1. Articles from Mark J. Kupersmith

    1-9 of 9
    1. Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial: Part II. Correlations and Relationship to Clinical Features

      Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial: Part II. Correlations and Relationship to Clinical Features

      Purpose: The accepted method to evaluate and monitor papilledema, Frisén grading, is an ordinal approach based on descriptive features. Part I showed spectral domain (SD) optical coherence tomography (OCT) in a clinical trial setting provides reliable measurement of the effects of papilledema on the optic nerve head (ONH) and peripapillary retina, particularly if a 3D-segmentation method is used for analysis.1 We evaluated how OCT parameters are interrelated and how they correlate with vision and other clinical features in idiopathic intracranial hypertension (IIH). Methods: 126 subjects in the IIH Treatment Trial (IIHTT) OCT substudy had Cirrus SD-OCT optic disc ...

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    2. Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial: Part I. Quality Control,Comparisons and Variability

      Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial: Part I. Quality Control,Comparisons and Variability

      Purpose: Optical coherence tomography (OCT) has been utilized to investigate papilledema in single site, mostly retrospective studies. We investigated whether spectral domain OCT (SD-OCT), which provides thickness and volume measurements of the optic nerve and retina, could reliably demonstrate structural changes due to papilledema in a prospective multi-site clinical trial setting. Methods: At entry, 126 subjects in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) with mild visual field loss had optic disc and macula scans using the Cirrus SD-OCT. Images were analyzed using the proprietary commercial and custom 3-D segmentation algorithms to calculate retinal nerve fiber layer (RNFL), total retinal ...

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    3. Optical Coherence Tomography Shape Analysis of the Peripapillary Retinal Pigment Epithelium Layer in Presumed Optic Nerve Sheath Meningiomas

      Optical Coherence Tomography Shape Analysis of the Peripapillary Retinal Pigment Epithelium Layer in Presumed Optic Nerve Sheath Meningiomas

      Background: Geometric morphometrics (GM) was used to compare the shape of the peripapillary retinal pigment epithelium-Bruch's membrane (ppRPE) layer imaged on spectral domain optical coherence tomography (SD-OCT) of patients with presumed optic nerve sheath meningiomas (pONSM) and normal subjects. Methods: We compared 2 groups: 30 normals to 10 patients (11 eyes) with pONSM. We digitized 20 equidistant semi-landmarks on OCT images of the ppRPE-layer, spanning 2500 [mu]m on each side of the neural canal opening (NCO). Data were analyzed using standard GM techniques including a generalized least squares Procrustes superimposition, principal component analysis (PCA), thin-plate spline, and permutation ...

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    4. Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy

      Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy

      Purpose. Scanning laser polarimetry (SLP) reveals abnormal retardance of birefringence in locations of the edematous peripapillary retinal nerve fiber layer (RNFL), which appear thickened by optical coherence tomography (OCT), in nonarteritic anterior ischemic optic neuropathy (NAION). We hypothesize initial sector SLP RNFL abnormalities will correlate with long-term regional visual field loss due to ischemic injury. Methods. We prospectively performed automated perimetry, SLP, and high definition OCT (HD-OCT) of the RNFL in 25 eyes with acute NAION. We grouped visual field threshold and RNFL values into Garway-Heath inferior/superior disc sectors and corresponding superior/inferior field regions. We compared sector SLP ...

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    5. Scanning Laser Polarimetry, but not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy

      Scanning Laser Polarimetry, but not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy

      Purpose Scanning laser polarimetry (SLP) reveals abnormal retardance of birefringence in locations of the edematous peripapillary retinal nerve fiber layer (RNFL), which appear thickened by OCT, in non-arteritic anterior ischemic optic neuropathy (NAION). We hypothesize initial sector SLP RNFL abnormalities will correlate with long-term regional visual field loss due to ischemic injury. Methods We prospectively performed automated perimetry, SLP and HD- OCT of the RNFL in 25 eyes with acute NAION. We grouped visual field threshold and RNFL values into Garway-Heath inferior/superior disc sectors and corresponding superior/inferior field regions. We compared sector SLP RNFL thickness with corresponding visual ...

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    6. Automated Quantification of Volumetric Optic Disc Swelling in Papilledema Using Spectral-Domain Optical Coherence Tomography

      Automated Quantification of Volumetric Optic Disc Swelling in Papilledema Using Spectral-Domain Optical Coherence Tomography

      Purpose: To develop an automated method for the quantification of volumetric optic disc swelling in papilledema subjects using spectral-domain optical coherence tomography (SD-OCT) and to determine the extent that such volumetric measurements correlate with Frisén scale grades (from fundus photographs) and 2-D peripapillary retinal-nerve-fiber-layer (RNFL) and total-retinal (TR) thickness measurements from SD-OCT. Methods: A custom image-analysis algorithm was developed to obtain peripapillary circular RNFL thickness, TR thickness, and TR volume measurements from SD-OCT volumes of subjects with papilledema. In addition, peripapillary RNFL thickness measures from the commercially available Zeiss SD-OCT machine were obtained. Expert Frisén scale grades were independently obtained ...

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    7. Scanning Laser Polarimetry Reveals Status of Retinal Nerve Fiber Layer (RNFL) Integrity in Eyes with Optic Nerve Head Swelling by OCT

      Scanning Laser Polarimetry Reveals Status of Retinal Nerve Fiber Layer (RNFL) Integrity in Eyes with Optic Nerve Head Swelling by OCT

      Purpose OCT shows retinal nerve fiber layer (RNFL) thickening in optic nerve head (ONH) swelling, but does not provide information on acute axonal disruption. We hypothesized that scanning laser polarimetry (SLP) in comparison with OCT might reveal the status of axon integrity and visual prognosis in acute RNFL swelling. Methods We used threshold perimetry, OCT, and SLP to prospectively study eyes with papilledema (24), optic neuritis (13), NAION (21), and ONH swelling (defined as having average RNFL by OCT > 95th percentile of controls at presentation). Regional RNFL was judged reduced if the OCT or SLP measure in a quadrant was < 5th percentile of controls. Results At presentation, average RNFL by OCT was similar for eyes with papilledema and NAION (p=0.97), and less for optic neuritis. Average RNFL by SLP was less often increased, similar for papilledema and optic neuritis, but less for NAION (p=0.02) eyes. The RNFL by SLP was reduced in at least 1 quadrant in 1/24 eyes with papilledema, 1/14 eyes with optic neuritis, and in 13/21 eyes with NAION. In NAION eyes, quadrants with reduced SLP had corresponding visual field loss that did not recover at 1 or 6 months. By 1 month, eyes with NAION showed RNFL thinning by OCT (7/17 eyes) and by SLP in14/16 eyes) in contrast to optic neuritis (by OCT, 0/12; p=0.006 and by SLP, 1/12; p=0.0004). Conclusion OCT and SLP reveal different aspects of RNFL changes associated with ONH swelling. OCT reveals thickening, due to edema. SLP reveals a decrease in retardance in eyes with axonal injury associated with visual field loss, which is unlikely to recover. This study provides evidence that SLP may be predictive of regions of permanent axon dysfunction and visual field loss in eyes with optic disc edema.

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    8. Optical coherence tomography of the swollen optic nerve head: deformation of the peripapillary RPE layer in papilledema

      Optical coherence tomography of the swollen optic nerve head: deformation of the peripapillary RPE layer in papilledema

      Purpose: To examine the biomechanical deformation of load bearing structures of the optic nerve head (ONH) resulting from raised intracranial pressure, using high definition optical coherence tomography (HD-OCT). We postulate that elevated intracranial pressure induces forces in the retrolaminar subarachnoid space that can deform ONH structures, particularly the peripapillary Bruch's membrane (BM) and retinal pigment epithelium (RPE) layers. Methods: We compared HD-OCT optic nerve and peripapillary retinal nerve fiber layer (RNFL) findings in eyes with papilledema due to raised intracranial pressure to findings in eyes with optic disc swelling due to optic neuritis and non-arteritic anterior ischemic optic neuropathy ...

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    1-9 of 9
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    1. (6 articles) New York Eye and Ear Infirmary
    2. (6 articles) Carl Zeiss Meditec
    3. (5 articles) University of Iowa
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    5. (4 articles) Mary K. Durbin
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    Optical coherence tomography of the swollen optic nerve head: deformation of the peripapillary RPE layer in papilledema Scanning Laser Polarimetry Reveals Status of Retinal Nerve Fiber Layer (RNFL) Integrity in Eyes with Optic Nerve Head Swelling by OCT Automated Quantification of Volumetric Optic Disc Swelling in Papilledema Using Spectral-Domain Optical Coherence Tomography Scanning Laser Polarimetry, but not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy Optical Coherence Tomography Shape Analysis of the Peripapillary Retinal Pigment Epithelium Layer in Presumed Optic Nerve Sheath Meningiomas Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial: Part I. Quality Control,Comparisons and Variability Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial: Part II. Correlations and Relationship to Clinical Features Optical Imaging of the Optic Nerve: Beyond Demonstration of Retinal Nerve Fiber Layer Loss. Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window Avinger Announces Full Commercial Launch of Pantheris SV Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hosptial