1. Articles from Yih-Chung Tham

    1-7 of 7
    1. Deep learning in glaucoma with optical coherence tomography: a review

      Deep learning in glaucoma with optical coherence tomography: a review

      Deep learning (DL), a subset of artificial intelligence (AI) based on deep neural networks, has made significant breakthroughs in medical imaging, particularly for image classification and pattern recognition. In ophthalmology, applying DL for glaucoma assessment with optical coherence tomography (OCT), including OCT traditional reports, two-dimensional (2D) B-scans, and three-dimensional (3D) volumetric scans, has increasingly raised research interests. Studies have demonstrated that using DL for interpreting OCT is efficient, accurate, and with good performance for discriminating glaucomatous eyes from normal eyes, suggesting that incorporation of DL technology in OCT for glaucoma assessment could potentially address some gaps in the current practice ...

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    2. Agreement in Measures of Macular Perfusion between Optical Coherence Tomography Angiography Machines

      Agreement in Measures of Macular Perfusion between Optical Coherence Tomography Angiography Machines

      We evaluated the agreements in foveal avascular zone (FAZ) area and vessel density (VD) parameters (within the superficial capillary plexus region), between two widely used optical coherence tomography angiography machines. Participants who attended the Singapore Malay Eye Study III between 29th March and 6th August 2018, were enrolled in this study. Participants underwent fovea-centered 6×6-mm macular cube scan, using both AngioVue and Cirrus HDOCT machines. Scans were analyzed automatically using built-in review software of each machine. 177 eyes (95 participants) without retinal diseases were included for final analysis. Mean FAZ area was 0.38 ± 0.11 mm 2 and ...

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    3. Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study

      Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study

      This study aimed to evaluate the association between optical coherence tomography (OCT)-measured retinal layer thickness parameters with clinical and patient-centred visual outcomes in healthy eyes. Participants aged 40 and above were recruited from the Singapore Epidemiology of Eye Diseases Study, a multi-ethnic population-based study. Average macular, ganglion cell-inner plexiform layer (GCIPL), and outer retinal thickness parameters were obtained using the Cirrus High Definition-OCT. Measurements of best-corrected visual acuity (BCVA) and 11-item visual functioning questionnaire (VF-11) were performed. Associations between macular thickness parameters, with BCVA and Rasch-transformed VF-11 scores (in logits) were assessed using multivariable linear regression models with generalized ...

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    4. Factors affecting signal strength in spectral-domain optical coherence tomography

      Factors affecting signal strength in spectral-domain optical coherence tomography

      Purpose To identify ocular factors that affect signal strength in spectral-domain optical coherence tomography (SD-OCT). Methods Data from 1312 participants of the population-based Singapore Malay Eye Study-2 (SiMES-2) were included in the analysis. All participants underwent standardized ophthalmic examination, including measurements of best-corrected visual acuity (BCVA), refractive error, axial length, corneal curvature and presence of cataracts. Optic disc and macular cube scans were acquired using the Cirrus HD-OCT (software version 6.0, Carl Zeiss Meditec, Dublin, CA, USA). Signal strength of the optical coherence tomography (OCT) scan was recorded for each study eye. Multivariable linear regression analyses were performed to ...

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    5. Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Purpose. To determine the distribution, variation, and determinants of ganglion cell–inner plexiform layer (GC-IPL) thickness in nonglaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT). Methods. Six hundred twenty-three Chinese adults aged 40 to 80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination, and automated perimetry. HD-OCT with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors. Results. The mean (±SD) age of study subjects was 52.84 ± 6.14 ...

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    6. Determinants of Ganglion Cell-Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Determinants of Ganglion Cell-Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Purpose. To determine the distribution, variation and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in non-glaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT). Methods. 623 Chinese adults aged 40-80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination and automated perimetry. HD-OCT (Cirrus, software version 6.0, Carl Zeiss Meditec, Dublin, CA) with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors. Results. The mean (± SD) age of study subjects ...

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    7. Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects

      Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects
      Purpose: To evaluate the ocular and systemic factors influencing measurements of optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thickness with spectral-domain optical coherence tomography (SD-OCT) in healthy Chinese adults. Methods: Adults aged 40 to 80 years were consecutively recruited from the population-based Singapore Chinese Eye Study. Cirrus high-definition OCT (Carl Zeiss Meditec Inc, Dublin, CA) was used to measure ONH and RNFL parameters. A total of 542 eyes from 542 non-glaucoma Chinese subjects were analyzed. Univariable and multiple linear regression analyses were performed to examine the effects of a range of ocular (e.g., intraocular pressure ...
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    1-7 of 7
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    1. (5 articles) National University of Singapore
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    Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects Determinants of Ganglion Cell-Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography Factors affecting signal strength in spectral-domain optical coherence tomography Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study Agreement in Measures of Macular Perfusion between Optical Coherence Tomography Angiography Machines Deep learning in glaucoma with optical coherence tomography: a review Deep learning differentiates between healthy and diabetic mouse ears from optical coherence tomography angiography images Spectral-Domain Optical Coherence Tomography For Evaluating Palisades of Vogt in Ocular Surface Disorders With Limbal Involvement Oral cancer detection using optical coherence tomography – A detailed review Increased crystalline lens coverage in optical coherence tomography with oblique scanning and volume stitching Imaging Hyperreflective Foci as an Inflammatory Biomarker after Anti-VEGF Treatment in Neovascular Age-Related Macular Degeneration Patients with Optical Coherence Tomography Angiography