1. Articles from Melinda Sanders

    1-9 of 9
    1. Classification of human ovarian tissue using full field optical coherence tomography

      Classification of human ovarian tissue using full field optical coherence tomography

      The feasibility of a full-field optical coherence tomography (FFOCT) system for rapid wide field optical analysis of normal and malignant human ovarian tissue pathologies was demonstrated. Five features were extracted from the normalized image histogram from 56 FFOCT images, based on the differences in the morphology of the normal and malignant tissue samples.

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    2. Classification and analysis of human ovarian tissue using full field optical coherence tomography

      Classification and analysis of human ovarian tissue using full field optical coherence tomography

      In this study, a full field optical coherence tomography (FFOCT) system was used to analyze and classify normal and malignant human ovarian tissue. 14 ovarian tissue samples (7 normal, 7 malignant) were imaged with the FFOCT system and five features were extracted by analyzing the normalized image histogram from 56 FFOCT images, based on the differences in the morphology of the normal and malignant tissue samples. A generalized linear model (GLM) classifier was trained using 36 images, and sensitivity of 95.3% and specificity of 91.1% was obtained. 20 images were used to test the model, and a sensitivity ...

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    3. Correlating optical coherence elastography based strain measurements with collagen content of the human ovarian tissue

      Correlating optical coherence elastography based strain measurements with collagen content of the human ovarian tissue

      In this manuscript, the initial feasibility of a catheter based phase stabilized swept source optical coherence tomography (OCT) system was studied for characterization of the strain inside different human ovarian tissue groups. The ovarian tissue samples were periodically compressed with 500 Hz square wave signal along the axial direction between the surface of an unfocused transducer and a glass cover slide. The displacement and corresponding strain were calculated during loading from different locations for each tissue sample. A total of 27 ex vivo ovaries from 16 patients were investigated. Statistically significant difference (p < 0.001) was observed between the average ...

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    4. Estimation of elastic parameters of ovarian tissue using phase stabilized swept source optical-coherence tomography

      Estimation of elastic parameters of ovarian tissue using phase stabilized swept source optical-coherence tomography

      We have estimated the micro-mechanical properties of ovarian tissue using phase-sensitive swept source optical coherence tomography. Ovary samples were mechanically excited by periodical vibration of an ultrasound transducer. The displacement and strain of the tissues were calculated during loading. Significant difference in strain was observed between the normal and malignant ovary groups, which indicates much softer and heterogeneous tissue structure for malignant ovaries. The initial results show that the phase sensitive swept source optical coherence elastography (OCE) can be an effective tool for characterization of stiffness and other micro-mechanical properties of normal and malignant ovarian tissue.

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    5. Assessment of collagen changes in ovarian tissue by extracting optical scattering coefficient from OCT images

      Assessment of collagen changes in ovarian tissue by extracting optical scattering coefficient from OCT images

      Optical scattering coefficient from ex-vivo unfixed normal and malignant ovarian tissue was quantitatively extracted by fitting optical coherence tomography (OCT) A-line signals to a single scattering model. 1097 average A-line measurements at a wavelength of 1310nm were performed at 108 sites obtained from 18 ovaries. The average scattering coefficient obtained from normal group consisted of 833 measurements from 88 sites was 2.41 mm-1 (±0.59), while the average coefficient obtained from malignant group consisted of 264 measurements from 20 sites was 1.55 mm-1 (±0.46). Using a threshold of 2 mm-1 for each ovary, a sensitivity of 100 ...

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    6. Feature Of The Week 10/23/11: Hybrid Intraoperative Probe Based on OCT and Positron Detection for Ovarian Cancer Detection

      Feature Of The Week 10/23/11: Hybrid Intraoperative Probe Based on OCT and Positron Detection for Ovarian Cancer Detection
      Multi-modality imaging involving OCT and one or more additional imaging technologies continues to show very promising results for increasing the diagnostic and interventional guidance capability of biomedical imaging probes. These synergistic effects have been published in numerous papers over the past year. This includes OCT in combination with fluorescence, Raman, NIR, ultrasound, and other technologies. Such approaches have the obvious disadvantage of increasing the cost and complexity of the imaging system but often that burden is offset by significantly increased performance. Recently a group from the University of Connecticut published a paper on a hybrid intraoperative probe that used OCT ...
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    7. Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue

      Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue
      Optical scattering coefficient from ex vivo unfixed normal and malignant ovarian tissue was quantitatively extracted by fitting optical coherence tomography (OCT) A-line signals to a single scattering model. 1097 average A-line measurements at a wavelength of 1310 nm were performed at 108 sites obtained from 18 ovaries. The average scattering coefficient obtained from the normal tissue group consisted of 833 measurements from 88 sites was 2.41 mm−1 (±0.59), while the average coefficient obtained from the malignant tissue group consisted of 264 measurements from 20 sites was 1.55 mm−1 (±0.46). The malignant ovarian tissue showed ...
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    8. Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization

      Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization
      Ovarian cancer has the lowest survival rate of the gynecologic cancers because it is predominantly diagnosed in Stages III or IV due to the lack of reliable symptoms, as well as the lack of efficacious screening techniques. Detection before the malignancy spreads or at the early stage would greatly improve the survival and benefit patient health. In this report, we present an integrated optical coherence tomography (OCT), ultrasound (US) and photoacoustic imaging (PAI) prototype endoscopy system for ovarian tissue characterization. The overall diameter of the prototype endoscope is 5 mm which is suitable for insertion through a standard 5-12.5mm ...
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    9. Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization

      Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization
      Ovarian cancer has the lowest survival rate of the gynecologic cancers because it is predominantly diagnosed in the late stages due to the lack of reliable symptoms and efficacious screening techniques. A novel hybrid intraoperative probe has been developed and evaluated for its potential role in detecting and characterizing ovarian tissue. The hybrid intraoperative dual-modality device consists of multiple scintillating fibers and an optical coherence tomography imaging probe for simultaneously mapping the local activities of 18F-FDG uptake and imaging of local morphological changes of the ovary. Ten patients were recruited to the study and a total of 18 normal, abnormal ...
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    1-9 of 9
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    1. (9 articles) Melinda Sanders
    2. (9 articles) Quing Zhu
    3. (8 articles) University of Connecticut
    4. (7 articles) Molly Brewer
    5. (7 articles) Tianheng Wang
    6. (5 articles) Yi Yang
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    Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue Feature Of The Week 10/23/11: Hybrid Intraoperative Probe Based on OCT and Positron Detection for Ovarian Cancer Detection Assessment of collagen changes in ovarian tissue by extracting optical scattering coefficient from OCT images Estimation of elastic parameters of ovarian tissue using phase stabilized swept source optical-coherence tomography Correlating optical coherence elastography based strain measurements with collagen content of the human ovarian tissue Classification and analysis of human ovarian tissue using full field optical coherence tomography Classification of human ovarian tissue using full field optical coherence tomography Feasibility study to improve deep learning in OCT diagnosis of rare retinal diseases with few-shot classification Functional characteristics of glaucoma related arcuate defects seen on OCT en face visualisation of the retinal nerve fibre layer Heads-up Digitally Assisted Surgical Viewing with Intraoperative Optical Coherence Tomography for Myopic Schisis Repair