1. Articles from Justin Migacz

    1-9 of 9
    1. Imaging of Macrophage-Like Cells in Living Human Retina Using Clinical OCT

      Imaging of Macrophage-Like Cells in Living Human Retina Using Clinical OCT

      Purpose : To image retinal macrophages at the vitreoretinal interface in the living human retina using a clinical optical coherence tomography (OCT) device. Methods : Eighteen healthy controls and three patients with retinopathies were imaged using a clinical spectral-domain OCT. In controls, 10 sequential scans were collected at three different locations: (1) ∼9 degrees temporal to the fovea, (2) the macula, and (3) the optic nerve head (ONH). Intervisit repeatability was evaluated by imaging the temporal retina twice on the same day and 3 days later. Only 10 scans at the temporal retina were obtained from each patient. A 3-µm OCT ...

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    2. Automated quantification of choriocapillaris anatomical features in ultrahigh-speed optical coherence tomography angiograms

      Automated quantification of choriocapillaris anatomical features in ultrahigh-speed optical coherence tomography angiograms

      In vivo visualization and quantification of choriocapillaris vascular anatomy is a fundamental step in understanding the relation between choriocapillaris degradation and atrophic retinopathies, including geographic atrophy. We describe a process utilizing ultrahigh-speed swept-source optical coherence tomography and a custom-designed “local min-max normalized masking” algorithm to extract in vivo anatomical metrics of the choriocapillaris. We used a swept-source optical coherence tomography system with a 1.6 MHz A-scan rate to image healthy retinas. With the postprocessing algorithm, we reduced noise, optimized visibility of vasculature, and skeletonized the vasculature within the images. These skeletonizations were in 89 % 89% agreement with those made ...

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    3. Intraframe motion correction for raster-scanned adaptive optics images using strip-based cross-correlation lag biases

      Intraframe motion correction for raster-scanned adaptive optics images using strip-based cross-correlation lag biases

      In retinal raster imaging modalities, fixational eye movements manifest as image warp, where the relative positions of the beam and retina change during the acquisition of single frames. To remove warp artifacts, strip-based registration methods–in which fast-axis strips from target images are registered to a reference frame–have been applied in adaptive optics (AO) scanning light ophthalmoscopy (SLO) and optical coherence tomography (OCT). This approach has enabled object tracking and frame averaging, and methods have been described to automatically select reference frames with minimal motion. However, inconspicuous motion artifacts may persist in reference frames and propagate themselves throughout the ...

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    4. Long working distance OCT with a compact 2f retinal scanning configuration for pediatric imaging

      Long working distance OCT with a compact 2f retinal scanning configuration for pediatric imaging

      Young and/or autistic children cannot be imaged with tabletop or handheld optical coherence tomography (OCT) because of their lack of attention and fear of large objects close to their face. We demonstrate a prototype retinal swept-source OCT system with a long working distance (from the last optical element to the subject’s eye) to facilitate pediatric imaging. To reduce the number of optical elements and axial length compared to the traditional 4

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    5. En face projection imaging of the human choroidal layers with tracking SLO and swept source OCT angiography methods

      En face projection imaging of the human choroidal layers with tracking SLO and swept source OCT angiography methods

      We tested and compared the capability of multiple optical coherence tomography (OCT) angiography methods: phase variance, amplitude decorrelation and speckle variance, with application of the split spectrum technique, to image the choroiretinal complex of the human eye. To test the possibility of OCT imaging stability improvement we utilized a real-time tracking scanning laser ophthalmoscopy (TSLO) system combined with a swept source OCT setup. In addition, we implemented a post- processing volume averaging method for improved angiographic image quality and reduction of motion artifacts. The OCT system operated at the central wavelength of 1040nm to enable sufficient depth penetration into the ...

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    6. Intrasurgical Human Retinal Imaging With Manual Instrument Tracking Using a Microscope-Integrated Spectral-Domain Optical Coherence Tomography Device

      Intrasurgical Human Retinal Imaging With Manual Instrument Tracking Using a Microscope-Integrated Spectral-Domain Optical Coherence Tomography Device

      Purpose: : To characterize the first in-human intraoperative imaging using a custom prototype spectral-domain microscope-integrated optical coherence tomography (MIOCT) device during vitreoretinal surgery with instruments in the eye. Methods: : Under institutional review board approval for a prospective intraoperative study, MIOCT images were obtained at surgical pauses with instruments held static in the vitreous cavity and then concurrently with surgical maneuvers. Postoperatively, MIOCT images obtained at surgical pauses were compared with images obtained with a high-resolution handheld spectral-domain OCT (HHOCT) system with objective endpoints, including acquisition of images acceptable for analysis and identification of predefined macular morphologic or pathologic features. Results: : Human ...

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    7. Preclinical Evaluation and Intraoperative Human Retinal Imaging With A High-Resolution Microscope-Integrated Spectral Domain Optical Coherence Tomography Device

      Preclinical Evaluation and Intraoperative Human Retinal Imaging With A High-Resolution Microscope-Integrated Spectral Domain Optical Coherence Tomography Device

      Purpose: The authors have recently developed a high-resolution microscope-integrated spectral domain optical coherence tomography (MIOCT) device designed to enable OCT acquisition simultaneous with surgical maneuvers. The purpose of this report is to describe translation of this device from preclinical testing into human intraoperative imaging. Methods: Before human imaging, surgical conditions were fully simulated for extensive preclinical MIOCT evaluation in a custom model eye system. Microscope-integrated spectral domain OCT images were then acquired in normal human volunteers and during vitreoretinal surgery in patients who consented to participate in a prospective institutional review board-approved study. Microscope-integrated spectral domain OCT images were obtained ...

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    8. Unprocessed real-time imaging of vitreoretinal surgical maneuvers using a microscope-integrated spectral-domain optical coherence tomography system

      Unprocessed real-time imaging of vitreoretinal surgical maneuvers using a microscope-integrated spectral-domain optical coherence tomography system

      BACKGROUND: We have recently developed a microscope-integrated spectral-domain optical coherence tomography (MIOCT) device towards intrasurgical cross-sectional imaging of surgical maneuvers. In this report, we explore the capability of MIOCT to acquire real-time video imaging of vitreoretinal surgical maneuvers without post-processing modifications. METHODS: Standard 3-port vitrectomy was performed in human during scheduled surgery as well as in cadaveric porcine eyes. MIOCT imaging of human subjects was performed in healthy normal volunteers and intraoperatively at a normal pause immediately following surgical manipulations, under an Institutional Review Board-approved protocol, with informed consent from all subjects. Video MIOCT imaging of live surgical manipulations was ...

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    9. The Use of Optical Coherence Tomography in Intraoperative Ophthalmic Imaging

      The Use of Optical Coherence Tomography in Intraoperative Ophthalmic Imaging
      Optical coherence tomography (OCT) has transformed diagnostic ophthalmic imaging but until recently has been limited to the clinic setting. The development of spectral-domain OCT (SD-OCT), with its improved speed and resolution, along with the development of a handheld OCT scanner, enabled portable imaging of patients unable to sit in a conventional tabletop scanner. This handheld SD-OCT unit has proven useful in examinations under anesthesia and, more recently, in intraoperative imaging of preoperative and postoperative manipulations. Recently, several groups have pioneered the development of novel OCT modalities, such as microscope-mounted OCT systems. Although still immature, the development of these systems is ...
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    1-9 of 9
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  2. Topics in the News

    1. (5 articles) Duke University
    2. (5 articles) Joseph A. Izatt
    3. (4 articles) Paul V. Hahn
    4. (4 articles) Cynthia A. Toth
    5. (3 articles) UC Davis
    6. (3 articles) John S. Werner
    7. (2 articles) Robert J. Zawadzki
    8. (2 articles) Oscar Carrasco-Zevallos
    9. (2 articles) Ravi S. Jonnal
    10. (2 articles) Leica
    11. (1 articles) Yamagata University
    12. (1 articles) Bern University of Applied Sciences
    13. (1 articles) Medical University of Vienna
    14. (1 articles) University of Maryland
    15. (1 articles) Koen A. Vermeer
    16. (1 articles) Vishali Gupta
    17. (1 articles) Bernhard Baumann
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    The Use of Optical Coherence Tomography in Intraoperative Ophthalmic Imaging Unprocessed real-time imaging of vitreoretinal surgical maneuvers using a microscope-integrated spectral-domain optical coherence tomography system Preclinical Evaluation and Intraoperative Human Retinal Imaging With A High-Resolution Microscope-Integrated Spectral Domain Optical Coherence Tomography Device Intrasurgical Human Retinal Imaging With Manual Instrument Tracking Using a Microscope-Integrated Spectral-Domain Optical Coherence Tomography Device En face projection imaging of the human choroidal layers with tracking SLO and swept source OCT angiography methods Long working distance OCT with a compact 2f retinal scanning configuration for pediatric imaging Intraframe motion correction for raster-scanned adaptive optics images using strip-based cross-correlation lag biases Automated quantification of choriocapillaris anatomical features in ultrahigh-speed optical coherence tomography angiograms Imaging of Macrophage-Like Cells in Living Human Retina Using Clinical OCT Hybrid registration of retinal fluorescein angiography and optical coherence tomography images of patients with diabetic retinopathy Optical Coherence Tomography Angiography Quality Across Three Multicenter Clinical Studies of Diabetic Retinopathy The Role of Optical Coherence Tomography Angiography(OCTA) in Detecting Choroidal Neovascularization in DifferentStages of Best Macular Dystrophy: A Case Series