1. Articles from Lauren S. Talman

    1-2 of 2
    1. Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Background Low-contrast letter acuity and optical coherence tomography (OCT) capture visual dysfunction and axonal loss in adult-onset multiple sclerosis (MS), and have been proposed as secondary outcome metrics for therapeutic trials. Clinical trials will soon be launched in pediatric MS, but such outcome metrics have not been well-validated in this population. Objectives To determine whether MS onset during childhood and adolescence is associated with measurable loss of visual acuity and thinning of the retinal nerve fiber layer (RNFL), whether such features are noted only in the context of clinical optic nerve inflammation (optic neuritis, ON) or are a feature of ...

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    2. Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique

      Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique
      Background: Neuronal loss in the retina has been demonstrated pathologically in eyes of patients with multiple sclerosis (MS). In vivo, MS eyes have reduced total macular volumes by optical coherence tomography (OCT). Using a high-resolution spectral-domain OCT, this pilot study used a manual method to measure ganglion cell layer (GCL) volumes and to determine the relation of these volumes to visual function in MS eyes. Methods: Sixteen eyes of 8 patients with MS and 8 eyes of 5 disease-free control participants were studied using fast macular OCT scans performed with Spectralis OCT (Heidelberg Engineering). Visual function tests of low-contrast letter ...
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    1-2 of 2
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    1. (2 articles) University of Pennsylvania
    2. (2 articles) Johns Hopkins University
    3. (2 articles) UT Southwestern Medical Center
    4. (2 articles) Peter A. Calabresi
    5. (2 articles) Laura J. Balcer
    6. (2 articles) Elliot M. Frohman
    7. (1 articles) Amy Conger
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    Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis Optical Coherence Tomography of De Novo Lesions and In-Stent Restenosis in Coronary Saphenous Vein Grafts (OCTOPUS Study) Optical clearing for luminal organ imaging with ultrahigh-resolution optical coherence tomography OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION IN FOUR INHERITED RETINAL DYSTROPHIES Agreement between intraoperative measurements and optical coherence tomography of the limbus-insertion distance of the extraocular muscles Impact of chronic kidney disease stages on atherosclerotic plaque components on optical coherence tomography in patients with coronary artery disease Central Corneal Thickness in Spectral-Domain OCT and Associations with Ocular and Systemic Parameters Clinical applications of spectral domain optical coherence tomography in retinal diseases Diagnostic performance of a novel 3D neuroretinal rim parameter for glaucoma using high-density volume scans Spectral-Domain Optical Coherence Tomography Angiography Findings in Multifocal Choroiditis with Active Lesions Subretinal hyperreflective material imaged with optical coherence tomography angiography