1. Articles from Robert N. Weinreb

    1-24 of 120 1 2 3 4 5 »
    1. Diagnostic accuracy of macular thickness map and texture en-face images for detecting glaucoma in eyes with axial high myopia

      Diagnostic accuracy of macular thickness map and texture en-face images for detecting glaucoma in eyes with axial high myopia

      To evaluate the diagnostic accuracy of a novel optical coherence tomography (OCT) texture-based en-face image analysis, called SALSA-Texture, that requires segmentation of only one retinal layer for glaucoma detection in eyes with axial high myopia, and to compare to standard macular ganglion cell-inner plexiform layer (GCIPL) thickness, macular retinal nerve fiber layer (mRNFL) thickness, and ganglion cell complex (GCC) thickness maps.

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      Mentions: UCSD
    2. OCT Angiography Face Mask-associated Artifacts During the COVID-19 Pandemic

      OCT Angiography Face Mask-associated Artifacts During the COVID-19 Pandemic

      Prcis: Face mask wearing has no significant effects on artifacts or vessel density measurements in optic nerve head and macular OCT-Angiography scans. Purpose: To assess the difference in area of artifacts observed in optical coherence tomography angiography (OCT-A) scans with and without face mask wear and to verify if mask wear interferes with OCT-A vessel density measurements. Subjects and controls: 64 eyes of 10 healthy subjects, 4 ocular hypertensive, 8 glaucoma suspects, and 17 glaucoma patients were included. Methods: High density optic nerve head (ONH) and macula OCT-A scans were obtained in patients with and without surgical masks. Seven different ...

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      Mentions: UCSD
    3. Association of Initial Optical Coherence Tomography Angiography Vessel Density Loss With Faster Visual Field Loss in Glaucoma

      Association of Initial Optical Coherence Tomography Angiography Vessel Density Loss With Faster Visual Field Loss in Glaucoma

      Importance: Rapid vessel density loss during an initial follow-up period may be associated with the rates of visual field loss over time. Objectives: To evaluate the association between the rate of vessel density loss during initial follow-up and the rate of visual field loss during an extended follow-up period in patients suspected of having glaucoma and patients with primary open-angle glaucoma. Design, setting, and participants: This retrospective cohort study assessed 124 eyes (86 with primary open-angle glaucoma and 38 suspected of having glaucoma) of 82 patients who were followed up at a tertiary glaucoma center for a mean of 4 ...

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      Mentions: UCSD
    4. Relationship of macular ganglion cell complex thickness to choroidal microvasculature drop-out in primary open-angle glaucoma

      Relationship of macular ganglion cell complex thickness to choroidal microvasculature drop-out in primary open-angle glaucoma

      Background/aims To investigate the rate of ganglion cell complex (GCC) thinning in primary open-angle glaucoma (POAG) patients with and without deep-layer microvasculature drop-out (MvD). Methods POAG patients who had at least 1.5 years of follow-up and a minimum of three visits were included from the Diagnostic Innovations in Glaucoma Study. MvD was detected at baseline by optical coherence tomography angiography (OCT-A). Area and angular circumference of MvD were evaluated on en face choroidal vessel density images and horizontal B-scans. Rates of global and hemisphere GCC thinning were compared in MvD and non-MvD eyes using linear mixed-effects models. Results ...

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      Mentions: UCSD
    5. Performances of machine learning in detecting glaucoma using fundus and retinal optical coherence tomography images: A meta-analysis

      Performances of machine learning in detecting glaucoma using fundus and retinal optical coherence tomography images: A meta-analysis

      Purpose To evaluate the performance of machine learning (ML) in detecting glaucoma using fundus and retinal optical coherence tomography (OCT) images. Design Meta-analysis. Methods PubMed and EMBASE were searched on August 11, 2021. Bivariate random-effects model was used to pool ML's diagnostic sensitivity, specificity, and area under the curve (AUC). Subgroup analyses were performed based on ML classifier categories and dataset types. Results 105 (3.3%) studies were retrieved. 73 (69.5%), 30 (28.6%), and 2 (1.9%) studies tested ML using fundus, OCT, and both image types, respectively. Total testing data size was 197174 for fundus and ...

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      Mentions: UCSD
    6. Optical microangiography and progressive ganglion cell-inner plexiform layer loss in primary open angle glaucoma

      Optical microangiography and progressive ganglion cell-inner plexiform layer loss in primary open angle glaucoma

      Purpose To evaluate the association between optical microangiography (OMAG) measurements and progressive ganglion cell-inner plexiform layer (GCIPL) loss in primary open angle glaucoma (POAG). Design Prospective case-series Methods Sixty-three eyes of 38 POAG patients were studied for at least 2 years and with at least 3 optical coherence tomography (OCT) examinations. Only those hemifields with mild to moderate functional damage at baseline (106 hemifields) were included in the analysis. OMAG imaging was performed at the baseline visit. Effect of clinical parameters (age, gender, central corneal thickness, presence of disc hemorrhage, mean and fluctuation of intraocular pressure), baseline mean deviation (MD ...

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    7. Deep learning image analysis of optical coherence tomography angiography measured vessel density improves classification of healthy and glaucoma eyes

      Deep learning image analysis of optical coherence tomography angiography measured vessel density improves classification of healthy and glaucoma eyes

      Purpose : To compare convolutional neural network (CNN) analysis of en face vessel density images to gradient boosting classifier (GBC) analysis of instrument provided, feature-based optical coherence tomography angiography (OCTA) vessel density measurements and OCT RNFL thickness measurements for classifying healthy and glaucomatous eyes. Design : Comparison of diagnostic approaches Methods : 130 eyes of 80 healthy individuals and 275 eyes of 185 glaucoma patients with optic nerve head (ONH) OCTA and OCT imaging were included. Classification performance of a VGG16 CNN trained and tested on entire en face 4.5 mm x 4.5 mm radial peripapillary capillary OCTA ONH images was ...

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      Mentions: UCSD
    8. Optic Disc Microvasculature Dropout in Glaucoma Detected by Swept-Source Optical Coherence Tomography Angiography

      Optic Disc Microvasculature Dropout in Glaucoma Detected by Swept-Source Optical Coherence Tomography Angiography

      Purpose To assess the clinical utility of swept-source optical coherence tomography angiography (SS-OCTA) in detecting optic disc microvasculature dropout (MvD-D) in primary open-angle glaucoma (POAG) eyes. Design Cross sectional study. Methods One hundred and ninety-seven eyes of 197 POAG patients with acceptable-quality SS-OCTA (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, CA, USA) images were enrolled. A whole-signal-mode 6.0 × 6.0-mm optic disc cube was obtained with projection artifact removal. Three groups were categorized: no MvD-D (Group 1), MvD-D (Group 2, complete loss of microvasculature within the optic disc), and indiscernible MvD-D (Group 3, poor visualization of the anterior lamina ...

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    9. Measurements of OCTA Complement OCT for Diagnosing Early Primary Open Angle Glaucoma

      Measurements of OCTA Complement OCT for Diagnosing Early Primary Open Angle Glaucoma

      Purpose: To compare measurements of global and regional circumpapillary capillary density (cpCD) with retinal nerve fiber layer (RNFL) thickness, and characterize their relationship with visual function in early primary open-angle glaucoma (POAG). Design: Cross-sectional study PARTICIPANTS: Eighty healthy eyes, 64 pre-perimetric, and 184 mild POAG eyes from the Diagnostic Innovations in Glaucoma Study. Methods: Global and regional RNFL thickness and cpCD measurements were obtained using optical coherence tomography (OCT) and OCT angiography (OCTA). For direct comparison at the individual and diagnostic group level, RNFL thickness and capillary density values were converted to a normalized relative loss scale. Main outcome measures ...

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      Mentions: UCSD
    10. Central macular OCTA parameters in glaucoma

      Central macular OCTA parameters in glaucoma

      Background/aims: To investigate the relationship between the foveal avascular zone (FAZ) parameters assessed by optical coherence tomography angiography (OCTA) and central visual field parameters in glaucoma and healthy subjects. Methods: One hundred and eighty-eight subjects (248 eyes), including 24 healthy (38 eyes), 37 glaucoma suspect (42 eyes, and 127 primary open angle glaucoma (POAG) patients (168 eyes), underwent imaging using OCTA and standard automated perimetry using the 24-2 and 10-2 Swedish Interactive Thresholding Algorithm. OCTA-based and OCT-based FAZ parameters (superficial FAZ area, FAZ circumference), foveal vessel density (FD300) and foveal thickness were measured. The correlation between FAZ parameters and ...

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      Mentions: UCSD
    11. Individualized Glaucoma Change Detection Using Deep Learning Auto Encoder-Based Regions of Interest

      Individualized Glaucoma Change Detection Using Deep Learning Auto Encoder-Based Regions of Interest

      Purpose : To compare change over time in eye-specific optical coherence tomography (OCT) retinal nerve fiber layer (RNFL)-based region-of-interest (ROI) maps developed using unsupervised deep-learning auto-encoders (DL-AE) to circumpapillary RNFL (cpRNFL) thickness for the detection of glaucomatous progression. Methods : Forty-four progressing glaucoma eyes (by stereophotograph assessment), 189 nonprogressing glaucoma eyes (by stereophotograph assessment), and 109 healthy eyes were followed for ≥3 years with ≥4 visits using OCT. The San Diego Automated Layer Segmentation Algorithm was used to automatically segment the RNFL layer from raw three-dimensional OCT images. For each longitudinal series, DL-AEs were used to generate individualized eye-based ROI maps ...

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      Mentions: UCSD
    12. Optical microangiography and progressive retinal nerve fiber layer loss in primary open angle glaucoma

      Optical microangiography and progressive retinal nerve fiber layer loss in primary open angle glaucoma

      Purpose : To evaluate the association between optical microangiography (OMAG) measurements and progressive retinal nerve fiber layer (RNFL) loss in primary open angle glaucoma (POAG). Design : Prospective case series Methods : Sixty-four eyes of 40 POAG patients (108 quadrants) with mild to moderate functional damage were longitudinally studied for at least 2 years and with a minimum of 3 optical coherence tomography (OCT) examinations. OMAG imaging was performed at the baseline visit. Effect of clinical parameters (age, gender, presence of systemic diseases, central corneal thickness, presence of disc hemorrhage, mean and fluctuation of intraocular pressure during follow-up), baseline hemifield mean deviation (MD ...

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    13. Long-Term Reproducibility of Optical Coherence Tomography Angiography in Stable Glaucomatous Eyes

      Long-Term Reproducibility of Optical Coherence Tomography Angiography in Stable Glaucomatous Eyes

      Purpose : To assess and compare long-term reproducibility of optical coherence tomography angiography (OCTA) vascular parameters and spectral-domain optical coherence tomography (OCT) thickness parameters in stable glaucoma, glaucoma suspect, and healthy eyes. Methods : A total of 88 eyes (15 healthy, 38 glaucoma suspect, and 35 non-progressive POAG) of 68 subjects were enrolled who had at least 3 visits within 1 to 1.5 years and both OCT and OCTA (Optovue Inc, Fremont, California, USA) imaging on the same day. A series of vascular and thickness parameters were measured including macula whole image vessel density (wiVD), optic nerve head (ONH) circumpapillary capillary ...

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    14. Predicting central 10 degrees visual field from peripapillary optical coherence tomography using deep learning approach

      Predicting central 10 degrees visual field from peripapillary optical coherence tomography using deep learning approach

      Purpose: To develop a deep learning (DL) simulation of standard automated perimetry (SAP) in the central 10 ° based on spectral domain optical coherence tomography (SD-OCT) retinal nerve fiber layer thickness (RNFLT). Methods : This study included 5352 pairs of SD-OCT and 10-2 SAP from 1365 eyes of 724 healthy, glaucoma suspect and glaucoma patients from the Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Glaucoma Evaluation Study (ADAGES). Each pair of SD-OCT and 10-2 SAP was obtained within a 6-month duration. The dataset was randomly divided into training (65%), validation (15%), and test (20%) sets at the patient ...

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      Mentions: UCSD
    15. Optical Coherence Tomography Angiography Artifacts in Glaucoma

      Optical Coherence Tomography Angiography Artifacts in Glaucoma

      Purpose: To determine the prevalence of different types of artifacts seen in optical coherence tomography angiography (OCTA) images of healthy and glaucoma eyes and to evaluate the characteristics associated with the increased likelihood of obtaining poor quality images. Design: Retrospective study. Participants: A total of 649 eyes of 368 healthy, glaucoma suspect, and glaucoma patients. Methods: Angiovue high density (HD) and non-HD optic nerve head and macula OCTA images of participants were evaluated by 4 expert reviewers for the presence of different artifacts including eye movement, defocus, shadow, decentration, segmentation error, blink and Z offset in the superficial vascular layer ...

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      Mentions: UCSD
    16. Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma

      Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma

      Precis: Lower whole enface disc (coefficient: 0.02, P =0.03) and macular vessel densities (coefficient: 0.04, P =0.02) on OCT angiography were significantly associated with faster rate of mean deviation decline. Purpose: To evaluate the association between optical coherence tomography angiography (OCTA) features and prior visual field (VF) progression in primary angle closure glaucoma (PACG). Methods: In a cross-sectional study, 46 eyes of 31 PACG patients with 5 reliable VF examinations performed over ≥3 years of follow-up underwent OCTA imaging. Effect of clinical (age, gender, number of anti-glaucoma medications, mean and SD of intraocular pressure during follow-up ...

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    17. OCT angiography measured changes in the foveal avascular zone area after glaucoma surgery

      OCT angiography measured changes in the foveal avascular zone area after glaucoma surgery

      Background/aims: To evaluate quantitative changes in the foveal avascular zone (FAZ) area after glaucoma surgery using swept-source optical coherence tomography angiography (SS-OCTA). Methods: Fifty-four consecutive patients with primary open-angle glaucoma (POAG) who met the inclusion criteria and underwent unilateral glaucoma surgery to reduce intraocular pressure (IOP) between April 2018 and July 2019.Eyes underwent IOP-lowering glaucoma surgery and their fellow (non-surgical) eyes were included. OCTA of the macula was performed in both eyes before glaucoma surgery and 3 months postoperatively. Two blinded examiners reviewed the image quality. Within- and between-group comparisons of the FAZ area and correlation of the ...

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      Mentions: UCSD
    18. Referenced scans improve the repeatability of optical coherence tomography angiography measurements in normal and glaucoma eyes

      Referenced scans improve the repeatability of optical coherence tomography angiography measurements in normal and glaucoma eyes

      Aim To compare the repeatability of peripapillary perfusion density and flux index measurements on referenced and non-referenced optical microangiography (OMAG) scans in normal, glaucoma suspect and glaucoma eyes. Methods In a cross-sectional study, 48 eyes (33 subjects) underwent three repeat, non-referenced peripapillary OMAG scans in the same session and 43 eyes (25 subjects) underwent three referenced peripapillary OMAG scans. In the referenced scan group, repeat scans (second and the third scan) were acquired exactly on the baseline (first) scan using the ‘track to prior scan’ option on the device. Repeatability estimates of the mean and four-sector (temporal, superior, nasal and ...

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      Mentions: UCSD
    19. Geometric Perfusion Deficits: A Novel OCT Angiography Biomarker for Diabetic Retinopathy Based on Oxygen Diffusion

      Geometric Perfusion Deficits: A Novel OCT Angiography Biomarker for Diabetic Retinopathy Based on Oxygen Diffusion

      Purpose To develop geometric perfusion deficits (GPD), an optical coherence tomography angiography (OCTA) biomarker based on oxygen diffusion, and to evaluate its utility in a pilot study of healthy subjects and patients with diabetic retinopathy (DR). Design Retrospective cross-sectional study. Methods Commercial spectral-domain OCTA instruments were used to acquire repeated 3×3 mm 2 and 6×6 mm 2 motion-corrected macular OCTA volumes. En face OCTA images corresponding to the superficial capillary plexus (SCP), deep capillary plexus (DCP), and full retinal projections were obtained using automatic segmentation. For each projection, the GPD percentage and the vessel density percentage, the control ...

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    20. Impact of Pupil Dilation on Optical Coherence Tomography Angiography Retinal Microvasculature in Healthy Eyes

      Impact of Pupil Dilation on Optical Coherence Tomography Angiography Retinal Microvasculature in Healthy Eyes

      Précis: Small but significant decreases in OCTA-measured circumpapillary capillary density were observed in healthy eyes dilated with 2.5% phenylephrine/0.5% tropicamide. Though likely clinically insignificant, ophthalmologists should consider these changes when interpreting OCTA results from dilated eyes. Purpose: To investigate the effect of pupil dilation using 2.5% phenylephrine and 0.5% tropicamide on quantitative assessment of retinal microvasculature using OCTA. Methods: OptoVue AngioVue high density (HD) and non-HD OCTA macula and optic nerve head (ONH) images were obtained at 15-minute intervals pre- and post- dilation in 26 healthy participants (mean age: 40.0; 95% CI=33 ...

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      Mentions: Visionix UCSD
    21. Iridocorneal Angle Assessment After Laser Iridotomy with Swept-source Optical Coherence Tomography

      Iridocorneal Angle Assessment After Laser Iridotomy with Swept-source Optical Coherence Tomography

      Aim: To investigate the reliability of anterior chamber angle (ACA) measurements in narrow angles and assess the effect of laser peripheral iridotomy (LPI) on these measurements using novel swept-source optical coherence tomography (SS-OCT) technology. Methods: In this prospective observational study, patients with gonioscopically narrow angles were enrolled and scheduled for prophylactic LPI. Twelve ACA sections were obtained in each eye using SS-OCT (ANTERION, Heidelberg Engineering, Germany) before and after Nd:YAG LPI. A built-in algorithm calculated ACA measurements after manual identification of the scleral spur and ACA recess. Eight ACA parameters were evaluated: ACA (ACA 500, ACA 750); Scleral Spur ...

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    22. Capillary Density Measured by OCT Angiography in Glaucomatous Optic Disc Phenotypes

      Capillary Density Measured by OCT Angiography in Glaucomatous Optic Disc Phenotypes

      Purpose To compare optical coherence tomography angiography (OCTA) measured capillary density of the optic disc among four glaucomatous optic disc phenotypes. Design Cross-sectional study. Methods Circumpapillary capillary density (cpCD) of four glaucomatous optic disc phenotypes in 193 eyes of 141 glaucoma patients and cpCD in 92 eyes of 55 healthy subjects from the Diagnostic Innovations in Glaucoma Study (DIGS) were compared. Areas under the receiver operating characteristic curves (AUROC) were used to evaluate diagnostic accuracy among groups after adjusting for confounders. Results Four glaucoma phenotypes were assessed including focal ischemic (n=45), generalized cup enlargement (n=60), myopic glaucoma (n ...

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      Mentions: UCSD
    23. Glaucomatous vertical vessel density asymmetry of the temporal raphe detected with optical coherence tomography angiography

      Glaucomatous vertical vessel density asymmetry of the temporal raphe detected with optical coherence tomography angiography

      Changes in retinal vasculature and ocular circulation may play an important role in the glaucoma development and progression. We evaluated the vertical asymmetry across the temporal raphe of the deep retinal layer vessel density, using swept-source optical coherence tomography angiography (SS-OCTA), and its relationship with the central visual field (VF) loss. Thirty-four eyes of 27 patients with open-angle glaucoma were included. SS-OCTA macular scanning was performed within a 3 × 3 mm (300 × 300 pixels) volume, centred on the fovea. The relationships between the vertical asymmetrical deep retinal vessel density reduction (ADRVD) across the temporal raphe and various ocular parameters were ...

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      Mentions: UCSD
    24. Gradient Bosting Classifiers Combining Vessel Density and Tissue Thickness Measurements for Classifying Early to Moderate Glaucoma

      Gradient Bosting Classifiers Combining Vessel Density and Tissue Thickness Measurements for Classifying Early to Moderate Glaucoma

      Purpose To compare gradient boosting classifier (GBC) analysis of optical coherence tomography angiography (OCTA)-measured vessel density (VD) and OCT-measured tissue thickness to standard OCTA VD and OCT thickness parameters for classifying healthy eyes and eyes with early to moderate glaucoma. Design Comparison of diagnostic tools. Methods One-hundred-eight healthy eyes and 193 glaucomatous eyes with OCTA and OCT imaging of the macula and optic nerve head (ONH) were studied. Four GBCs were evaluated that combined 1) all macula VD and thickness measurements (Macula GBC), 2) all ONH VD and thickness measurements (ONH GBC), 3) all VD measurements from the macula ...

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      Mentions: UCSD
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