1. Articles from Lauren S. Talman

    1-2 of 2
    1. Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Background Low-contrast letter acuity and optical coherence tomography (OCT) capture visual dysfunction and axonal loss in adult-onset multiple sclerosis (MS), and have been proposed as secondary outcome metrics for therapeutic trials. Clinical trials will soon be launched in pediatric MS, but such outcome metrics have not been well-validated in this population. Objectives To determine whether MS onset during childhood and adolescence is associated with measurable loss of visual acuity and thinning of the retinal nerve fiber layer (RNFL), whether such features are noted only in the context of clinical optic nerve inflammation (optic neuritis, ON) or are a feature of ...

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    2. Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique

      Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique
      Background: Neuronal loss in the retina has been demonstrated pathologically in eyes of patients with multiple sclerosis (MS). In vivo, MS eyes have reduced total macular volumes by optical coherence tomography (OCT). Using a high-resolution spectral-domain OCT, this pilot study used a manual method to measure ganglion cell layer (GCL) volumes and to determine the relation of these volumes to visual function in MS eyes. Methods: Sixteen eyes of 8 patients with MS and 8 eyes of 5 disease-free control participants were studied using fast macular OCT scans performed with Spectralis OCT (Heidelberg Engineering). Visual function tests of low-contrast letter ...
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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Pennsylvania
    2. (2 articles) Johns Hopkins University
    3. (2 articles) UT Southwestern Medical Center
    4. (2 articles) Peter A. Calabresi
    5. (2 articles) Laura J. Balcer
    6. (2 articles) Elliot M. Frohman
    7. (2 articles) National Institutes of Health
    8. (1 articles) Amy Conger
    9. (1 articles) Heidelberg Engineering
    10. (1 articles) Zeiss Stratus OCT
    11. (1 articles) Heidelberg Spectralis
    12. (1 articles) University of Washington
    13. (1 articles) Jost B. Jonas
    14. (1 articles) Florian M. Heussen
    15. (1 articles) Yanling Ouyang
    16. (1 articles) Eric J. Seibel
    17. (1 articles) Carl Zeiss Meditec
    18. (1 articles) Heidelberg Engineering
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    Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis University of Washington Received a 2014 NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 3D Pathology of Pancreas UC Irvine Receives NIH Grant for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging Fractional Flow Reserve and Optical Coherence Tomography Optical Coherence Tomography Velocimetry of Colloidal Suspensions Measurement of retinal nerve fiber layer and macular ganglion cell-inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen Retinal vessel diameter measurements by spectral domain optical coherence tomography Postdoctoral Research Associate at University of Liverpool Impact of Eicosapentaenoic Acid Treatment on the Fibrous Cap Thickness in Patients with Coronary Atherosclerotic Plaque: An Optical Coherence Tomography Study Mechanisms of Atherothrombosis and Vascular Response to Primary Percutaneous Coronary Intervention in Women Versus Men With Acute Myocardial Infarction : Results of the OCTAVIA (Optical Coherence Tomography Assessment of Gender Diversity in Primary Angiop Instant Stent-Accentuated 3-Dimensional Optical Coherence Tomography of a Bifurcation Lesion Treated With Reverse Minimum Overlapping Culotte Stenting