1. Articles from James T. Rosenbaum

    1-5 of 5
    1. Aqueous cell differentiation in anterior uveitis using optical coherence tomography

      Aqueous cell differentiation in anterior uveitis using optical coherence tomography

      Methods and systems for determining a percentage composition of aqueous cells in an anterior chamber of an eye of a subject based on cell reflectance distributions calculated from OCT image data are disclosed. In one example approach, determining a percentage composition of detected aqueous cells may comprise calculating a percentage of the detected aqueous cells which are polymorphonuclear and calculating a percentage of detected aqueous cells which are mononuclear.

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    2. Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy

      Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy

      Purpose To report novel optical coherence tomography findings in a case of anti-α-enolase cancer associated retinopathy. Observations An elderly female presented with bilateral decreased vision and a recent diagnosis of ovarian carcinoma. Optical coherence tomography demonstrated bilateral loss of outer retinal structures and macular edema. Serum testing found antibodies against α-enolase and 82–84 kDa proteins. Outer retinal structures showed recovery, macular edema resolved and repeat anti-retinal antibody testing became negative following cancer therapy and topical difluprednate treatment. Conclusions and Importance: Cancer associated retinopathy is a paraneoplastic disease that results in damage to retinal structures through an autoimmune response ...

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    3. Aqueous Cell Differentiation in Anterior Uveitis Using Fourier-domain Optical Coherence Tomography

      Aqueous Cell Differentiation in Anterior Uveitis Using Fourier-domain Optical Coherence Tomography

      Purpose: The differential diagnosis of a patient presenting with anterior uveitis is broad and can present a diagnostic challenge. In this study, we evaluate the characteristic findings of inflammatory cells on optical coherence tomography (OCT) both in vitro and in vivo. Methods: Blood from two healthy volunteers was prepared using standardized methods for cell sorting with a flow cytometer (FASCAria; BD Biosciences). Neutrophils, lymphocytes, monocytes, and red blood cells were placed in suspension and scanned with a 26 kHz Fourier-domain OCT system (RTVue; Optovue, Inc.) with 5 µm axial resolution. Custom software algorithms were used to identify cells based on ...

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    4. To Be or not TB?

      To Be or not TB?

      Relative to other specialties, ophthalmologists deal infrequently with uncertainty. Of course, every patient requires advice, which in turns requires a weighing of risks and benefits, and some pondering of potential unknowns. But unlike internists, ophthalmologists often see the pathology directly. And what once was hidden from us is now rapidly being revealed with new technologies like optical coherence tomography and adaptive optics. Within the ophthalmic kingdom, however, some subspecialties deal with more uncertainty than others. Specialists in uveitis, in particular, often confront uncertainty. Is the pathology autoimmune or infectious? Or even possibly a malignancy like lymphoma? And nothing confounds a ...

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    5. Characterization of serous retinal detachments in uveitis patients with optical coherence tomography

      Characterization of serous retinal detachments in uveitis patients with optical coherence tomography

      OBJECTIVES: To determine the prevalence of serous retinal detachments (SRD) using optical coherence tomography (OCT) in a large database of patients with uveitis from a tertiary referral setting, to describe clinical features of patients with SRD, and to ascertain retinal architectural features found in association with SRD. MAIN OUTCOME MEASURES: Prevalence of SRD in uveitis patients imaged with OCT, correlation of visual acuity with SRD, anatomic subtypes of uveitis identified, and association of SRD with various subtypes of macular edema (focal and diffuse) and retinal architectural abnormalities. DESIGN: Retrospective, single-setting cross-sectional study of all OCTs in a digital imaging base ...

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    1-5 of 5
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    1. (4 articles) Oregon Health & Science University
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    Characterization of serous retinal detachments in uveitis patients with optical coherence tomography To Be or not TB? Aqueous Cell Differentiation in Anterior Uveitis Using Fourier-domain Optical Coherence Tomography Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy Aqueous cell differentiation in anterior uveitis using optical coherence tomography Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia Higher-order regression three-dimensional motion-compensation method for real-time optical coherence tomography volumetric imaging of the cornea Optical coherence tomography image based eye disease detection using deep convolutional neural network Optical Coherence Tomography Biomarkers in Predicting Treatment Outcomes of Diabetic Macular Edema After Dexamethasone Implants Macular and Optic Disc Parameters in Children with Amblyopic and Nonamblyopic Eyes under Optical Coherence Tomography Fundus Images Optical coherence tomography assessment of the enamel surface after debonding the ceramic brackets using three different techniques Schizophrenia in Translation: Why the Eye?