1. Articles from Dipankan Bhattacharya

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    1. Feature Of The Week 2/12/12: Researchers at Yale University use OCT to Characterize Microfluidic Ciliary Induced Fluid Flow

      Feature Of The Week 2/12/12: Researchers at Yale University use OCT to Characterize Microfluidic Ciliary Induced Fluid Flow

      Recently researchers at Yale University demonstrated a very novel application of optical coherence tomography using a Thorlabs OCT system.  The research involved characterizing microfluidic flow of fluid driven by cilia.  Below is a summary of this interesting novel application of OCT.Motile cilia are fingerlike projections from different epithelial surfaces that move in a periodic manner to generate directional fluid flow. For example, respiratory cilia generate a microfluidic-scale flow that moves pathogen and allergen-containing mucus out of the lungs. Defects in motile cilia lead to recurrent respiratory infections. Despite the importance of cilia in rare disease such as primary ciliary ...

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    2. Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography-based particle tracking velocimetry

      Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography-based particle tracking velocimetry
      Motile cilia are cellular organelles that generate directional fluid flow across various epithelial surfaces including the embryonic node and respiratory mucosa. The proper functioning of cilia is necessary for normal embryo development and, for the respiratory system, the clearance of mucus and potentially harmful particulate matter. Here we show that optical coherence tomography (OCT) is well-suited for quantitatively characterizing the microfluidic-scale flow generated by motile cilia. Our imaging focuses on the ciliated epithelium of Xenopus tropicalis embryos, a genetically manipulable and experimentally tractable animal model of human disease. We show qualitative flow profile characterization using OCT-based particle pathline imaging. We ...
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    1. (2 articles) Yale University
    2. (2 articles) Michael A. Choma
    3. (1 articles) RWTH Aachen University
    4. (1 articles) Thorlabs
    5. (1 articles) Thorlabs OCT Imaging Systems
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