1. Articles from Tianheng Wang

    1-12 of 12
    1. Correlating optical coherence elastography based strain measurements with collagen content of the human ovarian tissue

      Correlating optical coherence elastography based strain measurements with collagen content of the human ovarian tissue

      In this manuscript, the initial feasibility of a catheter based phase stabilized swept source optical coherence tomography (OCT) system was studied for characterization of the strain inside different human ovarian tissue groups. The ovarian tissue samples were periodically compressed with 500 Hz square wave signal along the axial direction between the surface of an unfocused transducer and a glass cover slide. The displacement and corresponding strain were calculated during loading from different locations for each tissue sample. A total of 27 ex vivo ovaries from 16 patients were investigated. Statistically significant difference (p < 0.001) was observed between the average ...

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    2. Estimation of elastic parameters of ovarian tissue using phase stabilized swept source optical-coherence tomography

      Estimation of elastic parameters of ovarian tissue using phase stabilized swept source optical-coherence tomography

      We have estimated the micro-mechanical properties of ovarian tissue using phase-sensitive swept source optical coherence tomography. Ovary samples were mechanically excited by periodical vibration of an ultrasound transducer. The displacement and strain of the tissues were calculated during loading. Significant difference in strain was observed between the normal and malignant ovary groups, which indicates much softer and heterogeneous tissue structure for malignant ovaries. The initial results show that the phase sensitive swept source optical coherence elastography (OCE) can be an effective tool for characterization of stiffness and other micro-mechanical properties of normal and malignant ovarian tissue.

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    3. An overview of optical coherence tomography for ovarian tissue imaging and characterization

      An overview of optical coherence tomography for ovarian tissue imaging and characterization

      Ovarian cancer has the lowest survival rate among all the gynecologic cancers because it is predominantly diagnosed at late stages due to the lack of reliable symptoms and efficacious screening techniques. Optical coherence tomography (OCT) is an emerging technique that provides high-resolution images of biological tissue in real time, and demonstrates great potential for imaging of ovarian tissue. In this article, we review OCT studies for visualization and diagnosis of human ovaries as well as quantitative extraction of ovarian tissue optical properties for classifying normal and malignant ovaries. OCT combined with other imaging modalities to further improve ovarian tissue diagnosis ...

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    4. Optical and Photoacoustic Imaging for Ovarian Cancer Detection (Thesis)

      Optical and Photoacoustic Imaging for Ovarian Cancer Detection (Thesis)

      Ovarian cancer is the fifth most common cancer among women and has the highest mortality rate of all gynecologic cancers. Current clinical imaging modalities are limited by poor sensitivity and specificity. Therefore, there is an urgent need to develop effective tools to detect ovarian cancer. In this dissertation, two imaging modalities, optical coherence tomography (OCT) and photoacoustic imaging have been investigated for ovarian cancer detection and characterization. In the first modality, optical scattering coefficient, phase retardation and phase retardation rate were quantitatively extracted from polarization-sensitive OCT (PS-OCT) images. A highly positive correlation was found between those three parameters and collagen ...

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    5. A three-parameter logistic model to characterize ovarian tissue using polarization-sensitive optical coherence tomography

      A three-parameter logistic model to characterize ovarian tissue using polarization-sensitive optical coherence tomography

      Wang, Tianheng; Yang, Yi; Zhu, QuingIn this paper, a logistic prediction model is introduced to characterize the ovarian tissue. A new parameter, the phase retardation rate, was extracted from phase images of polarization-sensitive optical coherence tomography (PS-OCT). Statistical significance of this parameter between normal and ... [Biomed. Opt. Express 4, 772-777 (2013)]

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    6. Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomography

      Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomography

      Angle-resolved optical scattering properties of ovarian tissue, on different optical coherence tomography (OCT) imaging planes, were quantitatively measured by fitting the compounded OCT A-lines into a single scattering model. Higher cross correlation value of angle-resolved scattering coefficients between different OCT imaging planes was found in normal ovaries than was present in malignant ovaries. The mean cross correlation coefficient (MCC) was introduced in this pilot study to characterize and differentiate normal, n=6 , and malignant, n=4 , ovaries. A specificity of 100 percent and a sensitivity of 100 percent were achieved by setting MCC threshold at 0.6. Collagen properties, within ...

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    7. Assessment of collagen changes in ovarian tissue by extracting optical scattering coefficient from OCT images

      Assessment of collagen changes in ovarian tissue by extracting optical scattering coefficient from OCT images

      Optical scattering coefficient from ex-vivo unfixed normal and malignant ovarian tissue was quantitatively extracted by fitting optical coherence tomography (OCT) A-line signals to a single scattering model. 1097 average A-line measurements at a wavelength of 1310nm were performed at 108 sites obtained from 18 ovaries. The average scattering coefficient obtained from normal group consisted of 833 measurements from 88 sites was 2.41 mm-1 (±0.59), while the average coefficient obtained from malignant group consisted of 264 measurements from 20 sites was 1.55 mm-1 (±0.46). Using a threshold of 2 mm-1 for each ovary, a sensitivity of 100 ...

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    8. Feature Of The Week 10/23/11: Hybrid Intraoperative Probe Based on OCT and Positron Detection for Ovarian Cancer Detection

      Feature Of The Week 10/23/11: Hybrid Intraoperative Probe Based on OCT and Positron Detection for Ovarian Cancer Detection
      Multi-modality imaging involving OCT and one or more additional imaging technologies continues to show very promising results for increasing the diagnostic and interventional guidance capability of biomedical imaging probes. These synergistic effects have been published in numerous papers over the past year. This includes OCT in combination with fluorescence, Raman, NIR, ultrasound, and other technologies. Such approaches have the obvious disadvantage of increasing the cost and complexity of the imaging system but often that burden is offset by significantly increased performance. Recently a group from the University of Connecticut published a paper on a hybrid intraoperative probe that used OCT ...
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    9. Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue

      Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue
      Optical scattering coefficient from ex vivo unfixed normal and malignant ovarian tissue was quantitatively extracted by fitting optical coherence tomography (OCT) A-line signals to a single scattering model. 1097 average A-line measurements at a wavelength of 1310 nm were performed at 108 sites obtained from 18 ovaries. The average scattering coefficient obtained from the normal tissue group consisted of 833 measurements from 88 sites was 2.41 mm−1 (±0.59), while the average coefficient obtained from the malignant tissue group consisted of 264 measurements from 20 sites was 1.55 mm−1 (±0.46). The malignant ovarian tissue showed ...
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    10. Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization

      Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization
      Ovarian cancer has the lowest survival rate of the gynecologic cancers because it is predominantly diagnosed in Stages III or IV due to the lack of reliable symptoms, as well as the lack of efficacious screening techniques. Detection before the malignancy spreads or at the early stage would greatly improve the survival and benefit patient health. In this report, we present an integrated optical coherence tomography (OCT), ultrasound (US) and photoacoustic imaging (PAI) prototype endoscopy system for ovarian tissue characterization. The overall diameter of the prototype endoscope is 5 mm which is suitable for insertion through a standard 5-12.5mm ...
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    11. 3D imaging of dental hard tissues with Fourier domain optical coherence tomography

      3D imaging of dental hard tissues with Fourier domain optical coherence tomography
      A fiber optical coherence tomography (OCT) probe is used for three dimensional dental imaging. The probe has a lightweight miniaturized design with a size of a pen to facilitate clinic in vivo diagnostics. The probe is interfaced with a swept-source / Fourier domain optical coherence tomography at 20K axial scanning rate. The tooth samples were scanned from occlusal, buccal, lingual, mesial, and distal orientations. Three dimensional imaging covers tooth surface area up to 10 mm x 10 mm with a depth about 5 mm, where a majority of caries affection occurs. OCT image provides better resolution and contrast compared to gold ...
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    12. Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization

      Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization
      Ovarian cancer has the lowest survival rate of the gynecologic cancers because it is predominantly diagnosed in the late stages due to the lack of reliable symptoms and efficacious screening techniques. A novel hybrid intraoperative probe has been developed and evaluated for its potential role in detecting and characterizing ovarian tissue. The hybrid intraoperative dual-modality device consists of multiple scintillating fibers and an optical coherence tomography imaging probe for simultaneously mapping the local activities of 18F-FDG uptake and imaging of local morphological changes of the ovary. Ten patients were recruited to the study and a total of 18 normal, abnormal ...
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    1-12 of 12
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  2. Topics in the News

    1. (12 articles) University of Connecticut
    2. (12 articles) Tianheng Wang
    3. (12 articles) Quing Zhu
    4. (10 articles) Molly Brewer
    5. (8 articles) Yi Yang
    6. (7 articles) Melinda Sanders
    7. (4 articles) Nrusingh C. Biswal
    8. (3 articles) Patrick D. Kumavor
    9. (2 articles) Mozafareddin Karimeddini
    10. (2 articles) John Vento
    11. (1 articles) British Columbia Cancer Agency
    12. (1 articles) Simon Fraser University
    13. (1 articles) Shanghai Jiao Tong University
    14. (1 articles) Pierre M. Lane
    15. (1 articles) Stephen Lam
    16. (1 articles) Julia Welzel
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    Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization 3D imaging of dental hard tissues with Fourier domain optical coherence tomography Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue Feature Of The Week 10/23/11: Hybrid Intraoperative Probe Based on OCT and Positron Detection for Ovarian Cancer Detection Assessment of collagen changes in ovarian tissue by extracting optical scattering coefficient from OCT images Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomography A three-parameter logistic model to characterize ovarian tissue using polarization-sensitive optical coherence tomography Optical and Photoacoustic Imaging for Ovarian Cancer Detection (Thesis) Estimation of elastic parameters of ovarian tissue using phase stabilized swept source optical-coherence tomography Line-field confocal optical coherence tomography-Practical applications in dermatology and comparison with established imaging methods Optical coherence tomography detection of changes in inner retinal and choroidal thicknesses in patients with early retinitis pigmentosa