1. Articles from R. A. McLaughlin

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    1. Can normal lymph node architecture be characterised by optical coherence tomography?

      Can normal lymph node architecture be characterised by optical coherence tomography?

      Assessment of lymph node involvement is a key prognostic marker in early breast cancer. This paper demonstrates the ability of optical coherence tomography (OCT) to characterise the micro-architecture of healthy, non-cancerous lymph nodes. OCT is shown to differentiate stroma, cortex and adipose tissue. Characteristic patterns are also identified for germinal centres and blood vessels within the node. Results are correlated against a histopathological gold standard.

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    2. 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      Evaluation of degradation in the structure of skeletal muscle is important for the assessment or diagnosis of many myopathies, such as Duchenne muscular dystrophy. Histological analysis is the gold standard to evaluate such degradation but requires excision and fixation of the tissue. This is undesirably invasive in patients and precludes longitudinal study of disease progression in patients or animal models. Optical coherence tomography (OCT) is a high-resolution (∼10μm) imaging modality capable of visualising muscle structure and the morphological changes in muscular dystrophy. However, because of the limited image penetration of OCT (∼2mm), previous studies have been restricted to imaging ...

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    3. Identification of muscle necrosis in mdx mice using optical birefringence imaging

      Identification of muscle necrosis in mdx mice using optical birefringence imaging

      Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy, resulting in muscle degeneration and necrosis. Healthy skeletal muscle has a high degree of birefringence, caused by the regular arrangement of myofibrils. Birefringence decreases when the muscle becomes inflamed or necrotic and this arrangement breaks down. Hence birefringence is usable as a source of image contrast for identifying regions of damage. The mdx mouse is a well-established animal model for DMD. Assessment of the extent of muscle damage and necrosis in these mice is performed by analysis of histological sections, but this requires excision and fixation of the tissue ...

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    4. Ultrathin side-viewing needle probe for optical coherence tomography

      Ultrathin side-viewing needle probe for optical coherence tomography

      We present the smallest reported side-viewing needle probe for optical coherence tomography (OCT). Design, fabrication, optical characterization, and initial application of a 30-gauge (outer diameter 0.31 mm) needle probe are demonstrated. Extreme miniaturization is achieved by using a simple all-fiber probe design incorporating an angle-polished and reflection-coated fiber-tip beam deflector. When inserted into biological tissue, aqueous interstitial fluids reduce the probe’s inherent astigmatism ratio to 1.8, resulting in a working distance of 300 μm and a depth-of-field of 550 μm with beam diameters below 30 μm. The needle probe was interfaced with an 840 nm spectral-domain OCT ...

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    5. Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography

      Airway dimensions are difficult to quantify bronchoscopically because of optical distortion and a limited ability to gauge depth. Anatomical optical coherence tomography (aOCT), a novel imaging technique, may overcome these limitations. This study evaluated the accuracy of aOCT against existing techniques in phantom, excised pig and in vivo human airways. Three comparative studies were performed: (i) micrometer-derived area measurements in ten plastic tubes were compared to aOCT-derived area; (ii) aOCT-derived airway compliance curves from excised pig airways were compared to curves derived using an endoscopic technique; and (iii) airway dimensions from the trachea to subsegmental bronchi were measured using aOCT ...

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    6. Lymph node micro-architecture can be imaged using optical coherence tomography

      Lymph node micro-architecture can be imaged using optical coherence tomography
      Background: Histological assessment is the gold standard technique for identification of lymph node involvement in breast cancer. However, this may only be performed ex vivo and will often result in the unnecessary excision of healthy lymph nodes. In axillary clearance, this will result in lymphedema in approximately 26% of patients. Optical Coherence Tomography (OCT) is a real-time imaging modality with the potential to perform in vivo optical biopsy of lymph nodes. We undertook ex vivo imaging of excised lymph nodes to identify which aspects of the lymph node micro-architecture could be imaged using OCT, and to identify differences between cancerous ...
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    7. Anatomical optical coherence tomography: a safe and effective tool for quantitative long-term monitoring of upper airway size and shape

      J. J. Armstrong, S. Becker, R. A. McLaughlin et al. Anatomical optical coherence tomography (aOCT) is an endoscopic optical technique that enables continuous, quantitative assessment of hollow organ size and shape in three dimensions. It is a powerful alternative to X-ray computed tomography, magnetic resonance imaging, and video endoscopy for the as ... [Proc. SPIE Int. Soc. Opt. Eng. 6842, 68421N (2008)] published Fri Feb 8, 2008.
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    1-8 of 8
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  2. Topics in the News

    1. (8 articles) University of Western Australia
    2. (8 articles) David D. Sampson
    3. (7 articles) Robert A. McLaughlin
    4. (5 articles) Sir Charles Gairdner Hospital
    5. (3 articles) Peter R. Eastwood
    6. (3 articles) Julian J. Armstrong
    7. (3 articles) David R. Hillman
    8. (3 articles) Xiaojie Yang
    9. (3 articles) Blake R. Klyen
    10. (2 articles) Loretta Scolaro
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    Lymph node micro-architecture can be imaged using optical coherence tomography Ultrathin side-viewing needle probe for optical coherence tomography Identification of muscle necrosis in mdx mice using optical birefringence imaging 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe Can normal lymph node architecture be characterised by optical coherence tomography? Feature of the Week 10/19/14: Automated Classification of Optical Coherence Tomography Images for the Diagnosis of Oral Malignancy in the Hamster Cheek Pouch Fabrication method of ultra-small gradient-index fiber probe All-fiber wavelength swept ring laser based on  Fabry-Perot filter for optical frequency domain  imaging Comparison of Circulating Dendritic Cells and Monocyte Subsets at Different Stages of Atherosclerosis: insights from optical coherence tomography Swept-Source Optical Coherence Tomography Features of Choroidal Nevi Noise characterization of broadband fiber Cherenkov radiation as a visible-wavelength source for optical coherence tomography and two-photon fluorescence microscopy Optical Coherence Tomography Assessment of Angle Anatomy Changes After Trabeculectomy in Primary Angle-Closure Glaucoma