1. Articles from Mary Durbin

    1-7 of 7
    1. Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid

      Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid

      The choriocapillaris (CC) plays an essential role in maintaining the normal functions of the human eye. There is increasing interest in the community to develop an imaging technique for visualizing the CC, yet this remains underexplored due to technical limitations. We propose an approach for the visualization of the CC in humans via a complex signal-based optical microangiography (OMAG) algorithm, based on commercially available spectral domain optical coherence tomography (SD-OCT). We show that the complex signal-based OMAG was superior to both the phase and amplitude signal-based approaches in detailing the vascular lobules previously seen with histological analysis. With this improved ...

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    2. Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography

      Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography

      Purpose To analyse and compare the classification of eyes with diabetic retinopathy using fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) performed either with AngioPlex or AngioVue. Methods This was an observational cross-sectional study of 50 eyes from 26 diabetic subjects. Two independent graders classified the FA angiograms, to assess the presence and severity of several characteristics according to the ETDRS Report 11, and a similar evaluation was performed for each 3×3 mm OCTA image from the superficial retinal layer and for the full retina slab. Results Percentages of non-gradable images for the outline of foveal avascular zone ...

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    3. A novel retinal biomarker for Parkinson's disease: Quantifying the foveal pit with optical coherence tomography

      A novel retinal biomarker for Parkinson's disease: Quantifying the foveal pit with optical coherence tomography

      Background Optical coherence tomography offers a potential biomarker tool in Parkinson's disease (PD). A mathematical model quantifying symmetry, breadth, and depth of the fovea was applied. Methods Nintey-six subjects (72 PD and 24 healthy controls) were included in the study. Macular scans of each eye were obtained on two different optical coherence tomography devices: Cirrus and RTVue. Results The variables corresponding to the cardinal gradients of the fovea were the most sensitive indicators of PD for both devices. Principal component analysis distinguished 65% of PD patients from controls on Cirrus, 57% on RTVue. Conclusion Parkinson's disease shallows the ...

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    4. Widefield En Face Optical Coherence Tomography Imaging of Subretinal Drusenoid Deposits

      Widefield En Face Optical Coherence Tomography Imaging of Subretinal Drusenoid Deposits

      BACKGROUND AND OBJECTIVE: To determine whether subretinal drusenoid deposits (SDD) can be detected on widefield en face slab images derived from spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) volume scans. PATIENTS AND METHODS: Retrospective study of patients with dry age-related macular degeneration (AMD) enrolled prospectively in an OCT imaging study using SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA) with a central wavelength of 840 nm, and a prototype 100-kHz SS-OCT instrument (Carl Zeiss Meditec) with a central wavelength of 1,050 nm. Seven en face slabs were evaluated with thicknesses from 20 to 55 µm and positioned ...

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    5. Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy

      Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy

      Purpose. Scanning laser polarimetry (SLP) reveals abnormal retardance of birefringence in locations of the edematous peripapillary retinal nerve fiber layer (RNFL), which appear thickened by optical coherence tomography (OCT), in nonarteritic anterior ischemic optic neuropathy (NAION). We hypothesize initial sector SLP RNFL abnormalities will correlate with long-term regional visual field loss due to ischemic injury. Methods. We prospectively performed automated perimetry, SLP, and high definition OCT (HD-OCT) of the RNFL in 25 eyes with acute NAION. We grouped visual field threshold and RNFL values into Garway-Heath inferior/superior disc sectors and corresponding superior/inferior field regions. We compared sector SLP ...

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    6. A Novel Method to Detect Local Ganglion Cell Loss in Early Glaucoma Using Spectral-Domain Optical Coherence Tomography

      A Novel Method to Detect Local Ganglion Cell Loss in Early Glaucoma Using Spectral-Domain Optical Coherence Tomography

      Purpose: To test the glaucoma-discriminating ability of a new method for detecting local ganglion cell loss using spectral-domain optical coherence tomography (SD-OCT). Methods: This study included 58 eyes from glaucomatous patients and 48 healthy eyes from volunteers. The combined thickness of the ganglion cell layer and inner plexus layer (GCIPL) was measured on a macular cube scan (200 × 200) in Cirrus HD-OCT. GCIPL thicknesses on 360 spokes extending from the inner to the outer radius of a macular elliptical annulus were calculated. The lowest value (minimum GCIPL) was compared to the average GCIPL thickness within the elliptical annulus in the ...

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    7. Optical coherence tomography of the swollen optic nerve head: deformation of the peripapillary RPE layer in papilledema

      Optical coherence tomography of the swollen optic nerve head: deformation of the peripapillary RPE layer in papilledema

      Purpose: To examine the biomechanical deformation of load bearing structures of the optic nerve head (ONH) resulting from raised intracranial pressure, using high definition optical coherence tomography (HD-OCT). We postulate that elevated intracranial pressure induces forces in the retrolaminar subarachnoid space that can deform ONH structures, particularly the peripapillary Bruch's membrane (BM) and retinal pigment epithelium (RPE) layers. Methods: We compared HD-OCT optic nerve and peripapillary retinal nerve fiber layer (RNFL) findings in eyes with papilledema due to raised intracranial pressure to findings in eyes with optic disc swelling due to optic neuritis and non-arteritic anterior ischemic optic neuropathy ...

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    1-7 of 7
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    1. (7 articles) Mary K. Durbin
    2. (7 articles) Carl Zeiss Meditec
    3. (3 articles) Zeiss Cirrus HD-OCT
    4. (2 articles) University of Miami
    5. (2 articles) University of Iowa
    6. (2 articles) New York Eye and Ear Infirmary
    7. (2 articles) Randy H. Kardon
    8. (2 articles) Giovanni Gregori
    9. (1 articles) Jerome Sherman
    10. (1 articles) Optovue RTVue-100
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    Optical coherence tomography of the swollen optic nerve head: deformation of the peripapillary RPE layer in papilledema A Novel Method to Detect Local Ganglion Cell Loss in Early Glaucoma Using Spectral-Domain Optical Coherence Tomography Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy Widefield En Face Optical Coherence Tomography Imaging of Subretinal Drusenoid Deposits A novel retinal biomarker for Parkinson's disease: Quantifying the foveal pit with optical coherence tomography Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid Postdoctoral Associate Position at Duke Vision and Image Processing Laborator Anterior segment optical coherence tomography angiography Refining percutaneous coronary intervention: intracoronary imaging, haemodynamics, P2Y12 antagonists, and public outcomes reporting Optical Coherence Tomography/Fluorescence Imaging: Fiber assembly enables efficient multimodal endoscopy Optical Fabrication: Glassblowing technique creates arrays of axicon lenses