1. Articles from Hao-Li Liu

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    1. Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography

      Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography

      Focused ultrasound (FUS) in combination with microbubbles temporally and locally increases the permeability of the blood-brain barrier (BBB) for facilitating drug delivery. However, the temporary effects of FUS on the brain microstructure and microcirculation need to be addressed. We used label-free optical coherence tomography (OCT) and OCT angiography (OCTA) to investigate the morphological and microcirculation changes in mouse brains due to FUS exposure at different power levels. Additionally, the recovery progress of the induced effects was studied. The results show that FUS exposure causes cerebral vessel dilation and can be identified and quantitatively analyzed via OCT/OCTA. Micro-hemorrhages can be ...

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    2. Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles

      Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles

      In this study, we propose to use gas-filled microbubbles (MBs) simultaneously actuated by the acoustic wave to enhance the imaging contrast of optical coherence tomography (OCT)-based angiography. In the phantom experiments, MBs can result in stronger backscattered intensity, enabling to enhance the contrast of OCT intensity image. Moreover, simultaneous application of low-intensity acoustic wave enables to temporally induce local vibration of particles and MBs in the vessels, resulting in time-variant OCT intensity which can be used for enhancing the contrast of OCT intensitybased angiography. Additionally, different acoustic modes and different acoustic powers to actuate MBs are performed and compared ...

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    3. Acoustic-actuated optical coherence angiography

      Acoustic-actuated optical coherence angiography

      Optical coherence tomography (OCT) angiography requires high sensitivity and image penetration for detailed microvascular monitoring. Unfortunately, no effective contrast-medium-enhanced scheme is currently available for imaging improvement. We here propose the simultaneous use of gas-filled microbubbles (MBs) and acoustic actuation to enhance the imaging contrast of OCT angiography. OCT-synchronized acoustic actuation was applied in the presence of MBs, and different moving object tracking angiographic algorithms were tested in in vitro tubing and in vivo mouse experiments. This scheme significantly enhanced the OCT angiography performance, including its sensitivity and penetration, and should advance the utilization of OCT as an effective microvascular diagnostic ...

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    4. In vivo investigation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence tomography

      In vivo investigation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence tomography

      Transdermal drug-delivery systems (TDDS) have been a growing field in drug delivery because of their advantages over parenteral and oral administration. Recent studies illustrate that microneedles (MNs) can effectively penetrate through the stratum corneum barrier to facilitate drug delivery. However, the temporal effects on skin and drug diffusion are difficult to investigate in vivo . In this study, we used optical coherence tomography (OCT) to observe the process by which MNs dissolve and to investigate the temporal effects on mouse skin induced by MNs, including the morphological and vascular changes. Moreover, the recovery process of the skin was observed with OCT ...

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    5. Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography

      Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography

      Focused ultrasound (FUS) can be used to locally and temporally enhance vascular permeability, improving the efficiency of drug delivery from the blood vessels into the surrounding tissue. However, it is difficult to evaluate in real time the effect induced by FUS and to noninvasively observe the permeability enhancement. In this study, speckle-variance optical coherence tomography (SVOCT) was implemented for the investigation of temporal effects on vessels induced by FUS treatment. With OCT scanning, the dynamic change in vessels during FUS exposure can be observed and studied. Moreover, the vascular effects induced by FUS treatment with and without the presence of ...

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    6. Quantitative observation of focused-ultrasound-induced vascular leakage and deformation via fluorescein angiography and optical coherence tomography

      Quantitative observation of focused-ultrasound-induced vascular leakage and deformation via fluorescein angiography and optical coherence tomography

      Focused ultrasound (FUS) is a recently discovered noninvasive technique for local and temporal enhancement of vascular permeability, which facilitates drug delivery from the vessels into the surrounding tissue. However, exposure to FUS at a high intensity may cause permanent damage. To investigate the effects of the FUS treatment on blood vessels, we propose to use fluorescein angiography (FA) and optical coherence tomography (OCT) for real-time observation of the diffusion of fluorescence dye from blood vessels and to evaluate the morphological changes of the vessels in vivo . With time-resolved FA imaging, the relationship between the exposed power and the improved permeability ...

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    7. Microvascular Imaging Using Swept-Source Optical Coherence Tomography with Single-Channel Acquisition

      Microvascular Imaging Using Swept-Source Optical Coherence Tomography with Single-Channel Acquisition
      This study proposes a new approach to improve the phase stability for swept-source optical coherence tomography (SS-OCT) with single-channel acquisition. This approach can improve the phase instability due to the A-scan trigger jitter from the swept source, or the asynchronization between the A-scan trigger and high-speed digitizer, which enables the visualization of vascular structures by SS-OCT. Aside from reducing the phase noise of the OCT system, only one channel is required for the A-scan trigger, data storage, and wavelength calibration by implementing the proposed approach. Finally, human skin was scanned in vivo to demonstrate the vascular images.
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    1-7 of 7
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  2. Topics in the News

    1. (6 articles) Chang Gung University
    2. (1 articles) Tsinghua University
    3. (1 articles) National Taiwan University
    4. (1 articles) University of Bologna
    5. (1 articles) University of Cambridge
    6. (1 articles) FDA
    7. (1 articles) Notal Vision
    8. (1 articles) Topcon Medical Systems
    9. (1 articles) Tomey Corporation
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    Microvascular Imaging Using Swept-Source Optical Coherence Tomography with Single-Channel Acquisition Quantitative observation of focused-ultrasound-induced vascular leakage and deformation via fluorescein angiography and optical coherence tomography Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography In vivo investigation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence tomography Acoustic-actuated optical coherence angiography Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography Comparison of Anterior Segment Measurements with a New Multifunctional Unit and Five Other Devices Efficacy of Notal Vision Home OCT demonstrated by a series of scientific and clinical work Synergy Between morpHOlogical and inflammatoRy Evaluation in Predicting Long-term Coronary Plaque Progression Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy