1. Articles from Jan C. van Meurs

    1-4 of 4
    1. Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT

      Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT

      Purpose: We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT). Methods: Seven patients with age-related macular degeneration underwent an RPE-choroid graft translocation in a prospective institutional cohort study. Spectral domain optical coherence tomography (SD-OCT) was used to measure the revascularization stage. With PRD-OCT the presence of flow was imaged postoperatively. Results: The PRD-OCT confirmed flow in three patients when SD-OCT indicated the afferent vessel ingrowth stage, and in all seven patients when the SD-OCT indicated the efferent vessel ingrowth stage. Conclusions: The ...

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    2. Phase-stabilized optical frequency domain imaging at 1-µm for the measurement of blood flow in the human choroid

      Phase-stabilized optical frequency domain imaging at 1-µm for the measurement of blood flow in the human choroid
      In optical frequency domain imaging (OFDI) the measurement of interference fringes is not exactly reproducible due to small instabilities in the swept-source laser, the interferometer and the data-acquisition hardware. The resulting variation in wavenumber sampling makes phase-resolved detection and the removal of fixed-pattern noise challenging in OFDI. In this paper this problem is solved by a new post-processing method in which interference fringes are resampled to the exact same wavenumber space using a simultaneously recorded calibration signal. This method is implemented in a high-speed (100 kHz) high-resolution (6.5 µm) OFDI system at 1-µm and is used for the removal ...
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    3. Early Perfusion of a Free RPE-Choroid Graft in Patients with Exudative Macular Degeneration Can Be Imaged with Spectral Domain-OCT

      Early Perfusion of a Free RPE-Choroid Graft in Patients with Exudative Macular Degeneration Can Be Imaged with Spectral Domain-OCT
      Purpose. To study early flow and revascularization in a free, autologous, retinal pigment epithelium (RPE)–choroid graft. Methods. This prospective cohort study used spectral domain–optical coherence tomography (SD-OCT) after RPE–choroid graft surgery in 12 patients. This SD-OCT was combined with fluorescein angiography (FA) and indocyanine green angiography (ICGA) in 5 patients. Results. SD-OCT revealed that vessel diameter, number of vessels, and graft thickness increased in 10 of 12 patients, starting between 3 and 10 days after surgery. A subsequent decrease in thickness was found in all 10 patients, beginning as early as 8 days after surgery. Initially, the ...
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    4. Early Perfusion of a Free RPE-Choroid Graft in Patients with Exudative Macular Degeneration Can Be Imaged with Spectral Domain OCT

      Early Perfusion of a Free RPE-Choroid Graft in Patients with Exudative Macular Degeneration Can Be Imaged with Spectral Domain OCT
      Purpose. To study early flow and revascularization in a free, autologous, retinal pigment epithelium (RPE)-choroid graft. Methods. This prospective cohort study employed spectral domain optical coherence tomography (SD-OCT) after RPE-choroid graft surgery in 12 patients. This SD-OCT was combined with fluorescein angiography (FA) and indocyanine green angiography (ICGA) in 5 patients. Results. SD-OCT revealed that vessel diameter, number of vessels, and graft thickness increased in 10 of 12 patients, starting between three and ten days after surgery. A subsequent decrease in thickness was found in all ten patients, beginning as early as eight days after surgery. Initially, the graft ...
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    1-4 of 4
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  2. Topics in the News

    1. (2 articles) VU University Amsterdam
    2. (2 articles) Johannes F. de Boer
    3. (1 articles) Erasmus University
    4. (1 articles) Koen A. Vermeer
    5. (1 articles) Medical University of Vienna
    6. (1 articles) Harbin Medical University
    7. (1 articles) Université Pierre et Marie Curie
    8. (1 articles) University of Erlangen
    9. (1 articles) Wolfgang Drexler
    10. (1 articles) Adrian G. Podoleanu
    11. (1 articles) Mengyang Liu
    12. (1 articles) Bo Yu
    13. (1 articles) Rainer A. Leitgeb
    14. (1 articles) Angelika Unterhuber
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