1. Articles from M. Cuevas

    1-5 of 5
    1. Analysis of Murine Vascular Function In Vivo by Optical Coherence Tomography in Response to High-fat Diet

      In this study, we demonstrate the application of optical coherence tomography (OCT) as a contactless imaging technique to analyze vasodynamics in small blood vessels in vivo. The transluminal OCT imaging of vessels avoids micro traumata in the endothelium and circumvents surgical intervention. It can be performed in the intact perfused vessel and provides a new method to measure vascular function and dynamics in vivo. The resolution of 10 μm and the velocity of image acquisition are adequate to detect differences in the inner diameter, the maximal velocity, or the time to half-maximal diameter change of small vessels. We applied this ...
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    2. Phase-resolved Doppler Fourier Domain Optical Coherence Tomography in the in vivo mouse model

      Blood flow velocities within vasodynamic measurements in the in vivo mouse model were imaged by using phase-resolved Doppler Fourier Domain Optical Coherence Tomography with a spectrum read-out rate of 12 kHz. The high temporal resolution of the system is used to quantify the pulse from real-time cross-sectional images of the murine saphenous artery. The Doppler method was evaluated by imaging a 1% Intralipid emulsion flowing through a glass capillary with an inner diameter of approximately 320 um.
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    3. Transverse and oblique motion effects in Fourier Domain Optical Coherence Tomography

      In this study we describe the effects on the interference signal caused by transverse and oblique motion in spatially encoded Fourier Domain Optical Coherence Tomography (FD OCT). The artifacts caused by sample motion were analyzed theoretically and experimentally. The presented results supply an understanding of the SNR degradation caused by sample motion and demonstrates the importance of fast data acquisition in medical imaging.
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    4. Velocity Analysis by Using Doppler Fourier Domain Optical Coherence Tomography with Variable Reference Length

      The measurement of blood flow is important in studying the pathophysiology and treatment of several diseases of blood vessels, like atherosclerosis. We present a method for flow measurement using resonant Doppler imaging with spectrometer based Fourier Domain Optical Coherence Tomography (FD-OCT). A modified Michelson interferometer, integrated in a 3D scanner head, with a variable reference length is used to determine velocities. Two methods are applied where cross-sectional images (B-scans) are taken while the reference arm for each depth scan (A-scan) has different states. In the 2- state method the reference mirror is moving axial towards respectively backwards in successive A-scans ...
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    5. Fabrication of thin and flexible PDMS membranes for biomechanical test applications

      For continuous analysis of mechanical properties of soft biological tissues during mechanical stimulation we developed a bioreactor to apply controlled periodic deflection to a probe. The probe attached on an elastic membrane produces a counterpressure if a certain gas volume is applied to the pressure chamber under the membrane. The related counterpressure-volume relationship describes the mechanical properties of the membrane-probe combination. To improve the signal-to-noise ratio of measurements the use of highly flexible membranes is advantageous. We developed a specific adapter, attached securely to the central thread of a centrifuge, to fabricate silicone membranes on carrier rings with reproducible mechanical ...
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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Dresden University of Technology
    2. (5 articles) Edmund Koch
    3. (4 articles) Julia Walther
    4. (2 articles) Henning Morawietz
    5. (1 articles) University of Freiburg
    6. (1 articles) Sven Meissner
    7. (1 articles) Harvard University
    8. (1 articles) Massachusetts General Hospital
    9. (1 articles) University College London
    10. (1 articles) Masamichi Takano
    11. (1 articles) Tsunenari Soeda
    12. (1 articles) Ik-Kyung Jang
    13. (1 articles) Pearse A. Keane
    14. (1 articles) Hang Lee
    15. (1 articles) Kyoichi Mizuno
    16. (1 articles) Zeiss Cirrus HD-OCT
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