1. Articles from Melissa J. Suter

    1-24 of 40 1 2 »
    1. Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography

      Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography

      Purpose: With recent advancements in personalized medicine, biopsies must contain sufficient tumor for histologic diagnosis and molecular testing. However, inadvertent biopsy of tumor-associated fibrosis compromises tumor yield, resulting in delayed diagnoses and/or repeat procedures when additional tumor is needed. The ability to differentiate tumor from fibrosis intraprocedurally during biopsy could significantly increase tumor yield. Polarization-sensitive optical coherence tomography (PS-OCT) is an imaging modality that is endoscope- and/or needle-compatible, and provides large volumetric views of tissue microstructure with high resolution (∼10 μm) while simultaneously measuring birefringence of organized tissues such as collagen. We aim to determine whether PS-OCT can ...

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    2. Processing-based approach for resolving the sample optic axis in endoscopic polarization-sensitive optical coherence tomography

      Processing-based approach for resolving the sample optic axis in endoscopic polarization-sensitive optical coherence tomography

      Fiber-based polarization-sensitive optical coherence tomography (PS-OCT) that utilizes a rotationally-scanning catheter has a variety of potential biomedical applications in luminal organ systems due to its ability to provide intrinsic contrast for birefringent tissue. Incorporating the optic axis (OA) of the tissue greatly enhances this potential by also permitting information about the orientation of the tissue to be extracted; however, measurement distortion that occurs has up to this point made it impossible to obtain accurate sample OA measurements. In this paper we present a straightforward calibration technique that allows the sample OA to be recovered. This technique requires no hardware modifications ...

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    3. Nano-optic endoscope for high-resolution optical coherence tomography in vivo

      Nano-optic endoscope for high-resolution optical coherence tomography in vivo

      Acquisition of high-resolution images from within internal organs using endoscopic optical imaging has numerous clinical applications. However, difficulties associated with optical aberrations and the trade-off between transverse resolution and depth of focus significantly limit the scope of applications. Here, we integrate a metalens, with the ability to modify the phase of incident light at subwavelength level, into the design of an endoscopic optical coherence tomography catheter (termed nano-optic endoscope) to achieve near diffraction-limited imaging through negating non-chromatic aberrations. Remarkably, the tailored chromatic dispersion of the metalens in the context of spectral interferometry is utilized to maintain high-resolution imaging beyond the ...

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    4. Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy

      Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy

      Background: Transbronchial needle aspiration (TBNA), often used to sample lymph nodes for lung cancer staging , is subject to sampling error even when performed with endobronchial ultrasound. Optical coherence tomography (OCT) is a high-resolution imaging modality that rapidly generates helical cross-sectional images. We aim to determine if needle-based OCT can provide microstructural information in lymph nodes that may be used to guide TBNA, and improve sampling error. Methods: We performed ex vivo needle-based OCT on thoracic lymph nodes from patients with and without known lung cancer. OCT imaging features were compared against matched histology. Results: OCT imaging was performed in 26 ...

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    5. Optical coherence tomography (OCT) imaging of dynamic airway behavior in an asthma model

      Optical coherence tomography (OCT) imaging of dynamic airway behavior in an asthma model

      To better understand bronchoconstriction in asthma, it is critical to dynamically visualize airway behavior in vivo. However, currently available imaging techniques do not have sufficient temporal and spatial resolution to investigate airway dynamics. We propose to use endobronchial Optical Coherence Tomography (OCT) to provide real-time cross-sectional images of airway dynamics with a high spatial resolution. Our aim was to study the structure and function of spatially distinct airways during tidal breathing (TB), breath-holds (BH) at end inspiration, and in a response to single deep inspiration (DI) and multiple DI (MDI) in a preclinical sheep asthma model. Anesthetized and mechanically ventilated ...

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    6. Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography

      Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography

      We propose a novel suite of algorithms for automatically segmenting the airway lumen and mucus in endobronchial optical coherence tomography (OCT) data sets, as well as a novel approach for quantifying the contents of the mucus. Mucus and lumen were segmented using a robust, multi-stage algorithm that requires only minimal input regarding sheath geometry. The algorithm performance was highly accurate in a wide range of airway and noise conditions. Mucus was classified using mean backscattering intensity and grey level co-occurrence matrix (GLCM) statistics. We evaluated our techniques in vivo in asthmatic and non-asthmatic volunteers.

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    7. Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

      Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

      In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forward-viewing probes, along with different scanning mechanisms (proximal-scanning versus distal-scanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic ...

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    8. Endoscopic biopsy apparatus, system and method

      Endoscopic biopsy apparatus, system and method

      Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more arrangements) to receive information associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique. Further, it is possible to ...

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    9. Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo

      Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo

      The inability to visualize airway smooth muscle (ASM) cells in vivo is a major obstacle in understanding their role in normal physiology and diseases. At present, there is no imaging modality available to assess ASM in vivo. Confocal endomicroscopy lacks the penetration depth and field of view, and conventional optical coherence tomography (OCT) does not have sufficient contrast to differentiate ASM from surrounding tissues. We have developed a birefringence microscopy platform that leverages the micro-organization of tissue to add further dimension to traditional OCT. We have used this technology to validate ASM measurements in ex vivo swine and canine studies ...

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    10. Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study

      Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study

      Intracoronary optical frequency domain imaging (OFDI), requires the displacement of blood for clear visualization of the artery wall. Radiographic contrast agents are highly effective at displacing blood however, may increase the risk of contrast-induced nephropathy. Flushing media viscosity, flow rate, and flush duration influence the efficiency of blood displacement necessary for obtaining diagnostic quality OFDI images. The aim of this work was to determine the optimal flushing parameters necessary to reliably perform intracoronary OFDI while reducing the volume of administered radiographic contrast, and assess the influence of flushing media choice on vessel wall measurements. 144 OFDI pullbacks were acquired together ...

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    11. Diagnosing Lung Carcinomas with Optical Coherence Tomography

      Diagnosing Lung Carcinomas with Optical Coherence Tomography

      Rationale: Lung carcinoma diagnosis on tissue biopsy can be challenging due to insufficient tumor and lack of architectural information. Optical coherence tomography (OCT) is a high-resolution imaging modality that visualizes tissue microarchitecture in volumes orders of magnitude larger than biopsy. It has been proposed that OCT could potentially replace tissue biopsy. Objectives: We aim to determine if OCT could replace histology in diagnosing lung carcinomas . We develop and validate OCT interpretation criteria for common primary lung carcinomas : adenocarcinoma, squamous cell carcinoma (SCC), and poorly differentiated carcinoma . Methods: A total of 82 ex vivo tumor samples were included in a blinded ...

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    12. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Background Biopsy surveillance protocols for the assessment of Barrett's esophagus can be subject to sampling errors, resulting in diagnostic uncertainty. Optical coherence tomography is a cross-sectional imaging technique that can be used to conduct volumetric laser endomicroscopy (VLE) of the entire distal esophagus. We have developed a biopsy guidance platform that places endoscopically visible marks at VLE-determined biopsy sites. Objective The objective of this study was to demonstrate in human participants the safety and feasibility of VLE-guided biopsy in vivo. Design A pilot feasibility study. Setting Massachusetts General Hospital. Patients A total of 22 participants were enrolled from January ...

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    13. Toward the Guidance of Transbronchial Biopsy Identifying Pulmonary Nodules With Optical Coherence Tomography

      Toward the Guidance of Transbronchial Biopsy Identifying Pulmonary Nodules With Optical Coherence Tomography

      Background Solitary pulmonary nodules (SPNs) frequently require transbronchial needle aspiration (TBNA) or biopsy to determine malignant potential, but have variable diagnostic yields. Confirming needle placement within SPNs during TBNA could significantly increase diagnostic yield. Optical coherence tomography (OCT) provides nondestructive, high-resolution, microstructural imaging with potential to distinguish SPN from parenchyma. We have developed needle-based OCT probes compatible with TBNA. Before OCT can play any significant role in guiding clinical TBNA, OCT interpretation criteria for differentiating SPN from lung parenchyma must be developed and validated. Methods OCT of SPN and parenchyma was performed on 111 ex vivo resection specimens. OCT criteria ...

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    14. Towards the guidance of transbronchial biopsy: Identifying pulmonary nodules with optical coherence tomography

      Towards the guidance of transbronchial biopsy: Identifying pulmonary nodules with optical coherence tomography

      Background: Solitary pulmonary nodules (SPN) frequently require transbronchial needle aspiration (TBNA) or biopsy to determine malignant potential, but have variable diagnostic yields. Confirming needle placement within SPNs during TBNA could significantly increase diagnostic yield. Optical coherence tomography (OCT) provides non-destructive, high-resolution, microstructural imaging with potential to distinguish SPN from parenchyma. We have previously developed needle-based OCT probes compatible with TBNA. Before OCT can play any significant role in guiding clinical TBNA, OCT interpretation criteria for differentiating SPN from lung parenchyma must be developed and validated. Methods: OCT of SPN and parenchyma was performed in 111 ex vivo resection specimens. OCT ...

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    15. Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation

      Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation

      Lung cancer is the leading cause of cancer-related deaths 1 . Squamous cell and small cell cancers typically arise in association with the conducting airways, whereas adenocarcinomas are typically more peripheral in location. Lung malignancy detection early in the disease process may be difficult due to several limitations: radiological resolution, bronchoscopic limitations in evaluating tissue underlying the airway mucosa and identifying early pathologic changes, and small sample size and/or incomplete sampling in histology biopsies. High resolution imaging modalities, such as optical frequency domain imaging (OFDI), provide non-destructive, large area 3-dimensional views of tissue microstructure to depths approaching 2 mm in ...

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    16. Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure

      Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure

      Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 μm (lateral) × 7 μm (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.

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    17. In Vivo Optical Coherence Tomography: The Role of the Pathologist

      In Vivo Optical Coherence Tomography: The Role of the Pathologist

      Optical coherence tomography (OCT) is a nondestructive, high-resolution imaging modality, providing cross-sectional, architectural images at near histologic resolutions, with penetration depths up to a few millimeters. Optical frequency domain imaging is a second-generation OCT technology that has equally high resolution with significantly increased image acquisition speeds and allows for large area, high-resolution tissue assessments. These features make OCT and optical frequency domain imaging ideal imaging techniques for surface and endoscopic imaging, specifically when tissue is unsafe to obtain and/or suffers from biopsy sampling error. This review focuses on the clinical impact of OCT in coronary, esophageal, and pulmonary imaging ...

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    18. Feature Of The Week 9/23/12: MGH Researchers Demonstrate Flexible Transbronchial OCT Imaging Needles for Biopsy Guidance

      Feature Of The Week 9/23/12: MGH Researchers Demonstrate Flexible Transbronchial OCT Imaging Needles for Biopsy Guidance

      Optical coherence tomography (OCT) systems routinely use single-mode optical fibers to transfer light to and from biological samples.  The tiny cross section, low-cost, and flexibility of single-mode optical fibers have proven to be a powerful attribute that allows for a wide variety optical coherence tomography (OCT) probes to be constructed including ultra small catheters, guidewires, and endoscope to get light to and from hard to reach places in the human body.  OCT equipped fiber optic needle probes are increasingly proving to be powerful technique for guidance of needle placement (search "needle" in the search box to see some of the ...

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    19. Optical frequency domain imaging system and catheters for volumetric imaging of the human esophagus

      Optical frequency domain imaging system and catheters for volumetric imaging of the human esophagus

      Barrett's esophagus (BE) is a metaplastic disorder that can undergo dysplastic progression, leading to esophageal adenocarcinoma. Upper endoscopy is the standard of care for screening for BE, but this technique has a relatively low diagnostic accuracy and high cost due to the requirement of conscious sedation. Optical frequency domain imaging (OFDI) is a high-speed imaging modality that generates cross-sectional images of tissues with a resolution of approximately 10µm that is sufficient for detecting microscopic tissue architecture. In combination with a balloon-centering catheter, this method enables BE diagnosis over the entire distal esophagus.   Full Text: PDFReferences S. H. Yun ...

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    20. Intravascular Optical Imaging Technology for Investigating the Coronary Artery

      Intravascular Optical Imaging Technology for Investigating the Coronary Artery
      There is an ever-increasing demand for new imaging methods that can provide additional information about the coronary wall to better characterize and stratify high-risk plaques, and to guide interventional and pharmacologic management of patients with coronary artery disease. While there are a number of imaging modalities that facilitate the assessment of coronary artery pathology, this review paper focuses on intravascular optical imaging modalities that provide information on the microstructural, compositional, biochemical, biomechanical, and molecular features of coronary lesions and stents. The optical imaging modalities discussed include angioscopy, optical coherence tomography, polarization sensitive-optical coherence tomography, laser speckle imaging, near-infrared spectroscopy, time-resolved ...
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    1-24 of 40 1 2 »
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  2. Topics in the News

    1. (40 articles) Massachusetts General Hospital
    2. (40 articles) Harvard University
    3. (39 articles) Melissa J. Suter
    4. (27 articles) Brett E. Bouma
    5. (23 articles) Guillermo J. Tearney
    6. (15 articles) Lida P. Hariri
    7. (14 articles) Benjamin J. Vakoc
    8. (11 articles) Norman S. Nishioka
    9. (9 articles) Milen Shishkov
    10. (6 articles) Michael Lanuti
    11. (1 articles) Fujian Normal University
    12. (1 articles) UCLA
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    14. (1 articles) Srinivas R. Sadda
    15. (1 articles) Yuhua Zhang
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    Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging Three-Dimensional Coronary Artery Microscopy by Intracoronary Optical Frequency Domain Imaging Performance of reduced bit-depth acquisition for optical frequency domain imaging A Case of Lipid Core Plaque Progression and Rupture at the Edge of a Coronary Stent: Elucidating the Mechanisms of Drug-Eluting Stent Failure An automatic image processing algorithm for initiating and terminating intracoronary OFDI pullback Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems Feature Of The Week 9/23/12: MGH Researchers Demonstrate Flexible Transbronchial OCT Imaging Needles for Biopsy Guidance Accuracy of optical coherence tomography imaging in assessing aneurysmal remnants after flow diversion Subtype-differentiated impacts of subretinal drusenoid deposits on photoreceptors revealed by adaptive optics scanning laser ophthalmoscopy Can ocular changes be detected early in children and adolescents with type 1 diabetes mellitus without retinopathy by using optical biometry and optical coherence tomography? CD4+/CD8+ ratio positively correlates with coronary plaque instability in unstable angina pectoris patients but fails to predict major adverse cardiovascular events