1. Articles from Lauren S. Talman

    1-2 of 2
    1. Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Background Low-contrast letter acuity and optical coherence tomography (OCT) capture visual dysfunction and axonal loss in adult-onset multiple sclerosis (MS), and have been proposed as secondary outcome metrics for therapeutic trials. Clinical trials will soon be launched in pediatric MS, but such outcome metrics have not been well-validated in this population. Objectives To determine whether MS onset during childhood and adolescence is associated with measurable loss of visual acuity and thinning of the retinal nerve fiber layer (RNFL), whether such features are noted only in the context of clinical optic nerve inflammation (optic neuritis, ON) or are a feature of ...

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    2. Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique

      Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique
      Background: Neuronal loss in the retina has been demonstrated pathologically in eyes of patients with multiple sclerosis (MS). In vivo, MS eyes have reduced total macular volumes by optical coherence tomography (OCT). Using a high-resolution spectral-domain OCT, this pilot study used a manual method to measure ganglion cell layer (GCL) volumes and to determine the relation of these volumes to visual function in MS eyes. Methods: Sixteen eyes of 8 patients with MS and 8 eyes of 5 disease-free control participants were studied using fast macular OCT scans performed with Spectralis OCT (Heidelberg Engineering). Visual function tests of low-contrast letter ...
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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Pennsylvania
    2. (2 articles) Johns Hopkins University
    3. (2 articles) UT Southwestern Medical Center
    4. (2 articles) Peter A. Calabresi
    5. (2 articles) Laura J. Balcer
    6. (2 articles) Elliot M. Frohman
    7. (2 articles) Carl Zeiss Meditec
    8. (1 articles) Amy Conger
    9. (1 articles) Heidelberg Engineering
    10. (1 articles) Zeiss Stratus OCT
    11. (1 articles) Heidelberg Spectralis
    12. (1 articles) Massachusetts General Hospital
    13. (1 articles) Medical University of Vienna
    14. (1 articles) Harvard University
    15. (1 articles) Massachusetts Institute of Technology
    16. (1 articles) Guillermo J. Tearney
    17. (1 articles) Manabu Kashiwagi
    18. (1 articles) Ursula Schmidt-Erfurth
    19. (1 articles) Linbo Liu
    20. (1 articles) Zeiss Visante OCT
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