1. Articles from Rob Krams

    1-4 of 4
    1. 3D co-registration algorithm for catheter-based optical coherence tomography

      3D co-registration algorithm for catheter-based optical coherence tomography

      Applications of catheter-based optical coherence tomography (OCT) - originally developed for cardiovascular imaging - have expanded to other organ systems. However, currently available algorithms to co-register 3D OCT data to a second imaging modality were developed for cardiovascular applications and with it, are tailored to small tubular tissue structures. The available algorithms can often not be applied outside the cardiovascular system, e.g. when an OCT probe is introduced into the kidney, lungs, or wrist. Here, we develop a generic co-registration algorithm with potentially numerous applications. This algorithm only requires that the OCT probe is visible on the second imaging modality and ...

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    2. Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis

      Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis

      Aims: In-vivo validation of coronary optical coherence tomography (OCT) against histology and the effects of plaque burden (PB) on plaque classification remain unreported. We investigated this in a porcine model with human-like coronary atherosclerosis. Methods and results: Five female Yucatan D374Y-PCSK9 transgenic hypercholesterolemic mini-pigs were implanted with a coronary shear-modifying stent to induce advanced atherosclerosis. OCT frames (n=201) were obtained 34 weeks after implantation. Coronary arteries were perfusion-fixed, serially sectioned and co-registered with OCT using a validated algorithm. Lesions were adjudicated using the Virmani classification and PB assessed from histology. OCT had a high sensitivity, but modest specificity (92 ...

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    3. Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs

      Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs

      Background— Although disturbed flow is thought to play a central role in the development of advanced coronary atherosclerotic plaques, no causal relationship has been established. We evaluated whether inducing disturbed flow would cause the development of advanced coronary plaques, including thin cap fibroatheroma. Methods and Results— D374Y -PCSK9 hypercholesterolemic minipigs (n=5) were instrumented with an intracoronary shear-modifying stent (SMS). Frequency-domain optical coherence tomography was obtained at baseline, immediately poststent, 19 weeks, and 34 weeks, and used to compute shear stress metrics of disturbed flow. At 34 weeks, plaque type was assessed within serially collected histological sections and coregistered to ...

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    4. Jailed side branches: fate of unapposed struts studied with 3D frequency-domain optical coherence tomography

      Jailed side branches: fate of unapposed struts studied with 3D frequency-domain optical coherence tomography

      We report the case of a 64-year-old man treated for stable angina with two bare-metal stents in the proximal-mid segment of the left anterior descending artery at the bifurcation with the first diagonal and second septal branches without final kissing balloon dilatation. Seven months later he complained of recurrent angina. Frequency-domain optical coherence tomography (OCT) with three-dimensional (3D) reconstruction was performed, showing a thick rim of neointimal proliferation at the ostium of both branches, causing severe restenosis. Deployment of a stent in a bifurcation main branch without opening the struts at the side-branch ostium may facilitate focal restenosis.

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    1-4 of 4
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  2. Topics in the News

    1. (9 articles) National Institutes of Health
    2. (3 articles) Royal Brompton Hospital
    3. (2 articles) Duke University
    4. (2 articles) Harvard University
    5. (2 articles) Massachusetts General Hospital
    6. (2 articles) Columbia University
    7. (1 articles) Academic Medical Center at the University of Amsterdam
    8. (1 articles) Imperial College London
    9. (1 articles) Aarhus University
    10. (1 articles) UCLA
    11. (1 articles) Singapore Eye Research Institute
    12. (1 articles) Ryerson University
    13. (1 articles) State University of New York at Buffalo
    14. (1 articles) University of Toronto
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    Jailed side branches: fate of unapposed struts studied with 3D frequency-domain optical coherence tomography Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis 3D co-registration algorithm for catheter-based optical coherence tomography Precision of attenuation coefficient measurements by optical coherence tomography Machine learning classification of multiple sclerosis in children using optical coherence tomography Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery Duke University Receives NIH Grant for OCTA and Glaucoma Progression in the Non-Human Primate University of Alabama at Birmingham Receives NIH Grant for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease Massachusetts General Hosptial Receives NIH Grant for Intravascular microstructural, chemical and biomechanical characterization of coronary plaques Theia Imaging, LLD Receives NIH Grant for A Widefield, Handheld OCT system for Patients who are Unable to Cooperate Massachusetts General Hosptial Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography