1. Articles from Lauren S. Talman

    1-2 of 2
    1. Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis

      Background Low-contrast letter acuity and optical coherence tomography (OCT) capture visual dysfunction and axonal loss in adult-onset multiple sclerosis (MS), and have been proposed as secondary outcome metrics for therapeutic trials. Clinical trials will soon be launched in pediatric MS, but such outcome metrics have not been well-validated in this population. Objectives To determine whether MS onset during childhood and adolescence is associated with measurable loss of visual acuity and thinning of the retinal nerve fiber layer (RNFL), whether such features are noted only in the context of clinical optic nerve inflammation (optic neuritis, ON) or are a feature of ...

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    2. Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique

      Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique
      Background: Neuronal loss in the retina has been demonstrated pathologically in eyes of patients with multiple sclerosis (MS). In vivo, MS eyes have reduced total macular volumes by optical coherence tomography (OCT). Using a high-resolution spectral-domain OCT, this pilot study used a manual method to measure ganglion cell layer (GCL) volumes and to determine the relation of these volumes to visual function in MS eyes. Methods: Sixteen eyes of 8 patients with MS and 8 eyes of 5 disease-free control participants were studied using fast macular OCT scans performed with Spectralis OCT (Heidelberg Engineering). Visual function tests of low-contrast letter ...
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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Pennsylvania
    2. (2 articles) Johns Hopkins University
    3. (2 articles) UT Southwestern Medical Center
    4. (2 articles) Peter A. Calabresi
    5. (2 articles) Laura J. Balcer
    6. (2 articles) Elliot M. Frohman
    7. (1 articles) Amy Conger
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    11. (1 articles) Center for Ophthalmic Optics and Lasers
    12. (1 articles) Yale University
    13. (1 articles) University of Copenhagen
    14. (1 articles) Oregon Health & Science University
    15. (1 articles) Michael Larsen
    16. (1 articles) David Huang
    17. (1 articles) Michael A. Choma
    18. (1 articles) Steven T. Bailey
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    Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis: Application of a High-Precision Manual Estimation Technique Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis Dispersion and compensation of optical coherence tomography using double-path rapid scanning optical delay line Evaluation of the macular choroidal thickness using spectral-domain optical coherence tomography in patients with obstructive sleep apnoea syndrome: response Application of fractional flow reserve and optical coherence tomography examinations in a patient presenting with recurrent angina: a case report OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF DIABETIC RETINOPATHY Long-Term Changes of Macular Thickness after Pars Plana Vitrectomy in Optic Disc Pit Maculopathy: A Spectral-Domain Optical Coherence Tomography Study Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography Two-grating Talbot bands spectral-domain interferometer Natural History of Idiopathic Epiretinal Membrane in Eyes with Good Vision Assessed by Spectral-Domain Optical Coherence Tomography Optical coherence tomography angiography of shallow irregular pigment epithelial detachments in pachychoroid spectrum disease - American Journal of Ophthalmology