1. Articles from Mehmet Cilingiroglu

    1-15 of 15
    1. DIAMondback Atherectomy With OCT Visualization for Calcified PAD Lesions (DIAMOCT-PAD Study)

      DIAMondback Atherectomy With OCT Visualization for Calcified PAD Lesions (DIAMOCT-PAD Study)

      Objective . In this study, we aimed to describe the immediate and long-term vascular effects of OAS in patients with peripheral arterial disease (PAD) and moderate to severely calcified lesions. Background. Debulking the calcified atherosclerotic plaque with the orbital atherectomy system (OAS) can potentially enhance vessel compliance and increase the chance of reaching a desirable angioplasty result. Methods. A total of 7 patients were evaluated both at baseline and at 6-month follow-up. Following a diagnostic peripheral angiogram, patients with significant SFA disease had a baseline intravascular optical coherence tomography (IV-OCT) and the lesion was treated with OAS. Repeat IV-OCT was performed ...

      Read Full Article
    2. Coronary Stent Healing in Cancer Patients—An Optical Coherence Tomography Perspective

      Coronary Stent Healing in Cancer Patients—An Optical Coherence Tomography Perspective

      Objective: This study assessed stent healing patterns and cardiovascular outcomes by optical coherence tomography (OCT) in cancer patients after drug-eluting stent (DES) placement. Background: Cancer treatment, owing to its cytotoxic and antiproliferative effects, could delay stent healing and increase stent thrombosis risk, especially when dual antiplatelet therapy (DAPT) is discontinued early for oncological treatment. OCT can assess stent endothelialization and other healing parameters, which may provide clinical guidance in these challenging scenarios. Methods: This single-center retrospective study enrolled all cancer patients who underwent OCT for assessment of vascular healing patterns after prior DES placement from November 2009 to November 2018 ...

      Read Full Article
    3. Virtual Histology Optical Coherence Tomography Imaging of Orbital Rotational Atherectomy for Calcified Peripheral Arterial Disease

      Virtual Histology Optical Coherence Tomography Imaging of Orbital Rotational Atherectomy for Calcified Peripheral Arterial Disease

      A 72-year-old man with critical limb ischemia of the right lower extremity was referred for revascularization. His peripheral angiography showed severely calcified total occlusions of the right posterior tibial artery, peroneal arteries, and dorsalis pedis, with severe stenosis of the anterior tibial artery with collaterals (Figures 1A-1D). In order to assess the vascular effects of rotational orbital atherectomy, we performed intravascular imaging with virtual histology intravascular optical coherence tomography (VH-IVOCT) (Figures 2A-2F). We performed rotational orbital atherectomy of the calcified lesions in the anterior tibial artery using a 1.25 mm solid crown. Repeat angiography (Figure 1F) and VH-IVOCT (Figures ...

      Read Full Article
    4. The impact of therapeutic mediastinal radiation on stent healing in cancer patients: An optical coherence tomography study.

      The impact of therapeutic mediastinal radiation on stent healing in cancer patients: An optical coherence tomography study.

      Background: Cancer is a prothrombotic and proinflammatory state. Understanding stent healing in cancer patients could modify the approach to antiplatelet regimen and facilitate cancer treatment. Mediastinal radiation therapy brings an additional layer of complexity to an already challenging clinical scenario in cancer patients undergoing percutaneous coronary intervention (PCI). We sought to compare stent healing patterns with and without a history of mediastinal radiation therapy using optical coherence tomography (OCT) data. Methods: All cancer patients that underwent PCI and follow-up OCT less than 12 months post-PCI between 2009-2018 were retrospectively identified from our institutional cardiac catheterization laboratory registry. Stent healing, which ...

      Read Full Article
    5. Assessment of Vascular Patency and Inflammation with Intravascular Optical Coherence Tomography in Patients with Superficial Femoral Artery Disease Treated with Zilver PTX Stents

      Assessment of Vascular Patency and Inflammation with Intravascular Optical Coherence Tomography in Patients with Superficial Femoral Artery Disease Treated with Zilver PTX Stents

      Purpose Zilver PTX nitinol self-expanding drug-eluting stent with paclitaxel coating is effective for treatment of superficial femoral artery (SFA) disease. However, as with any stent, it induces a measure of vascular inflammatory response. The current clinical trial (NCT02734836) aimed to assess vascular patency, remodeling, and inflammatory markers with intravascular optical coherence tomography (OCT) in patients with SFA disease treated with Zilver PTX stents. Methods Serial OCT examinations were performed in 13 patients at baseline and 12-month follow-up. Variables evaluated included neointimal area, luminal narrowing, thrombus area, stent expansion as well as measures of inflammation including, peri-strut low-intensity area (PLIA), macrophage ...

      Read Full Article
    6. “Bringing on the light” in a complex clinical scenario: Optical coherence tomography–guided discontinuation of antiplatelet therapy in cancer patients with coronary artery disease (PROTECT-OCT registry)

      “Bringing on the light” in a complex clinical scenario: Optical coherence tomography–guided discontinuation of antiplatelet therapy in cancer patients with coronary artery disease (PROTECT-OCT registry)

      Background Cancer patients with recently placed drug-eluting stents (DESs) often require premature dual antiplatelet therapy (DAPT) discontinuation for cancer-related procedures. Optical coherence tomography (OCT) can identify risk factors for stent thrombosis such as stent malapposition, incomplete strut coverage and in-stent restenosis and may help guide discontinuation of DAPT. Methods We conducted a single-center prospective study in cancer patients with recently placed (1-12 months) DES who required premature DAPT discontinuation. Patients were evaluated with diagnostic coronary angiogram and OCT. Individuals with appropriate stent strut coverage, expansion, apposition, and absence of in-stent restenosis or intraluminal masses were considered low risk and transiently ...

      Read Full Article
    7. “Bringing on the light” in a complex clinical scenario - Optical coherence tomography-guided discontinuation of antiplatelet therapy in cancer patients with coronary artery disease (PROTECT-OCT registry)

      “Bringing on the light” in a complex clinical scenario - Optical coherence tomography-guided discontinuation of antiplatelet therapy in cancer patients with coronary artery disease (PROTECT-OCT registry)

      Background Cancer patients with recently placed drug-eluting stents (DESs) often require premature dual antiplatelet therapy (DAPT) discontinuation for cancer-related procedures. Optical coherence tomography (OCT) can identify risk factors for stent thrombosis such as stent malapposition, incomplete strut coverage and in-stent restenosis and may help guide discontinuation of DAPT. Methods We conducted a single-center prospective study in cancer patients with recently placed (1–12 months) DES who required premature DAPT discontinuation. Patients were evaluated with diagnostic coronary angiogram and OCT. Individuals with appropriate stent strut coverage, expansion, apposition, and absence of in-stent restenosis or intraluminal masses were considered low risk and ...

      Read Full Article
    8. Optical coherence tomography to guide below-the-knee endovascular interventions

      Optical coherence tomography to guide below-the-knee endovascular interventions

      Peripheral arterial disease remains a common cause of leg amputations causing significant morbidity and mortality. Data regarding below-the-knee endovascular interventions is scarce while long-term patency rates via different endovascular revascularization modalities remain limited. OCT offers excellent three dimension endothelial visualization; however its value to guide peripheral interventions has not been studied. We describe the use of OCT to guide endovascular below-the-knee interventions in order to achieve excellent OCT results.

      Read Full Article
    9. Optical Coherent Tomography to guide below-the-knee endovascular interventions

      Optical Coherent Tomography to guide below-the-knee endovascular interventions

      Peripheral arterial disease remains a common cause of leg amputations causing significant morbidity and mortality. Data regarding below-the-knee endovascular interventions is scarce while long-term patency rates via different endovascular revascularization modalities remain limited. OCT offers excellent three dimension endothelial visualization; however its value to guide peripheral interventions has not been studied. We describe the use of OCT to guide endovascular below-the-knee interventions in order to achieve excellent OCT results.

      Read Full Article
    10. Use of Optical Coherence Tomography During Superficial Femoral Artery Interventions

      Use of Optical Coherence Tomography During Superficial Femoral Artery Interventions

      Superficial femoral artery (SFA) disease accounts for approximately 40% of the symptomatic peripheral arterial disease and remains a common cause of critical limb ischemia and lower-extremity amputation. Optical coherence tomography (OCT) has been extensively studied in the coronary circulation; however, its use in the peripheral arterial circulation is scarce. We present two cases of OCT use as an ancillary imaging tool during SFA endovascular interventions

      Read Full Article
    11. Ocelot catheter for the recanalization of lower extremity arterial chronic total occlusion: Mini review

      Ocelot catheter for the recanalization of lower extremity arterial chronic total occlusion: Mini review

      Peripheral arterial disease (PAD) is a growing clinical condition affecting more than 10 million patients in the United States and it is responsible for more than 120,000 amputations annually. The presence of chronic total occlusions (CTO) increases the complexity of endovascular procedures and open surgery may often be the preferred approach. Despite the optimization of the CTO devices and technique, percutaneous CTO revascularization remains a challenging procedure even for experienced operators with important complication rates. The Ocelot TM system is a novel CTO device to use real-time optical coherence tomography (OCT) imaging guidance for the recanalization of peripheral CTOs ...

      Read Full Article
      Mentions: Avinger
    12. Optical coherence tomography imaging in asymptomatic patients with carotid artery stenosis

      Optical coherence tomography imaging in asymptomatic patients with carotid artery stenosis

      Assessment and treatment plan for asymptomatic patients with carotid stenosis are based on angiography at the present time. However, angiography or other imaging modalities are limited with their resolution to detect high-risk plaque features. Intravascular optical coherence tomography (IVOCT) recently emerged as a novel imaging modality with a unique resolution to identify vulnerable plaque characteristics. We report use of IVOCT in two separate asymptomatic patients with carotid stenosis with two different plaque types.

      Read Full Article
    13. Optical coherence tomographic detection of cells and compositions

      Optical coherence tomographic detection of cells and compositions
      Provided herein are systems and methods for the detection of cells and/or compositions using optical coherence tomography. The systems and methods comprise a plurality of magnets for applying a plurality of distinct magnetic field strengths to the cells and/or compositions and a phase sensitive optical coherence tomographic imaging modality for detecting the cells and/or compositions while same are disposed in the presence of at least one of the plurality of distinct magnetic field strengths.
      Read Full Article
    14. Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography

      Junghwan Oh, Marc D. Feldman, Jihoon Kim et al. We demonstrate the detection of iron oxide nanoparticles taken up by macrophages in atherosclerotic plaque with differential phase optical coherence tomography (DP-OCT). Magneto mechanical detection of nanoparticles is demonstrated in hyperlipidemic Watanabe and balloon-injured fat-fed New Zealand w ... [J. Biomed. Opt. 13, 054006 (2008)] published Tue Oct 14, 2008.
      Read Full Article
    1-15 of 15
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (6 articles) University of Texas at Austin
    2. (5 articles) University of Texas Health Science Center
    3. (3 articles) University of Alabama
    4. (2 articles) UT Southwestern Medical Center
    5. (2 articles) Leiden University
    6. (1 articles) University of Houston
    7. (1 articles) University of Pittsburgh
    8. (1 articles) Abbott
    9. (1 articles) Avinger
  3. Popular Articles

  4. Picture Gallery

    Optical coherence tomographic detection of cells and compositions Optical coherence tomography imaging in asymptomatic patients with carotid artery stenosis Ocelot catheter for the recanalization of lower extremity arterial chronic total occlusion: Mini review Use of Optical Coherence Tomography During Superficial Femoral Artery Interventions Optical Coherent Tomography to guide below-the-knee endovascular interventions Optical coherence tomography to guide below-the-knee endovascular interventions “Bringing on the light” in a complex clinical scenario - Optical coherence tomography-guided discontinuation of antiplatelet therapy in cancer patients with coronary artery disease (PROTECT-OCT registry) “Bringing on the light” in a complex clinical scenario: Optical coherence tomography–guided discontinuation of antiplatelet therapy in cancer patients with coronary artery disease (PROTECT-OCT registry) Assessment of Vascular Patency and Inflammation with Intravascular Optical Coherence Tomography in Patients with Superficial Femoral Artery Disease Treated with Zilver PTX Stents Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study Automatic Segmentation and Measurement of Choroid Layer in High Myopia for OCT Imaging Using Deep Learning In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography