1. Articles from D. D. Sampson

    1-13 of 13
    1. Can normal lymph node architecture be characterised by optical coherence tomography?

      Can normal lymph node architecture be characterised by optical coherence tomography?

      Assessment of lymph node involvement is a key prognostic marker in early breast cancer. This paper demonstrates the ability of optical coherence tomography (OCT) to characterise the micro-architecture of healthy, non-cancerous lymph nodes. OCT is shown to differentiate stroma, cortex and adipose tissue. Characteristic patterns are also identified for germinal centres and blood vessels within the node. Results are correlated against a histopathological gold standard.

      Read Full Article
    2. 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      Evaluation of degradation in the structure of skeletal muscle is important for the assessment or diagnosis of many myopathies, such as Duchenne muscular dystrophy. Histological analysis is the gold standard to evaluate such degradation but requires excision and fixation of the tissue. This is undesirably invasive in patients and precludes longitudinal study of disease progression in patients or animal models. Optical coherence tomography (OCT) is a high-resolution (∼10μm) imaging modality capable of visualising muscle structure and the morphological changes in muscular dystrophy. However, because of the limited image penetration of OCT (∼2mm), previous studies have been restricted to imaging ...

      Read Full Article
    3. Identification of muscle necrosis in mdx mice using optical birefringence imaging

      Identification of muscle necrosis in mdx mice using optical birefringence imaging

      Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy, resulting in muscle degeneration and necrosis. Healthy skeletal muscle has a high degree of birefringence, caused by the regular arrangement of myofibrils. Birefringence decreases when the muscle becomes inflamed or necrotic and this arrangement breaks down. Hence birefringence is usable as a source of image contrast for identifying regions of damage. The mdx mouse is a well-established animal model for DMD. Assessment of the extent of muscle damage and necrosis in these mice is performed by analysis of histological sections, but this requires excision and fixation of the tissue ...

      Read Full Article
    4. Ultrathin side-viewing needle probe for optical coherence tomography

      Ultrathin side-viewing needle probe for optical coherence tomography

      We present the smallest reported side-viewing needle probe for optical coherence tomography (OCT). Design, fabrication, optical characterization, and initial application of a 30-gauge (outer diameter 0.31 mm) needle probe are demonstrated. Extreme miniaturization is achieved by using a simple all-fiber probe design incorporating an angle-polished and reflection-coated fiber-tip beam deflector. When inserted into biological tissue, aqueous interstitial fluids reduce the probe’s inherent astigmatism ratio to 1.8, resulting in a working distance of 300 μm and a depth-of-field of 550 μm with beam diameters below 30 μm. The needle probe was interfaced with an 840 nm spectral-domain OCT ...

      Read Full Article
    5. Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

      The ability to measure airway dimensions is important for clinicians, interventional bronchoscopists and researchers in order to accurately quantify structural abnormalities and track their changes over time or in response to treatment. Most quantitative airway measurements are based on X-ray computed tomography and, more recently, on multidetector computed tomography. Quantitative bronchoscopic techniques have also been developed, although these are less widely employed. Emerging techniques, including magnetic resonance imaging, endoscopic optical coherence tomography, endobronchial ultrasound and confocal endomicroscopy, provide new research tools with potential clinical applications. An understanding of issues related to the acquisition, processing and analysis of images, and how ...
      Read Full Article
    6. Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography

      Airway dimensions are difficult to quantify bronchoscopically because of optical distortion and a limited ability to gauge depth. Anatomical optical coherence tomography (aOCT), a novel imaging technique, may overcome these limitations. This study evaluated the accuracy of aOCT against existing techniques in phantom, excised pig and in vivo human airways. Three comparative studies were performed: (i) micrometer-derived area measurements in ten plastic tubes were compared to aOCT-derived area; (ii) aOCT-derived airway compliance curves from excised pig airways were compared to curves derived using an endoscopic technique; and (iii) airway dimensions from the trachea to subsegmental bronchi were measured using aOCT ...

      Read Full Article
    7. Lymph node micro-architecture can be imaged using optical coherence tomography

      Lymph node micro-architecture can be imaged using optical coherence tomography
      Background: Histological assessment is the gold standard technique for identification of lymph node involvement in breast cancer. However, this may only be performed ex vivo and will often result in the unnecessary excision of healthy lymph nodes. In axillary clearance, this will result in lymphedema in approximately 26% of patients. Optical Coherence Tomography (OCT) is a real-time imaging modality with the potential to perform in vivo optical biopsy of lymph nodes. We undertook ex vivo imaging of excised lymph nodes to identify which aspects of the lymph node micro-architecture could be imaged using OCT, and to identify differences between cancerous ...
      Read Full Article
    8. Spatial information transmission beyond a system's diffraction limit using optical spectral encoding of spatial frequency,

      IOP PUBLISHING J. Opt. A: Pure Appl. Opt. 10 (2008) 025304 (5pp) JOURNAL OF OPTICS A: PURE AND APPLIED OPTICS doi:10.1088/1464-4258/10/2/025304 Spatial information transmission beyond a system’s diffraction limit using optical spectral encoding of the spatial frequency S A Alexandrov1 and D D Sampson Optical and Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia, Crawley, WA 6009, Australia E-mail: sergey@ee.uwa.edu
      Read Full Article
    9. Three-dimensional optical coherence tomography of whole muscle autografts as a precursor to morphological assessment of muscular dystrophy in mice

      Three-dimensional optical coherence tomography of whole muscle autografts as a precursor to morphological assessment of muscular dystrophy in mice
      Journal of Biomedical Optics 13 1 , 011003 January/February 2008 Three-dimensional optical coherence tomography of whole-muscle autografts as a precursor to morphological assessment of muscular dystrophy in mice Blake R. Klyen Julian J. Armstrong Steven G. Adie The University of Western Australia School of Electrical, Electronic and Computer Engineering Optical+Biomedical Engineering Laboratory 35 Stirling Highway Crawley, Western Australia 6009 Australia Hannah G. Radley Miranda D. Grounds Th
      Read Full Article
    10. Anatomical optical coherence tomography: a safe and effective tool for quantitative long-term monitoring of upper airway size and shape

      J. J. Armstrong, S. Becker, R. A. McLaughlin et al. Anatomical optical coherence tomography (aOCT) is an endoscopic optical technique that enables continuous, quantitative assessment of hollow organ size and shape in three dimensions. It is a powerful alternative to X-ray computed tomography, magnetic resonance imaging, and video endoscopy for the as ... [Proc. SPIE Int. Soc. Opt. Eng. 6842, 68421N (2008)] published Fri Feb 8, 2008.
      Read Full Article
    11. Real-time dispersion compensation in scanning interferometry.

      We propose and demonstrate a method of real-time dispersion compensation suitable for scanning interferometry and optical coherence tomography. Static grating tilt in a scanning frequency-domain optical delay line is shown to produce dispersion that is linearly proportional to scan position, and we use this property to achieve depth-dependent dispersion compensation during an interferometric scan through a dispersive sample. PMID: 18033424 [PubMed - in process]
      Read Full Article
    12. Real-time detection technique for Doppler optical coherence tomography.

      We propose and demonstrate a novel detection technique, based on a modified electronic phase-locked loop, for Doppler optical coherence tomography. The technique permits real-time simultaneous reflectivity and continuous, bidirectional velocity mapping in turbid media over a wide velocity range with minimal sensitivity penalty compared with conventional optical coherence tomography, which is a major advance over current postprocessing and discrete parallel detection techniques. PMID: 18066302 [PubMed - in process]
      Read Full Article
    1-13 of 13
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (13 articles) University of Western Australia
    2. (13 articles) David D. Sampson
    3. (7 articles) Robert A. McLaughlin
    4. (6 articles) Sir Charles Gairdner Hospital
    5. (4 articles) Peter R. Eastwood
    6. (4 articles) Julian J. Armstrong
    7. (4 articles) David R. Hillman
    8. (4 articles) Blake R. Klyen
    9. (3 articles) Jonathan P. Williamson
    10. (3 articles) Xiaojie Yang
  3. Popular Articles

  4. Picture Gallery

    Three-dimensional optical coherence tomography of whole muscle autografts as a precursor to morphological assessment of muscular dystrophy in mice Lymph node micro-architecture can be imaged using optical coherence tomography Ultrathin side-viewing needle probe for optical coherence tomography Identification of muscle necrosis in mdx mice using optical birefringence imaging 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe Application of anterior segment optical coherence tomography to identify eyes with posterior polar cataract at high risk for posterior capsule rupture Feature Of The Week 11/23/14: Stanford University Investigates an Approach to Scalable Multiplexing for Parallel Imaging with Interleaved OCT Is it safe to implant bioresorbable scaffolds in ostial side-branch lesions? Impact of ‘neo-carina’ formation on main-branch flow pattern. Longitudinal clinical observations SPARSE AND LOW RANK DECOMPOSITION BASED BATCH IMAGE ALIGNMENT FOR SPECKLE REDUCTION OF RETINAL OCT IMAGES Evaluation of Corneal Stromal Demarcation Line after Two Different Protocols of Accelerated Corneal Collagen Cross-Linking Procedures Using Anterior Segment Optical Coherence Tomography and Confocal Microscopy Optical coherence tomography imaging of microfluidic pattern with different refractive index contrast Intraoperative Optical Coherence Tomography Using the RESCAN 700: Preliminary Results in Collagen Crosslinking