1. Articles from Mari Mino-Kenudson

    1-12 of 12
    1. Diagnosing Lung Carcinomas with Optical Coherence Tomography

      Diagnosing Lung Carcinomas with Optical Coherence Tomography

      Rationale: Lung carcinoma diagnosis on tissue biopsy can be challenging due to insufficient tumor and lack of architectural information. Optical coherence tomography (OCT) is a high-resolution imaging modality that visualizes tissue microarchitecture in volumes orders of magnitude larger than biopsy. It has been proposed that OCT could potentially replace tissue biopsy. Objectives: We aim to determine if OCT could replace histology in diagnosing lung carcinomas . We develop and validate OCT interpretation criteria for common primary lung carcinomas : adenocarcinoma, squamous cell carcinoma (SCC), and poorly differentiated carcinoma . Methods: A total of 82 ex vivo tumor samples were included in a blinded ...

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    2. Toward the Guidance of Transbronchial Biopsy Identifying Pulmonary Nodules With Optical Coherence Tomography

      Toward the Guidance of Transbronchial Biopsy Identifying Pulmonary Nodules With Optical Coherence Tomography

      Background Solitary pulmonary nodules (SPNs) frequently require transbronchial needle aspiration (TBNA) or biopsy to determine malignant potential, but have variable diagnostic yields. Confirming needle placement within SPNs during TBNA could significantly increase diagnostic yield. Optical coherence tomography (OCT) provides nondestructive, high-resolution, microstructural imaging with potential to distinguish SPN from parenchyma. We have developed needle-based OCT probes compatible with TBNA. Before OCT can play any significant role in guiding clinical TBNA, OCT interpretation criteria for differentiating SPN from lung parenchyma must be developed and validated. Methods OCT of SPN and parenchyma was performed on 111 ex vivo resection specimens. OCT criteria ...

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    3. Towards the guidance of transbronchial biopsy: Identifying pulmonary nodules with optical coherence tomography

      Towards the guidance of transbronchial biopsy: Identifying pulmonary nodules with optical coherence tomography

      Background: Solitary pulmonary nodules (SPN) frequently require transbronchial needle aspiration (TBNA) or biopsy to determine malignant potential, but have variable diagnostic yields. Confirming needle placement within SPNs during TBNA could significantly increase diagnostic yield. Optical coherence tomography (OCT) provides non-destructive, high-resolution, microstructural imaging with potential to distinguish SPN from parenchyma. We have previously developed needle-based OCT probes compatible with TBNA. Before OCT can play any significant role in guiding clinical TBNA, OCT interpretation criteria for differentiating SPN from lung parenchyma must be developed and validated. Methods: OCT of SPN and parenchyma was performed in 111 ex vivo resection specimens. OCT ...

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    4. Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation

      Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation

      Lung cancer is the leading cause of cancer-related deaths 1 . Squamous cell and small cell cancers typically arise in association with the conducting airways, whereas adenocarcinomas are typically more peripheral in location. Lung malignancy detection early in the disease process may be difficult due to several limitations: radiological resolution, bronchoscopic limitations in evaluating tissue underlying the airway mucosa and identifying early pathologic changes, and small sample size and/or incomplete sampling in histology biopsies. High resolution imaging modalities, such as optical frequency domain imaging (OFDI), provide non-destructive, large area 3-dimensional views of tissue microstructure to depths approaching 2 mm in ...

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    5. In Vivo Optical Coherence Tomography: The Role of the Pathologist

      In Vivo Optical Coherence Tomography: The Role of the Pathologist

      Optical coherence tomography (OCT) is a nondestructive, high-resolution imaging modality, providing cross-sectional, architectural images at near histologic resolutions, with penetration depths up to a few millimeters. Optical frequency domain imaging is a second-generation OCT technology that has equally high resolution with significantly increased image acquisition speeds and allows for large area, high-resolution tissue assessments. These features make OCT and optical frequency domain imaging ideal imaging techniques for surface and endoscopic imaging, specifically when tissue is unsafe to obtain and/or suffers from biopsy sampling error. This review focuses on the clinical impact of OCT in coronary, esophageal, and pulmonary imaging ...

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    6. Barrett's Esophagus Screening Using Balloon-Based Optical Frequency Domain Imaging: A Comparison With Endoscopy

      Abstracts submitted to ASGE 2010. Optical coherence tomography (OCT) is a high-resolution cross-sectional imaging modality that has been shown to accurately differentiate esophageal pathology relevant to screening and surveillance in Barrett's patients. We have previously demonstrated that optical frequency domain imaging (OFDI), a high speed 2nd generation embodiment of OCT, may be used to perform volumetric microscopy of the distal esophagus in patients. In this present study we compare the sensitivity of OFDI to endoscopy for the diagnosis of specialized intestinal metaplasia (SIM), using histopathology as the gold standard.

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    7. Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine

      Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine
      Background: Random biopsy esophageal surveillance can be subject to sampling errors, resulting in diagnostic uncertainty. Optical frequency domain imaging (OFDI) is a high-speed, 3-dimensional endoscopic microscopy technique. When deployed through a balloon-centering catheter, OFDI can automatically image the entire distal esophagus (6.0 cm length) in approximately 2 minutes. Objective: To test a new platform for guided biopsy that allows the operator to select target regions of interest on an OFDI dataset, and then use a laser to mark the esophagus at corresponding locations. The specific goals include determining the optimal laser parameters, testing the accuracy of the laser marking ...
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    8. Combined Reflection Confocal Microscopy and Optical Coherence Tomography Imaging of Esophageal Biopsy

      Reflection confocal microscopy (RCM) and optical coherence tomography (OCT) are two non-contact optical imaging technologies that provide images of tissue cellular and architectural morphology, which are both used for histopathologic diagnosis. We have developed a combined RCM and OCT system to compare the accuracy of these imaging techniques for diagnosing esophageal pathology and to evaluate the potential utility of merging the two modalities into a single imaging system. Clinical study was conducted on 32 human esophageal biopsy samples from 23 patients with various histories. Esophageal mucosa was differentiated from gastric mucosa, Barrett's esophagus with intestinal metaplasia was distinguished from ...
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    9. Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging

      Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging
      Background: Optical coherence tomography (OCT) is a cross-sectional, high-resolution imaging modality that has been shown to accurately differentiate esophageal specialized intestinal metaplasia (SIM) from gastric cardia at the squamocolumnar junction (SCJ) and diagnose high-grade dysplasia and intramucosal carcinoma in patients with SIM. The clinical utility of OCT has been limited, however, by its inability to acquire images over large areas.Objective: The aim of this study was to use recently developed high-speed OCT technology, termed optical frequency domain imaging (OFDI), and a new balloon-centering catheter (2.5 cm diameter) to demonstrate the feasibility of large area, comprehensive optical microscopy of ...
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    1-12 of 12
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  2. Topics in the News

    1. (12 articles) Massachusetts General Hospital
    2. (12 articles) Harvard University
    3. (12 articles) Melissa J. Suter
    4. (8 articles) Lida P. Hariri
    5. (7 articles) Guillermo J. Tearney
    6. (6 articles) Brett E. Bouma
    7. (5 articles) Michael Lanuti
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    11. (1 articles) British Columbia Cancer Agency
    12. (1 articles) Shanghai Jiao Tong University
    13. (1 articles) Singapore Eye Research Institute
    14. (1 articles) Simon Fraser University
    15. (1 articles) Columbia University
    16. (1 articles) Stephen Lam
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    Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine In Vivo Optical Coherence Tomography: The Role of the Pathologist Seeing beyond the Bronchoscope to Increase the Diagnostic Yield of Bronchoscopic Biopsy Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation Towards the guidance of transbronchial biopsy: Identifying pulmonary nodules with optical coherence tomography Diagnosis Of Primary Lung Carcinomas Using Optical Coherence Tomography Diagnosing Lung Carcinomas with Optical Coherence Tomography Line-field confocal optical coherence tomography-Practical applications in dermatology and comparison with established imaging methods Optical coherence tomography detection of changes in inner retinal and choroidal thicknesses in patients with early retinitis pigmentosa Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement Characterization of microvascular tortuosity in retinal vein occlusion utilizing optical coherence tomography angiography