All Articles from Maurizio Battaglia Parodi -Optical Coherence Tomography News

Articles from Maurizio Battaglia Parodi

1-24 of 37 1 2 »
1. Quantitative OCTA parameter variations after treatment of macular neovascularization secondary to age-related macular degeneration
  
  Explore LWW Online Dec 16 2020 Ophthalmology
  
  Purpose: Macular neovascularization (MNV) secondary to age-related macular degeneration (AMD) can be characterized by quantitative optical coherence tomography angiography (OCTA). The aim of the study was to assess the evolution of quantitative OCTA parameters after one-year of anti-VEGF injections. Methods: Naïve AMD-related MNV eyes were prospectively recruited to analyze OCT and OCTA parameters, including MNV vessel tortuosity (VT) and reflectivity, at baseline and at the end of the follow-up. MNV eyes were categorized by a MNV VT cutoff and quantitative parameter variations were documented after one-year of treatment. We divided MNV eyes into Group 1 (MNV VT<8.40 ...
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  Mentions: Francesco Bandello Università Vita-Salute San Raffaele
2. Quantitative Optical Coherence Tomography Angiography Parameters in Type 1 Macular Neovascularization Secondary to Age-Related Macular Degeneration
  
  Explore TVST Journal Sep 5 2020 Ophthalmology
  
  Purpose : The purpose of this paper was to study type 1 macular neovascularization (MNV) quantitative optical coherence tomography (OCT) angiography (OCTA) features by means of advanced postprocessing analyses. Methods : We recruited patients affected by naïve type 1 MNV secondary to age-related macular degeneration (AMD) and age-matched controls. All patients underwent ophthalmologic examination and multimodal imaging. They were treated with pro-re-nata anti-VEGF injections. The ensuing follow-up lasted 24 months. Quantitative OCT and OCTA parameters were statistically analyzed to obtain cutoff values able to distinguish two clinically different patient subgroups. Main outcome measures were best-corrected visual acuity (BCVA), central macular thickness ...
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  Mentions: Università Vita-Salute San Raffaele
3. Analysis of optical coherence angiography in cystoid macular oedema associated with gyrate atrophy
  
  Explore Nature Publishing Group Sep 1 2020 Ophthalmology
  
  Background To evaluate the relationship between superficial, deep foveal avascular zone (FAZ) and foveal cyst areas in eyes with cystoid macular oedema (CMO) associated with gyrate atrophy of the choroid and retina (GA). Methods This is a retrospective collaborative multicenter study of optical coherence tomography-angiography (OCTA) images in GA. Superficial and deep FAZ and foveal cyst were measured using Image J by two independent experts. Values were corrected for myopia magnification. These values were compared with age-matched controls from normative data. Results Twenty-three eyes from 12 patients with GA and CMO were included in the study. The mean ± standard deviation ...
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4. Extrafoveal müller cells detection in vivo in the human retina: A pilot study based on optical coherence tomography
  
  Explore ScienceDirect Aug 11 2020 Ophthalmology
  
  Müller cells (MC) represent a key element for the metabolic and functional regulation of the vertebrate retina. The aim of the present study was to test the feasibility of a new method for the in-vivo detection and quantification of extrafoveal MC in human retina. We developed a new approach to isolate and analyse extrafoveal MC in vivo, starting from structural optical coherence tomography data. Our pilot investigation was based on the optical properties of MC, which are known to not interfere with the light reaching the outer retinal structures. We reconstructed MC in the macular region of 18 healthy ...
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  Mentions: Università Vita-Salute San Raffaele
5. Swept-source optical coherence tomography angiography vitreo-retinal segmentation in proliferative diabetic retinopathy
  
  Explore SAGE Journals Jul 30 2020 Ophthalmology
  
  Purpose: To identify a new cortical vitreous segmentation protocol for non invasive standardised investigation of Neovascularisation (NV) with detection of regression of NV activity in Proliferative Diabetic Retinopathy (PDR). Design: Retrospective study. Participants: One hundred and eighty-six eyes of 93 consecutive diabetic patients (mean age: 52.6 ± 11.0 years) imaged using Topcon Triton ® Swept-Source Optical Coherence Tomography Angiography (SS-OCTA) from June 2015 to January 2017. Methods: Scans were performed through the macula, optic disc and areas of possible NV in mid-peripheral retina using 6 × 6 mm and/or 9 × 9 mm raster-patterns in three segmentation protocols: Vitreo-Retinal (VRS), Outer-Vitreous ...
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  Mentions: Topcon Medical Systems Optos
6. Optical Coherence Tomography Angiography Quantitative Assessment of Macular Neovascularization in Best Vitelliform Macular Dystrophy
  
  Explore IOVS Journal Jul 1 2020 Ophthalmology
  
  Purpose : To describe quantitative characteristics of macular neovascularization (MNV) in vitelliform macular dystrophy (VMD) patients by means of optical coherence tomography angiography (OCTA). Methods : The study design was a prospective case series. All patients underwent complete ophthalmologic assessment, optical coherence tomography, and OCTA. The quantitative OCTA parameters examined included vessel tortuosity and vessel dispersion of the MNV. The primary outcome was OCTA characterization of MNV in VMD. Secondary outcomes included the evolution of MNV over the follow-up. Results : A total of 78 eyes were recruited for the study. MNV was identified in 50 eyes (64%) at baseline and in 51 ...
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  Mentions: Francesco Bandello Università Vita-Salute San Raffaele
7. Cone Dystrophies: An Optical Coherence Tomography Angiography Study
  
  Explore MDPI Open Access Journals Platform May 21 2020 Ophthalmology
  
  Background: This study investigates the relationship between retinal vascularization and macular function in patients with cone dystrophies (CDs). Methods: Twenty CD patients (40 eyes) and 20 healthy controls (20 eyes) were enrolled in this prospective case-control study. Patients underwent full ophthalmological examination, microperimetry, full-field, pattern and multifocal electroretinogram (ERG, PERG, mfERG) and optical coherence tomography angiography (OCTA). Main outcome measures were as follows: foveal and parafoveal inner and outer retinal thickness; microperimetry sensitivity in the central 4° and 8°, ERG b wave amplitudes and peak times, PERG P50 and N95 amplitudes and latencies, and mfERG N1 to P1 amplitudes; and ...
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  Mentions: San Raffaele Scientfic Institute
8. MultiColor imaging to detect different subtypes of retinal microaneurysms in diabetic retinopathy
  
  Explore Nature Publishing Group Feb 17 2020 Ophthalmology
  
  Background Retinal microaneurysms (MAs) are among the earliest signs of diabetic retinopathy (DR) and are typically detected by fluorescein angiography (FA). Confocal MultiColor is a noninvasive-imaging technique able to analyze different retinal features by capturing three simultaneous reflectance images. The main aim of the present study was to characterize morphological features of MAs by means of MultiColor images and to compare these with spectral domain optical coherence tomography (SD-OCT) and FA findings. Methods A cross-sectional, observational study setting was chosen. Multimodal imaging included MultiColor, SD-OCT and FA images. We performed a qualitative analysis in order to assess the relationship between ...
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  Mentions: San Raffaele Scientfic Institute Francesco Bandello
9. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY CAN CATEGORIZE DIFFERENT SUBGROUPS OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION
  
  Explore LWW Online Feb 14 2020 Ophthalmology
  
  Purpose: Choroidal neovascularization ( CNV ) is a common complication of patients affected by age-related macular degeneration , showing a highly variable visual outcome. The main aim of the study was, at baseline, to perform a quantitative optical coherence tomography angiography assessment of CNV secondary to age-related macular degeneration and to assess posttreatment outcomes. Methods: Seventy-eight naïve age-related macular degeneration -related CNV patients (39 men, mean age 78 ± 8 years) were recruited and underwent complete ophthalmologic evaluation and multimodal imaging. Several OCT and optical coherence tomography angiography parameters were collected, including vessel tortuosity and vessel dispersion (VDisp), measured for each segmented CNV ...
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  Mentions: San Raffaele Scientfic Institute Francesco Bandello
10. Optical Coherence Tomography Angiography in Extensive Macular Atrophy with Pseudodrusen-Like Appearance
  
  Explore TVST Journal Feb 12 2020
  
  Purpose : Analyses of quantitative features of optical coherence tomography angiography (OCTA) in patients affected by extensive macular atrophy with pseudodrusen-like appearance (EMAP). Methods : In a prospective case-control study, patients and age- and gender-matched healthy controls underwent complete ophthalmologic examination, including best corrected visual acuity (BCVA) measurement, biomicroscopy, fundus autofluorescence and spectral-domain optical coherence tomography (Spectralis HRA; Heidelberg Engineering GmbH, Heidelberg, Germany), and OCTA scans (DRI OCT Triton; Topcon Corporation, Tokyo, Japan). Vessel density in the superficial capillary plexus and deep capillary plexus (DCP) in the retina and choriocapillaris (CC) in the macula and optic disc were measured. The one-way analysis ...
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  Mentions: Heidelberg Engineering Topcon Medical Systems Francesco Bandello
11. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF FOCAL CHOROIDAL EXCAVATION AND THE CHOROIDAL STROMA VARIATIONS WITH OCCURRENCE OF EXCAVATION
  
  Explore LWW Online Feb 2 2020 Ophthalmology
  
  Purpose: To describe retinal and choroidal vascular changes and choroidal stroma variations occurring in focal choroidal excavation (FCE). Methods: Study design was a cross-sectional case series. Consecutive patients affected by FCE and healthy controls were recruited. All patients underwent complete ophthalmologic assessment and multimodal imaging, including structural optical coherence tomography and optical coherence tomography angiography. Choroidal thickness and stromal index were calculated from structural optical coherence tomography images. Moreover, we measured vessel density values of superficial capillary plexus, deep capillary plexus, and choriocapillaris at the level of the macula. Results: Twenty-two patients (28 eyes; mean age 57.2 ± 16.4 ...
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  Mentions: Northwestern University San Raffaele Scientfic Institute
12. Multimodal evaluation of central and peripheral alterations in Stargardt disease: a pilot study
  
  Explore BJO Online Nov 23 2019 Ophthalmology
  
  Background The clinical phenotype of Stargardt disease (STGD) can be extremely heterogeneous, with variable macular and peripheral retinal involvement. The study aim was to correlate peripheral ultrawide field (UWF) involvement with macular alterations, as assessed by structural optical coherence tomography (OCT) and OCT angiography (OCTA), in order to identify potentially different phenotypes. Methods The study involved patients with STGD and healthy controls. We performed a complete ophthalmologic assessment and multimodal imaging, including OCT, OCTA, fundus autofluorescence and UWF imaging. Patients with STGD were subdivided according to the peripheral involvement. OCT and OCTA quantitative parameters were analysed. The main outcome of ...
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13. An optical coherence tomography-based grading of diabetic maculopathy proposed by an international expert panel: The European School for Advanced Studies in Ophthalmology classification
  
  Explore SAGE Journals Nov 18 2019 Ophthalmology
  
  Aims: To present an authoritative, universal, easy-to-use morphologic classification of diabetic maculopathy based on spectral domain optical coherence tomography. Methods: The first draft of the project was developed based on previously published classifications and a literature search regarding the spectral domain optical coherence tomography quantitative and qualitative features of diabetic maculopathy. This draft was sent to an international panel of retina experts for a first revision. The panel met at the European School for Advanced Studies in Ophthalmology headquarters in Lugano, Switzerland, and elaborated the final document. Results: Seven tomographic qualitative and quantitative features are taken into account and scored ...
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  Mentions: Medical University of Vienna Universität Rostock Northwestern University
14. Vascular Patterns in Retinitis Pigmentosa on Swept-Source Optical Coherence Tomography Angiography
  
  Explore MDPI Open Access Journals Platform Sep 10 2019 Ophthalmology
  
  Background: Retinitis Pigmentosa (RP) represents a retinal dystrophy with an extremely complex pathogenesis further worsened by the impairment of the retinal vascular supply. The main goal of this study was to identify different vascular patterns in RP, by means of optical coherence tomography angiography (OCTA). Methods: A total of 32 RP patients (16 males, 50%; mean age 45.93 ± 11.4) and 32 healthy age-matched controls (16 males, 50%; age 42.8 ± 11.2). High resolution OCT and OCTA images were obtained from all participants. Several quantitative parameters were extracted both from structural OCT and OCTA images. A post-hoc analysis ...
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  Mentions: Francesco Bandello
15. Vascular Alterations Revealed With Optical Coherence Tomography Angiography In Patients With Choroideremia
  
  Explore LWW Online May 24 2019 Ophthalmology
  
  Purpose: Choroideremia is a rare degenerative retinal disease that causes incurable blindness. It occurs as a result of the deficiency of the X-linked CHM gene, which encodes the Rab escort protein 1 (REP1). Gene therapy has been developed to treat CHM using adeno-associated viral vectors and is currently undergoing clinical trials. Expression of the CHM gene is ubiquitous throughout the retina, and it is therefore important to identify which retinal layers are affected in the disease process. The purpose of this study was to assess in particular the choriocapillaris using optical coherence tomography angiography because this layer is difficult to ...
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  Mentions: Oxford University Università Vita-Salute San Raffaele
16. Swept-Source Optical Coherence Tomography Angiography Assessment Of Fellow Eyes In Coats Disease
  
  Explore LWW Online Feb 26 2019 Ophthalmology
  
  Purpose: To assess foveal and parafoveal vasculature at superficial capillary plexus (SCP), deep capillary plexus, and choriocapillaris using optical coherence tomography angiography in the fellow eyes of patients with Coats disease . Methods: Observational and prospective case series. Thirteen patients with unilateral Coats and 14 healthy age- and sex-matched controls were consecutively recruited at Manchester Royal Eye Hospital and the Department of Ophthalmology of San Raffaele Hospital. Both groups underwent complete ophthalmologic examination, including optical coherence tomography angiography (Topcon Corp) 3 mm × 3 mm scans. Images were imported into ImageJ software and binarized; foveal avascular zone area was manually outlined and ...
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  Mentions: Topcon Medical Systems University of Manchester Paulo E. Stanga
17. Choroidal Neovascularization in Torpedo Maculopathy Assessed on Optical Coherence Tomography Angiography
  
  Explore Healio.com Nov 26 2018 Ophthalmology
  
  Torpedo maculopathy is characterized by a congenital, unilateral, and torpedo-shaped chorioretinal lesion with unclear pathogenesis and evolution. Although the optical coherence tomography angiography (OCTA) characteristics have already been defined in literature, the authors describe for the first time the presence of choroidal neovascularization (CNV) on the temporal edge of this lesion in a 36-year-old woman with a history of altered visual field in her left eye. The authors' investigation supports the hypothesis of an aberrant choroidal circulation underlying the pathogenesis of this condition, and proves the advantage conferred by OCTA in CNV detection over the other angiographic techniques.
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  Mentions: Francesco Bandello Università Vita-Salute San Raffaele Luisa Pierro
18. Optical Coherence Tomography Angiography Findings in X-Linked Retinoschisis
  
  Explore Healio.com Sep 19 2018 Ophthalmology
  
  BACKGROUND AND OBJECTIVE: The aim of the study was to determine optical coherence tomography angiography (OCTA) findings and to identify mutations in the RS1 gene in a three-generation family with X-linked juvenile retinoschisis (XLRS). PATIENTS AND METHODS: Clinical and genetic assessments were performed in 12 family members. OCTA was performed at baseline (12 members including cases and carriers) and after acetazolamide administration (three cases). Twenty healthy subjects (20 eyes, controls) were chosen for comparison. Molecular genetic analysis of the RS1 gene was performed in all family members. RESULTS: Deep capillary plexus density was reduced in cases compared with controls ( P ...
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19. Advanced optical coherence tomography angiography analysis of age-related macular degeneration complicated by onset of unilateral choroidal neovascularization.
  
  Explore American Journal of Ophthalmology Aug 8 2018 Ophthalmology
  
  Purpose To analyze optical coherence tomography angiography (OCTA) quantitative features in patients affected by new-onset choroidal neovascularization (CNV) in one eye and early/intermediate age-related macular degeneration (AMD) in the fellow eye. Design Case-control study. Settings Clinical Practice. Study Population Thirty patients and thirty age-matched controls. Observation Procedures Both cohorts underwent complete ophthalmologic examination, including best corrected visual acuity (BCVA) measurement, biomicroscopy, fluorescein angiography (FA) and indocyanine green angiography (ICGA) examination (Spectralis HRA; Heidelberg Engineering, Germany), OCT and OCTA scans (DRI OCT Triton; Topcon Corporation, Japan). The one-way ANOVA test with Bonferroni correction was used to assess statistical significance and ...
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  Mentions: Heidelberg Engineering Francesco Bandello Luisa Pierro
20. Fluorescein Leakage and Optical Coherence Tomography Features of Choroidal Neovascularization Secondary to Pathologic Myopia
  
  Explore IOVS Journal Jul 1 2018 Ophthalmology
  
  Purpose : We compare the fluorescein angiography (FA) patterns with morphologic alterations detectable on spectral-domain OCT (SD-OCT) in myopic choroidal neovascularization (mCNV) and evaluate whether they influence the effects of intravitreal ranibizumab (IVRI) in an as-needed (PRN) regimen. Methods : The 49 patients enrolled in this prospective case series underwent a complete ophthalmologic examination, including best-corrected visual acuity (BCVA), FA, and SD-OCT assessment. The main outcome measure was correlation between FA patterns and SD-OCT features. Secondary outcomes were changes in BCVA and central macular thickness (CMT), and characterization of subretinal hyperreflective exudation (SHE). Results : Three main patterns were identified on the FA ...
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  Mentions: Francesco Bandello Università Vita-Salute San Raffaele
21. CAPILLARY NETWORK ALTERATIONS IN X-LINKED RETINOSCHISIS IMAGED ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
  
  Explore LWW Online Jun 12 2018 Ophthalmology
  
  Purpose: To assess foveal and parafoveal vasculature at the superficial capillary plexus, deep capillary plexus, and choriocapillaris of patients with X-linked retinoschisis by means of optical coherence tomography angiography. Methods: Six patients with X-linked retinoschisis (12 eyes) and seven healthy controls (14 eyes) were recruited and underwent complete ophthalmologic examination, including best-corrected visual acuity, dilated fundoscopy, and 3 × 3-mm optical coherence tomography angiography macular scans (DRI OCT Triton; Topcon Corp). After segmentation and quality review, optical coherence tomography angiography slabs were imported into ImageJ 1.50 (NIH; Bethesda) and digitally binarized. Quantification of vessel density was performed after foveal avascular ...
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  Mentions: National Institutes of Health Topcon Medical Systems Paulo E. Stanga
22. Acute macular neuroretinopathy: pathogenetic insights from optical coherence tomography angiography
  
  Explore BJO Online Jun 2 2018 Ophthalmology
  
  Aim To describe the optical coherence tomography angiography (OCT-A) features of patients affected by acute macular neuroretinopathy (AMN). Methods This is a prospective, observational, cross-sectional study. Multimodal imaging, including spectral domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany) and 6×6 mm swept source OCT-A (ZEISS PLEX Elite 9000; ZEISS, Dublin, California), was performed on all patients. The primary outcome measure was assessment of the vascular alterations of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC). A segmentation of the AMN lesions using enface OCT images of photoreceptors-retinal pigment epithelium complex was used to discriminate intralesional ...
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  Mentions: Heidelberg Engineering Carl Zeiss Meditec San Raffaele Scientfic Institute
23. Case Report: Optical Coherence Tomography Angiography in Morning Glory Disc Anomaly
  
  Explore LWW Online May 26 2018 Ophthalmology
  
  SIGNIFICANCE Morning glory disc anomaly is a congenital abnormality of the optic disc. Optical coherence tomography angiography shows vascular rarefaction of the superficial and deep capillary plexuses and increased vascularity of the radial peripapillary capillary plexus. We hypothesize that this congestion represents a compensatory mechanism to an abnormal vasculogenesis. PURPOSE The aim of this study was to describe the optic disc vascular alterations occurring at choriocapillaris and retinal vascular plexuses in a patient affected by bilateral morning glory disc anomaly with optical coherence tomography angiography. CASE REPORT A 24-year-old white man presented for clinical evaluation to our Department of Ophthalmology ...
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  Mentions: San Raffaele Scientfic Institute Francesco Bandello
24. Optical Coherence Tomography Angiography of Pigmented Paravenous Retinochoroidal Atrophy
  
  Explore Healio.com May 22 2018 Ophthalmology
  
  A 58-year-old man with bilateral pigmented paravenous retinochoroidal atrophy (PPRCA) associated with macular coloboma in the right eye underwent color fundus photography and fundus autofluorescence with the California ultra-widefield retinal imaging system (Optos, Dunfermline, UK), spectral-domain optical coherence tomography (SD-OCT) (Heidelberg Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany), and en face OCT angiography (OCTA) (AngioPlex, Cirrus HD-OCT 5000; Carl Zeiss Meditec, Dublin, CA). The patient presented with a visual acuity of counting fingers in the right eye and 20/32 in the left eye. Fundus examination and SD-OCT showed typical PPRCA alterations in both eyes and a macular coloboma in ...
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  Mentions: Heidelberg Engineering Carl Zeiss Meditec Optos
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