perimetry. HD-OCT (Cirrus, software version 6.0, Carl Zeiss Meditec, Dublin, CA) with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors. Results. The mean (± SD) age of study subjects ...

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      Mentions: Singapore Eye Research Institute Carl Zeiss Meditec National University of Singapore

    8. Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects

      Explore iovs.org Ophthalmology
      Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects
      Purpose: To evaluate the ocular and systemic factors influencing measurements of optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thickness with spectral-domain optical coherence tomography (SD-OCT) in healthy Chinese adults. Methods: Adults aged 40 to 80 years were consecutively recruited from the population-based Singapore Chinese Eye Study. Cirrus high-definition OCT (Carl Zeiss Meditec Inc, Dublin, CA) was used to measure ONH and RNFL parameters. A total of 542 eyes from 542 non-glaucoma Chinese subjects were analyzed. Univariable and multiple linear regression analyses were performed to examine the effects of a range of ocular (e.g., intraocular pressure ...
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      Mentions: Johns Hopkins University Singapore Eye Research Institute Carl Zeiss Meditec
    1-8 of 8
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    Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects Determinants of Ganglion Cell-Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography Factors affecting signal strength in spectral-domain optical coherence tomography Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study Agreement in Measures of Macular Perfusion between Optical Coherence Tomography Angiography Machines Deep learning in glaucoma with optical coherence tomography: a review Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study PREcise Percutaneous Coronary Intervention for Stent OptimizatION in Treatment of COMPLEX Lesion (PRECISION-COMPLEX) Real-Time Risk Score for Glaucoma Mass Screening by Spectral Domain Optical Coherence Tomography: Development and Validation Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease Vertical scan imaging of Anterior Segment Optical Coherence Tomography for descemet anchoring caterpillar seta: A case report and review of literature