1. Articles from Zhe Chen

    1-5 of 5
    1. Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging

      Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging

      The cutaneous vasculature is involved in many diseases. Current clinical examination techniques, however, cannot resolve the human vasculature with all plexus in a non-invasive manner. By combining an optical coherence tomography system with angiography extension and an all optical photoacoustic tomography system, we can resolve in 3D the blood vessels in human skin for all plexus non-invasively. With a customized imaging unit that permits access to various parts of patients’ bodies, we applied our multimodality imaging system to investigate several different types of skin conditions. Quantitative vascular analysis is given for each of the dermatological conditions to show the potential ...

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    2. Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Studies have proven the relationship between cutaneous vasculature abnormalities and dermatological disorders, but to image vasculature noninvasively in vivo , advanced optical imaging techniques are required. In this study, we imaged a palm of a healthy volunteer and three subjects with cutaneous abnormalities with photoacoustic tomography (PAT) and optical coherence tomography with angiography extension (OCTA). Capillaries in the papillary dermis that are too small to be discerned with PAT are visualized with OCTA. From our results, we speculate that the PA signal from the palm is mostly from hemoglobin in capillaries rather than melanin, knowing that melanin concentration in volar skin ...

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    3. Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculature in vivo in various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable to provide. Co-registered volumes for vessel network is further embedded in the morphologic image provided by OCT. This multi-modal system is therefore demonstrated as a valuable tool for comprehensive non-invasive ...

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    4. Feature Of The Week 3/18/12: Research Results from Shanghai Jiaotong University on Optical Coherence Tomography for Whole Eye Segment Imaging

      Feature Of The Week 3/18/12: Research Results from Shanghai Jiaotong University on Optical Coherence Tomography for Whole Eye Segment Imaging

      Researchers from Shanghai Jiao Tong University, Shanghai Institute of Technology, Peking University, and UCLA recently published a paper on “Optical coherence tomography for whole eye segment imaging". Below is a summary of their work. We proposed a dual focus dual channel spectral domain optical coherence tomography (SD-OCT) for simultaneous imaging of the whole eye segments from cornea to the retina. By using dual channels the system solved the problem of limited imaging depth of SD-OCT. By using dual focus the system solved the problem of simultaneous light focusing on the anterior segment of the eye and the retina. Dual focusing ...

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    5. Optical coherence tomography for whole eye segment imaging

      Optical coherence tomography for whole eye segment imaging

      We proposed a dual focus dual channel spectral domain optical coherence tomography (SD-OCT) for simultaneous imaging of the whole eye segments from cornea to the retina. By using dual channels the system solved the problem of limited imaging depth of SD-OCT. By using dual focus the system solved the problem of simultaneous light focusing on the anterior segment of the eye and the retina. Dual focusing was achieved by adjusting the collimating lenses so the divergence of the two probing beams was tuned to make them focused at different depth in the eye. We further achieved full range complex (FRC ...

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    1-5 of 5
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  2. Topics in the News

    1. (3 articles) Medical University of Vienna
    2. (3 articles) Michael P. Minneman
    3. (3 articles) Wolfgang Drexler
    4. (3 articles) Rainer A. Leitgeb
    5. (3 articles) Insight Photonic Solutions
    6. (2 articles) UCLA
    7. (2 articles) Shanghai Jiao Tong University
    8. (2 articles) Shuliang Jiao
    9. (2 articles) Chuanqing Zhou
    10. (2 articles) Mengyang Liu
    11. (1 articles) European Society of Cardiology
    12. (1 articles) Giulio Guagliumi
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    Optical coherence tomography for whole eye segment imaging Feature Of The Week 3/18/12: Research Results from Shanghai Jiaotong University on Optical Coherence Tomography for Whole Eye Segment Imaging Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging Expert consensus published on use of imaging to guide heart attack treatment Impact of Swept Source optical coherence tomography in patients with photoreceptor dystrophies ‘Primum non nocere’ aortic dissection involving ostium of right coronary artery diagnosed by optical coherence tomography Analysis of the Variation in Thickness of Per-papillary Retinal Optic Nerve Fibres in Professional Rugby Players Research Scientist for Optical Diagnostic at Carestream Dental Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent Apelin as a Potential Treatment for Chronic Kidney Disease