1. Articles from Lauren S. Talman

    1-2 of 2
    1. Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Background Low-contrast letter acuity and optical coherence tomography (OCT) capture visual dysfunction and axonal loss in adult-onset multiple sclerosis (MS), and have been proposed as secondary outcome metrics for therapeutic trials. Clinical trials will soon be launched in pediatric MS, but such outcome metrics have not been well-validated in this population. Objectives To determine whether MS onset during childhood and adolescence is associated with measurable loss of visual acuity and thinning of the retinal nerve fiber layer (RNFL), whether such features are noted only in the context of clinical optic nerve inflammation (optic neuritis, ON) or are a feature of ...

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    2. Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique

      Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique
      Background: Neuronal loss in the retina has been demonstrated pathologically in eyes of patients with multiple sclerosis (MS). In vivo, MS eyes have reduced total macular volumes by optical coherence tomography (OCT). Using a high-resolution spectral-domain OCT, this pilot study used a manual method to measure ganglion cell layer (GCL) volumes and to determine the relation of these volumes to visual function in MS eyes. Methods: Sixteen eyes of 8 patients with MS and 8 eyes of 5 disease-free control participants were studied using fast macular OCT scans performed with Spectralis OCT (Heidelberg Engineering). Visual function tests of low-contrast letter ...
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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Pennsylvania
    2. (2 articles) Johns Hopkins University
    3. (2 articles) UT Southwestern Medical Center
    4. (2 articles) Peter A. Calabresi
    5. (2 articles) Laura J. Balcer
    6. (2 articles) Elliot M. Frohman
    7. (2 articles) Richard F. Spaide
    8. (2 articles) Bruno Lumbroso
    9. (2 articles) David Huang
    10. (2 articles) James G. Fujimoto
    11. (2 articles) Philip J. Rosenfeld
    12. (1 articles) Amy Conger
    13. (1 articles) Heidelberg Engineering
    14. (1 articles) Zeiss Stratus OCT
    15. (1 articles) Heidelberg Spectralis
    16. (1 articles) Massachusetts Institute of Technology
    17. (1 articles) Ruikang K. Wang
    18. (1 articles) Srinivas R. Sadda
    19. (1 articles) Richard B. Rosen
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    Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis Arvo Special Interest Group Meeting on Optical Coherence Tomography Angiography of the Eye Call for Papers for the 3rd International "En Face" OCT and OCT Angiography Congress, Rome December 11 2015 Automated detection of dentinal lesions in OCT images using the RKT transformation Apices of maxillary premolars observed by swept source optical coherence tomography Observation of the pulp horn by swept source optical coherence tomography and cone beam computed tomography Signal processing of Spectral Domain Optical Coherence Tomography Feature Of The Week 03/01/15: Three-dimensional Imaging and Analysis of Human Cartilage Degeneration Using Optical Coherence Tomography Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy Optical coherence tomography features of angiographic complex and smooth lesions in acute coronary syndromes Assessment of defects at tooth/self-adhering flowable composite interface using swept-source optical coherence tomography (SS-OCT)