1. Articles from Natalia Gladkova

    1-10 of 10
    1. Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use

      Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use

      This work is dedicated to the development of the OCT system with angiography for everyday clinical use. Two major problems were solved during the development: compensation of specific natural tissue displacements, induced by contact scanning mode and physiological motion of patients (eg, respiratory and cardiac motions) and online visualization of vessel cross‐sections to provide feedback for the system operator.

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    2. Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography

      Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography

      A novel machine-learning method to distinguish between tumor and normal tissue in optical coherence tomography (OCT) has been developed. Pre-clinical murine ear model implanted with mouse colon carcinoma CT-26 was used. Structural-image-based feature sets were defined for each pixel and machine learning classifiers were trained using “ground truth” OCT images manually segmented by comparison with histology. The accuracy of the OCT tumour segmentation method was then quantified by comparing with fluorescence imaging of tumors expressing genetically encoded fluorescent protein KillerRed that clearly delineates tumor borders. Since the resultant 3D tumor/normal structural maps are inherently co-registered with OCT derived maps ...

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    3. Towards advanced OCT clinical applications

      Towards advanced OCT clinical applications

      In this paper we report on our recent achievement in application of conventional and cross-polarization OCT (CP OCT) modalities for in vivo clinical diagnostics in different medical areas including gynecology, dermatology, and stomatology. In gynecology, CP OCT was employed for diagnosing fallopian tubes and cervix; in dermatology OCT for monitoring of treatment of psoriasis, scleroderma and atopic dermatitis; and in stomatology for diagnosis of oral diseases. For all considered application, we propose and develop different image processing methods which enhance the diagnostic value of the technique. In particular, we use histogram analysis, Fourier analysis and neural networks, thus calculating different ...

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    4. Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography

      Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography

      Quantitative image analysis and parameter extraction using a specific implementation of polarization-sensitive optical coherence tomography (OCT) provides differential diagnosis of mucosal pathologies in in-vivo human bladders. We introduce a cross-polarization (CP) OCT image metric called Integral Depolarization Factor (IDF) to enable automatic diagnosis of bladder conditions (assessment the functional state of collagen fibers). IDF-based diagnostic accuracy of identification of the severe fibrosis of normal bladder mucosa is 79%; recurrence of carcinoma on the post-operative scar is 97%; and differentiation between neoplasia and acute inflammation is 75%. The promising potential of CP OCT combined with image analysis in human urology is ...

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    5. Combined use of fluorescence cystoscopy and cross-polarization OCT for diagnosis of bladder cancer and correlation with immunohistochemical markers

      Combined use of fluorescence cystoscopy and cross-polarization OCT for diagnosis of bladder cancer and correlation with immunohistochemical markers

      The combined use of fluorescence cystoscopy and cross-polarization optical coherence tomography (CP OCT) with quantitative estimation of the OCT signal was assessed in 92 bladder zones. It demonstrated the diagnostic accuracy in detecting superficial bladder cancer of 93.6%, sensitivity 96.4%, specificity 92.1%, positive predictive value 87% and negative predictive value 97.9%. Quantitative estimation of OCT signal standard deviation in cross-polarization (CP OCT SD index) makes the visual criteria of CP OCT image assessment more objective. The level of CP OCT SD index for diagnosing superficial bladder cancer, including cancer in situ, was 4.32 dB and ...

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    6. Evaluation of oral mucosa collagen condition with cross-polarization optical coherence tomography

      Evaluation of oral mucosa collagen condition with cross-polarization optical coherence tomography

      The goal of the research was analysis of the effect of collagen condition in formation of cross-polarized CP OCT images. We used of the CP OCT technique for studying collagen condition on an example of oral mucosa. Special histologic picrosirius red (PSR) staining of cheek mucosa specimens was used with subsequent assessing of the result of collagen staining in polarized light. High correlation (r = 0.692, p = 0.0001) between OCT signal standard deviation (SD) in cross-polarized images and brightness of PSR stained collagen fibers in cheek mucosa specimens was demonstrated in patients with inflammatory intestine and oral mucosa diseases ...

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    7. Cross polarization optical coherence tomography for diagnosis of oral soft tissues

      Cross polarization optical coherence tomography for diagnosis of oral soft tissues

      We consider the capabilities of cross-polarization OCT (CP OCT) focused on comparison of images resulting from cross-polarization and co-polarization scattering simultaneously for diagnosis of oral soft tissues. CP OCT was done for 35 patients with dental implants and 30 patients with inflammatory intestine diseases. Our study showed good diagnostic capabilities of CP OCT for detecting soft tissue pathology in the oral cavity. The cross-polarized images demonstrate the ability of tissue to depolarize. CP OCT demonstrates clinical capabilities for early diagnosis of inflammatory intestine diseases by the state of oral cavity mucosa and for early detection of gingivitis in patients above ...

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    8. Cross-polarization optical coherence tomography for early bladder-cancer detection: statistical study

      Cross-polarization optical coherence tomography for early bladder-cancer detection: statistical study
      The capabilities of cross-polarization optical coherence tomography (CP OCT) for early bladder-cancer detection are assessed in statistical study and compared with the traditional OCT. Unlike the traditional OCT that demonstrates images only in copolarization, CP OCT acquires images in cross-polarization and copolarization simultaneously. 116 patients with localized flat suspicious lesions in the bladder were enrolled, 360 CP OCT images were obtained and analyzed. CP OCT demonstrated sensitivity 93.7% (vs. 81.2%, <0.0001), specificity 84% (vs. 70.0%, <0.001) and accuracy 85.3% (vs. 71.5%, <0.001) in detecting flat malignant bladder lesions, which is significantly better ...
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    9. Monitoring oncological surgery using optical coherence tomography

      Monitoring oncological surgery using optical coherence tomography
      Detailed, real-time imaging allows for adjustment of surgical margins, thus sparing healthy tissue and increasing the likelihood of complete tumor removal. Development of local recurrence is one of the main causes of unsatisfactory long-term recovery prospects following cancer surgery. Determining the adequate balance between radical tumor removal and maximum preservation of the surrounding tissue is therefore very important for cancer management and, subsequently, the patient's quality of life. Rates of recurrence following surgical resection are appreciably high for a number of cancers. Following transurethral resection of bladder tumors (TURBT), they are reported to be as high as 40–80 ...
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    10. Application of optical coherence tomography in the diagnosis of mucositis in patients with head and neck cancer during a course of radio(chemo)therapy

      Objective Mucositis is the most common oral complication of non-surgical therapy (chemotherapy, radiotherapy, and radio(chemo)therapy) in patients with head and neck cancer. Growing evidence indicates that more aggressive treatment regimens improve local tumor control and the survival of patients with locally advanced head and neck cancer. However combined therapy approaches are associated with higher acute toxicity. Currently there are no in vivo methods to visualize microscopic changes of mucosal structure during a course of radio(chemo)therapy and to assess the development and healing of oral mucositis. As a result it has been impossible to predict its severity ...
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    1-10 of 10
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  2. Topics in the News

    1. (10 articles) Nizhny Novgorod State Medical Academy
    2. (10 articles) Natalia D. Gladkova
    3. (9 articles) Elena B. Kiseleva
    4. (6 articles) Elena V. Zagaynova
    5. (5 articles) Institute of Applied Physics
    6. (5 articles) Maria M. Karabut
    7. (4 articles) Grigory V. Gelikonov
    8. (4 articles) Valentin M. Gelikonov
    9. (4 articles) I. Alex Vitkin
    10. (3 articles) Felix I. Feldchtein
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    Monitoring oncological surgery using optical coherence tomography Cross-polarization optical coherence tomography for early bladder-cancer detection: statistical study Cross polarization optical coherence tomography for diagnosis of oral soft tissues Evaluation of oral mucosa collagen condition with cross-polarization optical coherence tomography Combined use of fluorescence cystoscopy and cross-polarization OCT for diagnosis of bladder cancer and correlation with immunohistochemical markers Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography Towards advanced OCT clinical applications Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use The multi-spectral signal properties of multiple reference optical coherence tomography (Thesis) Calibration-free time-stretch optical coherence tomography with large imaging depth Does Projection Artifact Removal Improve Visualization of Images in Optical Coherence Tomography Angiography?