1. Articles from Jay Duker

    1-5 of 5
    1. Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.

      Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.

      Purpose : In central serous chorioretinopathy (CSCR), choroidal hyperpermeability associated with retinal pigment epithelium (RPE) impairment causes a leakage of fluid from the choroid into the subretinal space, with potential damage to the photoreceptors. We hypothesize that ultrahigh-resolution spectral domain optical coherence tomography (UHR SD-OCT) will enable more detailed assessment of structural changes in this condition. Methods : Patients in all stages of CSCR (acute, chronic and post-resolution) were imaged using an UHR SD-OCT prototype, with an 850 nm center wavelength and an axial resolution of ~2.7 µm in tissue at a 128kHz A-scan rate. Volumetric cube scans and high-density (HD ...

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    2. Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography

      Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography

      Purpose : Optical coherence tomography angiography (OCTA) allows for precise, non-invasive monitoring of changes to choroidal neovascularization (CNV) structure over time. The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on CNV morphology is well described, but long-term studies on morphologic changes and correlation of such to the type of CNV have not been conducted. This study aims to determine if different types of CNVs in neovascular AMD (nAMD) behave differently with anti-VEGF treatment as visualized on OCTA. Methods : AMD Patients with treatment naive type 1, type 2, and type 3 CNVs were retrospectively screened for baseline and follow-up OCTA ...

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    3. Bringing Deep Learning Models to the Data: An Application in Recognizing Intra-Retinal Fluid on Optical Coherence Tomography (OCT) Images

      Bringing Deep Learning Models to the Data: An Application in Recognizing Intra-Retinal Fluid on Optical Coherence Tomography (OCT) Images

      Purpose : Amidst intense interest in deep learning in medicine, concerns regarding data privacy, security, and sharing are of increasing importance. A model-to-data approach, in which the model itself is transferred rather than data, can circumvent many of these challenges, but has not been previously tested in ophthalmology. The objective of our study was to determine whether a model-to-data deep learning approach (i.e. validation of the algorithm without any data transfer) can be successfully applied for the first time to deep learning in ophthalmology. Methods : This is a cross sectional study in which a deep learning algorithm model developed at ...

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    4. Atlas of Retinal OCT: Optical Coherence Tomography (Textbook)

      Atlas of Retinal OCT: Optical Coherence Tomography (Textbook)

      Optical Coherence Tomography has revolutionized today’s eye care. This remarkable non-invasive scanning technology is unparalleled for aiding diagnosis of retinal disease and recording disease progression. Atlas of Retinal OCT: Optical Coherence Tomography provides expert guidance in this rapidly evolving area with high-quality, oversized images that show precise detail and assist with rapid, accurate clinical decision making.

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    5. Three Dimensional Optical Coherence Tomography (3D-OCT) Image Enhancement with Segmentation Free Contour Modeling C-Mode

      Purpose: To develop a semi-automated method to visualize structures of interest (SoI) along their contour within three-dimensional, spectral domain optical coherence tomography (3D SD-OCT) data, without the need for segmentation. Methods: Using two SD-OCT devices (an ultrahigh resolution prototype of our own design and Cirrus OCT (Carl Zeiss Meditec, Dublin, CA)), we obtained 3D SD-OCT data within 6x6x1.4 mm and 6x6x2 mm volumes, respectively, centered on the fovea in healthy eyes and in eyes with retinal pathology. C-mode images were generated by sampling a variable thickness plane semi-automatically modeled to fit the contour of the SoI. Unlike the published ...
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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Tufts University
    2. (5 articles) Jay S. Duker
    3. (3 articles) James G. Fujimoto
    4. (3 articles) Nadia K. Waheed
    5. (2 articles) Massachusetts Institute of Technology
    6. (1 articles) University of Pittsburgh
    7. (1 articles) Gadi Wollstein
    8. (1 articles) Joel S. Schuman
    9. (1 articles) Larry Kagemann
    10. (1 articles) Carl Zeiss Meditec
    11. (1 articles) Columbia University
    12. (1 articles) Cardiovascular Research Foundation
    13. (1 articles) Gary S. Mintz
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    Atlas of Retinal OCT: Optical Coherence Tomography (Textbook) Bringing Deep Learning Models to the Data: An Application in Recognizing Intra-Retinal Fluid on Optical Coherence Tomography (OCT) Images Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study. Intravascular Imaging-Guided Percutaneous Coronary Intervention: A Universal Approach for Optimization of Stent Implantation Clinical Usefulness of a Novel Optical Coherence Tomography Procedure, “Low Molecular Weight Dextran Infusion Followed by Catheter PUSH (D-PUSH)” Optical Coherence Tomography to Guide Percutaneous Coronary Intervention of the Left Main Coronary Artery: the LEMON study Impact of optical coherence tomography findings on clinical outcomes in ST-segment elevation myocardial infarction patients: a MATRIX (Minimizing Adverse Hemorrhagic Events by Trans-radial Access Site and angioX) OCT sub-study OCTA Multilayer and Multisector Peripapillary Microvascular Modeling for Diagnosing and Staging of Glaucoma Optical coherence tomography angiography for identifying choroidal neovascular membranes: a masked study in clinical practice Preclinical ocular features in patients with Behçet’s disease detected by optical coherence tomography angiography Reconstruction of Optical Coherence Tomography Images Using Mixed Low Rank Approximation and Second Order Tensor Based Total Variation Method