1. Articles from D. Lorenser

    1-2 of 2
    1. 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      Evaluation of degradation in the structure of skeletal muscle is important for the assessment or diagnosis of many myopathies, such as Duchenne muscular dystrophy. Histological analysis is the gold standard to evaluate such degradation but requires excision and fixation of the tissue. This is undesirably invasive in patients and precludes longitudinal study of disease progression in patients or animal models. Optical coherence tomography (OCT) is a high-resolution (∼10μm) imaging modality capable of visualising muscle structure and the morphological changes in muscular dystrophy. However, because of the limited image penetration of OCT (∼2mm), previous studies have been restricted to imaging ...

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    2. Ultrathin side-viewing needle probe for optical coherence tomography

      Ultrathin side-viewing needle probe for optical coherence tomography

      We present the smallest reported side-viewing needle probe for optical coherence tomography (OCT). Design, fabrication, optical characterization, and initial application of a 30-gauge (outer diameter 0.31 mm) needle probe are demonstrated. Extreme miniaturization is achieved by using a simple all-fiber probe design incorporating an angle-polished and reflection-coated fiber-tip beam deflector. When inserted into biological tissue, aqueous interstitial fluids reduce the probe’s inherent astigmatism ratio to 1.8, resulting in a working distance of 300 μm and a depth-of-field of 550 μm with beam diameters below 30 μm. The needle probe was interfaced with an 840 nm spectral-domain OCT ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Western Australia
    2. (2 articles) Dirk Lorenser
    3. (2 articles) Xiaojie Yang
    4. (2 articles) David D. Sampson
    5. (2 articles) Rodney W. Kirk
    6. (2 articles) Optovue
    7. (2 articles) Optovue RTVue-100
    8. (1 articles) Robert A. McLaughlin
    9. (1 articles) LuEsther T. Mertz Retinal Research Center
    10. (1 articles) UCLA
    11. (1 articles) Duke University
    12. (1 articles) Srinivas R. Sadda
    13. (1 articles) Hideki Koizumi
    14. (1 articles) Sina Farsiu
    15. (1 articles) Leica
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    Ultrathin side-viewing needle probe for optical coherence tomography 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe Farsiu Wins ARVO Foundation/Pfizer Ophthalmics Carl Camras Translational Research Award Two- and three-dimensional topographic analysis of pathologically myopic eyes with dome-shaped macula and inferior staphyloma by spectral domain optical coherence tomography OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEA IN CHILDREN BORN PRETERM Evaluation of Retinal Changes Using Optical Coherence Tomography in a Pediatric Case of Susac Syndrome CHOROIDAL BLOOD VESSELS IN RETINAL PIGMENT EPITHELIAL ATROPHY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview OCT-based full crystalline lens shape change during accommodation in vivo Choroid Segmentation from Optical Coherence Tomography with Graph-Edge Weights Learned from Deep Convolutional Neural Networks Multimodal imaging analyses of hyperreflective dot-like lesions in acute syphilitic posterior placoid chorioretinopathy Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter