1. Articles from Geraldine Stock

    1-7 of 7
    1. Performance of Drusen Detection by Spectral-Domain Optical Coherence Tomography

      Performance of Drusen Detection by Spectral-Domain Optical Coherence Tomography
      Purpose. To evaluate the performance of automated analyses integrated in three spectral-domain optical coherence tomography (SD-OCT) devices to identify drusen in eyes with early (i.e., nonatrophic and nonneovascular) age-related macular degeneration (AMD). Methods. Twelve eyes of 12 AMD patients, classified as AREDS 2 and 3 and having a mean count of 113 drusen were examined with three clinical SD-OCT devices (Cirrus [Carl Zeiss Meditec, Dublin CA], 3DOCT-1000 [Topcon, Tokyo, Japan], and Spectralis [Heidelberg Engineering, GmbH, Heidelberg, Germany]) and five different scan patterns. After standard automated segmentation of the RPE was performed, every druse in each B-scan was identified and ...
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    2. Performance of OCT segmentation procedures to assess morphology and extension in geographic atrophy

      Performance of OCT segmentation procedures to assess morphology and extension in geographic atrophy
      Purpose: Investigating segmentation procedures and morphological findings in time domain (TD) and current spectral domain (SD) optical coherence tomography (OCT) devices in patients with geographic atrophy (GA).Methods: Fifty eyes of 46 patients with GA secondary to AMD and 15 control eyes were examined in this prospective noninterventional comparative case series. All patients underwent Stratus (model 3000), Cirrus (Carl Zeiss Meditec), Spectralis (Spectralis HRA+OCT; Heidelberg Engineering) and 3D-OCT-1000 (Topcon). Automated segmentation analyses were compared. An overlay of scanning laser ophthalmoscope (SLO) and three-dimensional retinal thickness (RT) maps were used to investigate whether areas of retinal thinning correspond to areas ...
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    3. Evaluation of anterior-segment inflammation and retinal thickness change following cataract surgery

      Purpose: To investigate the physiological retinal response to uneventful cataract surgery using conventional time-domain (TD-OCT) and current spectral-domain optical coherence tomography (SD-OCT) in combination with an assessment of the anterior chamber inflammatory reaction by laser flare/cell meter (LCFM).Methods: Thirty-four patients scheduled for cataract surgery were included in this prospective pilot study. Retinal parameters were examined according to a standardized examination procedure using TD-OCT (Stratus; Carl Zeiss Meditec, Dublin, California, USA) and SD-OCT (Cirrus; Carl Zeiss Meditec) devices. The inflammatory reaction of the anterior chamber was measured by LFCM (Kowa FC-1000, Kowa Co. Ltd, Tokyo, Japan). Examinations were carried ...
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    4. Automatic and manual segmentation of healthy retinas using high-definition optical coherence tomography

      Purpose: This study compared automatic- and manual segmentation modalities in the retina of healthy eyes using high-definition optical coherence tomography (HD-OCT).Methods: Twenty retinas in 20 healthy individuals were examined using an HD-OCT system (Carl Zeiss Meditec, Inc.). Three-dimensional imaging was performed with an axial resolution of 6 [mu]m at a maximum scanning speed of 25 000 A-scans/second. Volumes of 6 × 6 × 2 mm were scanned. Scans were analysed using a matlab-based algorithm and a manual segmentation software system (3D-Doctor). The volume values calculated by the two methods were compared.Results: Statistical analysis revealed a high correlation between ...
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    5. Alterations of intraretinal layers in acute central serous chorioretinopathy

      Purpose: Optical coherence tomography (OCT) is restricted by its low scanning speed and limited resolution. High-definition raster-scanning OCT (HD-OCT) was used to evaluate changes in retinal microstructure in patients with acute central serous chorioretinopathy (CSCR) and to find new morphological features.Methods: Eighteen patients with subretinal fluid accumulation caused by acute CSCR were imaged in a cross-sectional study design. High-speed frequency-domain HD-OCT was used to image an area of 6 × 6 mm in the macular retina. Three-dimensional analyses were performed using en-face imaging and section analysis of single HD-OCT scans.Results: Detailed information about fluid accumulation can be obtained in ...
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    6. Identification of optical density ratios in subretinal fluid as a clinically relevant biomarker in exudative macular disease

      Purpose: To investigate the potential role of optical density ratios (ODR) obtained from subretinal fluid analysis in exudative macular disease and to identify the predictive role of ODR under therapy in comparison to conventional morphometric measurements (CMM). Methods: Fifteen patients with neovascular age-related macular degeneration (nAMD) and 15 patients with acute central serous chorioretinopathy (CSC) were included into this prospective comparative and interventional case series. High-definition optical coherence tomography (SD-OCT) was performed according to a standardized protocol. NAMD patients received a standard treatment consisting of 3 monthly doses of intravitreal ranibizumab. Best-corrected visual acuity (BCVA) was assessed at baseline, week ...
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    7. Three-dimensional angiographic imaging of leakage in branch retinal vein occlusion

      Purpose: Optical coherence tomography (OCT) is used to image branch retinal vein occlusion (BRVO) but lacks information about leakage dynamics and perfusion status. Topographical angiography (TAG) is capable of providing this information and has been described previously in age-related macular degeneration. This study evaluates TAG in BRVO.Methods: We included 56 eyes of 40 consecutive patients with BRVO and a reduction in central vision. Two groups were established based on whether argon laser coagulation was performed or not. A standardized follow-up was performed. The chorioretinal fluorescence pattern was reconstructed following TAG. Quantitative measurements were also performed.Results: TAG performed from ...
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    1-7 of 7
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    1. (7 articles) Medical University of Vienna
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