1. Articles from Jonathan P. Williamson

    1-6 of 6
    1. Phenotyping Airways Disease With Optical Coherence Tomography

      Phenotyping Airways Disease With Optical Coherence Tomography

      Airway diseases are a major concern around the world. However, the pace of new drug and biomarker discovery has lagged behind those of other common disorders such as cardiovascular diseases and diabetes. One major barrier in airways research has been the inability to accurately visualize large and small airway remodeling or dysplastic/neoplastic (either pre or early cancerous) changes using non or minimally invasive instruments. The advent of optical coherence tomography (OCT) has the potential to revolutionize airway research and management by allowing investigators and clinicians to visualize the airway with resolution approaching histology without exposing patients to harmful effects ...

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    2. Elastic Properties of the Central Airways in Obstructive Lung Diseases Measured Using Anatomical Optical Coherence Tomography

      Elastic Properties of the Central Airways in Obstructive Lung Diseases Measured Using Anatomical Optical Coherence Tomography
      Rationale: Our understanding of how airway remodeling affects regional airway elastic properties is limited due to technical difficulties in quantitatively measuring dynamic, in vivo airway dimensions. Such knowledge could help elucidate mechanisms of excessive airway narrowing. Objectives: To utilize anatomical optical coherence tomography (aOCT) to compare central airway elastic properties in control subjects and those with obstructive lung diseases. Methods: Following bronchodilation, airway lumen area (Ai) was measured using aOCT during bronchoscopy in control subjects (n=10) and those with asthma (n=16), chronic obstructive pulmonary disease (COPD) (n=9) and bronchiectasis (n=8). Ai was measured in each of ...
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    3. Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function

      Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function

      Regulation of airway caliber by lung volume or bronchoconstrictor stimulation is dependent on physiological, structural and mechanical events within the airway wall, including airway smooth muscle (ASM) contraction, deformation of the mucosa and cartilage, and tensioning of elastic matrices linking wall components. Despite close association between events in the airway wall and the resulting airway caliber these have typically been studied separately: the former primarily using histological approaches, the latter with a range of imaging modalities. We describe a new optical technique, anatomical optical coherence tomography (aOCT), which allows changes at the luminal surface (airway caliber) to be temporally related ...

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    4. In vivo 4D imaging of the human lower airway using anatomical optical coherence tomography

      In vivo 4D imaging of the human lower airway using anatomical optical coherence tomography
      Anatomical optical coherence tomography (aOCT) is a long-range, fibre-optic endoscopic imaging modality capable of quantifying the size and shape of the human airway lumen. This paper presents the first application of respiratory gating to 3D aOCT volumetric data. A sequence of time-gated data volumes are generated, characterising the dynamic behaviour of a segment of the lower airway over an averaged respiratory cycle. The technique is demonstrated on in vivo data acquired from three human subjects.
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    5. Using Optical Coherence Tomography To Improve Diagnostic and Therapeutic Bronchoscopy

      Background Flexible bronchoscopy is a common procedure used in both diagnostic and therapeutic settings but does not readily permit measurement of central airway dimensions. Anatomical optical coherence tomography (aOCT), a modification of conventional optical coherence tomography (OCT), is a novel, light-based imaging tool with the capacity to accurately measure diameter and lumen area of the central airways during bronchoscopy. This study describes the first clinical use of anatomical optical coherence tomography in the lower airways in three individuals with common endobronchial pathologies. Methods During bronchoscopy, a specialized fiber-optic probe was passed through the biopsy channel of a standard flexible bronchoscope ...
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    6. Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway

      Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway
      Endoscopic treatment of lower airway pathologies requires accurate quantification of airway dimensions. We demonstrate the application of a real-time endoscopic optical coherence tomography system that can image lower airway anatomy and quantify airway lumen dimensions intra-operatively. Results ... [Opt. Express 16, 17521-17529 (2008)]
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    1-6 of 6
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  2. Topics in the News

    1. (6 articles) University of Western Australia
    2. (6 articles) Jonathan P. Williamson
    3. (5 articles) Sir Charles Gairdner Hospital
    4. (5 articles) Peter R. Eastwood
    5. (5 articles) Robert A. McLaughlin
    6. (5 articles) David R. Hillman
    7. (4 articles) Julian J. Armstrong
    8. (4 articles) David D. Sampson
    9. (2 articles) Martin J. Phillips
    10. (2 articles) Andrea Curatolo
    11. (1 articles) University of Pennsylvania
    12. (1 articles) National Institutes of Health
    13. (1 articles) Peking University
    14. (1 articles) FDA
    15. (1 articles) Washington University in St. Louis
    16. (1 articles) Lehigh University
    17. (1 articles) Duke University
    18. (1 articles) Massachusetts Institute of Technology
    19. (1 articles) Chao Zhou
    20. (1 articles) James G. Fujimoto
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    Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway In vivo 4D imaging of the human lower airway using anatomical optical coherence tomography Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function Elastic Properties of the Central Airways in Obstructive Lung Diseases Measured Using Anatomical Optical Coherence Tomography Phenotyping Airways Disease With Optical Coherence Tomography Optical Coherence Tomography Characteristics of the Choroid Underlying Congenital Hypertrophy of the Retinal Pigment Epithelium Kylee Hall joins Cylite as VP Sales and Marketing Consolidation of Imaging Modalities Utilizing Digitally Assisted Visualization Systems: The Development of a Surgical Information Handling Cockpit Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis Identification of atherosclerotic plaques in intravascular optical coherence tomography images based on textures and artificial neural network Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter Unstable Angina Caused by Honeycomb-Like Coronary Lesion Identified with Use of Optical Coherence Tomography