1. Articles from D. Lorenser

    1-2 of 2
    1. 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      Evaluation of degradation in the structure of skeletal muscle is important for the assessment or diagnosis of many myopathies, such as Duchenne muscular dystrophy. Histological analysis is the gold standard to evaluate such degradation but requires excision and fixation of the tissue. This is undesirably invasive in patients and precludes longitudinal study of disease progression in patients or animal models. Optical coherence tomography (OCT) is a high-resolution (∼10μm) imaging modality capable of visualising muscle structure and the morphological changes in muscular dystrophy. However, because of the limited image penetration of OCT (∼2mm), previous studies have been restricted to imaging ...

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    2. Ultrathin side-viewing needle probe for optical coherence tomography

      Ultrathin side-viewing needle probe for optical coherence tomography

      We present the smallest reported side-viewing needle probe for optical coherence tomography (OCT). Design, fabrication, optical characterization, and initial application of a 30-gauge (outer diameter 0.31 mm) needle probe are demonstrated. Extreme miniaturization is achieved by using a simple all-fiber probe design incorporating an angle-polished and reflection-coated fiber-tip beam deflector. When inserted into biological tissue, aqueous interstitial fluids reduce the probe’s inherent astigmatism ratio to 1.8, resulting in a working distance of 300 μm and a depth-of-field of 550 μm with beam diameters below 30 μm. The needle probe was interfaced with an 840 nm spectral-domain OCT ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Western Australia
    2. (2 articles) Dirk Lorenser
    3. (2 articles) Xiaojie Yang
    4. (2 articles) David D. Sampson
    5. (2 articles) Rodney W. Kirk
    6. (1 articles) Robert A. McLaughlin
    7. (1 articles) Bern University Hospital
    8. (1 articles) University of Bern
    9. (1 articles) Yale University
    10. (1 articles) University of St. Andrews
    11. (1 articles) Drexel University
    12. (1 articles) Michael A. Choma
    13. (1 articles) Kishan Dholakia
    14. (1 articles) Christian T. A. Brown
    15. (1 articles) Tomey Corporation
    16. (1 articles) Tomey SS-1000 CASIA
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    Ultrathin side-viewing needle probe for optical coherence tomography 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe GaAs-Based Superluminescent Light-Emitting Diodes with 290-nm Emission Bandwidth by Using Hybrid Quantum Well/Quantum Dot Structures 3D optical phase reconstruction within PMMA samples using a spectral OCT system Observation of drying process of multilayered paint using fOCT based on dynamic speckles Quantitative Analysis of Mouse Retinal Layers Using Automated Segmentation of Spectral Domain Optical Coherence Tomography Images Internal physiology of live krill revealed using new aquaria techniques and mixed optical microscopy and optical coherence tomography (OCT) imaging techniques Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography Screening for Subclinical Keratoconus Using Swept-Source Fourier Domain Anterior Segment Optical Coherence Tomography Enamel Quality after Debonding: Evaluation by Optical Coherence Tomography Real-Time Optical Coherence Tomography Segmentation? Dispersion and compensation of optical coherence tomography using double-path rapid scanning optical delay line