1. Articles from Scott Martin

    1-3 of 3
    1. The Application of Optical Coherence Tomography in Musculoskeletal Disease

      The Application of Optical Coherence Tomography in Musculoskeletal Disease

      Many musculoskeletal disorders (MDs) are associated with irreversible bone and cartilage damage; this is particularly true for osteoarthritis (OA). Therefore, a clinical need exists for modalities which can detect OA and other MDs at early stages. Optical coherence tomography (OCT) is an infrared-based imaging, currently FDA approved in cardiology and ophthalmology, which has a resolution greater than 10 microns and acquisition rate of 120 frames/second. It has shown feasibility for imaging early OA, identifying changes prior to cartilage thinning both in vitro and in vivo in patients and in OA animal models. In addition, OCT has shown an ability ...

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    2. Single-Detector Polarization-Sensitive Optical Coherence Tomography for Assessment of Rotator Cuff Tendon Integrity

      Single-Detector Polarization-Sensitive Optical Coherence Tomography for Assessment of Rotator Cuff Tendon Integrity

      This preliminary study assessed trimmed supraspinatus tendons from rotator cuff repairs (RCRs) to compare the samples’ surgically cut ends and torn ends with histopathology and polarization-sensitive optical coherence tomography (PS-OCT) imaging. PS-OCT can be used to assess collagen content and organization in birefringent tissue and shows promise in RCR. The data were compared to determine correlations between luminosity measured from histopathology and PS-OCT. Bivariate plots and a simple regression were performed to assess the linearity of the 2 groups, with a predictive value of less than .05 showing significant correlation. Approximately 50% of the visually inspected supraspinatus tendons acceptable for ...

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    3. High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery

      High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery
      Abstract  This study demonstrates the first real-time imaging in vivo of human cartilage in normal and osteoarthritic knee joints at a resolution of micrometers, using optical coherence tomography (OCT). This recently developed high-resolution imaging technology is analogous to B-mode ultrasound except that it uses infrared light rather than sound. Real-time imaging with 11-μm resolution at four frames per second was performed on six patients using a portable OCT system with a handheld imaging probe during open knee surgery. Tissue registration was achieved by marking sites before imaging, and then histologic processing was performed. Structural changes including cartilage thinning, fissures, and ...
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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Brigham and Women’s Hospital
    2. (3 articles) Mark E. Brezinski
    3. (2 articles) Harvard University
    4. (1 articles) FDA
    5. (1 articles) Massachusetts Institute of Technology
    6. (1 articles) Costas D. Pitris
    7. (1 articles) James G. Fujimoto
    8. (1 articles) Xingde Li
    9. (1 articles) Northwestern University
    10. (1 articles) Wenzhou Medical College
    11. (1 articles) Jay S. Duker
    12. (1 articles) Joel S. Schuman
    13. (1 articles) Jin Wook Jeoung
    14. (1 articles) Hao F. Zhang
    15. (1 articles) James G. Fujimoto
    16. (1 articles) Cheng Sun
    17. (1 articles) Andre J. Witkin
    18. (1 articles) Tomey Corporation
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