1. Articles from Elena B. Kiseleva

    1-9 of 9
    1. Cross-polarization optical coherence tomography for brain tumor imaging

      Cross-polarization optical coherence tomography for brain tumor imaging

      This paper considers valuable visual assessment criteria for distinguishing between tumorous and non-tumorous tissues, intraoperatively, using cross-polarization OCT (CP OCT) – OCT with a functional extension, that enables detection of the polarization properties of the tissues in addition to their conventional light scattering. Materials and methods. The study was performed on 176 ex vivo human specimens obtained from 30 glioma patients. To measure the degree to which the typical parameters of CP OCT images can be matched to the actual histology, 100 images of tumors and white matter were selected for visual analysis to be undertaken by three “single-blinded” investigators. An ...

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    2. Time-related ex vivo changes in the optical properties of normal brain tissues

      Time-related ex vivo changes in the optical properties of normal brain tissues

      The aim of the study was to observe time-related changes in the optical properties of normal brain tissues as measured using cross-polarization optical coherence tomography (CP OCT). 32 ex vivo tissue samples from 16 animals (rats) were monitored under different external conditions, over a period of 1 hour after excision, to measure time-related optical changes. It was found that the optical properties of white matter were quite stable over the time scales of the experiments, while the optical properties of the gray matter could change significantly. However, these changes could be minimized by using fresh sections from samples that had ...

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    3. Optical coherence angiography without motion correction preprocessing

      Optical coherence angiography without motion correction preprocessing

      The method for vessel visualization from optical coherence tomography (OCT) data is presented. The method is based on high-frequency filtration of the normalized absolute values of the scattered field measured with OCT. It is shown that in contrast with optical coherence angiography based on the processing of complex values of a scattered field, the proposed processing does not require motion correction preprocessing while providing resulting angiographic images of comparable quality.

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    4. Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal brain tissue were differentiated using two optical coefficients — attenuation and forward cross-scattering. Compared with white matter ...

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    5. Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma

      Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma

      In the case of infiltrative brain tumors the surgeon faces difficulties in determining their boundaries to achieve total resection. The aim of the investigation was to evaluate the performance of multimodal OCT (MM OCT) for differential diagnostics of normal brain tissue and glioma using an experimental model of glioblastoma. The spectral domain OCT device that was used for the study provides simultaneously two modes: cross-polarization and microangiographic OCT. The comparative analysis of the both OCT modalities images from tumorous and normal brain tissue areas concurrently with histologic correlation shows certain difference between when accordingly to morphological and microvascular tissue features.

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    6. Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy

      Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy

      A combination of approaches to the image analysis in cross-polarization optical coherence tomography (CP OCT) and high-resolution imaging by nonlinear microscopy and atomic force microscopy (AFM) at the different stages of atherosclerotic plaque development is studied. This combination allowed us to qualitatively and quantitatively assess the disorganization of collagen in the atherosclerotic arterial tissue (reduction and increase of CP backscatter), at the fiber (change of the geometric distribution of fibers in the second-harmonic generation microscopy images) and fibrillar (violation of packing and different nature of a basket-weave network of fibrils in the AFM images) organization levels. The calculated CP channel-related ...

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    7. Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography

      Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography

      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers in the development of the atherosclerotic plaque (AP). The study shows potential of CP OCT for the assessment of collagen and elastin fibers condition in atherosclerotic arteries. Specifically, the additional information afforded by CP OCT, related to birefringence and cross-scattering properties of arterial tissues, may improve the robustness and accuracy of assessment about the microstructure and composition of the plaque for different stages of atherosclerosis.

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    8. Multi-modal optical imaging characterization of atherosclerotic plaques

      Multi-modal optical imaging characterization of atherosclerotic plaques

      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers and other vascular structures in the development of atherosclerosis, including identification of vulnerable plaques, which remains an important clinical problem and imaging application. CP OCT's ability to visualize tissue birefringence and cross-scattering adds new information about the microstructure and composition of the plaque. However its interpretation can be ambiguous, because backscattering contrast may have a similar appearance to the birefringence related fringes. Our results represent a step towards minimally invasive characterization and ...

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    9. Feature Of The Week 3/13/11: Russian Scientists Investigate Cross Polarization OCT for Early Bladder Cancer Detection

      Feature Of The Week 3/13/11: Russian Scientists Investigate Cross Polarization OCT for Early Bladder Cancer Detection
      Feature Of The Week 3/13/11: This week OCT News has another exciting “Feature Of The Week” presentation of exciting scientific results on the use of co- and cross-polarization OCT information applied to early bladder cancer detection.  The work is from the prestigious Institute of Applied and Fundamental Medicine at the Nizhny Novgorod State Medical Academy and the Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia.  Please note the authors have some excellent animation techniques so go slowly when viewing the slides so the animation can complete.   Capabilities of Cross Polarization Optical Coherence Tomography ...
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    1-9 of 9
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  2. Topics in the News

    1. (9 articles) Natalia D. Gladkova
    2. (9 articles) Elena B. Kiseleva
    3. (8 articles) Institute of Applied Physics
    4. (8 articles) Grigory V. Gelikonov
    5. (5 articles) Nizhny Novgorod State Medical Academy
    6. (4 articles) Elena V. Zagaynova
    7. (3 articles) Felix I. Feldchtein
    8. (2 articles) Valentin M. Gelikonov
    9. (2 articles) Pavel A. Shilyagin
    10. (2 articles) Maria M. Karabut
    11. (2 articles) Nanyang Technological University
    12. (2 articles) Linbo Liu
    13. (1 articles) Harvard University
    14. (1 articles) University of Kent
    15. (1 articles) Kyushu University
    16. (1 articles) University of Miami
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    18. (1 articles) Yoshiyasu Minami
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    20. (1 articles) George M. Dobre
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    Feature Of The Week 3/13/11: Russian Scientists Investigate Cross Polarization OCT for Early Bladder Cancer Detection Multi-modal optical imaging characterization of atherosclerotic plaques Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography Optical coherence angiography without motion correction preprocessing Time-related ex vivo changes in the optical properties of normal brain tissues Cross-polarization optical coherence tomography for brain tumor imaging PhD Student and Postdoctoral Associate Positions at the University of Massachusetts Early Detection of Microvascular Changes in Patients with Diabetes Mellitus without and with Diabetic Retinopathy: Comparison between Different Swept-Source OCT-A Instruments In vivo tomographic visualization of intracochlear vibration using a supercontinuum multifrequency-swept optical coherence microscope